Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence

Journal of Pineal Research

Volumn 48, Issue 3, 2010, Pages 263-269

  Sidibe, Anissa ^a,b   Mullier, Amandine ^c   Chen, Patty ^a,b   Baroncini, Marc ^c,d   Boutin, Jean A ^e   Delagrange, Philippe ^e   Prevot, Vincent ^c   Jockers, Ralf ^a,b  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

^c JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^d UNIV LILLE   (France)

^e INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

GPCR; GPR50; Melatonin; MRR; Orphan receptor

Indexed keywords

MELATONIN RECEPTOR; PROTEIN GPR50; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN THIRD VENTRICLE; EPENDYMA; HUMAN; HYPOTHALAMUS NUCLEUS; IMMUNOREACTIVITY; MALE; MEDIAN EMINENCE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TANYCYTE;

EID: 77749341363     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00750.x     Document Type: Article

References (30)

1. Zawilska JB, Skene DJ, Arendt J. Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep 2009 61 : 383 410.
2. Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009 47 : 109 126.
3. Jockers R, Maurice P, Boutin JA et al. Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br J Pharmacol 2008 154 : 1182 1195.
4. Reppert SM, Weaver DR, Ebisawa T et al. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett 1996 386 : 219 224.
5. Dufourny L, Levasseur A, Migaud M et al. GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals. BMC Evol Biol 2008 8 : 105.
6. Levoye A, Dam J, Ayoub MA et al. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006 7 : 1094 1098.
7. Thomson PA, Wray NR, Thomson AM et al. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry 2005 10 : 470 478.
8. Bhattacharyya S, Luan J, Challis B et al. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. J Lipid Res 2006 47 : 761 766.
9. Levoye A, Dam J, Ayoub MA et al. The orphan GPR50 receptor specifically inhibits MT(1) melatonin receptor function through heterodimerization. EMBO J 2006 25 : 3012 3023.
10. Grunewald E, Kinnell HL, Porteous DJ et al. GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol Cell Neurosci 2009 42 : 363 371.
11. Ivanova EA, Bechtold D, Dupre S et al. Altered metabolism in the melatonin-related receptor (GPR50) knock out mouse. Am J Physiol Endocrinol Metab 2008 294 : E176 E182.
12. Barrett P, Ivanova E, Graham ES et al. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. J Endocrinol 2006 191 : 687 698.
13. Drew JE, Barrett P, Williams LM et al. The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. J Neuroendocrinol 1998 10 : 651 661.
14. Drew JE, Barrett P, Mercer JG et al. Localization of the melatonin-related receptor in the rodent brain and peripheral tissues. J Neuroendocrinol 2001 13 : 453 458.
15. Ould-Hamouda H, Chen P, Levoye A et al. Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes. J Pineal Res 2007 43 : 10 15.
16. Vassilatis DK, Hohmann JG, Zeng H et al. The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A 2003 100 : 4903 4908.
17. Mai JK, Assheuer J, Paxinos G. Atlas of the Human Brain. Academic Press, San Diego, CA, 1997.
18. Prevot V. Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion. J Neuroendocrinol 2002 14 : 247 255.
19. Baroncini M, Allet C, Leroy D et al. Morphological evidence for direct interaction between gonadotrophin-releasing hormone neurones and astroglial cells in the human hypothalamus. J Neuroendocrinol 2007 19 : 691 702.
20. Mullier A, Bouret S, Prevot V et al. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J Comp Neurol 2010 9999.
21. Bernardis LL, Bellinger LL. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc Soc Exp Biol Med 1998 218 : 284 306.
22. Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms. Science 2008 320 : 1074 1077.
23. Rodriguez EM, Blazquez JL, Pastor FE et al. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 2005 247 : 89 164.
24. Garcia MA, Millan C, Balmaceda-Aguilera C et al. Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing. J Neurochem 2003 86 : 709 724.
25. Prevot V, Dehouck B, Poulain P et al. Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction. Psychoneuroendocrinology 2007 32 (Suppl 1 S46 S51.
26. King JC, Letourneau RJ. Luteinizing hormone-releasing hormone terminals in the median eminence of rats undergo dramatic changes after gonadectomy, as revealed by electron microscopic image analysis. Endocrinology 1994 134 : 1340 1351.
27. Yamamura T, Hirunagi K, Ebihara S et al. Seasonal morphological changes in the neuro-glial interaction between gonadotropin-releasing hormone nerve terminals and glial endfeet in Japanese quail. Endocrinology 2004 145 : 4264 4267.
28. Diano S, Naftolin F, Goglia F et al. Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 1998 139 : 2879 2884.
29. Xu Y, Tamamaki N, Noda T et al. Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol 2005 192 : 251 264.
30. Kameda Y, Arai Y, Nishimaki T. Ultrastructural localization of vimentin immunoreactivity and gene expression in tanycytes and their alterations in hamsters kept under different photoperiods. Cell Tissue Res 2003 314 : 251 262.