Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons

Diabetes

Volumn 59, Issue 1, 2010, Pages 43-50

  Sanchez Alavez, Manuel ^a   Tabarean, Iustin V ^a   Osborn, Olivia ^a   Mitsukawa, Kayo ^a   Schaefer, Jean ^b   Dubins, Jeffrey ^b   Holmberg, Kristina H ^c   Klein, Izabella ^a   Klaus, Joe ^a   Gomez, Luis F ^d   Kolb, Hartmuth ^d   Secrest, James ^d   Jochems, Jeanine ^e   Myashiro, Kevin ^e   Buckley, Peter ^e   Hadcock, John R ^b   Eberwine, James ^e   Conti, Bruno ^a   Bartfai, Tamas ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c PFIZER INC   (United States)

^d SIEMENS CORPORATE RESEARCH   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FLUORODEOXYGLUCOSE F 18; INSULIN; INSULIN ANTIBODY; INSULIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORE TEMPERATURE; FATTY ACID OXIDATION; HYPERPOLARIZATION; HYPERTHERMIA; HYPOTHALAMUS; IN VIVO STUDY; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; RAT; TELEMETRY; THERMOGENESIS; THERMOREGULATION; ANIMAL; BODY TEMPERATURE; C57BL MOUSE; DRUG EFFECT; HYPERTHERMIC THERAPY; INJECTION; METHODOLOGY; NERVE CELL; PHYSIOLOGY;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE; HYPERTHERMIA, INDUCED; HYPOTHALAMUS; INJECTIONS; INSULIN; MALE; MICE; MICE, INBRED C57BL; NEURONS; PREOPTIC AREA; TELEMETRY;

EID: 77449097519     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1128     Document Type: Article

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