The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 30, 2006, Pages 11124-11129

  Tang, Yinyan ^a   Kim, Chu Young ^a,d   Mathews, Irimpan I ^b   Cane, David E ^c   Khosla, Chaitan ^a  

^a STANFORD UNIVERSITY   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^c BROWN UNIVERSITY   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Modular megasynthase; Multienzyme assembly; Polyketide synthase

Indexed keywords

6 DEOXYERYTHRONOLIDE B SYNTHASE; ACYL CARRIER PROTEIN; ACYLTRANSFERASE; FATTY ACID SYNTHASE; HOMODIMER; KETOSYNTHASE; PANTETHEINE PHOSPHATE; POLYKETIDE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; BINDING SITE; BIOLOGICAL MODEL; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYME SPECIFICITY; METABOLISM; MOLECULAR CLONING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SACCHAROPOLYSPORA;

BINDING SITES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; MODELS, BIOLOGICAL; MODELS, MOLECULAR; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROPOLYSPORA; SUBSTRATE SPECIFICITY;

EID: 33746776204     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601924103     Document Type: Article

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