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Volumn 19, Issue 4, 2006, Pages 255-265

The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome

Author keywords

C5a; C5aR; C5L2; Complement; MODS; Sepsis; SIRS

Indexed keywords

COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; IMMUNOMODULATING AGENT; MONOCLONAL ANTIBODY;

EID: 33746294701     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930600778263     Document Type: Review
Times cited : (36)

References (87)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • [INFOTRIEVE] [CSA]
    • Angus, D and Linde-Zwirble, W and Lidicker, J and Clermont, G and Carcillo, J and Pinsky, M. (2001) Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Crit Care Med, 29, pp. 1303-1310. [INFOTRIEVE] [CSA]
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.1    Linde-Zwirble, W.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.6
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Martin, G and Mannino, D and Eaton, S and Moss, M. (2003) The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med, 348, pp. 1546-1554. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.1    Mannino, D.2    Eaton, S.3    Moss, M.4
  • 3
    • 0024333745 scopus 로고
    • Sepsis syndrome: A valid clinical entity
    • [INFOTRIEVE] [CSA] Methylprednisolone Severe Sepsis Study Group
    • Bone, R and Fisher, C, Jr. and Clemmer, T and Slotman, G and Metz, C and Balk, R. (1989) Sepsis syndrome: A valid clinical entity. Methylprednisolone Severe Sepsis Study Group Crit Care Med, 17, pp. 389-393. [INFOTRIEVE] [CSA]
    • (1989) Crit Care Med , vol.17 , pp. 389-393
    • Bone, R.1    Fisher Jr., C.2    Clemmer, T.3    Slotman, G.4    Metz, C.5    Balk, R.6
  • 4
    • 0022364739 scopus 로고
    • Multiple-organ failure. Generalized autodestructive inflammation?
    • [INFOTRIEVE] [CSA]
    • Goris, R and te Boekhorst, T and Nuytinck, J and Gimbrere, J. (1985) Multiple-organ failure. Generalized autodestructive inflammation? Arch Surg, 120, pp. 1109-1115. [INFOTRIEVE] [CSA]
    • (1985) Arch Surg , vol.120 , pp. 1109-1115
    • Goris, R.1    te Boekhorst, T.2    Nuytinck, J.3    Gimbrere, J.4
  • 5
    • 0023790861 scopus 로고
    • Whole-body inflammation in trauma patients An autopsy study
    • [INFOTRIEVE] [CSA]
    • Nuytinck, H and Offermans, X and Kubat, K and Goris, J. (1988) Whole-body inflammation in trauma patients. An autopsy study Arch Surg, 123, pp. 1519-1524. [INFOTRIEVE] [CSA]
    • (1988) Arch Surg , vol.123 , pp. 1519-1524
    • Nuytinck, H.1    Offermans, X.2    Kubat, K.3    Goris, J.4
  • 6
    • 0026876699 scopus 로고
    • Definitions for sepsis and organ failure
    • [INFOTRIEVE] [CSA]
    • Bone, R and Sprung, C and Sibbald, W. (1992) Definitions for sepsis and organ failure Crit Care Med, 20, pp. 724-726. [INFOTRIEVE] [CSA]
    • (1992) Crit Care Med , vol.20 , pp. 724-726
    • Bone, R.1    Sprung, C.2    Sibbald, W.3
  • 7
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis The ACCP/SCCM Consensus Conference Committee
    • Bone, R and Balk, R and Cerra, F and et al. (1992). Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. In [pp. 1644-1655]. Chest
    • (1992) Chest , pp. 1644-1655
    • Bone, R.1    Balk, R.2    Cerra, F.3
  • 8
    • 17644388462 scopus 로고    scopus 로고
    • Role of C5a in inflammatory responses
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Guo, R and Ward, P. (2005) Role of C5a in inflammatory responses Annu Rev Immunol, 23, pp. 821-852. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2005) Annu Rev Immunol , vol.23 , pp. 821-852
    • Guo, R.1    Ward, P.2
  • 9
    • 0141608641 scopus 로고    scopus 로고
    • The enigma of sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Riedemann, N and Guo, R and Ward, P. (2003) The enigma of sepsis J Clin Invest, 112, pp. 460-467. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) J Clin Invest , vol.112 , pp. 460-467
    • Riedemann, N.1    Guo, R.2    Ward, P.3
  • 10
    • 1142310879 scopus 로고    scopus 로고
    • The dark side of C5a in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Ward, P. (2004) The dark side of C5a in sepsis Nat Rev Immunol, 4, pp. 133-142. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2004) Nat Rev Immunol , vol.4 , pp. 133-142
    • Ward, P.1
  • 11
    • 0023890664 scopus 로고
    • Molecular organization and function of the complement system
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Muller-Eberhard, H. (1988) Molecular organization and function of the complement system Annu Rev Biochem, 57, pp. 321-347. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1988) Annu Rev Biochem , vol.57 , pp. 321-347
    • Muller-Eberhard, H.1
  • 12
    • 0019364862 scopus 로고
    • The proteolytic activation systems of complement
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Reid, K and Porter, R. (1981) The proteolytic activation systems of complement Annu Rev Biochem, 50, pp. 433-464. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1981) Annu Rev Biochem , vol.50 , pp. 433-464
    • Reid, K.1    Porter, R.2
  • 13
    • 0036584407 scopus 로고    scopus 로고
    • Evolution of the lectin-complement pathway and its role in innate immunity
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Fujita, T. (2002) Evolution of the lectin-complement pathway and its role in innate immunity Nat Rev Immunol, 2, pp. 346-353. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) Nat Rev Immunol , vol.2 , pp. 346-353
    • Fujita, T.1
  • 14
    • 0345923834 scopus 로고    scopus 로고
    • The art of war: Innate and adaptive immune responses
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Dempsey, P and Vaidya, S and Cheng, G. (2003) The art of war: Innate and adaptive immune responses Cell Mol Life Sci, 60, pp. 2604-2621. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) Cell Mol Life Sci , vol.60 , pp. 2604-2621
    • Dempsey, P.1    Vaidya, S.2    Cheng, G.3
  • 15
    • 0036840236 scopus 로고    scopus 로고
    • Generation of C5a by phagocytic cells
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Younkin, E and Sarma, J and et al. (2002) Generation of C5a by phagocytic cells Am J Pathol, 161, pp. 1849-1859. [INFOTRIEVE] [CSA]
    • (2002) Am J Pathol , vol.161 , pp. 1849-1859
    • Huber-Lang, M.1    Younkin, E.2    Sarma, J.3    et al4
  • 16
    • 0037426723 scopus 로고    scopus 로고
    • Complement C5a in the sepsis syndrome - Too much of a good thing?
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Gerard, C. (2003) Complement C5a in the sepsis syndrome - Too much of a good thing? N Engl J Med, 348, pp. 167-169. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) N Engl J Med , vol.348 , pp. 167-169
    • Gerard, C.1
  • 17
    • 0024450510 scopus 로고
    • Endotoxin-induced shock in the rat. A role for C5a
    • [INFOTRIEVE] [CSA]
    • Smedegard, G and Cui, L and Hugli, T. (1989) Endotoxin-induced shock in the rat. A role for C5a Am J Pathol, 135, pp. 489-497. [INFOTRIEVE] [CSA]
    • (1989) Am J Pathol , vol.135 , pp. 489-497
    • Smedegard, G.1    Cui, L.2    Hugli, T.3
  • 18
    • 0033052453 scopus 로고    scopus 로고
    • Protective effects of C5a blockade in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Czermak, B and Sarma, V and Pierson, C and et al. (1999) Protective effects of C5a blockade in sepsis Nat Med, 5, pp. 788-792. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1999) Nat Med , vol.5 , pp. 788-792
    • Czermak, B.1    Sarma, V.2    Pierson, C.3
  • 19
    • 0036793526 scopus 로고    scopus 로고
    • Protection of innate immunity by C5aR antagonist in septic mice
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Huber-Lang, M and Riedeman, N and Sarma, J and et al. (2002) Protection of innate immunity by C5aR antagonist in septic mice FASEB J, 16, pp. 1567-1574. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) FASEB J , vol.16 , pp. 1567-1574
    • Huber-Lang, M.1    Riedeman, N.2    Sarma, J.3
  • 20
    • 0035286776 scopus 로고    scopus 로고
    • Protective effects of anti-C5a peptide antibodies in experimental sepsis
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Sarma, J and McGuire, S and et al. (2001) Protective effects of anti-C5a peptide antibodies in experimental sepsis FASEB J, 15, pp. 568-570. [INFOTRIEVE] [CSA]
    • (2001) FASEB J , vol.15 , pp. 568-570
    • Huber-Lang, M.1    Sarma, J.2    McGuire, S.3
  • 21
    • 0035863922 scopus 로고    scopus 로고
    • Role of C5a in multiorgan failure during sepsis
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Sarma, V and Lu, K and et al. (2001) Role of C5a in multiorgan failure during sepsis J Immunol, 166, pp. 1193-1199. [INFOTRIEVE] [CSA]
    • (2001) J Immunol , vol.166 , pp. 1193-1199
    • Huber-Lang, M.1    Sarma, V.2    Lu, K.3
  • 23
    • 0029912311 scopus 로고    scopus 로고
    • Chronological changes in the complement system in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Nakae, H and Endo, S and Inada, K and Yoshida, M. (1996) Chronological changes in the complement system in sepsis Surg Today, 26, pp. 225-229. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1996) Surg Today , vol.26 , pp. 225-229
    • Nakae, H.1    Endo, S.2    Inada, K.3    Yoshida, M.4
  • 24
    • 0029958832 scopus 로고    scopus 로고
    • Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome
    • [INFOTRIEVE] [CSA]
    • Stove, S and Welte, T and Wagner, T and et al. (1996) Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome Clin Diagn Lab Immunol, 3, pp. 175-183. [INFOTRIEVE] [CSA]
    • (1996) Clin Diagn Lab Immunol , vol.3 , pp. 175-183
    • Stove, S.1    Welte, T.2    Wagner, T.3
  • 25
    • 0024496137 scopus 로고
    • Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Hack, C and Nuijens, J and Felt-Bersma, R and et al. (1989) Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis Am J Med, 86, pp. 20-26. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1989) Am J Med , vol.86 , pp. 20-26
    • Hack, C.1    Nuijens, J.2    Felt-Bersma, R.3
  • 26
    • 0026656992 scopus 로고
    • Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease
    • [INFOTRIEVE] [CSA]
    • Gardinali, M and Padalino, P and Vesconi, S and et al. (1992) Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease Arch Surg, 127, pp. 1219-1224. [INFOTRIEVE] [CSA]
    • (1992) Arch Surg , vol.127 , pp. 1219-1224
    • Gardinali, M.1    Padalino, P.2    Vesconi, S.3
  • 27
    • 18044401434 scopus 로고    scopus 로고
    • C1-esterase-inhibitor treatment at early reperfusion of hemorrhagic shock reduces mesentry leukocyte adhesion and rolling
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Horstick, G and Kempf, T and Lauterbach, M and et al. (2001) C1-esterase-inhibitor treatment at early reperfusion of hemorrhagic shock reduces mesentry leukocyte adhesion and rolling Microcirculation, 8, pp. 427-433. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2001) Microcirculation , vol.8 , pp. 427-433
    • Horstick, G.1    Kempf, T.2    Lauterbach, M.3
  • 28
    • 0032937760 scopus 로고    scopus 로고
    • Combined antithrombin III and C1-esterase inhibitor treatment decreases intravascular fibrin deposition and attenuates cardiorespiratory impairment in rabbits exposed to Escherichia coli endotoxin
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Giebler, R and Schmidt, U and Koch, S and Peters, J and Scherer, R. (1999) Combined antithrombin III and C1-esterase inhibitor treatment decreases intravascular fibrin deposition and attenuates cardiorespiratory impairment in rabbits exposed to Escherichia coli endotoxin Crit Care Med, 27, pp. 597-604. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1999) Crit Care Med , vol.27 , pp. 597-604
    • Giebler, R.1    Schmidt, U.2    Koch, S.3    Peters, J.4    Scherer, R.5
  • 29
    • 0031570885 scopus 로고    scopus 로고
    • Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement
    • [INFOTRIEVE] [CSA]
    • Fischer, M and Prodeus, A and Nicholson-Weller, A and et al. (1997) Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement J Immunol, 159, pp. 976-982. [INFOTRIEVE] [CSA]
    • (1997) J Immunol , vol.159 , pp. 976-982
    • Fischer, M.1    Prodeus, A.2    Nicholson-Weller, A.3
  • 30
    • 0038445541 scopus 로고    scopus 로고
    • Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Zeerleder, S and Caliezi, C and van Mierlo, G and et al. (2003) Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis Clin Diagn Lab Immunol, 10, pp. 529-535. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) Clin Diagn Lab Immunol , vol.10 , pp. 529-535
    • Zeerleder, S.1    Caliezi, C.2    van Mierlo, G.3
  • 31
    • 0036348546 scopus 로고    scopus 로고
    • C1-inhibitor in patients with severe sepsis and septic shock: Beneficial effect on renal dysfunction
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Caliezi, C and Zeerleder, S and Redondo, M and et al. (2002) C1-inhibitor in patients with severe sepsis and septic shock: Beneficial effect on renal dysfunction Crit Care Med, 30, pp. 1722-1728. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) Crit Care Med , vol.30 , pp. 1722-1728
    • Caliezi, C.1    Zeerleder, S.2    Redondo, M.3
  • 32
    • 0034670027 scopus 로고    scopus 로고
    • Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock
    • [INFOTRIEVE] [CSA]
    • Kildsgaard, J and Hollmann, T and Matthews, K and Bian, K and Murad, F and Wetsel, R. (2000) Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock J Immunol, 165, pp. 5406-5409. [INFOTRIEVE] [CSA]
    • (2000) J Immunol , vol.165 , pp. 5406-5409
    • Kildsgaard, J.1    Hollmann, T.2    Matthews, K.3    Bian, K.4    Murad, F.5    Wetsel, R.6
  • 33
    • 23644456320 scopus 로고    scopus 로고
    • C3a expressed in the central nervous system protects against LPS-induced shock
    • [INFOTRIEVE] [CSA]
    • Boos, L and Szalai, A and Barnum, S. (2005) C3a expressed in the central nervous system protects against LPS-induced shock Neurosci Lett, 387, pp. 68-71. [INFOTRIEVE] [CSA]
    • (2005) Neurosci Lett , vol.387 , pp. 68-71
    • Boos, L.1    Szalai, A.2    Barnum, S.3
  • 34
    • 0018093401 scopus 로고
    • Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage
    • [INFOTRIEVE] [CSA]
    • Sacks, T and Moldow, C and Craddock, P and Bowers, T and Jacob, H. (1978) Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage J Clin Invest, 61, pp. 1161-1167. [INFOTRIEVE] [CSA]
    • (1978) J Clin Invest , vol.61 , pp. 1161-1167
    • Sacks, T.1    Moldow, C.2    Craddock, P.3    Bowers, T.4    Jacob, H.5
  • 35
    • 0014422327 scopus 로고
    • Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement
    • [INFOTRIEVE] [CSA]
    • Shin, H and Snyderman, R and Friedman, E and Mellors, A and Mayer, M. (1968) Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement Science, 162, pp. 361-363. [INFOTRIEVE] [CSA]
    • (1968) Science , vol.162 , pp. 361-363
    • Shin, H.1    Snyderman, R.2    Friedman, E.3    Mellors, A.4    Mayer, M.5
  • 36
    • 0016210354 scopus 로고
    • Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomes
    • [INFOTRIEVE] [CSA]
    • Goldstein, I and Weissmann, G. (1974) Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomes J Immunol, 113, pp. 1583-1588. [INFOTRIEVE] [CSA]
    • (1974) J Immunol , vol.113 , pp. 1583-1588
    • Goldstein, I.1    Weissmann, G.2
  • 37
    • 0026046011 scopus 로고
    • The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Schumacher, W and Fantone, J and Kunkel, S and Webb, R and Lucchesi, B. (1991) The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo Agents Actions, 34, pp. 345-349. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1991) Agents Actions , vol.34 , pp. 345-349
    • Schumacher, W.1    Fantone, J.2    Kunkel, S.3    Webb, R.4    Lucchesi, B.5
  • 38
    • 0344154671 scopus 로고
    • Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Chenoweth, D and Hugli, T. (1978) Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes Proc Natl Acad Sci USA, 75, pp. 3943-3947. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 3943-3947
    • Chenoweth, D.1    Hugli, T.2
  • 39
    • 0026078539 scopus 로고
    • The chemotactic receptor for human C5a anaphylatoxin
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Gerard, N and Gerard, C. (1991) The chemotactic receptor for human C5a anaphylatoxin Nature, 349, pp. 614-617. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1991) Nature , vol.349 , pp. 614-617
    • Gerard, N.1    Gerard, C.2
  • 40
    • 0029022132 scopus 로고
    • Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells
    • [INFOTRIEVE] [CSA]
    • Fureder, W and Agis, H and Willheim, M and et al. (1995) Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells J Immunol, 155, pp. 3152-3160. [INFOTRIEVE] [CSA]
    • (1995) J Immunol , vol.155 , pp. 3152-3160
    • Fureder, W.1    Agis, H.2    Willheim, M.3
  • 41
    • 0032941977 scopus 로고    scopus 로고
    • Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Zwirner, J and Gotze, O and Begemann, G and Kapp, A and Kirchhoff, K and Werfel, T. (1999) Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies Immunology, 97, pp. 166-172. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1999) Immunology , vol.97 , pp. 166-172
    • Zwirner, J.1    Gotze, O.2    Begemann, G.3    Kapp, A.4    Kirchhoff, K.5    Werfel, T.6
  • 42
    • 0032889730 scopus 로고    scopus 로고
    • Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Osaka, H and McGinty, A and Hoepken, U and Lu, B and Gerard, C and Pasinetti, G. (1999) Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration Neuroscience, 88, pp. 1073-1082. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1999) Neuroscience , vol.88 , pp. 1073-1082
    • Osaka, H.1    McGinty, A.2    Hoepken, U.3    Lu, B.4    Gerard, C.5    Pasinetti, G.6
  • 43
    • 0031031213 scopus 로고    scopus 로고
    • Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system
    • [INFOTRIEVE] [CSA]
    • Gasque, P and Singhrao, S and Neal, J and Gotze, O and Morgan, B. (1997) Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system Am J Pathol, 150, pp. 31-41. [INFOTRIEVE] [CSA]
    • (1997) Am J Pathol , vol.150 , pp. 31-41
    • Gasque, P.1    Singhrao, S.2    Neal, J.3    Gotze, O.4    Morgan, B.5
  • 44
    • 0033978132 scopus 로고    scopus 로고
    • The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Fayyazi, A and Scheel, O and Werfel, T and et al. (2000) The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells Immunology, 99, pp. 38-45. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2000) Immunology , vol.99 , pp. 38-45
    • Fayyazi, A.1    Scheel, O.2    Werfel, T.3
  • 45
    • 0033370490 scopus 로고    scopus 로고
    • Expression of the anaphylatoxin C5a receptor in non-myeloid cells
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Zwirner, J and Fayyazi, A and Gotze, O. (1999) Expression of the anaphylatoxin C5a receptor in non-myeloid cells Mol Immunol, 36, pp. 877-884. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1999) Mol Immunol , vol.36 , pp. 877-884
    • Zwirner, J.1    Fayyazi, A.2    Gotze, O.3
  • 47
    • 0031786533 scopus 로고    scopus 로고
    • Cultured human glomerular mesangial cells express the C5a receptor
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Braun, M and Davis, A, 3rd. (1998) Cultured human glomerular mesangial cells express the C5a receptor Kidney Int, 54, pp. 1542-1549. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1998) Kidney Int , vol.54 , pp. 1542-1549
    • Braun, M.1    Davis III, A.2
  • 48
    • 1542566334 scopus 로고
    • Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Mollison, K and Mandecki, W and Zuiderweg, E and et al. (1989) Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis Proc Natl Acad Sci USA, 86, pp. 292-296. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 292-296
    • Mollison, K.1    Mandecki, W.2    Zuiderweg, E.3
  • 49
    • 0024493978 scopus 로고
    • Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Zuiderweg, E and Nettesheim, D and Mollison, K and Carter, G. (1989) Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data Biochemistry, 28, pp. 172-185. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1989) Biochemistry , vol.28 , pp. 172-185
    • Zuiderweg, E.1    Nettesheim, D.2    Mollison, K.3    Carter, G.4
  • 50
    • 0038280149 scopus 로고    scopus 로고
    • Structure-function relationships of human C5a and C5aR
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Sarma, J and McGuire, S and et al. (2003) Structure-function relationships of human C5a and C5aR J Immunol, 170, pp. 6115-6124. [INFOTRIEVE] [CSA]
    • (2003) J Immunol , vol.170 , pp. 6115-6124
    • Huber-Lang, M.1    Sarma, J.2    McGuire, S.3
  • 51
    • 0028013658 scopus 로고
    • Two-site binding of C5a by its receptor: An alternative binding paradigm for G protein-coupled receptors
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Siciliano, S and Rollins, T and DeMartino, J and et al. (1994) Two-site binding of C5a by its receptor: An alternative binding paradigm for G protein-coupled receptors Proc Natl Acad Sci USA, 91, pp. 1214-1218. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1214-1218
    • Siciliano, S.1    Rollins, T.2    DeMartino, J.3
  • 52
    • 0036510770 scopus 로고    scopus 로고
    • The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
    • [INFOTRIEVE] [CSA]
    • Cain, S and Monk, P. (2002) The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74) J Biol Chem, 277, pp. 7165-7169. [INFOTRIEVE] [CSA]
    • (2002) J Biol Chem , vol.277 , pp. 7165-7169
    • Cain, S.1    Monk, P.2
  • 53
    • 0033709969 scopus 로고    scopus 로고
    • A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
    • [INFOTRIEVE] [CSA]
    • Ohno, M and Hirata, T and Enomoto, M and Araki, T and Ishimaru, H and Takahashi, T. (2000) A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells Mol Immunol, 37, pp. 407-412. [INFOTRIEVE] [CSA]
    • (2000) Mol Immunol , vol.37 , pp. 407-412
    • Ohno, M.1    Hirata, T.2    Enomoto, M.3    Araki, T.4    Ishimaru, H.5    Takahashi, T.6
  • 54
    • 0035977698 scopus 로고    scopus 로고
    • Identification of four novel human G protein-coupled receptors expressed in the brain
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Lee, D and George, S and Cheng, R and et al. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain Brain Res Mol Brain Res, 86, pp. 13-22. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2001) Brain Res Mol Brain Res , vol.86 , pp. 13-22
    • Lee, D.1    George, S.2    Cheng, R.3
  • 55
    • 0038662716 scopus 로고    scopus 로고
    • The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/ acylation-stimulating protein
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Kalant, D and Cain, S and Maslowska, M and Sniderman, A and Cianflone, K and Monk, P. (2003) The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein J Biol Chem, 278, pp. 11123-11129. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) J Biol Chem , vol.278 , pp. 11123-11129
    • Kalant, D.1    Cain, S.2    Maslowska, M.3    Sniderman, A.4    Cianflone, K.5    Monk, P.6
  • 56
    • 0041571471 scopus 로고    scopus 로고
    • C5L2, a nonsignaling C5A binding protein
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Okinaga, S and Slattery, D and Humbles, A and et al. (2003) C5L2, a nonsignaling C5A binding protein Biochemistry, 42, pp. 9406-9415. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) Biochemistry , vol.42 , pp. 9406-9415
    • Okinaga, S.1    Slattery, D.2    Humbles, A.3
  • 57
    • 0019446122 scopus 로고
    • Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation
    • [INFOTRIEVE] [CSA]
    • Solomkin, J and Jenkins, M and Nelson, R and Chenoweth, D and Simmons, R. (1981) Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation Surgery, 90, pp. 319-327. [INFOTRIEVE] [CSA]
    • (1981) Surgery , vol.90 , pp. 319-327
    • Solomkin, J.1    Jenkins, M.2    Nelson, R.3    Chenoweth, D.4    Simmons, R.5
  • 58
    • 1142292743 scopus 로고    scopus 로고
    • Neutrophil C5a receptor and the outcome in a rat model of sepsis
    • [INFOTRIEVE] [CSA]
    • Guo, R and Riedemann, N and Bernacki, K and et al. (2003) Neutrophil C5a receptor and the outcome in a rat model of sepsis FASEB J, 17, pp. 1889-1891. [INFOTRIEVE] [CSA]
    • (2003) FASEB J , vol.17 , pp. 1889-1891
    • Guo, R.1    Riedemann, N.2    Bernacki, K.3
  • 59
    • 0036336515 scopus 로고    scopus 로고
    • Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Furebring, M and Hakansson, L and Venge, P and Nilsson, B and Sjolin, J. (2002) Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis Crit Care, 6, pp. 363-370. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) Crit Care , vol.6 , pp. 363-370
    • Furebring, M.1    Hakansson, L.2    Venge, P.3    Nilsson, B.4    Sjolin, J.5
  • 60
    • 0036211296 scopus 로고    scopus 로고
    • Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Seely, A and Naud, J and Campisi, G and et al. (2002) Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo Ann Surg, 235, pp. 550-559. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) Ann Surg , vol.235 , pp. 550-559
    • Seely, A.1    Naud, J.2    Campisi, G.3
  • 61
    • 0026754770 scopus 로고
    • Cytokine-induced neutrophil-derived interleukin-8
    • [INFOTRIEVE] [CSA]
    • Strieter, R and Kasahara, K and Allen, R and et al. (1992) Cytokine-induced neutrophil-derived interleukin-8 Am J Pathol, 141, pp. 397-407. [INFOTRIEVE] [CSA]
    • (1992) Am J Pathol , vol.141 , pp. 397-407
    • Strieter, R.1    Kasahara, K.2    Allen, R.3
  • 62
    • 0029980816 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies
    • [INFOTRIEVE] [CSA]
    • Hopken, U and Mohr, M and Struber, A and et al. (1996) Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies Eur J Immunol, 26, pp. 1103-1109. [INFOTRIEVE] [CSA]
    • (1996) Eur J Immunol , vol.26 , pp. 1103-1109
    • Hopken, U.1    Mohr, M.2    Struber, A.3
  • 63
    • 0037111535 scopus 로고    scopus 로고
    • Expression and function of C5a receptor in mouse microvascular endothelial cells
    • [INFOTRIEVE] [CSA]
    • Laudes, I and Chu, J and Huber-Lang, M and et al. (2002) Expression and function of C5a receptor in mouse microvascular endothelial cells J Immunol, 169, pp. 5962-5970. [INFOTRIEVE] [CSA]
    • (2002) J Immunol , vol.169 , pp. 5962-5970
    • Laudes, I.1    Chu, J.2    Huber-Lang, M.3
  • 64
    • 0037083361 scopus 로고    scopus 로고
    • Expression and function of the C5a receptor in rat alveolar epithelial cells
    • [INFOTRIEVE] [CSA]
    • Riedemann, N and Guo, R and Sarma, V and et al. (2002) Expression and function of the C5a receptor in rat alveolar epithelial cells J Immunol, 168, pp. 1919-1925. [INFOTRIEVE] [CSA]
    • (2002) J Immunol , vol.168 , pp. 1919-1925
    • Riedemann, N.1    Guo, R.2    Sarma, V.3
  • 65
    • 0037871469 scopus 로고    scopus 로고
    • Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Monsinjon, T and Gasque, P and Chan, P and Ischenko, A and Brady, J and Fontaine, M. (2003) Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells FASEB J, 17, pp. 1003-1014. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) FASEB J , vol.17 , pp. 1003-1014
    • Monsinjon, T.1    Gasque, P.2    Chan, P.3    Ischenko, A.4    Brady, J.5    Fontaine, M.6
  • 66
    • 0036304968 scopus 로고    scopus 로고
    • Increased C5a receptor expression in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Riedemann, N and Guo, R and Neff, T and et al. (2002) Increased C5a receptor expression in sepsis J Clin Invest, 110, pp. 101-108. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) J Clin Invest , vol.110 , pp. 101-108
    • Riedemann, N.1    Guo, R.2    Neff, T.3
  • 67
    • 0037313970 scopus 로고    scopus 로고
    • Differential cytokine expression of human retinal pigment epithelial cells in response to stimulation by C5a
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Fukuoka, Y and Strainic, M and Medof, M. (2003) Differential cytokine expression of human retinal pigment epithelial cells in response to stimulation by C5a Clin Exp Immunol, 131, pp. 248-253. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2003) Clin Exp Immunol , vol.131 , pp. 248-253
    • Fukuoka, Y.1    Strainic, M.2    Medof, M.3
  • 68
    • 19944428475 scopus 로고    scopus 로고
    • Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Sarma, J and Rittirsch, D and et al. (2005) Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans J Immunol, 174, pp. 1104-1110. [INFOTRIEVE] [CSA]
    • (2005) J Immunol , vol.174 , pp. 1104-1110
    • Huber-Lang, M.1    Sarma, J.2    Rittirsch, D.3
  • 69
    • 20444460795 scopus 로고    scopus 로고
    • Evidence for a functional role of the second C5a receptor C5L2
    • [INFOTRIEVE] [CSA]
    • Gao, H and Neff, T and Guo, R and et al. (2005) Evidence for a functional role of the second C5a receptor C5L2 FASEB J, 19, pp. 1003-1005. [INFOTRIEVE] [CSA]
    • (2005) FASEB J , vol.19 , pp. 1003-1005
    • Gao, H.1    Neff, T.2    Guo, R.3
  • 70
    • 0037105426 scopus 로고    scopus 로고
    • Complement-induced impairment of innate immunity during sepsis
    • [INFOTRIEVE] [CSA]
    • Huber-Lang, M and Younkin, E and Sarma, J and et al. (2002) Complement-induced impairment of innate immunity during sepsis J Immunol, 169, pp. 3223-3231. [INFOTRIEVE] [CSA]
    • (2002) J Immunol , vol.169 , pp. 3223-3231
    • Huber-Lang, M.1    Younkin, E.2    Sarma, J.3
  • 71
    • 18344412674 scopus 로고    scopus 로고
    • New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes
    • [INFOTRIEVE] [CSA]
    • Zaitsu, M and Hamasaki, Y and Matsuo, M and et al. (2000) New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes Blood, 96, pp. 601-609. [INFOTRIEVE] [CSA]
    • (2000) Blood , vol.96 , pp. 601-609
    • Zaitsu, M.1    Hamasaki, Y.2    Matsuo, M.3
  • 72
    • 11844295677 scopus 로고    scopus 로고
    • Role of C5a-C5aR interaction in sepsis
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Guo, R and Riedemann, N and Ward, P. (2004) Role of C5a-C5aR interaction in sepsis Shock, 21, pp. 1-7. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2004) Shock , vol.21 , pp. 1-7
    • Guo, R.1    Riedemann, N.2    Ward, P.3
  • 74
    • 0030843156 scopus 로고    scopus 로고
    • Sepsis: A new hypothesis for pathogenesis of the disease process
    • [INFOTRIEVE] [CSA]
    • Bone, R and Grodzin, C and Balk, R. (1997) Sepsis: A new hypothesis for pathogenesis of the disease process Chest, 112, pp. 235-243. [INFOTRIEVE] [CSA]
    • (1997) Chest , vol.112 , pp. 235-243
    • Bone, R.1    Grodzin, C.2    Balk, R.3
  • 75
    • 0037389094 scopus 로고    scopus 로고
    • SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001
    • Levy, M and Fink, M and Marshall, J and et al. (2003). SCCM/ESICM/ACCP/ ATS/SIS International Sepsis Definitions Conference 2001. In [pp. 1250-1256]. Crit Care Med
    • (2003) Crit Care Med , pp. 1250-1256
    • Levy, M.1    Fink, M.2    Marshall, J.3
  • 76
    • 0028082347 scopus 로고
    • Immunologic assessment of host defense impairment in patients with septic multiple organ failure: Relationship between complement activation and changes in neutrophil function
    • [INFOTRIEVE] [CSA]
    • Goya, T and Morisaki, T and Torisu, M. (1994) Immunologic assessment of host defense impairment in patients with septic multiple organ failure: Relationship between complement activation and changes in neutrophil function Surgery, 115, pp. 145-155. [INFOTRIEVE] [CSA]
    • (1994) Surgery , vol.115 , pp. 145-155
    • Goya, T.1    Morisaki, T.2    Torisu, M.3
  • 77
    • 31344464342 scopus 로고    scopus 로고
    • An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Niederbichler, A and Hoesel, L and Westfall, M and et al. (2006) An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction J Exp Med, 203, pp. 53-61. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2006) J Exp Med , vol.203 , pp. 53-61
    • Niederbichler, A.1    Hoesel, L.2    Westfall, M.3
  • 78
    • 0028962832 scopus 로고
    • Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Roumen, R and Redl, H and Schlag, G and et al. (1995) Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma Crit Care Med, 23, pp. 474-480. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1995) Crit Care Med , vol.23 , pp. 474-480
    • Roumen, R.1    Redl, H.2    Schlag, G.3
  • 79
    • 0023925627 scopus 로고
    • Anaphylatoxin formation in sepsis
    • [INFOTRIEVE] [CSA]
    • Bengtson, A and Heideman, M. (1988) Anaphylatoxin formation in sepsis Arch Surg, 123, pp. 645-649. [INFOTRIEVE] [CSA]
    • (1988) Arch Surg , vol.123 , pp. 645-649
    • Bengtson, A.1    Heideman, M.2
  • 80
    • 0023868786 scopus 로고
    • Terminal complement complexes and anaphylatoxins in septic and ischemic patients
    • [INFOTRIEVE] [CSA]
    • Heideman, M and Norder-Hansson, B and Bengtson, A and Mollnes, T. (1988) Terminal complement complexes and anaphylatoxins in septic and ischemic patients Arch Surg, 123, pp. 188-192. [INFOTRIEVE] [CSA]
    • (1988) Arch Surg , vol.123 , pp. 188-192
    • Heideman, M.1    Norder-Hansson, B.2    Bengtson, A.3    Mollnes, T.4
  • 81
    • 0024179111 scopus 로고
    • Complement activation and organ function in critically ill surgical patients
    • [CSA]
    • Bengtson, A and Haljamae, H. (1988) Complement activation and organ function in critically ill surgical patients Acute Care, 14-15, pp. 111-137. [CSA]
    • (1988) Acute Care , vol.14-15 , pp. 111-137
    • Bengtson, A.1    Haljamae, H.2
  • 82
    • 0024407841 scopus 로고
    • The role of the complement system in the pathogenesis of multiple organ failure in shock
    • [INFOTRIEVE] [CSA]
    • Zimmermann, T and Laszik, Z and Nagy, S and Kaszaki, J and Joo, F. (1989) The role of the complement system in the pathogenesis of multiple organ failure in shock Prog Clin Biol Res, 308, pp. 291-297. [INFOTRIEVE] [CSA]
    • (1989) Prog Clin Biol Res , vol.308 , pp. 291-297
    • Zimmermann, T.1    Laszik, Z.2    Nagy, S.3    Kaszaki, J.4    Joo, F.5
  • 83
    • 0032554141 scopus 로고    scopus 로고
    • Microvascular endothelial activation in the skeletal muscles of patients with multiple organ failure
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Helliwell, T and Wilkinson, A and Griffiths, R and Palmer, T and McClelland, P and Bone, J. (1998) Microvascular endothelial activation in the skeletal muscles of patients with multiple organ failure J Neurol Sci, 154, pp. 26-34. [INFOTRIEVE] [CSA] [CROSSREF]
    • (1998) J Neurol Sci , vol.154 , pp. 26-34
    • Helliwell, T.1    Wilkinson, A.2    Griffiths, R.3    Palmer, T.4    McClelland, P.5    Bone, J.6
  • 84
    • 0022459082 scopus 로고
    • Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal aortic surgery
    • [INFOTRIEVE] [CSA]
    • Bengtson, A and Heideman, M. (1986) Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal aortic surgery J Trauma, 26, pp. 631-637. [INFOTRIEVE] [CSA]
    • (1986) J Trauma , vol.26 , pp. 631-637
    • Bengtson, A.1    Heideman, M.2
  • 85
    • 0021705436 scopus 로고
    • Anaphylatoxin generation in multisystem organ failure
    • [INFOTRIEVE] [CSA]
    • Heideman, M and Hugli, T. (1984) Anaphylatoxin generation in multisystem organ failure J Trauma, 24, pp. 1038-1043. [INFOTRIEVE] [CSA]
    • (1984) J Trauma , vol.24 , pp. 1038-1043
    • Heideman, M.1    Hugli, T.2
  • 86
    • 0027788092 scopus 로고
    • Complement activation during cardiopulmonary bypass in infants and children. Relation to postoperative multiple system organ failure
    • [INFOTRIEVE] [CSA]
    • Seghaye, M and Duchateau, J and Grabitz, R and et al. (1993) Complement activation during cardiopulmonary bypass in infants and children. Relation to postoperative multiple system organ failure J Thorac Cardiovasc Surg, 106, pp. 978-987. [INFOTRIEVE] [CSA]
    • (1993) J Thorac Cardiovasc Surg , vol.106 , pp. 978-987
    • Seghaye, M.1    Duchateau, J.2    Grabitz, R.3
  • 87
    • 0036736807 scopus 로고    scopus 로고
    • Hot new therapy for sepsis and the acute respiratory distress syndrome
    • [INFOTRIEVE] [CSA] [CROSSREF]
    • Slutsky, A. (2002) Hot new therapy for sepsis and the acute respiratory distress syndrome J Clin Invest, 110, pp. 737-739. [INFOTRIEVE] [CSA] [CROSSREF]
    • (2002) J Clin Invest , vol.110 , pp. 737-739
    • Slutsky, A.1


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