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1
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0028933795
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The regulation of immunity to Leishmania major
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Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol. 13:1995;151-177.
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Annu Rev Immunol
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Reiner, S.L.1
Locksley, R.M.2
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2
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0028222669
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Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major
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Assreuy J, Cunha FQ, Epperlein M, Noronha-Dutra A, O'Donnell CA, Liew FY, Moncada S. Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major. Eur J Immunol. 24:1994;672-676.
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Assreuy, J.1
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O'Donnell, C.A.5
Liew, F.Y.6
Moncada, S.7
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3
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0028326103
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+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major
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+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med. 179:1994;1367-1371.
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(1994)
J Exp Med
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Wang, Z.E.1
Reiner, S.L.2
Zheng, S.3
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Locksley, R.M.5
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4
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0028963901
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+ T cell response
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+ T cell response. J Exp Med. 181:1995;961-971.
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(1995)
J Exp Med
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Swihart, K.1
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Huang, S.6
Del Giudice, G.7
Aguet, M.8
Louis, J.A.9
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5
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0029035476
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Altered immune responses in mice lacking inductible nitric oxide synthase
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Wei X-Q, Charles IG, Smith A, Feng G-J, Huang F-P, Xu D, Muller W, Moncada S, Liew FY. Altered immune responses in mice lacking inductible nitric oxide synthase. Nature. 375:1995;408-411.
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Nature
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Wei X-Q1
Charles, I.G.2
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Feng G-J4
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Xu, D.6
Muller, W.7
Moncada, S.8
Liew, F.Y.9
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6
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0029976423
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Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
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Stenger S, Donhauser N, Thürin H, Röllinghoff M, Bogdan C. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J Exp Med. 183:1996;1501-1514.
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J Exp Med
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Stenger, S.1
Donhauser, N.2
Thürin, H.3
Röllinghoff, M.4
Bogdan, C.5
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7
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0031907920
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Type 1 Interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
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of special interest. This paper shows that genetic deletion or functionnal inactivation of type 2 nitric oxide synthase abolishes the natural killer cell response seen one day after infection with Leishmania major. Neutralisation of IFNα/β has a similar effect.
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of special interest Diefenbach A, Schindler H, Donhauser N, Lorenz E, Laskay T, MacMicking J, Röllinghoff M, Gresser I, Bogdan C. Type 1 Interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity. 8:1998;77-87 This paper shows that genetic deletion or functionnal inactivation of type 2 nitric oxide synthase abolishes the natural killer cell response seen one day after infection with Leishmania major. Neutralisation of IFNα/β has a similar effect.
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(1998)
Immunity
, vol.8
, pp. 77-87
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-
Diefenbach, A.1
Schindler, H.2
Donhauser, N.3
Lorenz, E.4
Laskay, T.5
MacMicking, J.6
Röllinghoff, M.7
Gresser, I.8
Bogdan, C.9
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8
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0027464928
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Immune response in mice that lack the interferon-γ receptor
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Huang S, Hendricks W, Althage A, Hemmi S, Bluethmann H, Vilcek J, Zinkernagel RM, Aguet M. Immune response in mice that lack the interferon-γ receptor. Science. 259:1993;1742-1745.
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(1993)
Science
, vol.259
, pp. 1742-1745
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Huang, S.1
Hendricks, W.2
Althage, A.3
Hemmi, S.4
Bluethmann, H.5
Vilcek, J.6
Zinkernagel, R.M.7
Aguet, M.8
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9
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-
0027400726
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Multiple defects of immune cell function in mice with disrupted interferon gamma gene
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Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon gamma gene. Science. 259:1993;1739-1742.
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(1993)
Science
, vol.259
, pp. 1739-1742
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Dalton, D.K.1
Pitts-Meek, S.2
Keshav, S.3
Figari, I.S.4
Bradley, A.5
Stewart, T.A.6
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11
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2642613665
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The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity
-
of special interest. This paper shows for the first time the requirement of a functional Fas/Fas-ligand pathway of cytotoxicity for the resolution by resistant mice of lesions induced by infection with L. major.
-
of special interest Conceiçao-Silva F, Hahne M, Schröter M, Louis J, Tschopp J. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur J Immunol. 28:1998;237-245 This paper shows for the first time the requirement of a functional Fas/Fas-ligand pathway of cytotoxicity for the resolution by resistant mice of lesions induced by infection with L. major.
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(1998)
Eur J Immunol
, vol.28
, pp. 237-245
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Conceiçao-Silva, F.1
Hahne, M.2
Schröter, M.3
Louis, J.4
Tschopp, J.5
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12
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2642610290
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Selective expression of a stable cell surface molecule on type 2 but not on type 1 helper T cells
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Xu D, Chan WL, Leung BP, Huang FP, Wheeler R, Piedrafita D, Robinson JH, Liew FY. Selective expression of a stable cell surface molecule on type 2 but not on type 1 helper T cells. J Exp Med. 187:1998;787-794.
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(1998)
J Exp Med
, vol.187
, pp. 787-794
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Xu, D.1
Chan, W.L.2
Leung, B.P.3
Huang, F.P.4
Wheeler, R.5
Piedrafita, D.6
Robinson, J.H.7
Liew, F.Y.8
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13
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0029847368
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Functional diversity of helper T lymphocytes
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Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
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(1996)
Nature
, vol.383
, pp. 787-793
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Abbas, A.K.1
Murphy, K.M.2
Sher, A.3
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14
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0031308702
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IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages
-
of special interest. This paper shows that interferon (IFN)-γ-induced expression of the gene for IFN regulatory factor 1 (IRF-1) is suppressed by IL-4.
-
of special interest Ohmori Y, Hamilton TA. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages. J Immunol. 159:1997;5474-5482 This paper shows that interferon (IFN)-γ-induced expression of the gene for IFN regulatory factor 1 (IRF-1) is suppressed by IL-4.
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(1997)
J Immunol
, vol.159
, pp. 5474-5482
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Ohmori, Y.1
Hamilton, T.A.2
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15
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0030805936
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Effect of IL-4 and IL-13 on IFN-gamma induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2
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Paludan SR, Lovmand J, Ellermann-Eriksen S, Mogensen SC. Effect of IL-4 and IL-13 on IFN-gamma induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2. FEBS Lett. 414:1997;61-64.
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(1997)
FEBS Lett
, vol.414
, pp. 61-64
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Paludan, S.R.1
Lovmand, J.2
Ellermann-Eriksen, S.3
Mogensen, S.C.4
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16
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0028908222
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The role of natural killer cells in host-parasite interactions
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Scott P, Trinchieri G. The role of natural killer cells in host-parasite interactions. Curr Opin Immunol. 7:1995;34-40.
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(1995)
Curr Opin Immunol
, vol.7
, pp. 34-40
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Scott, P.1
Trinchieri, G.2
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17
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0030917140
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Natural killer cells: From no receptors to too many
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of outstanding interest. This excellent review summarises the current status of knowledge concerning inhibitory receptors on natural killer cells.
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of outstanding interest Lanier LL. Natural killer cells: from no receptors to too many. Immunity. 6:1997;371-378 This excellent review summarises the current status of knowledge concerning inhibitory receptors on natural killer cells.
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(1997)
Immunity
, vol.6
, pp. 371-378
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Lanier, L.L.1
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18
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0027255488
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+ T cell subsets and induces early resistance to L. major in mice
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+ T cell subsets and induces early resistance to L. major in mice. J Exp Med. 178:1993;567-577.
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(1993)
J Exp Med
, vol.178
, pp. 567-577
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Sharton, T.M.1
Scott, P.2
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19
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0029805028
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The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo
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Duncan GS, Mittrücker H-W, Kägi D, Matsuyama T, Mak TW. The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo. J Exp Med. 184:1996;2043-2048.
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(1996)
J Exp Med
, vol.184
, pp. 2043-2048
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Duncan, G.S.1
Mittrücker H-W2
Kägi, D.3
Matsuyama, T.4
Mak, T.W.5
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20
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0030741433
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Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
-
of special interest. This paper shows for the first time the in vitro importance of interferon regulatory factor 1 (IRF-1) in the regulation of Th1 responses.
-
of special interest Taki S, Sato T, Ogasawa K, Fukuda T, Sato M, Suzuki G, Mitsuyama M, Shin EH, Taniguchi T, Asano Y. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity. 6:1997;673-679 This paper shows for the first time the in vitro importance of interferon regulatory factor 1 (IRF-1) in the regulation of Th1 responses.
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(1997)
Immunity
, vol.6
, pp. 673-679
-
-
Taki, S.1
Sato, T.2
Ogasawa, K.3
Fukuda, T.4
Sato, M.5
Suzuki, G.6
Mitsuyama, M.7
Shin, E.H.8
Taniguchi, T.9
Asano, Y.10
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21
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0030747793
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Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
-
of special interest. This paper shows the in vivo importance of IRF-1 in the regulation of Th1 responses using the murine model of Leishmania major.
-
of special interest Lohoff M, Ferrick D, Mittrücker H-W, Duncan GS, Bischof S, Röllinghoff M, Mak TW. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity. 6:1998;681-689 This paper shows the in vivo importance of IRF-1 in the regulation of Th1 responses using the murine model of Leishmania major.
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(1998)
Immunity
, vol.6
, pp. 681-689
-
-
Lohoff, M.1
Ferrick, D.2
Mittrücker H-W3
Duncan, G.S.4
Bischof, S.5
Röllinghoff, M.6
Mak, T.W.7
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22
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0028049247
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The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
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Afonso LCC, Sharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science. 263:1994;235-237.
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(1994)
Science
, vol.263
, pp. 235-237
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Afonso, L.C.C.1
Sharton, T.M.2
Vieira, L.Q.3
Wysocka, M.4
Trinchieri, G.5
Scott, P.6
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23
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0029077326
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IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis
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Scharton-Kersten T, Afonso LCC, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol. 154:1995;5320-5330.
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(1995)
J Immunol
, vol.154
, pp. 5320-5330
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Scharton-Kersten, T.1
Afonso, L.C.C.2
Wysocka, M.3
Trinchieri, G.4
Scott, P.5
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24
-
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0029965957
-
CD40 ligand is required for protective cell-mediated immunity to Leishmania major
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Campbell KA, Ovendale PJ, Kennedy MK, Fanslow WC, Reed SG, Maliszewski CR. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity. 4:1996;283-289.
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(1996)
Immunity
, vol.4
, pp. 283-289
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Campbell, K.A.1
Ovendale, P.J.2
Kennedy, M.K.3
Fanslow, W.C.4
Reed, S.G.5
Maliszewski, C.R.6
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25
-
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0029933509
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Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
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Kamanaka M, Yu P, Yasui T, Yoshida K, Kawabe T, Horii T, Kishimoto T, Kikutani H. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity. 4:1996;275-281.
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(1996)
Immunity
, vol.4
, pp. 275-281
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Kamanaka, M.1
Yu, P.2
Yasui, T.3
Yoshida, K.4
Kawabe, T.5
Horii, T.6
Kishimoto, T.7
Kikutani, H.8
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26
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0029925517
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Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
-
Soong L, Xu J-C, Grewa LIS, Kima P, Sun J, Longley BJ, Ruddle NH, McMahon-Pratt D, Flavell RA. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity. 4:1996;263-273.
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(1996)
Immunity
, vol.4
, pp. 263-273
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Soong, L.1
Xu J-C2
Grewa, L.I.S.3
Kima, P.4
Sun, J.5
Longley, B.J.6
Ruddle, N.H.7
McMahon-Pratt, D.8
Flavell, R.A.9
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27
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0029807762
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Blockade of CD86 ameliorates Leishmania major infection by down regulating the Th2 response
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Brown JA, Titus RG, Nabavi N, Glimcher LH. Blockade of CD86 ameliorates Leishmania major infection by down regulating the Th2 response. J Infec Dis. 147:1996;1303-1308.
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(1996)
J Infec Dis
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, pp. 1303-1308
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Brown, J.A.1
Titus, R.G.2
Nabavi, N.3
Glimcher, L.H.4
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28
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0029788151
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Limited role of CD28-mediated signals in T helper subset differenciation
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Brown DR, Green JM, Moskowitz NH, Davis M, Thompson CB, Reiner SL. Limited role of CD28-mediated signals in T helper subset differenciation. J Exp Med. 184:1996;803-810.
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(1996)
J Exp Med
, vol.184
, pp. 803-810
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Brown, D.R.1
Green, J.M.2
Moskowitz, N.H.3
Davis, M.4
Thompson, C.B.5
Reiner, S.L.6
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29
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0030917080
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Impaired Th2 subset development in the absence of CD4
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of outstanding interest. An interesting study demonstrating the importance of the CD4 molecule in Th2 cell development.
-
of outstanding interest Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired Th2 subset development in the absence of CD4. Immunity. 6:1997;559-569 An interesting study demonstrating the importance of the CD4 molecule in Th2 cell development.
-
(1997)
Immunity
, vol.6
, pp. 559-569
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Fowell, D.J.1
Magram, J.2
Turck, C.W.3
Killeen, N.4
Locksley, R.M.5
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30
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0030825464
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A role of CD4 in peripheral T cell differentiation
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of outstanding interest. This paper demonstrates the importance of the CD4 molecule in Th2 cell development.
-
of outstanding interest Brown DR, Moskowitz NH, Killeen N, Reiner SL. A role of CD4 in peripheral T cell differentiation. J Exp Med. 186:1997;101-107 This paper demonstrates the importance of the CD4 molecule in Th2 cell development.
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(1997)
J Exp Med
, vol.186
, pp. 101-107
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Brown, D.R.1
Moskowitz, N.H.2
Killeen, N.3
Reiner, S.L.4
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31
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0032033419
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Cytokines induce the development of functionally heterogeneous T helper cell subsets
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O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 8:1998;275-283.
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(1998)
Immunity
, vol.8
, pp. 275-283
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O'Garra, A.1
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32
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0031568526
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IFN-γ inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
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Kohno K, Kataoka J, Ohtsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M, Kurimoto M. IFN-γ inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol. 158:1997;1541-1550.
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(1997)
J Immunol
, vol.158
, pp. 1541-1550
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Kohno, K.1
Kataoka, J.2
Ohtsuki, T.3
Suemoto, Y.4
Okamoto, I.5
Usui, M.6
Ikeda, M.7
Kurimoto, M.8
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33
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0030694235
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IGIF does not drive Th1 development but synergizes with IL-12 for IFN-γ production and activates IRAK and NF-κB
-
of outstanding interest. This paper shows that IL-18 does not by itself induce Th1 cell development but acts in synergy with IL-12, activating the IL-1-receptor-associated kinase (IRAK) transcription factor.
-
of outstanding interest Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, Hartley SB, Menon S, Kastelein R, Bazan F, O'Garra A. IGIF does not drive Th1 development but synergizes with IL-12 for IFN-γ production and activates IRAK and NF-κB. Immunity. 7:1997;571-581 This paper shows that IL-18 does not by itself induce Th1 cell development but acts in synergy with IL-12, activating the IL-1-receptor-associated kinase (IRAK) transcription factor.
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(1997)
Immunity
, vol.7
, pp. 571-581
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-
Robinson, D.1
Shibuya, K.2
Mui, A.3
Zonin, F.4
Murphy, E.5
Sana, T.6
Hartley, S.B.7
Menon, S.8
Kastelein, R.9
Bazan, F.10
O'Garra, A.11
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34
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0032519903
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IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ In BALB/c but not C57BL/6 mice
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Shibuya K, Robinson D, Zonin F, Hartley SB, Macatonia SE, Somoza C, Hunter CA, Murphy KM, O'Garra A. IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice. J Immunol. 160:1998;1708-1716.
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(1998)
J Immunol
, vol.160
, pp. 1708-1716
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Shibuya, K.1
Robinson, D.2
Zonin, F.3
Hartley, S.B.4
MacAtonia, S.E.5
Somoza, C.6
Hunter, C.A.7
Murphy, K.M.8
O'Garra, A.9
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35
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18844481515
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Defective NK cell activity and Th1 response in IL-18-deficient mice
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Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8:1998;383-390.
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(1998)
Immunity
, vol.8
, pp. 383-390
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Takeda, K.1
Tsutsui, H.2
Yoshimoto, T.3
Adachi, O.4
Yoshida, N.5
Kishimoto, T.6
Okamura, H.7
Nakanishi, K.8
Akira, S.9
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36
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0029787798
-
IL-4 deficient BALB/c mice resist infection with Leishmania major
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Kopf M, Brombacher F, Kölher G, Kienzle G, Widmann K-H, Lefrang K, Humborg C, Ledermann B, Solbach W. IL-4 deficient BALB/c mice resist infection with Leishmania major. J Exp Med. 184:1996;1127-1136.
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J Exp Med
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Kopf, M.1
Brombacher, F.2
Kölher, G.3
Kienzle, G.4
Widmann K-H5
Lefrang, K.6
Humborg, C.7
Ledermann, B.8
Solbach, W.9
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40
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0029959243
-
+ T cells are not essential for T helper cell 2 immune responses
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+ T cells are not essential for T helper cell 2 immune responses. J Exp Med. 184:1996;1295-1304.
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(1996)
J Exp Med
, vol.184
, pp. 1295-1304
-
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Brown, D.R.1
Fowell, D.J.2
Corry, D.B.3
Wynn, T.A.4
Moskowitz, N.M.5
Cheever, A.W.6
Locksley, R.M.7
Reiner, S.L.8
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42
-
-
0001123104
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+ T cells in BALB/c mice infected with Leishmania major instructs Th2 cell development and susceptibility to infection
-
+ T cells recognising a specific epitope of the Leishmania-activated C kinase (LACK) antigen of L. major produces IL-4 very rapidly in response to infection. The importance of these cells in Th2 cell development and susceptibility to infection is clearly demonstrated.
-
+ T cells recognising a specific epitope of the Leishmania-activated C kinase (LACK) antigen of L. major produces IL-4 very rapidly in response to infection. The importance of these cells in Th2 cell development and susceptibility to infection is clearly demonstrated.
-
(1997)
Immunity
, vol.6
, pp. 541-549
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Launois, P.1
Maillard, I.2
Pingel, S.3
Swihart, K.4
Xenarios, I.5
Acha-Orbea, H.6
Diggelmann, H.7
Locksley, R.M.8
MacDonald, H.R.9
Louis, J.A.10
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43
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0029030456
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Expression cloning of a protective Leishmania antigen
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Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. Expression cloning of a protective Leishmania antigen. Science. 268:1995;563-566.
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Mougneau, E.1
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Zheng, S.4
Coppola, T.5
Wang, Z.E.6
Waldmann, R.7
Locksley, R.M.8
Glaichenhaus, N.9
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44
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0031114125
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Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness
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+ T cells. It is related to reference [58].
-
+ T cells. It is related to reference [58].
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(1997)
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Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
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53
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54
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of special interest Sutterwala FS, Noel GJ, Clynes R, Mosser DM. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J Exp Med. 185:1997;1977-1985 This paper shows that ligation of some receptors on the surface of macrophages results in impaired IL-12 production.
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55
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Regulation of interleukin-12 by complement receptor 3 signaling
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of special interest. This paper could provide a basis for the inhibition of IL-12 production by macrophages infected with Leishmania.
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of special interest Marth T, Kelsall BL. Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med. 185:1997;1987-1995 This paper could provide a basis for the inhibition of IL-12 production by macrophages infected with Leishmania.
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Marth, T.1
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56
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0029861329
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Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses
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Gorham JD, Güler ML, Steen RG, Mackey AA, Daly MJ, Frederick K, Dietrich WF, Murphy KM. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc Natl Acad Sci USA. 93:1996;12467-12472.
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61
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0030445948
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A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
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Presky DH, Yang H, Minetti LJ, Chu AO, Nabavi N, Wu C-Y, Gately M, Gübler U. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc Natl Acad Sci USA. 93:1996;14002-14007.
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Presky, D.H.1
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62
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Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper (Th) 1 and Th2 cells
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0027491655
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+ T cells to enhance priming for inteferon-γ production and diminishes interleukin-4 inhibition of such priming
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+ T cells to enhance priming for inteferon-γ production and diminishes interleukin-4 inhibition of such priming. Proc Natl Acad Sci USA. 90:1993;10188-10192.
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Seder, R.A.1
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66
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0030612781
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Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice
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of outstanding interest. This provides an interesting genetic analysis which has led to the identification of six loci related to resistance to infection with L. major. It is noteworthy that none of these loci, individually, was sufficient for the expression of a resistant phenotype.
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of outstanding interest Beebe A, Mauze S, Schork NJ, Coffman RL. Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 6:1997;551-557 This provides an interesting genetic analysis which has led to the identification of six loci related to resistance to infection with L. major. It is noteworthy that none of these loci, individually, was sufficient for the expression of a resistant phenotype.
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Beebe, A.1
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67
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Resistance to Leishmania major is linked to the H2 region on chromosome 17 and chromosome 9
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Roberts LJ, Badwin TM, Curtis JM, Handman E, Foote SJ. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and chromosome 9. J Exp Med. 185:1997;1705-1710.
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Roberts, L.J.1
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Foote, S.J.5
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