Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2723-2730

  Wu, Chang You ^a   Wang, Kening ^a   McDyer, John F ^a   Seder, Robert A ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN RECEPTOR; MESSENGER RNA; OKT 3;

ARTICLE; CYTOKINE PRODUCTION; IMMUNE RESPONSE; IMMUNOREGULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; BIOSYNTHESIS; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; PROTEIN BINDING; T LYMPHOCYTE;

CELLS, CULTURED; CYCLIC AMP; DEXAMETHASONE; DINOPROSTONE; DOWN-REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MUROMONAB-CD3; PROTEIN BINDING; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032529844     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Chua, A. O., R. Chizzonite, B. B. Desai, T. P. Truitt, P. Nunes, L. J. Minetti, R. R. Warrier, D. H. Presky, J. F. Levine, M. K. Gately, and U. Gubler. 1994. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153: 128.
2. Desai, B. B., P. M. Quinn, A. G. Wolitzky, P. K. A. Mongini, R. Chizzonite, and M. K. Gately. 1992. IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol. 148:3125.
3. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C.-Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002.
4. Chizzonite, R., T. Truitt, B. B. Desai, P. Nunes, F. J. Podlaski, A. S. Sturn, and M. K. Gately. 1992. IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol. 148:3117.
5. Wu, C.-Y., R. R. Warrier, D. M. Carvajal, A. O. Chua, L. J. Minetti, R. Chizzinite, P. K. A. Mongini, A. S. Stern, U. Gubler, D. H. Presky, and M. K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor β chain. Eur. J. Immunol. 26:345.
6. Wu, C.-Y., J. Ferrante, M. K. Gately, and J. Magram. 1997. Characterization of IL-12 receptor-β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J. Immunol. 159:1658.
7. Wu, C.-Y., R. R. Warrier, X. Wang, D. H. Presky, and M. K. Gately. 1997. Regulation of interleukin-12 receptor β1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. Eur. J. Immunol. 27:147.
8. + T cells by costimulation with B7-2 molecules. J. Immunol. 160:1638.
9. Gollob, J. A., H. Kawasaki, and J. Ritz. 1997. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol. 27:647.
10. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
11. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigalia. 1997. Selective expression of an interleukin-IL-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.
12. Mary, D., C. Aussel, B. Ferrua, and M. Fehlmann. 1987. Regulation of interleukin 2 synthesis by cAMP in human T cells. J. Immunol. 139:1179.
13. 2 and the increase of intracellular cAMP inhibit the expression of interleukin 2 receptors in human T cells. Eur. J. Immunol. 18:1791.
14. 2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R gene expression at multiple levels. J. Immunol. 148:2845.
15. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108.
16. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:5321.
17. + T cells inhibits acquisition of ability to produce IFN-γ and IL-2. but not IL-4 and IL-5. J. Immunol. 155:4604.
18. 2 primes naive T cells for the production of anti-inflammatory cytokines. Eur. J. Immunol. 27:3526.
19. 2 critically depends on interleukin-2. Eur. J. Immunol. 25:59.
20. + T cells. J. Immunol. 156: 1722.
21. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
22. 2 and tumor necrosis factor β cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J. Exp. Med. 186:1603.
23. + lymphocytes. J. Immunol. 158:5589.
24. + lymphocytes by inhibiting IL-12 production. J. Immunol. 160:2231.
25. 2. J. Exp. Med. 180: 2365.
26. 2 and prostacyclin elevate cyclic AMP levels in elicited populations of mouse peritoneal macrophages. Adv. Prostaglandin Thromboxane Res. 8:1681.
27. Novak, T. J., and E. V. Rothenberg. 1990. cAMP inhibits induction of interleukin 2 but not interleukin 4 in T cells. Proc. Natl. Acad. Sci. USA 87:9353.
28. Munoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter, and B. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
29. Daynes, R. A., D. J. Dudley, and B. A. Araneo. 1990. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur. J. Immunol. 20:793.
30. Wu, C. Y., C. Fargeas, T. Nakajima, and G. Delespesse. 1991. Glucocorticoids suppress the production of interleukin 4 by human lymphocytes. Eur. J. Immunol. 21:2645.
31. Snijdewint, F. G., M. L. Kapsenberg, P. J. Wauben-Penris, and J. D. Bos. 1995. Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production. Immunopharmacology 29:93.
32. Braun, C. M., S.-K. Huang, G. G. Bashian, A. Kagey-Sobotka, L. M. Lichtenstein, and D. M. Essayan. 1997. Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses. J. Allergy Clin. Immunol. 100:400.
33. + T cells in vitro. J. Immunol. 156:2406.
34. + subsets. J. Immunol. 155:3322.
35. Zieg, G., G. Lack, R. J. Harbeck, E. W. Gelfand, and D. Y. Leung. 1994. In vivo effects of glucocorticoids on IgE production. J. Allergy Clin. Immunol. 94:222.
36. Leung, D. Y., R. J. Martin, S. J. Szefler, E. R. Sher, S. Ying, A. B. Kay, and Q. Hamid. 1995. Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma. J. Exp. Med. 181:33.