Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin

Metabolism: Clinical and Experimental

Volumn 61, Issue 10, 2012, Pages 1486-1493

  Dubins, Jeffrey S ^a   Sanchez Alavez, Manuel ^b   Zhukov, Victor ^b   Sanchez Gonzalez, Alejandro ^b   Moroncini, Gianluca ^c   Carvajal Gonzalez, Santos ^a   Hadcock, John R ^d   Bartfai, Tamas ^b   Conti, Bruno ^b  

^a PFIZER INC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Adiponectin; Body temperature; G protein coupled receptor 83; IGF 1; Insulin; Knockdown; Lentivirus; Leptin; Preoptic area; RNAi; shRNA; Thermoregulation; Warm sensitive neurons

Indexed keywords

ADIPONECTIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 83; INSULIN; LENTIVIRUS VECTOR; LEPTIN; SHORT HAIRPIN RNA; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; CORE TEMPERATURE; DOWN REGULATION; FOOD INTAKE; IN VITRO STUDY; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT GAIN;

ADIPONECTIN; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BODY TEMPERATURE REGULATION; DOWN-REGULATION; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PREOPTIC AREA; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; WEIGHT GAIN;

EID: 84866732705     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.03.015     Document Type: Article

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