Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene

Experimental Parasitology

Volumn 85, Issue 1, 1997, Pages 35-42

  Muyombwe, Anthony ^b   Olivier, Martin ^b   Ouellette, Marc ^b   Papadopoulou, Barbara ^a  

^a LAVAL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HUMAN CELL; INFECTION CONTROL; INTRACELLULAR KILLING; LEISHMANIA; LEISHMANIASIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0038211674     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1996.4115     Document Type: Article

References (31)

1. Agabian N. Trans-splicing of nuclear pre-mRNAs. Cell. 61:1990;1157-1160.
2. Austin E. A., Huber B. E. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing and expression ofE. coli. Molecular Pharmacology. 43:1993;380-387.
3. Averett D. R., Koszalka G. W., Fyfe J. A., Roberts G. B., Purifoy D. J. M., Krenitsky T. A. 6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus. Antimicrobial Agents of Chemotherapy. 35:1991;851-857.
4. Borst P. Discontinuous transcription and antigenic variation in trypanosomes. Annual Review of Biochemistry. 55:1986;701-732.
5. Borst P., Ouellette M. New mechanisms of drug resistance in parasitic protozoa. Annual Review of Microbiology. 49:1995;427-460.
6. Borrelli E., Heyma R., Hsi M., Evans R. M. Targeting of an inducible toxic phenotype in animal cells. Proceedings of National Academy of Science USA. 85:1988;7572-7576.
7. Brun R., Schönenberger M. Cultivation and in vitro cloning of procyclic culture forms ofTrypanosoma brucei. Acta Tropica. 36:1979;289-289.
8. Caruso M., Klatzmann D. Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. Proceedings of the National Academy of Sciences USA. 89:1992;182-186.
9. Chen S. H., Shine H. D., Goodman J. C., Grossman R. G., Woo S. L. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proceedings of the National Academy of Sciences USA. 91:1994;3054-3057.
10. Curotto De Lafaille M. A., Laban A., Wirth D. F. Gene expression inLeishmania. Proceedings of the National Academy of Sciences USA. 89:1992;2703-2707.
11. Descoteaux A., Garraway L. A., Ryan K. A., Garrity L. K., Turco S. J., Beverley S. M. Identification of genes by functional complementation in protozoan parasiteLeishmania. Methods in Molecular Genetics. 3:1994;22-48.
12. Elion G. B. The biochemistry and mechanism of action of acyclovir. Journal of Antimicrobial Chemotherapy. 12:1983;9-17.
13. Fyfe J. A., Keller P. M., Furman P. A., Miller R. L., Elion G. B. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. Journal of Biological Chemistry. 253:1978;8721-8727.
14. Heyman R. A., Borrelli E., Lesley J., Anderson D., Richman D. D., Baird S. M., Hyman R., Evans R. M. Thymidine kinase obliteration: Creation of transgenic mice with controlled immune deficiency. Proceedings of the National Academy of Sciences USA. 86:1989;2698-2702.
15. Hirsch M. S., Kaplan J. C. Antiviral agents. Virology. 1990;Raven, New York. p. 441-468.
16. Laban A., Tobin J. F., Curotto De Lafaille M. A., Wirth D. F. Stable expression of the bacterial neoR gene inLeishmania enriettii. Nature. 343:1990;572-574.
17. Laird P. W. Trans-splicing in trypanosomes-archaism or adaption. Trends in Genetics. 5:1989;204-208.
18. Lebowitz J. H., Cruz A., Beverley S. M. Thymidine kinase as a negative selectable marker inLeishmania major. Molecular Biochemical Parasitology. 51:1992;321-326.
19. Lebowitz J. H., Smith H. Q., Rusche L., Beverley S. M. Coupling of poly(A) site selection and trans-splicing inLeishmania. Genes and Development. 7:1993;996-1007.
20. Manome Y., Abe M., Hagen M. F., Fine H. A., Kufe D. W. Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer Research. 54:1994;5408-5413.
21. Moolten F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Research. 46:1986;5276-5281.
22. Morse G. D., Shelton M. J., O'Donnell A. M. Comparative pharmacokinetics of antiviral nucleoside analogues. Clinical Pharmacokinetics. 24:1993;101-123.
23. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 65:1983;55-63.
24. Mullen C. A. Metabolic suicide genes in gene therapy. Pharmacology and Therapeutics. 63:1994;199-207.
25. Olivier M., Baimbridge K. G., Reiner N. E. Stimulus-response coupling in monocytes infected withLeishmania. Journal of Immunology. 148:1992;1188-1196.
26. Ouellette M., Fase-Fowler F., Borst P. The amplified H circle of methotrexate-resistantLeishmania tarentolae. EMBO Journal. 9:1990;1027-1033.
27. Papadopoulou B., Roy G., Ouellette M. A novel antifolate resistance gene on the amplified H circle ofLeishmania. EMBO Journal. 11:1992;3601-3608.
28. Papadopoulou B., Roy G., Ouellette M. Autonomous replication of bacterial DNA plasmid oligomers inLeishmania. Molecular Biochemical Parasitology. 65:1994;39-49.
29. Thomashow L. S., Milhausen M., Rutter W. J., Agabian N. Tubulin genes are tandemly linked and clustered in the genome ofTrypanosoma brucei. Cell. 32:1983;35-43.
30. Valdés J., Taylor M. C., Cross M. A., Ligtenberg M. J.L., Rudenko G., Borst P. The viral thymidine kinase gene as a tool for the study of mutagenesis inTrypanosoma brucei. Nucleic Acids Research. 24:1996;1809-1815.
31. Watson N. A new revision of the sequence of plasmid pBR322. Gene. 70:1988;399-403.