Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Frontiers in Genetics

Volumn 3, Issue OCT, 2012, Pages

  Bartfai, Tamas ^a   Conti, Bruno ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Calorie restriction; Core body temperature; GPCR; Homeostasis; Hypothalamus; Neuropeptides; Warm sensitive neurons

Indexed keywords

MUS;

EID: 84874066514     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00184     Document Type: Article

References (192)

1. Adachi, A., Shimizu, N., Oomura, Y., and Kobashi, M. (1984). Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract. Neurosci. Lett. 46,215-218.
2. Adamantidis, A., and de Lecea, L. (2009). The hypocretins as sensors for metabolism and arousal. J. Physiol 587, 33-40.
3. Adams, R, Grassie, M., Shahid, M., Hill, D. R., and Henry, B. (2003). Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced receptor (GIR) mRNA in rodent brain: potential role in HPA-axis function. Brain Res. Mol Brain Res. 117, 39-46.
4. Ahima, R. S. (2000). Leptin and the neu-roendocrinology of fasting. Front. Hortn. Res. 26,42-56.
5. Ahima, R. S., Prabakaran, D., Mant-zoros, C, Qu, D., Lowell, B., Maratos-Flier, E., et al. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252.
6. Ahima, R. S., Saper, C. B., Flier, J. S., and Elmquist, J. K. (2000). Leptin regulation of neuroendocrine systems. Front. Neuroendocrinol. 21, 263-307.
7. Anand, B. K., Chhina, G. S., Sharma, K. N., Dua, S., and Singh, B. (1964). Activity of single neurons in the hypothalamic feeding centers: effect of glucose. Am. ]. Physiol 207, 1 Hell 54.
8. Baskin, D. G., Figlewicz, D. P., Woods, S. C, Porte, D. Jr., and Dorsa, D. M. (1987). Insulin in the brain. Annu. Rev. Physiol 49, 335-347.
9. Batailler, M., Mullier, A., Sidibe, A., Delagrange, P., Prevot, V., Jockers, R., et al. (2011). Neu-roanataomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains. J. Neuroendocrinol doi: lO.llll/j.1365-2826.2011.02274.x [Epub ahead of print].
10. Baughman, G., Harrigan, M. T., Campbell, N. E, Nurrish, S. J., and Bourgeois, S. (1991). Genes newly identified as regulated by glucocor-ticoids in murine thymocytes. Mol. Endocrinol 5, 637-644.
11. Bechtold, D. A., Sidibe, A., Saer, B. R., Li, J., Hand, L. E., Ivanova, E. A., et al. (2012). A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor. Curr. Biol 22, 70-77.
12. Belgardt, B. E, andBruning, J. C. (2010). CNS leptin and insulin action in the control of energy homeostasis. Ann. N Y.Acad. Sci. 1212, 97-113.
13. Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947-953.
14. Berg, A. H., Combs, T. P., and Scherer, P. E. (2002). ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 13,84-89.
15. Billington, C. J., Briggs, J. E., Grace, M., and Levine, A. S. (1991). Effects of intracerebroven-tricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol 260,21-27.
16. Bjorbaek, C, and Hollenberg, A. N. (2002). Leptin and melanocortin signaling in the hypothalamus. Vitam. Harm. 65,281-311.
17. Bjursell, M., Ahnmark, A., Bohlooly, Y. M., William-Olsson, L, Rhedin, M., Peng, X. R., et al. (2007). Opposing effects of adiponectin receptors 1 and 2 on energy metabolism. Diabetes 56, 583-593.
18. Blake, N. G., Eckland, D. J., Foster, O. J., and Lightman, S. L. (1991). Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. Endocrinology 129, 2714-2718.
19. Blake, N. G., Johnson, M. R., Eckland, D. J., Foster, O. J., and Lightman, S. L. (1992). Effect of food deprivation and altered thyroid status on the hypothalamic-pituitary-thyroid axis in the rat. J. Endocrinol 133,183-188.
20. Bonnavion, P., and de Lecea, L. (2010). Hypocretins in the control of sleep and wakefulness. Curr. Neurol Neurosci. Rep. 10,174-179.
21. Bouali, S. M., Fournier, A., St-Pierre, S., and Jolicoeur, F. B. (1995). Effects of NPY and NPY2-36 on body temperature and food intake following administration into hypothalamic nuclei. Brain Res. Bull 36, 31-35.
22. Boulant, J. A. (2000). Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin. Infect. Dis. 31(Suppl. 5) S157-S161.
23. Brezillon, S., Detheux, M., Parmen-tier, M., Hokfelt, T., and Hurd, Y. L. (2001). Distribution of an orphan G-protein coupled receptor (JP05) mRNA in the human brain. Brain Res. 921,21-30.
24. Briski, K. P., and Sylvester, P. W. (2001). Co-distribution of Fos and mu opioid receptor immunoreactivity within the rat septopreoptic area and hypothalamus during acute glucose deprivation: effects of the mu receptor antagonist CTOP. Neurosci. Lett. 306, 141-144.
25. Brown, L. M., Clegg, D. J., Benoit, S. C, and Woods, S. C. (2006). Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav. 89, 687-691.
26. Bruning, J. C, Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C, et al. (2000). Role of brain insulin receptor in control of body weight and reproduction. Science289,2122- 2125.
27. Butler, A. A., Marks, D. L, Fan, W Kuhn, C. M., Bartolome, M., and Cone, R. D. (2001). Melanocortin-4 receptor is required for acute home-ostatic responses to increased dietary fat. Nat. Neurosci. 4, 605-611.
28. Campfield, L. A., Smith, F. J., Guisez, Y, Devos, R., and Burn, P. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549.
29. Cannon, B., and Nedergaard, J. (2004). Brown adipose tissue: function and physiological significance. Physiol Rev. 84, 277-359.
30. Cannon, B., and Nedergaard, J. (2010). Thyroid hormones: igniting brown fat via the brain. Nat. Med. 16, 965-967.
31. Cardona-Gomez, G. P., DonCarlos, L., and Garcia-Segura, L. M. (2000). Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain. Neuroscience 99, 751-760.
32. Cerri, M., and Morrison, S. F. (2005). Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis. Neuroscience 135,627-638.
33. Chavez, M., Kaiyala, K., Madden, L. J., Schwartz, M. W., and Woods, S. C. (1995). Intraventricular insulin and the level of maintained body weight in rats. Behav. Neurosri. 109, 528-531.
34. Cone, R. D. (1999). The central melanocortin system and energy homeostasis. Trends Endocrinol Metab. 10,211-216.
35. Connors, J. M., DeVito, W. J., and Hedge, G. A. (1985). Effects of food deprivation on the feedback regulation of the hypothalamic-pituitary-thyroid axis of the rat. Endocrinology 117,900-906.
36. Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C, Lucero, J., Brownell, S., et al. (2006). Trans-genic mice with a reduced core body temperature have an increased life span. Science 314, 825-828.
37. Coope, A., Milanski, M., Araujo, E. P., Tambascia, M., Saad, M. J., Geloneze, B., et al. (2008). AdipoRl mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEES Lett. 582, 1471-1476.
38. Coppari, R. (2012). Metabolic actions of hypothalamic SIRT1. Trends Endocrinol. Metab. 23, 179-185.
39. Costa-e-Sousa, R. H., Souza, L. L., Calvino, C, Cabanelas, A., Almeida, N. A., Oliveira, K. J., et al. (2011). Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul. Pept 171, 43-47.
40. Currie, P. J., and Coscina, D. V. (1995). Dissociated feeding and hypother-mic effects of neuropeptide Y in the paraventriculai and perifornical hypothalamus. Peptides 16, 599-604.
41. Dallaporta, M., Himmi, T., Perrin, J., and Orsini, J. C. (1999). Solitary tract nucleus sensitivity to moderate changes in glucose level. Neuroreport 10,2657-2660.
42. Dark, J., and Pelz, K. M. (2008). NPY Yl receptor antagonist prevents NPY-induced torpor-like hypothermia in cold-acclimated Siberian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R236-R245.
43. de Lecea, L., Kilduff, T. S., Peyron, C, Gao, X., Foye, P. E., Danielson, P. E., et al. (1998). The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U.S.A 95, 322-327.
44. Diano, S., Naftolin, F., Goglia, F, and Horvath, T. L. (1998). Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 139,2879-2884.
45. Dietrich, M. O., Antunes, C, Geliang, G., Liu, Z. W., Borok, E., Nie, Y, et al. (2010). Agrp neurons mediate Sirtl's action on the melanocortin system and energy balance: roles for Sirtl in neuronal firing and synaptic plasticity. J. Neurosci. 30, 11815-11825.
46. Drew, J. E., Barrett, P., Mercer, J. G., Moar, K. M., Canet, E., Dela-grange, P., et al. (2001). Localization of the melatonin-related receptor in the rodent brain and peripheral tissues. J. Neuroendocrinol. 13, 453-458.
47. Drew, J. E., Barrett, P., Williams, L. M., Conway, S., and Morgan, P. J. (1998). The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. J. Neuroendocrinol. 10, 651-661.
48. Dubins, J. S., Sanchez-Alavez, M., Zhukov, V., Sanchez-Gonzalez, A., Moroncini, G., Carvajal-Gonzalez, S., et al. (2012). Downregulation of GPR83 in the hypothalamic pre-optic area reduces core body temperature and elevates circulating levels of adiponectin. Metabolism. doi: 10.1016/j.metabol.2012.03.015 [Epub ahead of print].
49. Duffy, P. H., Feuers, R. J., Leakey, J. A., Nakamura, K., Turturro, A., and Hart, R. W (1989). Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. Mech. Ageing Dev. 48, 117-133.
50. Dufourny, L., Levasseur, A., Migaud, M., Callebaut, I., Pontarotti, P., Mal-paux, B., et al. (2008). GPR50 is the mammalian ortholog of Mellc: evidence of rapid evolution in mammals. BMC Evol. Biol. 8, 105. doi: 10.1186/1471-2148-8-105
51. Dufourny, L., Levasseur, A., Migaud, M., Callebaut, I., Pontarotti, P., Malpaux, B., et al. (2012). Correction: GPR50 is the mammalian ortholog of Mellc: evidence of rapid evolution in mammals. BMC Evol. Biol. 12, 28. doi: 10.1186/1471-2148-12-28
52. Dunn-Meynell, A. A., Rawson, N. E., and Levin, B. E. (1998). Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. Brain Res. 814, 41-54.
53. Eberwine, J., and Bartfai, T. (2011). Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response signaling asymmetry and an extension of chemical neu-roanatomy. Pharmacol. Ther. 129, 241-259.
54. Egawa, M., Yoshimatsu, H., and Bray, G. A. (1989). Lateral hypothalamic injection of 2-deoxy-D-glucose suppresses sympathetic activity. Am. J. Physiol. 257, R1386-R1392.
55. Egawa, M., Yoshimatsu, H., and Bray, G. A. (1991).NeuropeptideYsuppresses sympathetic activity to interscapular brown adipose tissue in rats. Am. J. Physiol. 260, R328-R334.
56. Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., and Lowell, B. B. (2005). Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J. Comp. Neurol. 493, 63-71.
57. Fan, W, Voss-Andreae, A., Cao, W H., and Morrison, S. F. (2005). Regulation of thermogenesis by the central melanocortin system. Peptides 26, 1800-1813.
58. Fekete, C, Kelly, J., Mihaly, E., Sarkar, S., Rand, W. M., Legradi, G., et al. (2001). Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology 142, 2606- 2613.
59. Fekete, C, Legradi, G., Mihaly, E., Huang, Q. H., Tatro, J. B., Rand, W M., et al. (2000a). alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventriculai nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 20,1550-1558.
60. Fekete, C, Mihaly, E., Luo, L. G., Kelly, J., Clausen, J. T., Mao, Q., et al. (2000b). Association of cocaine and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventriculai nucleus and its lole in the legula-tion of the hypothalamic-pituitaiy-thyioid axis duiing fasting. J. Neurosci. 20, 9224-9234.
61. Fekete, C, Maiks, D. L., Saikai, S., Emeison, C. H., Rand, W. M., Cone, R.D., et al. (2004). Effect of agouti-lelated piotein in legulation of the hypothalamic-pituitaiy-thyioid axis in the melanocoitin 4 leceptoi knockout mouse. Endocrinology 145, 4816-4821.
62. Fekete, C, Saikai, S., Rand, W. M., Har-ney, J. W., Emerson, C. H., Bianco, A. C, and Lechan, R. M. (2002a). Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology 143, 3846-3853.
63. Fekete, C, Saikai, S., Rand, W. M., Hainey, J. W, Emeison, C. H., Bianco, A. C, et al. (2002b). Neu-lopeptide Yl andY5 receptois mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology 143, 4513- 4519.
64. Fekete, C, Singru, P. S., Sanchez, E. S., Sarkar, S., Christoffolete, M. A., Riberio, R. S., et al. (2006). Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitaiy- thyioid axis and feeding-ielated neuions in the aicuate nucleus. Endocrinology 147, 520-529.
65. Fioiamonti, X., Loisignol, A., Taupignon, A., and Penicaud, L. (2004). A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neuions of mouse aicuate nucleus. Diabetes 53,2767-2775.
66. Fieinkel, N., Metzgei, B. E., Hanis, E., Robinson, S., and Magei, M. (1972). The hypotheimia of hypoglycemia. Studies with 2-deoxy-D-glucose in noimal human subjects and mice. N Engl. }. Med. 287, 841-845.
67. Fiuebis, J., Tsao, T. S., Javoischi, S., Ebbets-Reed, D., Eiickson, M. R., Yen, F. T., et al. (2001). Pio-teolytic cleavage pioduct of 30-kDa adipocyte complement-ielated piotein incieases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U.S.A. 98, 2005-2010.
68. Fiy, M., Smith, P. M., Hoyda, T. D., Duncan, M., Ahima, R. S., Shaikey, K. A., et al. (2006). Aiea postiema neuions aie modulated by the adipocyte hoimone adiponectin. J. Neurosci. 26, 9695-9702.
69. Gao, Q., and Hoivath, T. L. (2007). Neuiobiology of feeding and eneigy expendituie. Annu. Rev. Neurosci. 30, 367-398.
70. Gao, Q., Wolfgang, M. J., Neschen, S., Moiino, K., Hoivath, T. L., Shul-man, G. I., et al. (2004). Disiuption of neuial signal tiansducei and acti-vatoi of tiansciiption 3 causes obesity, diabetes, infertility, and theimal dysiegulation. Proc. Natl. Acad. Sci. U.S.A. 101,4661-4666.
71. Gavrilova, O., Leon, L. R., Marcus-Samuels, B., Mason, M. M., Castle, A. L. Refetoff, S., et al. (1999). Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc. Nail. Acad. Sci. U.S.A. 96,14623-14628.
72. Gluck, E. E, Stephens, N., and Swoap, S. J. (2006). Peripheral ghrelin deepens torpor bouts in mice through the arcuate nucleus neuropeptide Y signaling pathway. Am. J. Physiol Regul. Integr. Cotnp. Physiol. 291, R1303-R1309.
73. Guarente, L, and Picard, E (2005). Calorie restriction-the SIR2 connection. Cell 120,473-482.
74. Guillod-Maximin, E., Roy, A. F., Vacher, C. M., Aubourg, A., Bailleux, V., Lor-signol, A., et al. (2009). Adiponectin receptors are expressed in hypotha-lamus and colocalized with proo-piomelanocortin and neuropeptide Y in rodent arcuate neurons. J. Endocrinol. 200, 93-105.
75. Halaas, J. L, Gajiwala, K. S., Maf-fei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., et al. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546.
76. Hammel, H., Hardy, J. D., and Fusco, M. M. (1960). Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am. J. Physiol. 198,481-486.
77. Hamouda, H. O., Chen, P., Levoye, A., Sozer-Topcular, N., Daulat, A. M., Guillaume, J. L, et al. (2007). Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes. J. Pineal Res. 43,10-15.
78. Harrigan, M. T., Baughman, G., Campbell, N. F., and Bourgeois, S. (1989). Isolation and characterization of glucocorticoid and cyclic AMP-induced genes in T lymphocytes. Mol. Cell. Biol. 9, 3438-3446.
79. Harrigan, M. T., Campbell, N. F., and Bourgeois, S. (1991). Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol. Endocrinol. 5, 1331-1338.
80. Harris, M., Aschkenasi, C, Elias, C. F., Chandrankunnel, A., Nillni, E. A., Bjoorbaek, C, et al. (2001). Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J. Clin. Invest. 107, 111-120.
81. Havrankova, J., Roth, J., and Brown-stein, M. (1978). Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829.
82. Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., and Sivitz, W I. (1997). Receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100, 270-278.
83. Heppner, K. M., Muller, T. D., Kirch-ner, H., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., et al. (2012). The role of ghrelin-octanoyl-acyl-transferase (GOAT) in thermoreg-ulation. J. Endocrinol. Invest, doi: 10.3275/8388 [Epub ahead of print].
84. Hori, T., Yamasaki, M., Asami, T., Koga, H., and Kiyohara, T. (1988). Responses of anterior hypothalamic-preoptic thermosensitive neurons to thyrotropin releasing hormone and cyclo(His-Pro). Neuropharmacology 27,895-901.
85. Hoyda,T.D.,andFerguson,A.V. (2010). Adiponectin modulates excitability of rat paraventricular nucleus neurons by differential modulation of potassium currents. Endocrinology 151, 3154-3162.
86. Hwa, J. J., Witten, M. B., Williams, P., Ghibaudi, L., Gao, J., Salisbury, B. G., et al. (1999). Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am. J. Physiol. 277, R1428-R1434.
87. Ito, M., Gomori, A., Ishihara, A., Oda, Z., Mashiko, S., Matsushita, H., et al. (2003). Characterization of MCH-mediated obesity in mice. Am. J. Physiol. Endocrinol. Metab. 284, E940-E945.
88. Jolicoeur, E B., Bouali, S. M., Fournier, A., and St-Pierre, S. (1995). Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. Brain Res. Bull. 36, 125-129.
89. Kim, M. S., Small, C. J., Stanley, S. A., Morgan, D. G., Seal, L. J., Kong, W. M., et al. (2000). The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J. Clin. Invest. 105, 1005-1011.
90. Kishi, T., Aschkenasi, C. J., Lee, C. E., Mountjoy, K. G., Saper, C. B., and Elmquist, J. K. (2003). Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 457, 213-235.
91. Klein, I., Sanchez-Alavez, M., Tabarean, I., Schaefer, J., Holmberg, K. H., Klaus, J.,et al. (2011).AdipoRl and2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyper-thermic effects of adiponectin. Brain Res. 1423,1-9.
92. Koch, L., Wunderlich, E T., Seibler, J., Konner, A. C, Hampel, B., Irlenbusch, S., et al. (2008). Central insulin action regulates peripheral glucose and fat metabolism in mice. J. Clin. Invest. 118,2132-2147.
93. Kos, K., Harte, A. L., da Silva, N. F., Tonchev, A., Chaldakov, G., James, S., et al. (2007). Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothala-mus. J. Clin. Endocrinol. Metab. 92, 1129-1136.
94. Kubota, N., Yano, W, Kubota, T., Yamauchi, T., Itoh, S., Kuma-gai, H., et al. (2007). Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 6, 55-68.
95. Lane, M. A., Baer, D. J., Rumpler, W V., Weindruch, R., Ingram, D. K., Tilmont, E. M., et al. (1996). Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc. Natl. Acad. Sci. U.S.A. 93,4159-4164.
96. Lawrence, C. B., Snape, A. C, Baudoin, E M., and Luckman, S. M. (2002). Acute central ghrelin and GH secre-tagogues induce feeding and activate brain appetite centers. Endocrinology 143,155-162.
97. Lechan, R. M., and Fekete, C. (2006). The TRH neuron: a hypothalamic integrator of energy metabolism. Prog. Brain Res. 153,209-235.
98. Legradi, G., Emerson, C. H., Ahima, R. S., Rand, W M., Flier, J. S., and Lechan, R. M. (1998). Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus. Neuroendocrinology 68, 89-97.
99. Legradi, G., and Lechan, R. M. (1999). Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 140, 3643-3652.
100. Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J. L., Couturier, C, Dela-grange, P., et al. (2006). The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J.25,3012-3023.
101. Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., et al. (2003). Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J. Neurosd. 23, 7143-7154.
102. Lopez, M., Varela, L., Vazquez, M. J., Rodriguez-Cuenca, S., Gonzalez, C. R., Velagapudi, V. R., et al. (2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 16, 1001-1008.
103. Lopez-Valpuesta, E J., Nyce, J. W, and Myers, R. D. (1996). NPY-Y1 receptor antisense injected centrally in rats causes hyperthermia and feeding. Neuroreport 7, 2781-2784.
104. Luheshi, G. N., Gardner, J. D., Rush-forth, D. A., Loudon, A. S., and Rothwell, N. J. (1999). Leptin actions on food intake and body temperature are mediated by IL-1. Proc. Natl. Acad. Sci. U.S.A. 96, 7047-7052.
105. Marks, J. L., Porte, D. Jr., Stahl, W L, and Baskin, D. G. (1990). Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127, 3234-3236.
106. Masaki, T., Chiba, S., Yasuda, T., Tsubone, T., Kakuma, T., Shimo-mura, I., et al. (2003). Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice. Diabetes 52, 2266-2273.
107. Mashiko, S., Ishihara, A., Iwaasa, H., Sano, H., Ito, J., Gomori, A., et al. (2007). A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol. Pharmacol. 71, 602-608.
108. Mayer, C. M., and Belsham, D. D. (2009). Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons. Mol. Cell. Endocrinol. 307, 99-108.
109. McCormack, J. G. (1982). The regulation of fatty acid synthesis in brown adipose tissue by insulin. Prog. Lipid. Res. 21,195-223.
110. McGowan, M. K., Andrews, K. M., and Grossman, S. P. (1992a). Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat. Physiol. Behav. 51, 753-766.
111. McGowan, M. K., Andrews, K. M., and Grossman, S. P. (1992b). Role of intrahypothalamic insulin in cir-cadian patterns of food intake, activity, and body temperature. Behav. Neurosd. 106, 380-385.
112. Menendez, J. A., and Atrens, D. M. (1991). Insulin and the paraventricular hypothalamus: modulation of energy balance. Brain Res. 555, 193-201.
113. Mizuno, Y, and Oomura, Y. (1984). Glucose responding neurons in the nucleus tractus solitarius of the rat: in vitro study. Brain Res. 307, 109-116.
114. Morrison, S. R, and Nakamura, K. (2011). Central neural pathways for thermoregulation. Front. Biosci. 16, 74-104.
115. Morton, G. J., Cummings, D. E., Baskin, D G., Barsh, G. S., and Schwartz, M. W. (2006). Central nervous system control of food intake and body weight. Nature 443, 289-295.
116. Mounien, L., Marty, N., Tarussio, D., Metref, S., Genoux, D., Preitner, E, et al. (2010). Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sen sitivity of NPY and POMC neurons. FASEBJ. 24, 1747-1758.
117. Muntzel, M. S., Anderson, E. A., Johnson, A. K., and Mark, A. L. (1995). Mechanisms of insulin action on sympathetic nerve activity. Clin. Exp. Hypertens. 17,39-50.
118. Nakayama, T., Hammel, H. T., Hardy, J. D., and Eisenman, J. S. (1963). Thermal stimulation of electrical activity of single units of the preoptic region. Am. ]. Pkysiol 204, 1122-1126.
119. Nillni, E. A., Vaslet, C, Harris, M. A., Hollenberg, A., Bjorbak, C, and Flier, J. S. (2000). Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J. Biol Chem. 275, 36124-36133.
120. Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., and Rossetti, L. (2002). Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosd. 5, 566-572.
121. Oldfield, B. J., Giles, M. E., Watson, A., Anderson, C, Colvill, L. M., and McKinley, M. J. (2002). The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110, 515-526.
122. Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., et al. (2003). Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J. Biol Chem. 278, 9073-9085.
123. Pedrazzini, T., Seydoux, J., Kunstner, P., Aubert, J. E, Grouzmann, E., Beermann, E, et al. (1998). Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPYY1 receptor. Nat. Med. 4, 722-726.
124. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., et al. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
125. Pelz, K. M., and Dark, J. (2007). ICV NPY Yl receptor agonist but not Y5 agonist induces torpor-like hypother-miain cold-acclimated Siberian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol 292.R2299-R2311.
126. Perello, M., Cakir, I., Cyr, N. E., Romero, A., Stuart, R. C, Chiappini, F., et al. (2010). Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level. Am. J. Physiol Endocrinol. Metab. 299, E976-E989.
127. Pesini, P., Detheux, M., Parmentier, M., and Hokfelt, T. (1998). Distribution of a glucocorticoid-induced orphan receptor (JP05) mRNA in the central nervous system of the mouse. Brain Res. Mol Brain Res. 57, 281-300.
128. Plum, L., Belgardt, B. F., and Bruning, J. C. (2006). Central insulin action in energy and glucose homeostasis. J. Clin. Invest. 116,1761-1766.
129. Plum, L., Schubert, M., and Bruning, J. C. (2005). The role of insulin receptor signaling in the brain. Trends Endocrinol Metab. 16,59-65.
130. Porte, D. Jr., Baskin, D. G., and Schwartz, M. W. (2002). Leptin and insulin action in the central nervous system. Nutr. Rev. 60, S20-S29; discussion S68-S84, 85-87.
131. Porte, D. Jr., Baskin, D. G., and Schwartz, M. W. (2005). Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes 54,1264-1276.
132. Psilopanagioti, A., Papadaki, H., Kran-ioti, E. F., Alexandrides, T. K., and Varakis, J. N. (2009). Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology 89, 38-47.
133. Qi, Y, Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., et al. (2004). Adiponectin acts in the brain to decrease body weight. Nat. Med. 10, 524-529.
134. Rampone, A. J., and Shirasu, M. E. (1964). Temperature changes in the rat in response to feeding. Science 144,317-319.
135. Reppert, S. M., Weaver, D. R., Ebisawa, T., Mahle, C. D., and Kolakowski, L. F. Jr. (1996). Cloning of amelatonin-related receptor from human pituitary. FEBS Lett. 386,219-224.
136. Rikke, B. A., Yerg, J. E. Ill, Battaglia, M. E., Nagy, T. R., Allison, D. B., and Johnson, T. E. (2003). Strain variation in the response of body temperature to dietary restriction. Mech. Ageing Dev. 124, 663-678.
137. Ritter, S., and Dinh, T. T. (1994). 2-Mercaptoacetate and 2-deoxy-D-glucose induce Fos-like immunore-activity in rat brain. Brain Res. 641, 111-1120.
138. Robinson, S. W, Dinulescu, D. M., and Cone, R. D. (2000). Genetic models of obesity and energy balance in the mouse. Annu. Rev. Genet. 34, 687-745.
139. Rothwell, N. J., and Stock, M. J. (1981). A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats. Metabolism 30, 673-678.
140. Rothwell, N. J., and Stock, M. J. (1986). "Brown adipose tissue and diet-induced thermogenesis," in Brown Adipose Tissue, eds P. Trayhurn and D. G. Nicholls (New York: Edward Arnold), 269-298.
141. Rothwell, N. J., and Stock, M. J. (1988). Insulin and thermogenesis. Int. J. Obes. 12, 93-102.
142. Routh, V. H. (2002). Glucose-sensing neurons: are they physiologically relevant? Physiol Behav. 76,403-413.
143. Sah, R., Parker, S. L., Sheriff, S., Eaton, S., Balasubramaniam, A., and Sallee, F. R. (2007). Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides 28, 302-309.
144. Sah, R., Pritchard, L. M., Richtand, N. M., Ahlbrand, R., Eaton, K., Sallee, F. R., et al. (2005). Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience 133, 281-292.
145. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., et al. (1998). Orex-ins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585.
146. Sanchez-Alavez, M., Osborn, O., Tabarean, I. V., Holmberg, K. H., Eberwine, J., Kahn, C. R., et al. (2011). Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J. Biol Chem. 286, 14983-14990.
147. Sanchez-Alavez, M., Tabarean, I. V., Osborn, O., Mitsukawa, K., Schae-fer, J., Dubins, J., et al. (2010). Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes 59, 43-50.
148. Sanchez-Lasheras, C, Konner, A. C, and Bruning, J. C. (2010). Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators. Front. Neuro endocrinol. 31, 4-15.
149. Schwartz, M. W., Woods, S. C, Porte, D. Jr., Seeley, R. J., and Baskin, D. G. (2000). Central nervous system control of food intake. Nature 404, 661-671.
150. Segal-Lieberman, G., Bradley, R. L., Kokkotou, E., Carlson, M., Trombly, D. J., Wang, X., et al. (2003). Melanin-concentrating hormone is a critical mediator of the leptin-deficient phe-notype. Proc. Natl. Acad. Sci. U.S.A 100,10085-10090.
151. Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., and Maratos-Flier, E. (1998). Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-674.
152. Shklyaev, S., Aslanidi, G., Tennant, M., Prima, V., Kohlbrenner, E., Kroutov, V., et al. (2003). Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc. Natl Acad. Sci. U.S.A. 100, 14217-14222.
153. Sidibe, A., Mullier, A., Chen, P., Baroncini, M., Boutin, J. A., Dela-grange, P., et al. (2010). Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence. J. Pineal Res. 48, 263-269.
154. Silva, J. E. (2006). Thermogenic mechanisms and their hormonal regulation. Physiol Rev. 86, 435-464.
155. Silva, N. L., and Boulant, J. A. (1984). Effects of osmotic pressure, glucose, and temperature on neurons in preoptic tissue slices. Am. J. Physiol 247, R335-R345.
156. Silver, I. A., and Erecinska, M. (1998). Glucose-induced intracellu-lar ion changes in sugar-sensitive hypothalamic neurons. J. Neurophys-iol. 79, 1733-1745.
157. Skibicka, K. P., Alhadeff, A. L., and Grill, H. J. (2009). Hindbrain cocaine-and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors. J. Neurosd. 29, 6973-6981.
158. Smirnov, M. S., and Kiyatkin, E. A. (2008). Fluctuations in central and peripheral temperatures associated with feeding behavior in rats. Am. J. Physiol Regul Integr. Comp. Physiol 295.R1415-R1424.
159. Soare, A., Cangemi, R., Omodei, D., Holloszy, J. O., and Fontana, L. (2011). Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans. Aging (Albany NY) 3, 374-379.
160. Spencer, C. A., Lum, S. M., Wilber, J. F., Kaptein, E. M., and Nicoloff, J. T. (1983). Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J. Clin. Endocrinol Metab. 56, 883-888.
161. Spiegelman, B. M., and Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell 104, 531-543.
162. Stanley, B. G., Kyrkouli, S. E., Lam-pert, S., and Leibowitz, S. E (1986). Neuropeptide-Y chronically injected into the hypothalamus - a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189-1192.
163. Ste Marie, L., Miura, G. I., Marsh, D. J., Yagaloff, K., and Palmiter, R. D. (2000). A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc. Natl. Acad. Sci. U.S.A. 97,12339-12344.
164. Stevenson, J. A., and Montemurro, D. G. (1963). Loss of weight and metabolic rate of rats with lesions in the medial and lateral hypothalamus. Nature 198,92.
165. Szentirmai, E., Kapas, L., Sun, Y., Smith, R. G., and Krueger, J. M. (2009). The preproghrelin gene is required for the normal integration of ther-moregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106, 14069-14074.
166. Tang-Christensen, M., Vrang, N., Ort-mann, S., Bidlingmaier, M., Horvath, T. L, and Tschop, M. (2004). Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145, 4645-4652.
167. Teitelbaum, P., and Epstein, A. N. (1962). The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol. Rev. 69, 74-90.
168. Theander-Carrillo, C, Wiedmer, P., Cettour-Rose, P., Nogueiras, R., Perez-Tilve, D., Pfluger, P., et al. (2006). Ghrelin action in the brain controls adipocyte metabolism. J. Clin. Invest. 116, 1983-1993.
169. Thundyil, J., Pavlovski, D., Sobey, C. G., and Arumugam, T. V. (2011). Adiponectin receptor signalling in the brain. Br. J. Pharmacol. 165, 313-327.
170. Tomas, E., Tsao, T. S., Saha, A. K., Murrey, H. E., Zhang Cc, C, Itani, S. I., et al. (2002). Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl. Acad. Sci. U.S.A. 99, 16309-16313.
171. Tschop, M., Smiley, D. L., and Heiman, M. L. (2000). Ghrelin induces adiposity in rodents. Nature 407, 908-913.
172. Unger, J., McNeill, T. H., Moxley, R. T. Ill, White, M., Moss, A., and Livingston, J. N. (1989). Distribution of insulin receptor-like immunoreactivity in the rat forebrain. Neuroscience 31, 143-157.
173. van Baak, M. A. (2008). Meal-induced activation of the sympathetic nervous system and its cardiovascular and thermogenic effects in man. Physiol. Behav. 94, 178-186.
174. Vella, K. R., Ramadoss, P., Lam, F. S., Harris, J. C, Ye, F. D., Same, P. D., et al. (2011). NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab. 14,780-790.
175. Voss-Andreae, A., Murphy, J. G., Ella-cott, K. L., Stuart, R. C, Nillni, E. A., Cone, R. D., et al. (2007). Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology 148,1550-1560.
176. Walford, R. L., and Spindler, S. R. (1997). The response to calorie restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis. J. Gerontol. A Biol. Sci. Med. Sci. 52, B179-B183.
177. Walker, H. C, and Romsos, D. R. (1993). Similar effects of NPY on energy metabolism and on plasma insulin in adrenalectomized ob/ob and lean mice. Am. J. Physiol. 264, E226-E230.
178. Wang, C, Billington, C. J., Levine, A. S., and Kotz, C. M. (2000). Effect of CART in the hypothalamic par-aventricular nucleus on feeding and uncoupling protein gene expression. Neuroreport 11, 3251-3255.
179. Wang, D., Herman, J. P., Pritchard, L. M., Spitzer, R. H., Ahlbrand, R. L, Kramer, G. L, et al. (2001). Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: effect of repetitive amphetamine. J. Neurosci. 21, 9027-9035.
180. Wang, H. S., and Lin, M. T. (1985). Effects of insulin on thermoregu-latory responses and hypothalamic neuronal activity. Pharmacology 30, 86-94.
181. Wang, R., Liu, X., Hentges, S. T., Dunn-Meynell, A. A., Levin, B. E., Wang, W., et al. (2004). The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 53, 1959-1965.
182. Werther, G. A., Hogg, A., Oldfield, B. J., McKinley, M. J., Figdor, R., Allen, A. M., et al. (1987). Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 121,1562-1570.
183. Wiedmer, P., Strasser, E, Horvath, T. L., Blum, D., Dimarchi, R., Lutz, T., et al. (2011). Ghrelin-induced hypothermia: a physiological basis but no clinical risk. Physiol. Behav. 105,43-51.
184. Williams, G., Bing, C, Cai, X. J., Harrold, J. A., King, P. J., and Liu, X. H. (2001). The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol. Behav. 74, 683-701.
185. Woods, S. C, Lotter, E. C, McKay, L. D., and Porte, D. Jr. (1979). Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282, 503-505.
186. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., et al. (2003). Cloning of adiponectin receptors that mediate antidia-betic metabolic effects. Nature 423, 762-769.
187. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y, Kubota, N., Hara, K., et al. (2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoa-trophy and obesity. Nat. Med. 7, 941-946.
188. Yang, X. J., Kow, L. M., Pfaff, D. W., and Mobbs, C. V. (2004). Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose. Diabetes 53, 67-73.
189. Yasuda, T., Masaki, T., Kakuma, T., andYoshimatsu.H. (2003). Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci. Lett. 349, 75-78.
190. Yasuda, T., Masaki, T., Kakuma, T., andYoshimatsu, H. (2004). Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Exp. Biol. Med. (May-wood) 229,235-239.
191. Yettefti, K., Orsini, J. C, el Ouazzani, T., Himmi, T., Boyer, A., and Per-rin, J. (1995). Sensitivity of nucleus tractus solitarius neurons to induced moderate hyperglycemia, with special reference to catecholaminergic regions. J. Auton. Nerv. Syst. 51, 191-197.
192. Yoshimichi, G., Yoshimatsu, H., Masaki, T., and Sakata, T. (2001). Orexin-A regulates body temperature in coordination with arousal status. Exp. Biol. Med. (Maywood) 226, 468-476.