Anti-Leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice

Advances in Experimental Medicine and Biology

Volumn 452, Issue , 1998, Pages 53-60

  Louis, Jacques A ^a   Conceiçao Silva, Fatima ^a   Himmelrich, Hayo ^a   Tacchini Cottier, Fabienne ^a   Launois, Pascal ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 4; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

CONFERENCE PAPER; CYTOTOXICITY; HELPER CELL; INFECTION SENSITIVITY; LEISHMANIA MAJOR; LEISHMANIASIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

LEISHMANIA MAJOR;

EID: 0031756309     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5355-7_7     Document Type: Conference Paper

References (22)

1. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015, 1991.
2. Holaday B. J., Sadick M.D., Wang Z.-E., Reiner S.L., Heinzel F.P., Parslow T.G., Locksley R.M.: Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol. 147:1653-1658, 1991.
3. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549, 1993.
4. Hsieh C.-S., Heimberger A. B., Gold J. S., O'Garra A., Murphy K. M.: Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89:6065-6069, 1992.
5. + T cells from T cell receptor trangenic mice. J. Exp. Med. 176:1091-1098, 1992.
6. + T cells to enhance priming for inteferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188-10192, 1993.
7. Titus R. G., Ceredig R., Cerottini J. C., Louis J. A.: Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J. Immunol. 135:2108-2114, 1985.
8. Sadick M. D., Heinzel F. P., Holaday J., Pu R. T., Dawkins R. S., Locksley R. M.: Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon-γ independent mechanism. J. Exp. Med. 171:115-127, 1990.
9. Müller I., Garcia-Sanz J. A., Titus R., Behin R., Louis J.: Analysis of the cellular parameters of the immune responses contributing to resistance and susceptibility of mice to infection with the intracellular parasite, Leishmania major. Immunol. Rev. 112:95-113, 1989.
10. Reiner S. L., Locksley R. M.: The regulation of immunity to Leishmania major. Ann. Rev. Immunol. 13:151-77, 1995.
11. Heinzel F. P., Rerko R. M., Hatam F., Locksley R. M.: IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924-3931, 1993.
12. Heinzel F. P., Schoenhaut D. S., Rerko R. M., Rosser L. E., Gately M. K.: Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509, 1993.
13. Sypek J. P., Chung C. L., Mayor S. E. U., Subramanyam S. J., Goldman S. J., Sieburth D. S., Wolf S. F., Schaub R. G.: Resolution of cutaneous leishmaniasis: interleukin 12 iniates a protective T helper type 1 immune response. J. Exp. Med. 177:1793-1802, 1993.
14. Heinzel F. P., Rerko R. M., Ahmed F., Pearlman E. : Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating Leishmaniasis in normally resistant mice. J. Immunol. 155:730-739, 1995.
15. Assreuy J. F., Cunha Q., Epperlein M., Noronha-Dutra A., O'Donnell C. A., Liew F. Y., Moncada S.: Production of nitric oxide and Superoxide by activated macrophages and killing of Leishmania major. Eur. J. Immunol. 24:672-676., 1994.
16. Ramsdell F., Seaman M., Miller R., Picha K., Kennedy M., Lynch D.: Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6:1545-1553, 1994.
17. + T cell mediated cytotoxicity. J. Immunol. 152:1127-1133, 1994.
18. + cytotoxic T cells. Proc. Natl. Acad. Sci. USA 91:4285-4189, 1994.
19. + T cells. Immunol. Rev. 146:223-239, 1995.
20. Nagata, S.: Fas and Fas ligand: a death factor and its receptor. Adv. Immunol. 57:129-144, 1994.
21. Conceiçao-Silva, F., Hahne M., Schröter M., Louis J., Tschopp J.: The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur. J. Immunol. in press.: 1998.
22. + T cells which are NK1.1. Eur. J. Immunol. 25:3298-307, 1995.