IL-12 as an adjuvant for cell-mediated immunity

Seminars in Immunology

Volumn 9, Issue 5, 1997, Pages 285-291

  Scott, Phillip ^a   Trinchieri, Giorgio ^b  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

Adjuvant; IL 12; Leishmania; Vaccine

Indexed keywords

ADJUVANT; INTERLEUKIN 12; VACCINE;

CELLULAR IMMUNITY; INFECTION RESISTANCE; LEISHMANIA MAJOR; LEISHMANIASIS; REVIEW; VACCINATION;

EID: 0031252118     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1997.0084     Document Type: Article

References (47)

1. 1. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145-173
2. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549
3. 3. Manetti R, Parronchi P, Giudizi MG, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S (1993) Natural killer cell stimulatory factor (NKSF/ IL-12) induces Th 1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 177:1199-1204
4. 4. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon F, Sherman B, Perussia B, Trinchieri G (1989) Identification and purification of Natural Killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-846
5. 5. Stern AS, Podlaski FJ, Hulmes JD, Pan YE, Quinn PM, Wolitzky AG, Familletti PC, Stremlo DL, Truitt T, Chizzonite R, Gately MK (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor form human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87:6808-6812
6. 6. Trinchieri G (1995) Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251-276
7. 7. Trinchieri G, Scot P (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res Immunol 146:423-431
8. 8. Ma X, D'Andrea A, Kubin M, Aste-Amezaga M, Sartori A, Monteiro J, Showe L, Wysocka M, Trinchieri G (1995) Production of interleukin-12. Res Immunol 146:432-438
9. 9. Chua AO, Wilkinson VL, Presky DH, Gubler U (1995) Cloning and characterization of a mouse IL-12 receptor-β component. J Immunol 155:4286-4294
10. 10. Presky DG, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu C-Y, Gately MK, Gubler U (1996) A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci USA 93:14002-14007
11. 11. Locksley RM, Scott P (1991) Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today 12:A58-A61
12. 12. Scott P (1996) T helper cell development and regulation in experimental cutaneous leishmaniasis. Chem Immunol 63:98-114
13. 13. Reiner SL, Locksley RM (1995) The regulation of immunity to Leishmania major. Annu Rev Immunol 13:151-177
14. 14. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A (1988) Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 168:1675-1684
15. 15. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM (1989) Reciprocal expression of interferon gamma or IL-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 169:59-72
16. 16. Scott P (1991) IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 147:3149-3155
17. 17. Chatelain R, Varkila K, Coffman RL (1992) IL-4 induces a Th2 response in Leishmania major-infected mice.. J Immunol 148:1182-1187
18. 18. Scharton-Kersten T, Afonso LCC, Wysocka M, Trinchieri G, Scott P (1995) IL-12 is required for Natural Killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 154:5320-5330
19. 19. Heinzel FP, Rerko RM, Ahmed F, Pearlman E (1995) Endogenous IL-12 is required for control of Th2 cytokine responses. J Immunol 155:730-739
20. 20. Sypek JP, Chung CL, Mayor SEH, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF, Schaub RG (1993) Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Th1 immune response. J Exp Med 177:1797-1802
21. 21. O'Garra A, Murphy K (1994) Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 6:458-466
22. 22. Afonso LCC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P (1994) The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237
23. 23. Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZW, Waldmann R, Locksley RM, Glaichenhaus N (1995) Expression cloning of a protective Leishmania antigen. Science 268:563-566
24. 24. Julia V, Rassoulzadegan M, Glaichenhaus N (1996) Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421-423
25. 25. Reiner SL, Wang Z-E, Hatam F, Scott P, Locksley RM (1993) Common lineage of Th1 and Th2 subsets in leishmaniasis. Science 259:1457-1460
26. + T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med 178:567-577
27. 27. Scharton-Kersten T, Scott P (1995) The role of the innate immune response in Th1 cell development following Leishmania major infection. J Leukocyte Biol 57:515-522
28. 28. Mountford AP, Anderson S, Wilson RA (1996) Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant. J Immunol 156:4739-4745
29. 29. Miller MA, Skeen MJ, Ziegler HK (1995) Non viable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. J Immunol 155:4817-4828
30. 30. Mahon BP, Ryan MS, Griffin F, Mills KHG (1996) Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular Pertussis vaccine by promoting induction of Th1 cells. Infect Immun 64:5295-5301
31. 31. Wynn TA, Jankovic D, Hieny S, Cheever AW, Sher A (1995) IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production and tissue eosinophilia. J Immunol 154:4701-4709
32. 32. Schijns VE, Haagmans BL, Horzinek MC (1995) IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor deficient mice. J Immunol 155:2525-2532
33. 33. Tang YW, Graham BS (1995) Interleukin-12 treatment during immunization elicits a T helper type-1 like response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity. J Infect Dis 172:734-738
34. 34. O'Toole M, Wooters J, Brown E, Swiniarski H, Cull G, Leger L, Herrmann S (1996) Interleukin-12 as an adjuvant in peptide vaccines. Ann NY Acad Sci 795:379-381
35. 35. Bliss J, Maylor R, Stokes K, Murray KS, Ketchum MA, Wolf SF (1996) Interleukin-12 as vaccine adjuvant: Characteristics of primary, recall, and long-term resistance. Ann NY Acad Sci 795:26-35
36. 36. McKnight AJ, Zimmer GJ, Fogelman I, Wolf SF, Abbas AK (1994) Effects of IL-12 on helper T cell-dependent immune responses in vivo. J Immunol 152:2172-2179
37. 37. Bliss J, VanCleave V, Murray K, Wiencis A, Ketchum M, Maylor R, Haire T, Resmini C, Abbas AK, Wolf S (1996) Interleukin-12 as an adjuvant, promotes a T helper 1 but does not suppress a T helper 2 recall response. J Immunol 156:887-894
38. 38. Germann T, Bongartz M, Dlugonska H, Hess H, Schmitt E, Kolbe L, Kolsch E, Podlaski FJ, Gately MK, Rude E ( 1995) Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement fixing IgG2a, IgG2b, IgG3 antibody subclasses in vivo. Eur J Immunol 25:823-829
39. 39. Murphy EE, Terres G, Macatonia SE, Hsieh C-S, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A (1994) B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 180:223-231
40. 40. Kubin M, Kamoun M, Trinchieri G (1994) Interleukin 12 synergizes with B7/ CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 180:211-222
41. 41. Coughlin CM, Wysocka M, Kurzawa HL, Lee WM, Trinchieri G, Eck SL (1995) B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Cancer Res 55:4980-4987
42. 42. Zitvogel L, Robbins PD, Storkus WJ, Clarke MR, Maeurer MJ, Campbell RL, Davis CG, Tahara H, Schreiber RD, Lotze MT (1996) Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors. Eur J Immunol 26:1335-1341
43. 43. Roa JB, Chamberlain RS, Bronte V, Carroll MW, Irvine KR, Moss B, Rosenberg SA, Restifo NP (1996) IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression. J Immunol 156:3357-3365
44. 44. Nabors GS, Afonso LCC, Farrell JP, Scott P (1995) Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin-12 and pentostam. Proc Natl Acad Sci USA 92:3142-3146
45. 45. Wynn TA, Eltoum I, Oswald I, Cheever A, Sher A (1994) Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibit and prophylactically immunizes against egg pathology. J Exp Med 179:1551-1561
46. 46. Wynn TA, Cheever AW, Jankovic D, Poindexter RW, Caspar P, Lewis FA, Sher A ( 1995) An IL-12 based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594-596
47. 47. Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon MA, Dang K, Wang B, Boyer JD, Weiner DB (1997) In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 158:816-826