메뉴 건너뛰기




Volumn 3, Issue MAY, 2012, Pages

Protective immunity and vaccination against cutaneous leishmaniasis

Author keywords

Adaptive immunity; Cutaneous leishmaniasis; Infection induced resistance; Innate immunity; Vaccination; Vaccine

Indexed keywords


EID: 84874066814     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00128     Document Type: Review
Times cited : (46)

References (172)
  • 1
    • 0027395378 scopus 로고
    • Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host
    • Aebischer, T., Moody, S. F., and Handman, E. (1993). Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect. Immun. 61, 220-226.
    • (1993) Infect. Immun. , vol.61 , pp. 220-226
    • Aebischer, T.1    Moody, S.F.2    Handman, E.3
  • 2
    • 0028049247 scopus 로고
    • The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
    • Afonso, L. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G., and Scott, P. (1994). The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263, 235-237.
    • (1994) Science , vol.263 , pp. 235-237
    • Afonso, L.C.1    Scharton, T.M.2    Vieira, L.Q.3    Wysocka, M.4    Trinchieri, G.5    Scott, P.6
  • 3
    • 0037100438 scopus 로고    scopus 로고
    • Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major
    • Aga, E., Katschinski, D. M., van Zandbergen, G., Laufs, H., Hansen, B., Müller, K., Solbach, W., and Laskay, T. (2002). Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major. J. Immunol. 169, 898-905.
    • (2002) J. Immunol. , vol.169 , pp. 898-905
    • Aga, E.1    Katschinski, D.M.2    van Zandbergen, G.3    Laufs, H.4    Hansen, B.5    Müller, K.6    Solbach, W.7    Laskay, T.8
  • 4
    • 76249133497 scopus 로고    scopus 로고
    • Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1
    • Akilov, O. E., Ustyugova, I. V., Zhi, L., Hasan, T., and Wu, M. X. (2009). Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1. J. Immunol. 183, 7994-8003.
    • (2009) J. Immunol. , vol.183 , pp. 7994-8003
    • Akilov, O.E.1    Ustyugova, I.V.2    Zhi, L.3    Hasan, T.4    Wu, M.X.5
  • 5
    • 0032469359 scopus 로고    scopus 로고
    • DNA vaccines: technology and application as anti-parasite and anti-microbial agents
    • Alarcon, J. B., Waine, G. W., and McManus, D. P. (1999). DNA vaccines: technology and application as anti-parasite and anti-microbial agents. Adv. Parasitol. 42, 343-410.
    • (1999) Adv. Parasitol. , vol.42 , pp. 343-410
    • Alarcon, J.B.1    Waine, G.W.2    McManus, D.P.3
  • 6
    • 0036773192 scopus 로고    scopus 로고
    • An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection
    • Alexander, J., Brombacher, F., McGachy, H. A., McKenzie, A. N., Walker, W., and Carter, K. C. (2002). An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection. Eur. J. Immunol. 32, 2923-2933.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2923-2933
    • Alexander, J.1    Brombacher, F.2    McGachy, H.A.3    McKenzie, A.N.4    Walker, W.5    Carter, K.C.6
  • 7
    • 0032534577 scopus 로고    scopus 로고
    • Leishmania mexicana cysteine proteinasedeficient mutants have attenuated virulence for mice and potentiate a Th1 response
    • Alexander, J., Coombs, G. H., and Mottram, J. C. (1998). Leishmania mexicana cysteine proteinasedeficient mutants have attenuated virulence for mice and potentiate a Th1 response. J. Immunol. 161, 6794-6801.
    • (1998) J. Immunol. , vol.161 , pp. 6794-6801
    • Alexander, J.1    Coombs, G.H.2    Mottram, J.C.3
  • 9
    • 14044275712 scopus 로고    scopus 로고
    • Nonhealing infection despite Th1 polarization produced byastrainofLeishmania major in C57BL/6 mice
    • Anderson, C. F., Mendez, S., and Sacks, D. L. (2005). Nonhealing infection despite Th1 polarization produced byastrainofLeishmania major in C57BL/6 mice. J. Immunol. 174, 2934-2941.
    • (2005) J. Immunol. , vol.174 , pp. 2934-2941
    • Anderson, C.F.1    Mendez, S.2    Sacks, D.L.3
  • 10
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson, C. F., Oukka, M., Kuchroo, V. J., and Sacks, D. (2007). CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204, 285-297.
    • (2007) J. Exp. Med. , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 11
    • 70449732757 scopus 로고    scopus 로고
    • IL27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    • Anderson,C. F.,Stumhofer,J. S.,Hunter, C. A., and Sacks, D. (2009). IL27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J. Immunol. 183, 4619-4627.
    • (2009) J. Immunol. , vol.183 , pp. 4619-4627
    • Anderson, C.F.1    Stumhofer, J.S.2    Hunter, C.A.3    Sacks, D.4
  • 12
    • 1542360794 scopus 로고    scopus 로고
    • Safety, immunogenecity, and efficacy of an autoclaved Leishmania amazonensis vaccine plus BCG adjuvant against New World cutaneous leishmaniasis
    • Armijos, R. X., Weigel, M. M., Calvopina, M., Hidalgo, A., Cevallos, W., and Correa, J. (2004). Safety, immunogenecity, and efficacy of an autoclaved Leishmania amazonensis vaccine plus BCG adjuvant against New World cutaneous leishmaniasis. Vaccine 22, 1320-1326.
    • (2004) Vaccine , vol.22 , pp. 1320-1326
    • Armijos, R.X.1    Weigel, M.M.2    Calvopina, M.3    Hidalgo, A.4    Cevallos, W.5    Correa, J.6
  • 13
    • 80054797283 scopus 로고    scopus 로고
    • Cutaneous leishmaniasis in British troops following jungle training in Belize
    • Bailey, M. S. (2011). Cutaneous leishmaniasis in British troops following jungle training in Belize. Travel Med. Infect Dis. 9, 253-254.
    • (2011) Travel Med. Infect Dis. , vol.9 , pp. 253-254
    • Bailey, M.S.1
  • 14
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid, Y., Piccirillo, C. A., Mendez, S., Shevach, E. M., and Sacks, D. L. (2002). CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420, 502-507.
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 15
    • 0024412797 scopus 로고
    • Administration of monoclonal anti-IFNgamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major
    • Belosevic, M., Finbloom, D. S., Van Der Meide, P. H., Slayter, M. V., and Nacy, C. A. (1989). Administration of monoclonal anti-IFNgamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143, 266-274.
    • (1989) J. Immunol. , vol.143 , pp. 266-274
    • Belosevic, M.1    Finbloom, D.S.2    Van Der Meide, P.H.3    Slayter, M.V.4    Nacy, C.A.5
  • 16
    • 78649352827 scopus 로고    scopus 로고
    • Innate immunity and Leishmania vaccination strategies
    • Birnbaum, R., and Craft, N. (2011). Innate immunity and Leishmania vaccination strategies. Dermatol. Clin. 29, 89-102.
    • (2011) Dermatol. Clin. , vol.29 , pp. 89-102
    • Birnbaum, R.1    Craft, N.2
  • 18
    • 63149186257 scopus 로고    scopus 로고
    • Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis
    • Bourreau, E., Ronet, C., Darcissac, E., Lise, M. C., Sainte Marie, D., Clity, E., Tacchini-Cottier, F., Couppie, P., and Launois, P. (2009). Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect. Immun. 77, 1465-1474.
    • (2009) Infect. Immun. , vol.77 , pp. 1465-1474
    • Bourreau, E.1    Ronet, C.2    Darcissac, E.3    Lise, M.C.4    Sainte Marie, D.5    Clity, E.6    Tacchini-Cottier, F.7    Couppie, P.8    Launois, P.9
  • 19
    • 25444511090 scopus 로고    scopus 로고
    • Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis
    • Breton, M., Tremblay, M. J., Ouellette, M., and Papadopoulou, B. (2005). Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis. Infect. Immun. 73, 6372-6382.
    • (2005) Infect. Immun. , vol.73 , pp. 6372-6382
    • Breton, M.1    Tremblay, M.J.2    Ouellette, M.3    Papadopoulou, B.4
  • 20
    • 0033969991 scopus 로고    scopus 로고
    • Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro
    • Brodskyn, C., Beverley, S. M., and Titus, R. G. (2000). Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro. Clin. Exp. Immunol. 119, 299-304.
    • (2000) Clin. Exp. Immunol. , vol.119 , pp. 299-304
    • Brodskyn, C.1    Beverley, S.M.2    Titus, R.G.3
  • 21
    • 0033949735 scopus 로고    scopus 로고
    • The role of interleukin-13 in infectious diseases and allergy
    • Brombacher, F. (2000). The role of interleukin-13 in infectious diseases and allergy. Bioessays 22, 646-656.
    • (2000) Bioessays , vol.22 , pp. 646-656
    • Brombacher, F.1
  • 22
    • 84874050293 scopus 로고    scopus 로고
    • (ed.). Interleukin-13. Georgetown, TX: Landes Bioscience.
    • Brombacher, F. (ed.). (2003). Interleukin-13. Georgetown, TX: Landes Bioscience.
    • (2003)
    • Brombacher, F.1
  • 24
    • 80755133721 scopus 로고    scopus 로고
    • Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E
    • Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martinez, G. J., and Dong, C. (2011). Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity 35, 611-621.
    • (2011) Immunity , vol.35 , pp. 611-621
    • Chang, S.H.1    Reynolds, J.M.2    Pappu, B.P.3    Chen, G.4    Martinez, G.J.5    Dong, C.6
  • 26
    • 0032898950 scopus 로고    scopus 로고
    • Experimental Leishmania major infection in mice: role of IL-10
    • Chatelain, R., Mauze, S., and Coffman, R. L. (1999). Experimental Leishmania major infection in mice: role of IL-10. Parasite Immunol. 21, 211-218.
    • (1999) Parasite Immunol , vol.21 , pp. 211-218
    • Chatelain, R.1    Mauze, S.2    Coffman, R.L.3
  • 27
    • 34547870667 scopus 로고    scopus 로고
    • Leish-111f, a recombinant polyprotein vaccine that protects against visceral Leishmaniasis by elicitation of CD4+ T cells
    • Coler, R. N., Goto, Y., Bogatzki, L., Raman, V., and Reed, S. G. (2007). Leish-111f, a recombinant polyprotein vaccine that protects against visceral Leishmaniasis by elicitation of CD4+ T cells. Infect. Immun. 75, 4648-4654.
    • (2007) Infect. Immun. , vol.75 , pp. 4648-4654
    • Coler, R.N.1    Goto, Y.2    Bogatzki, L.3    Raman, V.4    Reed, S.G.5
  • 28
    • 70350568636 scopus 로고    scopus 로고
    • Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent Leishmania major
    • Daneshvar, H., Burchmore, R., Hagan, P., and Phillips, R. S. (2009). Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent Leishmania major. Parasitology 136, 1243-1250.
    • (2009) Parasitology , vol.136 , pp. 1243-1250
    • Daneshvar, H.1    Burchmore, R.2    Hagan, P.3    Phillips, R.S.4
  • 29
    • 11144243422 scopus 로고    scopus 로고
    • Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials
    • Davoudi, N., Tate, C. A., Warburton, C., Murray, A., Mahboudi, F., and McMaster, W. R. (2005). Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials. Vaccine 23, 1170-1177.
    • (2005) Vaccine , vol.23 , pp. 1170-1177
    • Davoudi, N.1    Tate, C.A.2    Warburton, C.3    Murray, A.4    Mahboudi, F.5    McMaster, W.R.6
  • 31
  • 32
    • 79960933515 scopus 로고    scopus 로고
    • C-terminal domain deletion enhances the protective activity of cpa/cpb loaded solid lipid nanoparticles against Leishmania major in BALB/c mice
    • doi:10.1371/journal.pntd.0001236
    • Doroud, D., Zahedifard, F., Vatanara, A., Taslimi, Y., Vahabpour, R., Torkashvand, F., Vaziri, B., Rouholamini Najafabadi, A., and Rafati, S. (2011a). C-terminal domain deletion enhances the protective activity of cpa/cpb loaded solid lipid nanoparticles against Leishmania major in BALB/c mice. PLoS Negl. Trop. Dis. 5,e1236. doi:10.1371/journal.pntd.0001236
    • (2011) PLoS Negl. Trop. Dis. , vol.5
    • Doroud, D.1    Zahedifard, F.2    Vatanara, A.3    Taslimi, Y.4    Vahabpour, R.5    Torkashvand, F.6    Vaziri, B.7    Rouholamini Najafabadi, A.8    Rafati, S.9
  • 34
    • 0028243802 scopus 로고
    • Interleukin13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma
    • Doyle, A. G., Herbein, G., Montaner, L. J., Minty, A. J., Caput, D., Ferrara, P., and Gordon, S. (1994). Interleukin13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma. Eur. J. Immunol. 24, 1441-1445.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1441-1445
    • Doyle, A.G.1    Herbein, G.2    Montaner, L.J.3    Minty, A.J.4    Caput, D.5    Ferrara, P.6    Gordon, S.7
  • 38
    • 0035825586 scopus 로고    scopus 로고
    • Immunisation with DNA encoding Leishmania infantum protein papLe22 decreases the frequency of parasitemic episodes in infected hamsters
    • Fragaki, K., Suffia, I., Ferrua, B., Rousseau, D., Le Fichoux, Y., and Kubar, J. (2001). Immunisation with DNA encoding Leishmania infantum protein papLe22 decreases the frequency of parasitemic episodes in infected hamsters. Vaccine 19, 1701-1709.
    • (2001) Vaccine , vol.19 , pp. 1701-1709
    • Fragaki, K.1    Suffia, I.2    Ferrua, B.3    Rousseau, D.4    Le Fichoux, Y.5    Kubar, J.6
  • 39
    • 0035167274 scopus 로고    scopus 로고
    • Vervet monkeys vaccinated with killed Leishmania major parasites and interleukin-12 develop a type 1 immune response but are not protected against challenge infection
    • Gicheru, M. M., Olobo, J. O., Anjili, C. O., Orago, A. S., Modabber, F., and Scott, P. (2001). Vervet monkeys vaccinated with killed Leishmania major parasites and interleukin-12 develop a type 1 immune response but are not protected against challenge infection. Infect. Immun. 69, 245-251.
    • (2001) Infect. Immun. , vol.69 , pp. 245-251
    • Gicheru, M.M.1    Olobo, J.O.2    Anjili, C.O.3    Orago, A.S.4    Modabber, F.5    Scott, P.6
  • 41
    • 26644448719 scopus 로고    scopus 로고
    • Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals
    • Gradoni, L., Foglia Manzillo,V., Pagano, A., Piantedosi, D., De Luna, R., Gramiccia, M., Scalone, A., Di Muccio, T., and Oliva, G. (2005). Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals. Vaccine 23, 5245-5251.
    • (2005) Vaccine , vol.23 , pp. 5245-5251
    • Gradoni, L.1    Foglia Manzillo, V.2    Pagano, A.3    Piantedosi, D.4    De Luna, R.5    Gramiccia, M.6    Scalone, A.7    Di Muccio, T.8    Oliva, G.9
  • 42
    • 0019251264 scopus 로고
    • The present and future of vaccination for cutaneous leishmaniasis
    • Greenblatt, C. L. (1980). The present and future of vaccination for cutaneous leishmaniasis. Prog. Clin. Biol. Res. 47, 259-285.
    • (1980) Prog. Clin. Biol. Res. , vol.47 , pp. 259-285
    • Greenblatt, C.L.1
  • 43
    • 0031757985 scopus 로고    scopus 로고
    • Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection
    • Gurunathan, S., Prussin, C., Sacks, D. L., and Seder, R. A. (1998). Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection. Nat. Med. 4, 1409-1415.
    • (1998) Nat. Med. , vol.4 , pp. 1409-1415
    • Gurunathan, S.1    Prussin, C.2    Sacks, D.L.3    Seder, R.A.4
  • 44
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • Gurunathan, S., Sacks, D. L., Brown, D. R., Reiner, S. L., Charest, H., Glaichenhaus, N., and Seder, R. A. (1997). Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186, 1137-1147.
    • (1997) J. Exp. Med. , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6    Seder, R.A.7
  • 45
    • 0034086797 scopus 로고    scopus 로고
    • DNA vaccines: a key for inducing longterm cellular immunity
    • Gurunathan, S., Wu, C. Y., Freidag, B. L., and Seder, R. A. (2000a). DNA vaccines: a key for inducing longterm cellular immunity. Curr. Opin. Immunol. 12, 442-447.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 442-447
    • Gurunathan, S.1    Wu, C.Y.2    Freidag, B.L.3    Seder, R.A.4
  • 46
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: immunology, application, and optimization*
    • Gurunathan, S., Klinman, D. M., and Seder, R. A. (2000b). DNA vaccines: immunology, application, and optimization*. Annu. Rev. Immunol. 18, 927-974.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 47
    • 0035067363 scopus 로고    scopus 로고
    • Leishmaniasis: current status of vaccine development
    • Handman, E. (2001). Leishmaniasis: current status of vaccine development. Clin. Microbiol. Rev. 14, 229-243.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 229-243
    • Handman, E.1
  • 48
    • 0025316640 scopus 로고
    • Leishmania major: production of recombinant gp63, its antigenicity and immunogenicity in mice
    • Handman,E.,Button,L. L.,and McMaster, R. W. (1990). Leishmania major: production of recombinant gp63, its antigenicity and immunogenicity in mice. Exp. Parasitol. 70, 427-435.
    • (1990) Exp. Parasitol. , vol.70 , pp. 427-435
    • Handman, E.1    Button, L.L.2    McMaster, R.W.3
  • 49
    • 0029076809 scopus 로고
    • Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice
    • Heinzel, F. P., Rerko, R. M., Ahmed, F., and Pearlman, E. (1995). Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J. Immunol. 155, 730-739.
    • (1995) J. Immunol. , vol.155 , pp. 730-739
    • Heinzel, F.P.1    Rerko, R.M.2    Ahmed, F.3    Pearlman, E.4
  • 51
    • 0027528795 scopus 로고
    • Recombinant interleukin 12 cures mice infected with Leishmania major
    • Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E., and Gately, M. K. (1993). Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177, 1505-1509.
    • (1993) J. Exp. Med. , vol.177 , pp. 1505-1509
    • Heinzel, F.P.1    Schoenhaut, D.S.2    Rerko, R.M.3    Rosser, L.E.4    Gately, M.K.5
  • 53
    • 0032403583 scopus 로고    scopus 로고
    • The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12
    • Himmelrich, H., Parra-Lopez, C., Tacchini-Cottier, F., Louis, J. A., and Launois, P. (1998). The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12. J. Immunol. 161, 6156-6163.
    • (1998) J. Immunol. , vol.161 , pp. 6156-6163
    • Himmelrich, H.1    Parra-Lopez, C.2    Tacchini-Cottier, F.3    Louis, J.A.4    Launois, P.5
  • 54
    • 0025820205 scopus 로고
    • Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1and Th2-like cell lines
    • Holaday, B. J., Sadick, M. D., Wang, Z. E., Reiner, S. L., Heinzel, F. P., Parslow, T. G., and Locksley, R. M. (1991). Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1and Th2-like cell lines. J. Immunol. 147, 1653-1658.
    • (1991) J. Immunol. , vol.147 , pp. 1653-1658
    • Holaday, B.J.1    Sadick, M.D.2    Wang, Z.E.3    Reiner, S.L.4    Heinzel, F.P.5    Parslow, T.G.6    Locksley, R.M.7
  • 55
    • 0031825618 scopus 로고    scopus 로고
    • Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice
    • Huber, M., Timms, E., Mak, T. W., Röllinghoff, M., and Lohoff, M. (1998). Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect. Immun. 66, 3968-3970.
    • (1998) Infect. Immun. , vol.66 , pp. 3968-3970
    • Huber, M.1    Timms, E.2    Mak, T.W.3    Röllinghoff, M.4    Lohoff, M.5
  • 56
    • 34447513762 scopus 로고    scopus 로고
    • The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome
    • Jaafari, M. R., Badiee, A., Khamesipour, A., Samiei, A., Soroush, D., Kheiri, M. T., Barkhordari, F., McMaster, W. R., and Mahboudi, F. (2007). The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome. Vaccine 25, 6107-6117.
    • (2007) Vaccine , vol.25 , pp. 6107-6117
    • Jaafari, M.R.1    Badiee, A.2    Khamesipour, A.3    Samiei, A.4    Soroush, D.5    Kheiri, M.T.6    Barkhordari, F.7    McMaster, W.R.8    Mahboudi, F.9
  • 58
    • 0033987177 scopus 로고    scopus 로고
    • Leishmania parasites and their ploys to disrupt macrophage activation
    • Kane, M. M., and Mosser, D. M. (2000). Leishmania parasites and their ploys to disrupt macrophage activation. Curr. Opin. Hematol. 7, 26-31.
    • (2000) Curr. Opin. Hematol. , vol.7 , pp. 26-31
    • Kane, M.M.1    Mosser, D.M.2
  • 59
    • 58149354341 scopus 로고    scopus 로고
    • Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites
    • Kedzierski, L., Curtis, J. M., Doherty, P. C., Handman, E., and Kedzierska, K. (2008). Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites. Eur. J. Immunol. 38, 3090-3100.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3090-3100
    • Kedzierski, L.1    Curtis, J.M.2    Doherty, P.C.3    Handman, E.4    Kedzierska, K.5
  • 60
    • 33846847777 scopus 로고    scopus 로고
    • Leishmania vaccines: progress and problems
    • Kedzierski, L., Zhu, Y., and Handman,E. (2006). Leishmania vaccines: progress and problems. Parasitology 133(Suppl.), S87-S112.
    • (2006) Parasitology , vol.133 , Issue.SUPPL.
    • Kedzierski, L.1    Zhu, Y.2    Handman, E.3
  • 62
  • 63
    • 12744273260 scopus 로고    scopus 로고
    • Natural killer cells and innate immunity to protozoan pathogens
    • Korbel, D. S., Finney, O. C., and Riley, E. M. (2004). Natural killer cells and innate immunity to protozoan pathogens. Int. J. Parasitol. 34, 1517-1528.
    • (2004) Int. J. Parasitol. , vol.34 , pp. 1517-1528
    • Korbel, D.S.1    Finney, O.C.2    Riley, E.M.3
  • 64
    • 70350719508 scopus 로고    scopus 로고
    • Vaccination with live Leishmania major and CpG DNA promotes interleukin-2 production by dermal dendritic cells and NK cell activation
    • Laabs, E. M., Wu, W., and Mendez, S. (2009). Vaccination with live Leishmania major and CpG DNA promotes interleukin-2 production by dermal dendritic cells and NK cell activation. Clin. Vaccine Immunol. 16, 1601-1606.
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 1601-1606
    • Laabs, E.M.1    Wu, W.2    Mendez, S.3
  • 65
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., and Chougnet, C. (2008). Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 181, 1835-1848.
    • (2008) J. Immunol. , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5    Hildeman, D.A.6    Belkaid, Y.7    Chougnet, C.8
  • 66
    • 0032899553 scopus 로고    scopus 로고
    • The role of natural killer cells in the early period of infection in murine cutaneous leishmaniasis
    • Laurenti, M. D., Gidlund, M., Ura, D. M., Sinhorini, I. L., Corbett, C. E., and Goto, H. (1999). The role of natural killer cells in the early period of infection in murine cutaneous leishmaniasis. Braz. J. Med. Biol. Res. 32, 323-325.
    • (1999) Braz. J. Med. Biol. Res. , vol.32 , pp. 323-325
    • Laurenti, M.D.1    Gidlund, M.2    Ura, D.M.3    Sinhorini, I.L.4    Corbett, C.E.5    Goto, H.6
  • 67
    • 34247104151 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania
    • Leon, B., Lopez-Bravo, M., and Ardavin, C. (2007). Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity 26, 519-531.
    • (2007) Immunity , vol.26 , pp. 519-531
    • Leon, B.1    Lopez-Bravo, M.2    Ardavin, C.3
  • 71
    • 0033509735 scopus 로고    scopus 로고
    • Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani
    • Lira, R., Sundar, S., Makharia, A., Kenney, R., Gam, A., Saraiva, E., and Sacks, D. (1999). Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. J. Infect. Dis. 180, 564-567.
    • (1999) J. Infect. Dis. , vol.180 , pp. 564-567
    • Lira, R.1    Sundar, S.2    Makharia, A.3    Kenney, R.4    Gam, A.5    Saraiva, E.6    Sacks, D.7
  • 72
    • 77951910952 scopus 로고    scopus 로고
    • The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets
    • Liu, D., and Uzonna, J. E. (2010). The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets. J. Immunol. 184, 3098-3105.
    • (2010) J. Immunol. , vol.184 , pp. 3098-3105
    • Liu, D.1    Uzonna, J.E.2
  • 73
    • 68149100422 scopus 로고    scopus 로고
    • The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
    • Liu, D., Zhang, T., Marshall, A. J., Okkenhaug, K., Vanhaesebroeck, B., and Uzonna, J. E. (2009). The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J. Immunol. 183, 1921-1933.
    • (2009) J. Immunol. , vol.183 , pp. 1921-1933
    • Liu, D.1    Zhang, T.2    Marshall, A.J.3    Okkenhaug, K.4    Vanhaesebroeck, B.5    Uzonna, J.E.6
  • 75
    • 0029451961 scopus 로고
    • The development of effector T cell subsets in murine Leishmania major infection
    • Locksley, R. M., Wakil, A. E., Corry, D. B., Pingel, S., Bix, M., and Fowell, D. J. (1995). The development of effector T cell subsets in murine Leishmania major infection. Ciba Found. Symp. 195, 110-117; discussion 117-122.
    • (1995) Ciba Found. Symp. , vol.195 , pp. 110-117
    • Locksley, R.M.1    Wakil, A.E.2    Corry, D.B.3    Pingel, S.4    Bix, M.5    Fowell, D.J.6
  • 77
    • 0031756309 scopus 로고    scopus 로고
    • Anti-leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice
    • Louis, J. A., Conceiçao-Silva, F., Himmelrich, H., Tacchini-Cottier, F., and Launois, P. (1998a). Anti-leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Adv. Exp. Med. Biol. 452, 53-60.
    • (1998) Adv. Exp. Med. Biol. , vol.452 , pp. 53-60
    • Louis, J.A.1    Conceiçao-Silva, F.2    Himmelrich, H.3    Tacchini-Cottier, F.4    Launois, P.5
  • 80
    • 79960906779 scopus 로고    scopus 로고
    • Efficacy of Leishmania donovani ribosomal P1 gene as DNA vaccine in experimental visceral leishmaniasis
    • Masih, S., Arora, S. K., and Vasishta, R. K. (2011). Efficacy of Leishmania donovani ribosomal P1 gene as DNA vaccine in experimental visceral leishmaniasis. Exp. Parasitol. 129, 55-64.
    • (2011) Exp. Parasitol. , vol.129 , pp. 55-64
    • Masih, S.1    Arora, S.K.2    Vasishta, R.K.3
  • 83
    • 0034911854 scopus 로고    scopus 로고
    • Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis
    • Melby, P. C., Yang, J., Zhao, W., Perez, L. E., and Cheng, J. (2001). Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis. Infect. Immun. 69, 4719-4725.
    • (2001) Infect. Immun. , vol.69 , pp. 4719-4725
    • Melby, P.C.1    Yang, J.2    Zhao, W.3    Perez, L.E.4    Cheng, J.5
  • 84
    • 3242787209 scopus 로고    scopus 로고
    • Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    • Mendez, S., Reckling, S. K., Piccirillo, C. A., Sacks, D., and Belkaid, Y. (2004). Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J. Exp. Med. 200, 201-210.
    • (2004) J. Exp. Med. , vol.200 , pp. 201-210
    • Mendez, S.1    Reckling, S.K.2    Piccirillo, C.A.3    Sacks, D.4    Belkaid, Y.5
  • 85
    • 0041322722 scopus 로고    scopus 로고
    • Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability
    • Mendez, S., Tabbara, K., Belkaid, Y., Bertholet, S., Verthelyi, D., Klinman, D., Seder, R. A., and Sacks, D. L. (2003). Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability. Infect. Immun. 71, 5121-5129.
    • (2003) Infect. Immun. , vol.71 , pp. 5121-5129
    • Mendez, S.1    Tabbara, K.2    Belkaid, Y.3    Bertholet, S.4    Verthelyi, D.5    Klinman, D.6    Seder, R.A.7    Sacks, D.L.8
  • 86
    • 0030027099 scopus 로고    scopus 로고
    • Ex vivo evidence for PGE2 and LTB4 involvement in cutaneous leishmaniasis: relation with infection status and cytokine production
    • Milano, S., Arcoleo, F., Dieli, M., D'Agostino, R., De Nucci, G., D'Agostino, P., and Cillari, E. (1996). Ex vivo evidence for PGE2 and LTB4 involvement in cutaneous leishmaniasis: relation with infection status and cytokine production. Parasitology 112(Pt 1), 13-19.
    • (1996) Parasitology , vol.112 , Issue.PART 1 , pp. 13-19
    • Milano, S.1    Arcoleo, F.2    Dieli, M.3    D'Agostino, R.4    De Nucci, G.5    D'Agostino, P.6    Cillari, E.7
  • 87
    • 70849122402 scopus 로고    scopus 로고
    • Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis
    • Mizbani, A., Taheri, T., Zahedifard, F., Taslimi, Y., Azizi, H., Azadmanesh, K., Papadopoulou, B., and Rafati, S. (2009). Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis. Vaccine 28, 53-62.
    • (2009) Vaccine , vol.28 , pp. 53-62
    • Mizbani, A.1    Taheri, T.2    Zahedifard, F.3    Taslimi, Y.4    Azizi, H.5    Azadmanesh, K.6    Papadopoulou, B.7    Rafati, S.8
  • 88
    • 0033564686 scopus 로고    scopus 로고
    • Differences between IL-4and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    • Mohrs, M., Ledermann, B., Köhler, G., Dorfmüller, A., Gessner, A., and Brombacher, F. (1999). Differences between IL-4and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J. Immunol. 162, 7302-7308.
    • (1999) J. Immunol. , vol.162 , pp. 7302-7308
    • Mohrs, M.1    Ledermann, B.2    Köhler, G.3    Dorfmüller, A.4    Gessner, A.5    Brombacher, F.6
  • 89
    • 0029246243 scopus 로고
    • Treatment of recurrent cutaneous Leishmaniasis
    • Momeni, A. Z., and Aminjavaheri, M. (1995). Treatment of recurrent cutaneous Leishmaniasis. Int. J. Dermatol. 34, 129-133.
    • (1995) Int. J. Dermatol. , vol.34 , pp. 129-133
    • Momeni, A.Z.1    Aminjavaheri, M.2
  • 92
    • 0025733855 scopus 로고
    • The role of IL-10 in crossregulation of TH1 and TH2 responses
    • Mosmann, T. R., and Moore, K. W. (1991). The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol. Today 12, A49-A53.
    • (1991) Immunol. Today , vol.12
    • Mosmann, T.R.1    Moore, K.W.2
  • 93
    • 78649924183 scopus 로고    scopus 로고
    • Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice
    • Mou, Z., Jia, P., Kuriakose, S., Khadem, F., and Uzonna, J. E. (2010). Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice. Infect. Immun. 78, 5271-5279.
    • (2010) Infect. Immun. , vol.78 , pp. 5271-5279
    • Mou, Z.1    Jia, P.2    Kuriakose, S.3    Khadem, F.4    Uzonna, J.E.5
  • 95
    • 79951919391 scopus 로고    scopus 로고
    • Cell biology and immunology of Leishmania
    • Mougneau, E., Bihl, F., and Glaichenhaus, N. (2011). Cell biology and immunology of Leishmania. Immunol. Rev. 240, 286-296.
    • (2011) Immunol. Rev. , vol.240 , pp. 286-296
    • Mougneau, E.1    Bihl, F.2    Glaichenhaus, N.3
  • 96
    • 0037064548 scopus 로고    scopus 로고
    • Structure, binding, and antagonists in the IL-4/IL-13 receptor system
    • Mueller, T. D., Zhang, J. L., Sebald, W., and Duschl, A. (2002). Structure, binding, and antagonists in the IL-4/IL-13 receptor system. Biochim. Biophys. Acta 1592, 237-250.
    • (2002) Biochim. Biophys. Acta , vol.1592 , pp. 237-250
    • Mueller, T.D.1    Zhang, J.L.2    Sebald, W.3    Duschl, A.4
  • 97
    • 0038211674 scopus 로고    scopus 로고
    • Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene
    • Muyombwe, A., Olivier, M., Ouellette, M., and Papadopoulou, B. (1997). Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene. Exp. Parasitol. 85, 35-42.
    • (1997) Exp. Parasitol. , vol.85 , pp. 35-42
    • Muyombwe, A.1    Olivier, M.2    Ouellette, M.3    Papadopoulou, B.4
  • 99
    • 0033984474 scopus 로고    scopus 로고
    • Activated T cells induce macrophages to produce NO and control Leishmania major in the absence of tumor necrosis factor receptor p55
    • Nashleanas, M., and Scott, P. (2000). Activated T cells induce macrophages to produce NO and control Leishmania major in the absence of tumor necrosis factor receptor p55. Infect. Immun. 68, 1428-1434.
    • (2000) Infect. Immun. , vol.68 , pp. 1428-1434
    • Nashleanas, M.1    Scott, P.2
  • 101
    • 0038560975 scopus 로고    scopus 로고
    • The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major
    • Noben-Trauth, N., Lira, R., Nagase, H., Paul, W. E., and Sacks, D. L. (2003). The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. J. Immunol. 170, 5152-5158.
    • (2003) J. Immunol. , vol.170 , pp. 5152-5158
    • Noben-Trauth, N.1    Lira, R.2    Nagase, H.3    Paul, W.E.4    Sacks, D.L.5
  • 102
    • 0033563135 scopus 로고    scopus 로고
    • IL-4and IL4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
    • Noben-Trauth, N., Paul, W. E., and Sacks, D. L. (1999). IL-4and IL4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains. J. Immunol. 162, 6132-6140.
    • (1999) J. Immunol. , vol.162 , pp. 6132-6140
    • Noben-Trauth, N.1    Paul, W.E.2    Sacks, D.L.3
  • 104
    • 0037340450 scopus 로고    scopus 로고
    • Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma
    • Nylen, S., Maasho, K., Söderstrom, K., Ilg, T., and Akuffo, H. (2003). Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma. Clin. Exp. Immunol. 131, 457-467.
    • (2003) Clin. Exp. Immunol. , vol.131 , pp. 457-467
    • Nylen, S.1    Maasho, K.2    Söderstrom, K.3    Ilg, T.4    Akuffo, H.5
  • 105
    • 77955052282 scopus 로고    scopus 로고
    • Repeated inoculation of killed Leishmania major induces durable immune response that protects mice against virulent challenge
    • Okwor, I., Kuriakose, S., and Uzonna, J. (2010). Repeated inoculation of killed Leishmania major induces durable immune response that protects mice against virulent challenge. Vaccine 28, 5451-5457.
    • (2010) Vaccine , vol.28 , pp. 5451-5457
    • Okwor, I.1    Kuriakose, S.2    Uzonna, J.3
  • 106
    • 69549126593 scopus 로고    scopus 로고
    • Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process
    • Okwor, I., Liu, D., Beverley, S. M., and Uzonna, J. E. (2009). Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process. Proc. Natl. Acad. Sci. U.S.A. 106, 13951-13956.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 13951-13956
    • Okwor, I.1    Liu, D.2    Beverley, S.M.3    Uzonna, J.E.4
  • 107
    • 53749088914 scopus 로고    scopus 로고
    • Persistent parasites and immunologic memory in cutaneous leishmaniasis: implications for vaccine designs and vaccination strategies
    • Okwor, I., and Uzonna, J. (2008). Persistent parasites and immunologic memory in cutaneous leishmaniasis: implications for vaccine designs and vaccination strategies. Immunol. Res. 41, 123-136.
    • (2008) Immunol. Res. , vol.41 , pp. 123-136
    • Okwor, I.1    Uzonna, J.2
  • 108
    • 70349548782 scopus 로고    scopus 로고
    • Vaccines and vaccination strategies against human cutaneous leishmaniasis
    • Okwor, I., and Uzonna, J. (2009). Vaccines and vaccination strategies against human cutaneous leishmaniasis. Hum. Vaccin. 5, 291-301.
    • (2009) Hum. Vaccin. , vol.5 , pp. 291-301
    • Okwor, I.1    Uzonna, J.2
  • 109
    • 0028803795 scopus 로고
    • Vaccination of vervet monkeys against cutaneous Leishmaniosis using recombinant Leishmania "major surface glycoprotein" (gp63)
    • Olobo, J. O., Anjili, C. O., Gicheru, M. M., Mbati, P. A., Kariuki, T. M., Githure, J. I., Koech, D. K., and McMaster, W. R. (1995). Vaccination of vervet monkeys against cutaneous Leishmaniosis using recombinant Leishmania "major surface glycoprotein" (gp63). Vet. Parasitol. 60, 199-212.
    • (1995) Vet. Parasitol. , vol.60 , pp. 199-212
    • Olobo, J.O.1    Anjili, C.O.2    Gicheru, M.M.3    Mbati, P.A.4    Kariuki, T.M.5    Githure, J.I.6    Koech, D.K.7    McMaster, W.R.8
  • 110
    • 0141886173 scopus 로고    scopus 로고
    • The role of interleukin10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis
    • Padigel, U. M., Alexander, J., and Farrell, J. P. (2003). The role of interleukin10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. J. Immunol. 171, 3705-3710.
    • (2003) J. Immunol. , vol.171 , pp. 3705-3710
    • Padigel, U.M.1    Alexander, J.2    Farrell, J.P.3
  • 111
    • 40649091062 scopus 로고    scopus 로고
    • Vaccines for leishmaniasis in the fore coming 25 years
    • Palatnik-de-Sousa, C. B. (2008). Vaccines for leishmaniasis in the fore coming 25 years. Vaccine 26, 1709-1724.
    • (2008) Vaccine , vol.26 , pp. 1709-1724
    • Palatnik-de-Sousa, C.B.1
  • 112
    • 0030805936 scopus 로고    scopus 로고
    • Effect of IL-4 and IL13 on IFN-gamma-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2
    • Paludan, S. R., Lovmand, J., EllermannEriksen, S., and Mogensen, S. C. (1997). Effect of IL-4 and IL13 on IFN-gamma-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2. FEBS Lett. 414, 61-64.
    • (1997) FEBS Lett , vol.414 , pp. 61-64
    • Paludan, S.R.1    Lovmand, J.2    EllermannEriksen, S.3    Mogensen, S.C.4
  • 113
    • 0034661678 scopus 로고    scopus 로고
    • IL-12 is required to maintain a Th1 response during Leishmania major infection
    • Park, A. Y., Hondowicz, B. D., and Scott, P. (2000). IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 165, 896-902.
    • (2000) J. Immunol. , vol.165 , pp. 896-902
    • Park, A.Y.1    Hondowicz, B.D.2    Scott, P.3
  • 116
    • 0031105071 scopus 로고    scopus 로고
    • Leishmania major:promastigotes induce expression of a subset of chemokine genes in murine macrophages
    • Racoosin, E. L., and Beverley, S. M. (1997). Leishmania major:promastigotes induce expression of a subset of chemokine genes in murine macrophages. Exp. Parasitol. 85, 283-295.
    • (1997) Exp. Parasitol. , vol.85 , pp. 283-295
    • Racoosin, E.L.1    Beverley, S.M.2
  • 117
    • 0041669532 scopus 로고    scopus 로고
    • Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis
    • Rafati, S., Nakhaee, A., Taheri, T., Ghashghaii, A., Salmanian, A. H., Jimenez, M., Mohebali, M., Masina, S., and Fasel, N. (2003). Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis. Exp. Parasitol. 103, 143-151.
    • (2003) Exp. Parasitol. , vol.103 , pp. 143-151
    • Rafati, S.1    Nakhaee, A.2    Taheri, T.3    Ghashghaii, A.4    Salmanian, A.H.5    Jimenez, M.6    Mohebali, M.7    Masina, S.8    Fasel, N.9
  • 118
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S. L., and Locksley, R. M. (1995). The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13, 151-177.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 122
    • 0032831347 scopus 로고    scopus 로고
    • IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production
    • Rey, A., Quartulli, F., Escoubet, L., Sozzani, P., Caput, D., Ferrara, P., and Pipy, B. (1999). IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production. Biochim. Biophys. Acta 1440, 183-193.
    • (1999) Biochim. Biophys. Acta , vol.1440 , pp. 183-193
    • Rey, A.1    Quartulli, F.2    Escoubet, L.3    Sozzani, P.4    Caput, D.5    Ferrara, P.6    Pipy, B.7
  • 123
    • 83755163757 scopus 로고    scopus 로고
    • Leishmania mexicana Gp63 cDNA using gene gun induced higher immunity to L. mexicana infection compared to soluble Leishmania antigen in BALB/C
    • Rezvan, H., Rees, R., and Ali, S. (2011). Leishmania mexicana Gp63 cDNA using gene gun induced higher immunity to L. mexicana infection compared to soluble Leishmania antigen in BALB/C. Iran. J. Parasitol. 6, 60-75.
    • (2011) Iran. J. Parasitol. , vol.6 , pp. 60-75
    • Rezvan, H.1    Rees, R.2    Ali, S.3
  • 125
    • 0035865047 scopus 로고    scopus 로고
    • Cutting edge: Stat6dependent substrate depletion regulates nitric oxide production
    • Rutschman, R., Lang, R., Hesse, M., Ihle, J. N., Wynn, T. A., and Murray, P. J. (2001). Cutting edge: Stat6dependent substrate depletion regulates nitric oxide production. J. Immunol. 166, 2173-2177.
    • (2001) J. Immunol. , vol.166 , pp. 2173-2177
    • Rutschman, R.1    Lang, R.2    Hesse, M.3    Ihle, J.N.4    Wynn, T.A.5    Murray, P.J.6
  • 126
    • 34948860200 scopus 로고    scopus 로고
    • Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World
    • Salay, G., Dorta, M. L., Santos, N. M., Mortara, R. A., Brodskyn, C., Oliveira, C. I., Barbiéri, C. L., and Rodrigues, M. M. (2007). Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clin. Vaccine Immunol. 14, 1173-1181.
    • (2007) Clin. Vaccine Immunol. , vol.14 , pp. 1173-1181
    • Salay, G.1    Dorta, M.L.2    Santos, N.M.3    Mortara, R.A.4    Brodskyn, C.5    Oliveira, C.I.6    Barbiéri, C.L.7    Rodrigues, M.M.8
  • 127
    • 32544450112 scopus 로고    scopus 로고
    • Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs
    • Saldarriaga, O. A., Travi, B. L., Park, W., Perez, L. E., and Melby, P. C. (2006). Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs. Vaccine 24, 1928-1940.
    • (2006) Vaccine , vol.24 , pp. 1928-1940
    • Saldarriaga, O.A.1    Travi, B.L.2    Park, W.3    Perez, L.E.4    Melby, P.C.5
  • 128
    • 33646131385 scopus 로고    scopus 로고
    • Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models
    • Saravia, N. G., Escorcia, B., Osorio, Y., Valderrama, L., Brooks, D., Arteaga, L., Coombs, G., Mottram, J., and Travi, B. L. (2006). Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine 24, 4247-4259.
    • (2006) Vaccine , vol.24 , pp. 4247-4259
    • Saravia, N.G.1    Escorcia, B.2    Osorio, Y.3    Valderrama, L.4    Brooks, D.5    Arteaga, L.6    Coombs, G.7    Mottram, J.8    Travi, B.L.9
  • 129
    • 0027255488 scopus 로고
    • Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice
    • Scharton, T. M., and Scott, P. (1993). Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178, 567-577.
    • (1993) J. Exp. Med. , vol.178 , pp. 567-577
    • Scharton, T.M.1    Scott, P.2
  • 130
    • 0024653524 scopus 로고
    • The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis
    • Scott, P. (1989). The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis. Exp. Parasitol. 68, 369-372.
    • (1989) Exp. Parasitol. , vol.68 , pp. 369-372
    • Scott, P.1
  • 131
    • 0026056142 scopus 로고
    • IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
    • Scott, P. (1991). IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147, 3149-3155.
    • (1991) J. Immunol. , vol.147 , pp. 3149-3155
    • Scott, P.1
  • 134
    • 0024854755 scopus 로고
    • Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease
    • Scott, P., Pearce, E., Cheever, A. W., Coffman, R. L., and Sher, A. (1989). Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 112, 161-182.
    • (1989) Immunol. Rev. , vol.112 , pp. 161-182
    • Scott, P.1    Pearce, E.2    Cheever, A.W.3    Coffman, R.L.4    Sher, A.5
  • 135
    • 33744898842 scopus 로고    scopus 로고
    • Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar
    • Singh, S. P., Reddy, D. C., Rai, M., and Sundar, S. (2006). Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India. Trop. Med. Int. Health 11, 899-905.
    • (2006) India. Trop. Med. Int. Health , vol.11 , pp. 899-905
    • Singh, S.P.1    Reddy, D.C.2    Rai, M.3    Sundar, S.4
  • 137
    • 0344482144 scopus 로고    scopus 로고
    • Induction of a Th1 immune response and simultaneous lack of activation of a [2Th] response are required for generation of immunity to leishmaniasis
    • Sjolander, A., Baldwin, T. M., Curtis, J. M., and Handman, E. (1998). Induction of a Th1 immune response and simultaneous lack of activation of a [2Th] response are required for generation of immunity to leishmaniasis. J. Immunol. 160, 3949-3957.
    • (1998) J. Immunol. , vol.160 , pp. 3949-3957
    • Sjolander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Handman, E.4
  • 139
    • 0035184650 scopus 로고    scopus 로고
    • IL-13 gene-deficient mice are susceptible to cutaneous L. mexicana infection
    • Sosa, M. R., Rosas, L. E., McKenzie, A. N., and Satoskar, A. R. (2001). IL-13 gene-deficient mice are susceptible to cutaneous L. mexicana infection. Eur. J. Immunol. 31, 3255-3260.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3255-3260
    • Sosa, M.R.1    Rosas, L.E.2    McKenzie, A.N.3    Satoskar, A.R.4
  • 140
    • 0043180475 scopus 로고    scopus 로고
    • The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
    • Spath, G. F., Garraway, L. A., Turco, S. J., and Beverley, S. M. (2003a). The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts. Proc. Natl. Acad. Sci. U.S.A. 100, 9536-9541.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9536-9541
    • Spath, G.F.1    Garraway, L.A.2    Turco, S.J.3    Beverley, S.M.4
  • 141
    • 0042322609 scopus 로고    scopus 로고
    • Persistence without pathology in phosphoglycandeficient Leishmania major
    • Spath, G. F., Lye, L. F., Segawa, H., Sacks, D. L., Turco, S. J., and Beverley, S. M. (2003b). Persistence without pathology in phosphoglycandeficient Leishmania major. Science 301, 1241-1243.
    • (2003) Science , vol.301 , pp. 1241-1243
    • Spath, G.F.1    Lye, L.F.2    Segawa, H.3    Sacks, D.L.4    Turco, S.J.5    Beverley, S.M.6
  • 142
    • 2542594797 scopus 로고    scopus 로고
    • Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies
    • Spath, G. F., Lye, L.-F., Segawa, H., Turco, S. J., and Beverley Stephen, M. (2004). Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies. Infect. Immun. 72, 3622-3627.
    • (2004) Infect. Immun. , vol.72 , pp. 3622-3627
    • Spath, G.F.1    Lye, L.-F.2    Segawa, H.3    Turco, S.J.4    Beverley Stephen, M.5
  • 143
    • 17844364002 scopus 로고    scopus 로고
    • A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection
    • Suffia, I., Reckling, S. K., Salay, G., and Belkaid, Y. (2005). A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J. Immunol. 174, 5444-5455.
    • (2005) J. Immunol. , vol.174 , pp. 5444-5455
    • Suffia, I.1    Reckling, S.K.2    Salay, G.3    Belkaid, Y.4
  • 144
    • 33645077332 scopus 로고    scopus 로고
    • Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
    • Suffia, I. J., Reckling, S. K., Piccirillo, C. A., Goldszmid, R. S., and Belkaid, Y. (2006). Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 203, 777-788.
    • (2006) J. Exp. Med. , vol.203 , pp. 777-788
    • Suffia, I.J.1    Reckling, S.K.2    Piccirillo, C.A.3    Goldszmid, R.S.4    Belkaid, Y.5
  • 145
    • 0028963901 scopus 로고
    • Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response
    • Swihart, K., Fruth, U., Messmer, N., Hug, K., Behin, R., Huang, S., Del Giudice, G., Aguet, M., and Louis, J. A. (1995). Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J. Exp. Med. 181, 961-971.
    • (1995) J. Exp. Med. , vol.181 , pp. 961-971
    • Swihart, K.1    Fruth, U.2    Messmer, N.3    Hug, K.4    Behin, R.5    Huang, S.6    Del Giudice, G.7    Aguet, M.8    Louis, J.A.9
  • 146
    • 23344449993 scopus 로고    scopus 로고
    • Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection
    • Tabbara, K. S., Peters, N. C., Afrin, F., Mendez, S., Bertholet, S., Belkaid, Y., and Sacks, D. L. (2005). Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection. Infect. Immun. 73, 4714-4722.
    • (2005) Infect. Immun. , vol.73 , pp. 4714-4722
    • Tabbara, K.S.1    Peters, N.C.2    Afrin, F.3    Mendez, S.4    Bertholet, S.5    Belkaid, Y.6    Sacks, D.L.7
  • 147
    • 3843131921 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides are potent enhancers of protective immunity in mice immunized with recombinant ORFF leishmanial antigen
    • Tewary, P., Sukumaran, B., Saxena, S., and Madhubala, R. (2004). Immunostimulatory oligodeoxynucleotides are potent enhancers of protective immunity in mice immunized with recombinant ORFF leishmanial antigen. Vaccine 22, 3053-3060.
    • (2004) Vaccine , vol.22 , pp. 3053-3060
    • Tewary, P.1    Sukumaran, B.2    Saxena, S.3    Madhubala, R.4
  • 149
    • 0024331482 scopus 로고
    • Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis
    • Titus, R. G., Sherry, B., and Cerami, A. (1989). Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis. J. Exp. Med. 170, 2097-2104.
    • (1989) J. Exp. Med. , vol.170 , pp. 2097-2104
    • Titus, R.G.1    Sherry, B.2    Cerami, A.3
  • 150
    • 2942679337 scopus 로고    scopus 로고
    • Low dose Leishmania major promotes a transient T helper cell type 2 response that is downregulated by interferon gammaproducing CD8+ T cells
    • Uzonna, J. E., Joyce, K. L., and Scott, P. (2004a). Low dose Leishmania major promotes a transient T helper cell type 2 response that is downregulated by interferon gammaproducing CD8+ T cells. J. Exp. Med. 199, 1559-1566.
    • (2004) J. Exp. Med. , vol.199 , pp. 1559-1566
    • Uzonna, J.E.1    Joyce, K.L.2    Scott, P.3
  • 151
    • 1542619246 scopus 로고    scopus 로고
    • Vaccination with phosphoglycandeficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response
    • Uzonna, J. E., Späth, G. F., Beverley, S. M., and Scott, P. (2004b). Vaccination with phosphoglycandeficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response. J. Immunol. 172, 3793-3797.
    • (2004) J. Immunol. , vol.172 , pp. 3793-3797
    • Uzonna, J.E.1    Späth, G.F.2    Beverley, S.M.3    Scott, P.4
  • 152
    • 0035893005 scopus 로고    scopus 로고
    • Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease
    • Uzonna, J. E., Wei, G., Yurkowski, D., and Bretscher, P. (2001). Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease. J. Immunol. 167, 6967-6974.
    • (2001) J. Immunol. , vol.167 , pp. 6967-6974
    • Uzonna, J.E.1    Wei, G.2    Yurkowski, D.3    Bretscher, P.4
  • 156
    • 47249165577 scopus 로고    scopus 로고
    • Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses
    • Vargas-Inchaustegui, D. A., Xin, L., and Soong, L. (2008). Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J. Immunol. 180, 7537-7545.
    • (2008) J. Immunol. , vol.180 , pp. 7537-7545
    • Vargas-Inchaustegui, D.A.1    Xin, L.2    Soong, L.3
  • 159
    • 33947413426 scopus 로고    scopus 로고
    • Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity
    • Von Stebut, E. (2007). Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity. Eur. J. Dermatol. 17, 115-122.
    • (2007) Eur. J. Dermatol. , vol.17 , pp. 115-122
    • Von Stebut, E.1
  • 160
    • 0027200941 scopus 로고
    • Targeted activation of CD8 cells and infection of beta 2-microglobulindeficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis
    • Wang, Z. E., Reiner, S. L., Hatam, F., Heinzel, F. P., Bouvier, J., Turck, C. W., and Locksley, R. M. (1993). Targeted activation of CD8 cells and infection of beta 2-microglobulindeficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J. Immunol. 151, 2077-2086.
    • (1993) J. Immunol. , vol.151 , pp. 2077-2086
    • Wang, Z.E.1    Reiner, S.L.2    Hatam, F.3    Heinzel, F.P.4    Bouvier, J.5    Turck, C.W.6    Locksley, R.M.7
  • 162
    • 0032529844 scopus 로고    scopus 로고
    • Prostaglandin E2 and dexamethasone inhibit IL12 receptor expression and IL-12 responsiveness
    • Wu, C. Y., Wang, K., McDyer, J. F., and Seder, R. A. (1998). Prostaglandin E2 and dexamethasone inhibit IL12 receptor expression and IL-12 responsiveness. J. Immunol. 161, 2723-2730.
    • (1998) J. Immunol. , vol.161 , pp. 2723-2730
    • Wu, C.Y.1    Wang, K.2    McDyer, J.F.3    Seder, R.A.4
  • 163
    • 77956478102 scopus 로고    scopus 로고
    • A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL/6 mice
    • Wu, W., Huang, L., and Mendez, S. (2010). A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL/6 mice. Eur. J. Immunol. 40, 2517-2527.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2517-2527
    • Wu, W.1    Huang, L.2    Mendez, S.3
  • 164
    • 33845578705 scopus 로고    scopus 로고
    • Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides
    • Wu, W., Weigand, L., Belkaid, Y., and Mendez, S. (2006). Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur. J. Immunol. 36, 3238-3247.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 3238-3247
    • Wu, W.1    Weigand, L.2    Belkaid, Y.3    Mendez, S.4
  • 165
    • 67749114317 scopus 로고    scopus 로고
    • The IL-6-deficient mouse exhibits impaired lymphocytic responses to a vaccine combining live Leishmania major and CpG oligodeoxynucleotides
    • Wu, W., Weigand, L., and Mendez, S. (2009). The IL-6-deficient mouse exhibits impaired lymphocytic responses to a vaccine combining live Leishmania major and CpG oligodeoxynucleotides. Can. J. Microbiol. 55, 705-713.
    • (2009) Can. J. Microbiol. , vol.55 , pp. 705-713
    • Wu, W.1    Weigand, L.2    Mendez, S.3
  • 166
    • 47249133986 scopus 로고    scopus 로고
    • Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice
    • Xu, G., Liu, D., Fan, Y., Yang, X., Korner, H., Fu, Y. X., and Uzonna, J. E. (2007a). Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice. J. Immunol. 179, 5358-5366.
    • (2007) J. Immunol. , vol.179 , pp. 5358-5366
    • Xu, G.1    Liu, D.2    Fan, Y.3    Yang, X.4    Korner, H.5    Fu, Y.X.6    Uzonna, J.E.7
  • 167
    • 38449084034 scopus 로고    scopus 로고
    • LIGHT is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major
    • Xu, G., Liu, D., Okwor, I., Wang, Y., Korner, H., Kung, S. K., Fu, Y. X., and Uzonna, J. E. (2007b). LIGHT is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major. J. Immunol. 179, 6901-6909.
    • (2007) J. Immunol. , vol.179 , pp. 6901-6909
    • Xu, G.1    Liu, D.2    Okwor, I.3    Wang, Y.4    Korner, H.5    Kung, S.K.6    Fu, Y.X.7    Uzonna, J.E.8
  • 168
    • 0141888314 scopus 로고    scopus 로고
    • The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function
    • Yao, C., Donelson, J. E., and Wilson, M. E. (2003). The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function. Mol. Biochem. Parasitol. 132, 1-16.
    • (2003) Mol. Biochem. Parasitol. , vol.132 , pp. 1-16
    • Yao, C.1    Donelson, J.E.2    Wilson, M.E.3
  • 169
    • 33750530395 scopus 로고    scopus 로고
    • CCR5dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence
    • Yurchenko, E., Tritt, M., Hay, V., Shevach, E. M., Belkaid, Y., and Piccirillo, C. A. (2006). CCR5dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J. Exp. Med. 203, 2451-2460.
    • (2006) J. Exp. Med. , vol.203 , pp. 2451-2460
    • Yurchenko, E.1    Tritt, M.2    Hay, V.3    Shevach, E.M.4    Belkaid, Y.5    Piccirillo, C.A.6
  • 170
    • 2342461107 scopus 로고    scopus 로고
    • Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis
    • Zadeh-Vakili, A., Taheri, T., Taslimi, Y., Doustdari, F., Salmanian, A. H., and Rafati, S. (2004). Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis. Vaccine 22, 1930-1940.
    • (2004) Vaccine , vol.22 , pp. 1930-1940
    • Zadeh-Vakili, A.1    Taheri, T.2    Taslimi, Y.3    Doustdari, F.4    Salmanian, A.H.5    Rafati, S.6
  • 171
    • 7044254507 scopus 로고    scopus 로고
    • Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites
    • Zaph,C., Uzonna, J., Beverley,S. M.,and Scott, P. (2004). Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nat. Med. 10, 1104-1110.
    • (2004) Nat. Med. , vol.10 , pp. 1104-1110
    • Zaph, C.1    Uzonna, J.2    Beverley, S.M.3    Scott, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.