메뉴 건너뛰기




Volumn 35, Issue SUPPL. 1, 2012, Pages 3-20

A review of pharmacogenetics of adverse drug reactions in elderly people

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVITAMIN K; BIOLOGICAL MARKER; CARRIER PROTEIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DONEPEZIL; DRUG METABOLIZING ENZYME; GALANTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPNOTIC AGENT; MEMANTINE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; ORAL ANTIDIABETIC AGENT; PROTON PUMP INHIBITOR; PSYCHOTROPIC AGENT; RIVASTIGMINE; TAMOXIFEN; UNINDEXED DRUG; WARFARIN;

EID: 84873864620     PISSN: 01145916     EISSN: 11791942     Source Type: Journal    
DOI: 10.1007/BF03319099     Document Type: Review
Times cited : (20)

References (141)
  • 1
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean AJ, Le Couter DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004; 56: 163-84
    • (2004) Pharmacol Rev , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couter, D.G.2
  • 2
    • 0033015230 scopus 로고    scopus 로고
    • The epidemiology of serious adverse drug reactions among the elderly
    • Atkin PA, Veitch PC, Veitch EM, et al. The epidemiology of serious adverse drug reactions among the elderly. Drugs Aging 1999; 14 (2): 141-52
    • (1999) Drugs Aging , vol.14 , Issue.2 , pp. 141-152
    • Atkin, P.A.1    Veitch, P.C.2    Veitch, E.M.3
  • 3
    • 84860869658 scopus 로고    scopus 로고
    • Incidence and predictors of adverse drug reactions caused by drug-drug interactions in elderly outpatients: A prospective cohort study
    • Obreli Neto PR, Nobili A, de Lyra Júnior DP, et al. Incidence and predictors of adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study. J Pharm Pharmaceut Sci 2012; 15 (2): 332-43 (www.cspsCanada.org)
    • (2012) J Pharm Pharmaceut Sci , vol.15 , Issue.2 , pp. 332-343
    • Obreli Neto, P.R.1    Nobili, A.2    De Lyra Jr., D.P.3
  • 5
    • 0036904903 scopus 로고    scopus 로고
    • Adverse drug reactions as cause of hospital admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA)
    • Dec
    • Onder G, Pedone C, Landi F, et al. Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc 2002 Dec; 50 (12): 1962-8
    • (2002) J Am Geriatr Soc , vol.50 , Issue.12 , pp. 1962-1968
    • Onder, G.1    Pedone, C.2    Landi, F.3
  • 6
    • 84857853686 scopus 로고    scopus 로고
    • Adverse drug reaction-related hospitalizations in persons aged 55 years and over: A population-based study in the Netherlands
    • Mar
    • Ruiter R, Visser LE, Rodenburg EM, et al. Adverse drug reaction-related hospitalizations in persons aged 55 years and over: a population-based study in the Netherlands. Drugs Aging 2012 Mar; 29 (3): 225-32
    • (2012) Drugs Aging , vol.29 , Issue.3 , pp. 225-232
    • Ruiter, R.1    Visser, L.E.2    Rodenburg, E.M.3
  • 7
    • 84864134728 scopus 로고    scopus 로고
    • Adverse drug reactions in a population of hospitalized very elderly patients
    • Aug
    • Tangiisuran B, Davies JG, Wright JE, et al. Adverse drug reactions in a population of hospitalized very elderly patients. Drugs Aging 2012 Aug; 29 (8): 669-79
    • (2012) Drugs Aging , vol.29 , Issue.8 , pp. 669-679
    • Tangiisuran, B.1    Davies, J.G.2    Wright, J.E.3
  • 8
    • 80053610820 scopus 로고    scopus 로고
    • Adverse drug reactions (ADRs) associated with hospital admissions-elderly female patients are at highest risk
    • Oct
    • Hofer-Dueckelmann C, Prinz E, Beindl W, et al. Adverse drug reactions (ADRs) associated with hospital admissions-elderly female patients are at highest risk. Int J Clin Pharmacol Ther 2011 Oct; 49 (10): 577-86
    • (2011) Int J Clin Pharmacol Ther , vol.49 , Issue.10 , pp. 577-586
    • Hofer-Dueckelmann, C.1    Prinz, E.2    Beindl, W.3
  • 9
    • 84864675995 scopus 로고    scopus 로고
    • Adverse drug reactions in older patients: An Italian observational prospective hospital study
    • Conforti A, Costantini D, Zanetti F, et al. Adverse drug reactions in older patients: an Italian observational prospective hospital study. Drug Healthc Patient Saf 2012; 4: 75-80
    • (2012) Drug Healthc Patient Saf , vol.4 , pp. 75-80
    • Conforti, A.1    Costantini, D.2    Zanetti, F.3
  • 10
    • 84864117968 scopus 로고    scopus 로고
    • Effects of a drug minimization guide on prescribing intentions in elderly persons with polypharmacy
    • Scott IA, Gray LC, Martin JH, et al. Effects of a drug minimization guide on prescribing intentions in elderly persons with polypharmacy. Drugs Aging 2012; 29: 659-67
    • (2012) Drugs Aging , vol.29 , pp. 659-667
    • Scott, I.A.1    Gray, L.C.2    Martin, J.H.3
  • 11
    • 0001355595 scopus 로고
    • The hemolytic effect of primaquine. VII. Biochemical studies of drugsensitive erythrocytes
    • Beutler E, Dern RJ, Flanagan CL, et al. The hemolytic effect of primaquine. VII. Biochemical studies of drugsensitive erythrocytes. J Lab Clin Med 1955; 45: 286-95
    • (1955) J Lab Clin Med , vol.45 , pp. 286-295
    • Beutler, E.1    Dern, R.J.2    Flanagan, C.L.3
  • 12
    • 35748961114 scopus 로고    scopus 로고
    • Identifying genetic risk factors for serious adverse drug reactions: Current progress and challenges
    • Wilke RA, Lin DW, Roden DM, et al. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov 2007; 6: 904-16
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 904-916
    • Wilke, R.A.1    Lin, D.W.2    Roden, D.M.3
  • 13
    • 84873820754 scopus 로고    scopus 로고
    • American Association of Pharmaceutical Scientists[Accessed 2011Sep 9]
    • American Association of Pharmaceutical Scientists. Pharmacogenomics (PGx) Focus Group. https://www.aapsj.org/inside/focus-groups/PGX/index.asp.[Accessed 2011Sep 9]
  • 14
    • 84873857120 scopus 로고    scopus 로고
    • Note for guidance on definitions for genomic biomarkers, pharmacogenomics, pharmacogenetics, genomic data and sample coding categories. EMEA/CHMP/ICH/437986/2006
    • November
    • Note for guidance on definitions for genomic biomarkers, pharmacogenomics, pharmacogenetics, genomic data and sample coding categories. EMEA/CHMP/ICH/437986/2006. November 2007 from the ICH Topic E15 Definitions for genomic biomarkers, pharmacogenomics, pharmacogenetics, genomic data and sample coding categories. http://www.ema.europa.eu/docs/en-GB/document-library/ Scientific-guideline/2009/09/WC500002880.pdf
    • (2007) ICH Topic E15 Definitions for Genomic Biomarkers, Pharmacogenomics, Pharmacogenetics, Genomic Data and Sample Coding Categories
  • 15
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286 (5439): 487-91
    • (1999) Science , vol.286 , Issue.5439 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 16
    • 0842263894 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Are they still promising?
    • Apr
    • Pirazzoli A, Recchia G. Pharmacogenetics and pharmacogenomics: are they still promising? Pharmacol Res 2004 Apr; 49 (4): 357-61
    • (2004) Pharmacol Res , vol.49 , Issue.4 , pp. 357-361
    • Pirazzoli, A.1    Recchia, G.2
  • 17
    • 77953922472 scopus 로고    scopus 로고
    • Pharmacogenomics: Bridgingthe gap between science and practice
    • Jan-Feb, quiz e15-17
    • Lee KC, Ma JD, Kuo GM. Pharmacogenomics: bridgingthe gap between science and practice. J Am Pharm Assoc (2003) 2010 Jan-Feb; 50 (1): e1-14; quiz e15-17
    • (2010) J Am Pharm Assoc (2003) , vol.50 , Issue.1
    • Lee, K.C.1    Ma, J.D.2    Kuo, G.M.3
  • 18
    • 79955685734 scopus 로고    scopus 로고
    • Clinically relevant genetic variations in drug metabolizing enzymes
    • Jun
    • Pinto N, Dolan ME. Clinically relevant genetic variations in drug metabolizing enzymes. Curr Drug Metab 2011 Jun; 12 (5): 487-97
    • (2011) Curr Drug Metab , vol.12 , Issue.5 , pp. 487-497
    • Pinto, N.1    Dolan, M.E.2
  • 20
    • 80052847569 scopus 로고    scopus 로고
    • Novel advances in cytochrome P450research
    • Sep
    • Singh D, Kashyap A, Pandey RV, et al. Novel advances in cytochrome P450research. Drug Discov Today 2011 Sep; 16 (17-18): 793-9
    • (2011) Drug Discov Today , vol.16 , Issue.17-18 , pp. 793-799
    • Singh, D.1    Kashyap, A.2    Pandey, R.V.3
  • 21
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, includingnomenclature recommendations for genes, pseudogenes and alternative-splicevariants
    • Jan
    • Nelson DR, Zeldin DC, Hoffman SM, et al. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, includingnomenclature recommendations for genes, pseudogenes and alternative-splicevariants. Pharmacogenetics 2004 Jan; 14 (1): 1-18
    • (2004) Pharmacogenetics , vol.14 , Issue.1 , pp. 1-18
    • Nelson, D.R.1    Zeldin, D.C.2    Hoffman, S.M.3
  • 22
    • 36148976077 scopus 로고    scopus 로고
    • Influence ofcytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Dec
    • Ingelman-Sundberg M, Sim SC, Gomez A, et al. Influence ofcytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 2007 Dec; 116 (3): 496-526
    • (2007) Pharmacol Ther , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3
  • 23
    • 70049083263 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic strategies for dementia
    • Sep
    • Cacabelos R. Pharmacogenomics and therapeutic strategies for dementia. Expert Rev Mol Diagn 2009 Sep; 9 (6): 567-611
    • (2009) Expert Rev Mol Diagn , vol.9 , Issue.6 , pp. 567-611
    • Cacabelos, R.1
  • 24
    • 33644658662 scopus 로고    scopus 로고
    • The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease
    • Jan, ix-xi 1-160
    • Loveman E, Green C, Kirby J, et al. The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease. Health Technol Assess 2006 Jan; 10 (1): iii-iv, ix-xi, 1-160
    • (2006) Health Technol Assess , vol.10 , Issue.1
    • Loveman, E.1    Green, C.2    Kirby, J.3
  • 25
    • 70349565396 scopus 로고    scopus 로고
    • Effect of a CYP2D6 polymorphism on the efficacy of donepezil inpatients with Alzheimer disease
    • Sep
    • Pilotto A, Franceschi M, D'Onofrio G, et al. Effect of a CYP2D6 polymorphism on the efficacy of donepezil inpatients with Alzheimer disease. Neurology 2009 Sep; 73 (10): 761-7
    • (2009) Neurology , vol.73 , Issue.10 , pp. 761-767
    • Pilotto, A.1    Franceschi, M.2    D'Onofrio, G.3
  • 26
    • 79955452038 scopus 로고    scopus 로고
    • Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease
    • Apr
    • Seripa D, Bizzarro A, Pilotto A, et al. Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease. Pharmacogenet Genomics 2011 Apr; 21 (4): 225-30
    • (2011) Pharmacogenet Genomics , vol.21 , Issue.4 , pp. 225-230
    • Seripa, D.1    Bizzarro, A.2    Pilotto, A.3
  • 27
    • 80054742063 scopus 로고    scopus 로고
    • BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors
    • Chianella C, Gragnaniello D, Maisano Delser P, et al. BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors. Eur J Clin Pharmacol 2011 Nov; 67 (11): 1147-57
    • Eur J Clin Pharmacol 2011 Nov , vol.67 , Issue.11 , pp. 1147-1157
    • Chianella, C.1    Gragnaniello, D.2    Maisano Delser, P.3
  • 28
    • 74949134529 scopus 로고    scopus 로고
    • Effects of donepezil galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: A prospective observational study
    • Feb
    • Santoro A, Siviero P, Minicuci N, et al. Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study. CNS Drugs 2010 Feb; 24 (2): 163-76
    • (2010) CNS Drugs , vol.24 , Issue.2 , pp. 163-176
    • Santoro, A.1    Siviero, P.2    Minicuci, N.3
  • 29
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Dec
    • Johansson I, Lundqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad SciUSA1993 Dec; 90 (24): 11825-9
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.24 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3
  • 31
    • 0242543259 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C9 gene
    • Schwarz UI. Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Investig 2003; 33 Suppl. 2: 23-30
    • (2003) Eur J Clin Investig , vol.33 , Issue.SUPPL. 2 , pp. 23-30
    • Schwarz, U.I.1
  • 32
    • 11844304376 scopus 로고    scopus 로고
    • Clinical consequences of cytochrome P450 2C9 polymorphisms
    • Kirchheiner J, Brockmoller J. Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin Pharmacol Ther 2005; 77: 1-16
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 1-16
    • Kirchheiner, J.1    Brockmoller, J.2
  • 33
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • Feb
    • Aithal GP, Day CP, Kesteven PJ, et al. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 1999 Feb; 353 (9154): 717-9
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3
  • 34
    • 1542346414 scopus 로고    scopus 로고
    • Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin
    • Mar
    • Kamali F, Khan TI, King BP, et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin. Clin Pharmacol Ther 2004 Mar; 75 (3): 204-12
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.3 , pp. 204-212
    • Kamali, F.1    Khan, T.I.2    King, B.P.3
  • 35
    • 1642335299 scopus 로고    scopus 로고
    • Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX,and X; Proteins S and C; And gamma-glutamyl carboxylase) gene variants with warfarin sensitivity
    • Apr
    • Shikata E, Ieiri I, Ishiguro S, et al. Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX,and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity. Blood 2004 Apr; 103 (7): 2630-5
    • (2004) Blood , vol.103 , Issue.7 , pp. 2630-2635
    • Shikata, E.1    Ieiri, I.2    Ishiguro, S.3
  • 37
    • 84872047801 scopus 로고    scopus 로고
    • Pharmacogenetics in older people: What we know and what we need to know
    • Seripa D, Paroni G, Urbano M, et al. Pharmacogenetics in older people: what we know and what we need to know. J Nephrol 2012; 25 Suppl. 19: 38-47
    • (2012) J Nephrol , vol.25 , Issue.SUPPL. 19 , pp. 38-47
    • Seripa, D.1    Paroni, G.2    Urbano, M.3
  • 38
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulationrelated outcomes during warfarin therapy
    • Apr
    • Higashi MK, Veenstra DL, Kondo LM, et al. Association between CYP2C9 genetic variants and anticoagulationrelated outcomes during warfarin therapy. JAMA 2002 Apr; 287 (13): 1690-8
    • (2002) JAMA , vol.287 , Issue.13 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3
  • 39
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • Wadelius M, Chen LY, Lindh JD, et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood 2009; 113 (4): 784-92
    • (2009) Blood , vol.113 , Issue.4 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3
  • 40
    • 21144448879 scopus 로고    scopus 로고
    • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
    • Rieder MJ, Reiner AP, Gage BF, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005; 352 (22): 2285-93
    • (2005) N Engl J Med , vol.352 , Issue.22 , pp. 2285-2293
    • Rieder, M.J.1    Reiner, A.P.2    Gage, B.F.3
  • 41
    • 34548822941 scopus 로고    scopus 로고
    • Genetic-based dosing in orthopedic patients beginning warfarin therapy
    • Sep
    • Millican EA, Lenzini PA, Milligan PE, et al. Genetic-based dosing in orthopedic patients beginning warfarin therapy. Blood 2007 Sep; 110 (5): 1511-5
    • (2007) Blood , vol.110 , Issue.5 , pp. 1511-1515
    • Millican, E.A.1    Lenzini, P.A.2    Milligan, P.E.3
  • 42
    • 49849105411 scopus 로고    scopus 로고
    • Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedicpatients
    • Oct
    • Lenzini PA, Grice GR, Milligan PE, et al. Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedicpatients. J Thromb Haemost 2008 Oct; 6 (10): 1655-62
    • (2008) J Thromb Haemost , vol.6 , Issue.10 , pp. 1655-1662
    • Lenzini, P.A.1    Grice, G.R.2    Milligan, P.E.3
  • 43
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • International Warfarin Pharmacogenetics Consortium
    • International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 2009; 360 (8): 753-64
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 753-764
    • Klein, T.E.1    Altman, R.B.2
  • 44
    • 77950353192 scopus 로고    scopus 로고
    • Pharmacogenetics of coumarinic oral anticoagulants
    • Manolopoulos VG, Ragia G, Tavridou A. Pharmacogenetics of coumarinic oral anticoagulants. Pharmacogenomics 2010; 11 (4): 493-6
    • (2010) Pharmacogenomics , vol.11 , Issue.4 , pp. 493-496
    • Manolopoulos, V.G.1    Ragia, G.2    Tavridou, A.3
  • 45
    • 72849127064 scopus 로고    scopus 로고
    • Genetic factors (VKORC1 CYP2C9 EPHX1 and CYP4F2) are predictor variables for warfarin response in very elderly frail inpatients
    • Pautas E, Moreau C, Gouin-Thibault I, et al. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. Clin Pharmacol Ther 2010; 87 (1): 57-64
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.1 , pp. 57-64
    • Pautas, E.1    Moreau, C.2    Gouin-Thibault, I.3
  • 46
    • 79953331201 scopus 로고    scopus 로고
    • Predicting the warfarin maintenance dose in elderly inpatients at treatment initiation: Accuracy of dosing algorithms incorporating or not VKORC1/CYP2C9 genotypes
    • Moreau C, Pautas E, Gouin-Thibault I, et al. Predicting the warfarin maintenance dose in elderly inpatients at treatment initiation: accuracy of dosing algorithms incorporating or not VKORC1/CYP2C9 genotypes. J Thromb Haemost 2011; 9 (4): 711-8
    • (2011) J Thromb Haemost , vol.9 , Issue.4 , pp. 711-718
    • Moreau, C.1    Pautas, E.2    Gouin-Thibault, I.3
  • 47
    • 84873861813 scopus 로고    scopus 로고
    • Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation
    • Jul 6. [Epub ahead of print]
    • Kovac MK, Rakicevic LB, Kusic-Tisma JS, et al. Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation. J Thromb Thrombolysis 2012 Jul 6. [Epub ahead of print]
    • (2012) J Thromb Thrombolysis
    • Kovac, M.K.1    Rakicevic, L.B.2    Kusic-Tisma, J.S.3
  • 48
    • 22844442802 scopus 로고    scopus 로고
    • Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs
    • Pilotto A, Franceschi M, Vitale DF, et al. Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs. Aliment Pharmacol Ther 2005; 22 (2): 147-55
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.2 , pp. 147-155
    • Pilotto, A.1    Franceschi, M.2    Vitale, D.F.3
  • 49
    • 34547558049 scopus 로고    scopus 로고
    • Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: Role of cytochrome P450 2C9 polymorphisms
    • Pilotto A, Seripa D, Franceschi M, et al. Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. Gastroenterology 2007; 133 (2): 465-71
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 465-471
    • Pilotto, A.1    Seripa, D.2    Franceschi, M.3
  • 50
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • Ingelman-Sundberg M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 2004; 25: 193-200
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 51
    • 33745914612 scopus 로고    scopus 로고
    • Clinical impact of CYP2C19 polymorphism on theaction of proton pump inhibitors: A review of a special problem
    • Klotz U. Clinical impact of CYP2C19 polymorphism on theaction of proton pump inhibitors: a review of a special problem. Int J Clin Pharmacol Ther 2006; 44 (7): 297-302
    • (2006) Int J Clin Pharmacol Ther , vol.44 , Issue.7 , pp. 297-302
    • Klotz, U.1
  • 52
    • 34247346587 scopus 로고    scopus 로고
    • Cytochrome p450 polymorphism as a predictor of ovarian toxicity to pulse cyclophosphamide in systemic lupus erythematosus
    • Singh G, Saxena N, Aggarwal A, et al. Cytochrome p450 polymorphism as a predictor of ovarian toxicity to pulse cyclophosphamide in systemic lupus erythematosus. J Rheumatol 2007; 34: 731-3
    • (2007) J Rheumatol , vol.34 , pp. 731-733
    • Singh, G.1    Saxena, N.2    Aggarwal, A.3
  • 53
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, et al. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 2002; 41: 913-58
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3
  • 54
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • Jan
    • Sim SC, Risinger C, Dahl ML, et al. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 2006 Jan; 79 (1): 103-13
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.1 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3
  • 55
    • 0036795262 scopus 로고    scopus 로고
    • Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole
    • Oct
    • Furuta T, Shirai N, Watanabe F, et al. Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. Clin Pharmacol Ther 2002 Oct; 72 (4): 453-60
    • (2002) Clin Pharmacol Ther , vol.72 , Issue.4 , pp. 453-460
    • Furuta, T.1    Shirai, N.2    Watanabe, F.3
  • 56
    • 0037392311 scopus 로고    scopus 로고
    • The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism
    • Kawamura M, Ohara S, Koike T, et al. The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. Aliment Pharmacol Ther 2003; 17: 965-73
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 965-973
    • Kawamura, M.1    Ohara, S.2    Koike, T.3
  • 57
    • 0036935332 scopus 로고    scopus 로고
    • Treatment of acid-related diseases in the elderly with emphasis on the use of proton pump inhibitors
    • Thjodleifsson B. Treatment of acid-related diseases in the elderly with emphasis on the use of proton pump inhibitors. Drugs Aging 2002; 19 (12): 911-27
    • (2002) Drugs Aging , vol.19 , Issue.12 , pp. 911-927
    • Thjodleifsson, B.1
  • 58
    • 26944440101 scopus 로고    scopus 로고
    • The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics
    • Ishizawa Y, Yasui-Furukori N, Takahata T, et al. The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clin Pharmacokinet 2005; 44 (11): 1179-89
    • (2005) Clin Pharmacokinet , vol.44 , Issue.11 , pp. 1179-1189
    • Ishizawa, Y.1    Yasui-Furukori, N.2    Takahata, T.3
  • 59
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010; 304 (16): 1821-30
    • (2010) JAMA , vol.304 , Issue.16 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 60
    • 78049348037 scopus 로고    scopus 로고
    • Clopidogrel and the reducedfunction CYP2C19 genetic variant: A limited piece of the overall therapeutic puzzle
    • Fuster V, Sweeny JM. Clopidogrel and the reducedfunction CYP2C19 genetic variant: a limited piece of the overall therapeutic puzzle. JAMA 2010; 304 (16): 1839-40
    • (2010) JAMA , vol.304 , Issue.16 , pp. 1839-1840
    • Fuster, V.1    Sweeny, J.M.2
  • 61
    • 84861494090 scopus 로고    scopus 로고
    • Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: The GIFT (Genotype Information and Functional Testing) study
    • May
    • PriceMJ,Murray SS, AngiolilloDJ, et al. Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study. J Am Coll Cardiol 2012 May; 59 (22): 1928-37
    • (2012) J Am Coll Cardiol , vol.59 , Issue.22 , pp. 1928-1937
    • Price, M.J.1    Murray, S.S.2    Angiolillo, D.J.3
  • 62
    • 84860792104 scopus 로고    scopus 로고
    • Paraoxonase 1 Q192R variant and clopidogrel efficacy: Fact or fiction?
    • Apr
    • Lewis JP, Shuldiner AR. Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction? Circ Cardiovasc Genet 2012 Apr; 5 (2): 153-5
    • (2012) Circ Cardiovasc Genet , vol.5 , Issue.2 , pp. 153-155
    • Lewis, J.P.1    Shuldiner, A.R.2
  • 63
    • 84863294612 scopus 로고    scopus 로고
    • Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response
    • Kreutz RP, Nystrom P, Kreutz Y, et al. Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response. Clin Pharmacol 2012; 4: 13-20
    • (2012) Clin Pharmacol , vol.4 , pp. 13-20
    • Kreutz, R.P.1    Nystrom, P.2    Kreutz, Y.3
  • 64
    • 84863500468 scopus 로고    scopus 로고
    • PON1 Meta-Analysis Group. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: A systematic review and metaanalysis
    • Jul
    • Reny JL, Combescure C, Daali Y, et al., PON1 Meta-Analysis Group. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and metaanalysis. J Thromb Haemost 2012 Jul; 10 (7): 1242-51
    • (2012) J Thromb Haemost , vol.10 , Issue.7 , pp. 1242-1251
    • Reny, J.L.1    Combescure, C.2    Daali, Y.3
  • 65
    • 69049095976 scopus 로고    scopus 로고
    • PON1 is a longevity gene: Results of a meta-analysis
    • Oct
    • Lescai F, Marchegiani F, Franceschi C. PON1 is a longevity gene: results of a meta-analysis. Ageing Res Rev 2009 Oct; 8 (4): 277-84
    • (2009) Ageing Res Rev , vol.8 , Issue.4 , pp. 277-284
    • Lescai, F.1    Marchegiani, F.2    Franceschi, C.3
  • 66
    • 70349728399 scopus 로고    scopus 로고
    • Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients
    • Nov
    • Marchegiani F, Spazzafumo L, Provinciali M, et al. Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients. Mol Genet Metab 2009 Nov; 98 (3): 314-8
    • (2009) Mol Genet Metab , vol.98 , Issue.3 , pp. 314-318
    • Marchegiani, F.1    Spazzafumo, L.2    Provinciali, M.3
  • 67
    • 84873808527 scopus 로고    scopus 로고
    • Paraoxonase- 1 55 LL genotype is associated with no STelevation myocardial infarction and with high levels of myoglobin
    • Marchegiani F, Spazzafumo L, Cardelli M, et al. Paraoxonase- 1 55 LL genotype is associated with no STelevation myocardial infarction and with high levels of myoglobin. J Lipids 2012; 2012: 601796
    • (2012) J Lipids , vol.2012 , pp. 601796
    • Marchegiani, F.1    Spazzafumo, L.2    Cardelli, M.3
  • 68
    • 39449136466 scopus 로고    scopus 로고
    • Paraoxonase 1: Genetics and activities during aging
    • Feb
    • Marchegiani F, Marra M, Olivieri F, et al. Paraoxonase 1: genetics and activities during aging. Rejuvenation Res 2008 Feb; 11 (1): 113-27
    • (2008) Rejuvenation Res , vol.11 , Issue.1 , pp. 113-127
    • Marchegiani, F.1    Marra, M.2    Olivieri, F.3
  • 69
    • 12944281041 scopus 로고    scopus 로고
    • Amitriptyline or not, that is the question: Pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy
    • Steimer W, Zopf K, von Amelunxen S, et al. Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. Clin Chem 2005; 51: 376-85
    • (2005) Clin Chem , vol.51 , pp. 376-385
    • Steimer, W.1    Zopf, K.2    Von Amelunxen, S.3
  • 70
    • 84862600938 scopus 로고    scopus 로고
    • Clinical Pharmacogenomics Implementation Consortium (CPIC). The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
    • Jul
    • Wilke RA, Ramsey LB, Johnson SG, et al., Clinical Pharmacogenomics Implementation Consortium (CPIC). The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin Pharmacol Ther 2012 Jul; 92 (1): 112-7
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.1 , pp. 112-117
    • Wilke, R.A.1    Ramsey, L.B.2    Johnson, S.G.3
  • 71
    • 0036918664 scopus 로고    scopus 로고
    • Gemfibrozil greatly increases plasma concentrations of cerivastatin
    • Dec
    • Backman JT, Kyrklund C, Neuvonen M, et al. Gemfibrozil greatly increases plasma concentrations of cerivastatin. Clin Pharmacol Ther 2002 Dec; 72 (6): 685-91
    • (2002) Clin Pharmacol Ther , vol.72 , Issue.6 , pp. 685-691
    • Backman, J.T.1    Kyrklund, C.2    Neuvonen, M.3
  • 72
    • 2942627194 scopus 로고    scopus 로고
    • Pharmacogenetic study of statin therapy and cholesterol reduction
    • Chasman DI, Posada D, Subrahmanyan L, et al. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 2004; 291 (23): 2821-7
    • (2004) JAMA , vol.291 , Issue.23 , pp. 2821-2827
    • Chasman, D.I.1    Posada, D.2    Subrahmanyan, L.3
  • 73
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzymeA reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • Medina MW, Gao F, Ruan W, et al. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzymeA reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation 2008; 118 (4): 355-62
    • (2008) Circulation , vol.118 , Issue.4 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3
  • 74
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic druguptake
    • Mar
    • Niemi M, Pasanen MK, Neuvonen PJ. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic druguptake. Pharmacol Rev 2011 Mar; 63 (1): 157-81
    • (2011) Pharmacol Rev , vol.63 , Issue.1 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 75
    • 84855932024 scopus 로고    scopus 로고
    • Genetic variationat the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly
    • Akao H, Polisecki E, Kajinami K, et al. Genetic variationat the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Atherosclerosis 2012; 220 (2): 413-7
    • (2012) Atherosclerosis , vol.220 , Issue.2 , pp. 413-417
    • Akao, H.1    Polisecki, E.2    Kajinami, K.3
  • 76
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-inducedmyopathy - A genomewide study
    • Aug
    • SEARCH Collaborative Group, Link E, Parish S, et al. SLCO1B1 variants and statin-inducedmyopathy - a genomewide study. N Engl JMed 2008 Aug; 359 (8): 789-99
    • (2008) N Engl JMed , vol.359 , Issue.8 , pp. 789-799
    • Link, E.1    Parish, S.2
  • 77
    • 70349739250 scopus 로고    scopus 로고
    • TheSLCO1B1&z.ast;l5 genetic variant is associated with statin-induced side effects
    • Oct
    • Voora D, Shah SH, Spasojevic I, et al. TheSLCO1B1&z.ast;l5 genetic variant is associated with statin-induced side effects. J AmColl Cardiol 2009 Oct; 54 (17): 1609-16
    • (2009) J AmColl Cardiol , vol.54 , Issue.17 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3
  • 78
    • 84861459835 scopus 로고    scopus 로고
    • Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associatedwith simvastatin and atorvastatin
    • Jun
    • Brunham LR, Lansberg PJ, Zhang L, et al. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associatedwith simvastatin and atorvastatin. Pharmacogenomics J 2012 Jun; 12 (3): 233-7
    • (2012) Pharmacogenomics J , vol.12 , Issue.3 , pp. 233-237
    • Brunham, L.R.1    Lansberg, P.J.2    Zhang, L.3
  • 79
    • 36549006511 scopus 로고    scopus 로고
    • Clinical practice. Late-life depression
    • Unützer J. Clinical practice. Late-life depression. N Engl J Med 2007; 357 (22): 2269-75
    • (2007) N Engl J Med , vol.357 , Issue.22 , pp. 2269-2275
    • Unützer, J.1
  • 80
    • 4344641185 scopus 로고    scopus 로고
    • The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder
    • Aug
    • Durham LK, Webb SM, Milos PM, et al. The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder. Psychopharmacology (Berl) 2004 Aug; 174 (4): 525-9
    • (2004) Psychopharmacology (Berl) , vol.174 , Issue.4 , pp. 525-529
    • Durham, L.K.1    Webb, S.M.2    Milos, P.M.3
  • 81
    • 0029895783 scopus 로고    scopus 로고
    • Allelic variation of human serotonin transporter gene expression
    • Jun
    • Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996 Jun; 66 (6): 2621-4
    • (1996) J Neurochem , vol.66 , Issue.6 , pp. 2621-2624
    • Heils, A.1    Teufel, A.2    Petri, S.3
  • 82
    • 58149195303 scopus 로고    scopus 로고
    • Pharmacogenetics and the serotonin transporter in late-life depression
    • Dec
    • Gerretsen P, Pollock BG. Pharmacogenetics and the serotonin transporter in late-life depression. Expert Opin Drug Metab Toxicol 2008 Dec; 4 (12): 1465-78
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.12 , pp. 1465-1478
    • Gerretsen, P.1    Pollock, B.G.2
  • 83
    • 33646072813 scopus 로고    scopus 로고
    • Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    • May
    • Hu XZ, Lipsky RH, Zhu G, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006 May; 78 (5): 815-26
    • (2006) Am J Hum Genet , vol.78 , Issue.5 , pp. 815-826
    • Hu, X.Z.1    Lipsky, R.H.2    Zhu, G.3
  • 84
    • 0033807374 scopus 로고    scopus 로고
    • Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    • Nov
    • Pollock BG, Ferrell RE, Mulsant BH, et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 2000 Nov; 23 (5): 587-90
    • (2000) Neuropsychopharmacology , vol.23 , Issue.5 , pp. 587-590
    • Pollock, B.G.1    Ferrell, R.E.2    Mulsant, B.H.3
  • 85
    • 41149146056 scopus 로고    scopus 로고
    • Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients
    • Mar
    • Lotrich FE, Pollock BG, Kirshner M, et al. Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients. J Psychiatry Neurosci 2008 Mar; 33 (2): 123-30
    • (2008) J Psychiatry Neurosci , vol.33 , Issue.2 , pp. 123-130
    • Lotrich, F.E.1    Pollock, B.G.2    Kirshner, M.3
  • 86
    • 34347374871 scopus 로고    scopus 로고
    • Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    • Jul
    • Hu XZ, Rush AJ, Charney D, et al. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch GenPsychiatry 2007 Jul; 64 (7): 783-92
    • (2007) Arch GenPsychiatry , vol.64 , Issue.7 , pp. 783-792
    • Hu, X.Z.1    Rush, A.J.2    Charney, D.3
  • 88
    • 80052944892 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity
    • Sep
    • Amstutz U, Froehlich TK, Largiadèr CR. Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity. Pharmacogenomics 2011 Sep; 12 (9): 1321-36
    • (2011) Pharmacogenomics , vol.12 , Issue.9 , pp. 1321-1336
    • Amstutz, U.1    Froehlich, T.K.2    Largiadèr, C.R.3
  • 89
    • 83855160887 scopus 로고    scopus 로고
    • Phase II study of pharmacogenetic-tailored therapy in elderly colorectal cancer patients
    • Scartozzi M, Loretelli C, Berardi R, et al. Phase II study of pharmacogenetic-tailored therapy in elderly colorectal cancer patients. Dig Liver Dis 2012; 44 (1): 74-9
    • (2012) Dig Liver Dis , vol.44 , Issue.1 , pp. 74-79
    • Scartozzi, M.1    Loretelli, C.2    Berardi, R.3
  • 90
    • 76749098737 scopus 로고    scopus 로고
    • Overview of the immune response
    • Feb
    • Chaplin DD. Overview of the immune response. J Allergy Clin Immunol 2010 Feb; 125 (2 Suppl. 2): S3-23
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.2 SUPPL. 2
    • Chaplin, D.D.1
  • 92
    • 0035693524 scopus 로고    scopus 로고
    • Diagnosis and treatment of allergic skin disorders in the elderly
    • Nedorost ST, Stevens SR. Diagnosis and treatment of allergic skin disorders in the elderly. Drugs Aging 2001; 18 (11): 827-35
    • (2001) Drugs Aging , vol.18 , Issue.11 , pp. 827-835
    • Nedorost, S.T.1    Stevens, S.R.2
  • 93
    • 1842784823 scopus 로고    scopus 로고
    • Medical genetics: A marker for Stevens-Johnson syndrome
    • Chung WH, Hung SI, Hong HS, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428: 486
    • (2004) Nature , vol.428 , pp. 486
    • Chung, W.H.1    Hung, S.I.2    Hong, H.S.3
  • 94
    • 34248589506 scopus 로고    scopus 로고
    • Association between HLA-B&z.ast;1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    • Man CB, Kwan P, Baum L, et al. Association between HLA-B&z.ast;1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 2007; 48: 1015-8
    • (2007) Epilepsia , vol.48 , pp. 1015-1018
    • Man, C.B.1    Kwan, P.2    Baum, L.3
  • 95
    • 57449118501 scopus 로고    scopus 로고
    • Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with the HLA-B&z.ast;1502 allele in a Thai population
    • Locharernkul C, Loplumlert J, Limotai C, et al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with the HLA-B&z.ast;1502 allele in a Thai population. Epilepsia 2008; 49: 2087-91
    • (2008) Epilepsia , vol.49 , pp. 2087-2091
    • Locharernkul, C.1    Loplumlert, J.2    Limotai, C.3
  • 96
    • 70450205028 scopus 로고    scopus 로고
    • Association of HLA-B&z.ast;1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
    • Mehta TY, Prajapati LM, Mittal B, et al. Association of HLA-B&z.ast;1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian J Dermatol Venereol Leprol 2009; 75: 579-82
    • (2009) Indian J Dermatol Venereol Leprol , vol.75 , pp. 579-582
    • Mehta, T.Y.1    Prajapati, L.M.2    Mittal, B.3
  • 97
    • 61549115662 scopus 로고    scopus 로고
    • JSAR research group HLA -B locus in Japaneses patients treated with antiepileptic or antimicrobial agents
    • Kaniwa N, Saito Y, Aihara M, et al. JSAR research group HLA -B locus in Japaneses patients treated with antiepileptic or antimicrobial agents. Pharmacogenomics 2008; 9: 1617-22
    • (2008) Pharmacogenomics , vol.9 , pp. 1617-1622
    • Kaniwa, N.1    Saito, Y.2    Aihara, M.3
  • 98
    • 33646934721 scopus 로고    scopus 로고
    • RegiSCAR Group A marker for Stevens-Johnson syndrome: Ethnicity matters
    • Lonjou C, Thomas L, Borot N, et al. RegiSCAR Group A marker for Stevens-Johnson syndrome: ethnicity matters. Pharmacogenomics J 2006; 6: 265-8
    • (2006) Pharmacogenomics J , vol.6 , pp. 265-268
    • Lonjou, C.1    Thomas, L.2    Borot, N.3
  • 99
    • 58149250548 scopus 로고    scopus 로고
    • FDA: Epilepsy drugs may carry skin risks for Asians
    • Kuehn BM. FDA: epilepsy drugs may carry skin risks for Asians. JAMA 2008; 300 (24): 2845
    • (2008) JAMA , vol.300 , Issue.24 , pp. 2845
    • Kuehn, B.M.1
  • 100
    • 33645082244 scopus 로고    scopus 로고
    • Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
    • Hung SI, Chung WH, Jee SH, et al. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics 2006; 16 (4): 297-306
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.4 , pp. 297-306
    • Hung, S.I.1    Chung, W.H.2    Jee, S.H.3
  • 101
    • 79953197983 scopus 로고    scopus 로고
    • HLA-A&z.ast;3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    • McCormackM, Alfirevic A, Bourgeois S, et al. HLA-A&z.ast;3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011; 364 (12): 1134-43
    • N Engl J Med 2011 , vol.364 , Issue.12 , pp. 1134-1143
    • McCormack, M.1    Alfirevic, A.2    Bourgeois, S.3
  • 102
    • 79551600984 scopus 로고    scopus 로고
    • Genome-wide association study identifies HLA-A&z.ast;3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
    • Ozeki T, Mushiroda T, Yowang A, et al. Genome-wide association study identifies HLA-A&z.ast;3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet 2011; 20 (5): 1034-41
    • (2011) Hum Mol Genet , vol.20 , Issue.5 , pp. 1034-1041
    • Ozeki, T.1    Mushiroda, T.2    Yowang, A.3
  • 103
    • 78650007285 scopus 로고    scopus 로고
    • HLA-B&z.ast;1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    • Kaniwa N, Saito Y, Aihara M, et al. HLA-B&z.ast;1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia 2010; 51 (12): 2461-5
    • (2010) Epilepsia , vol.51 , Issue.12 , pp. 2461-2465
    • Kaniwa, N.1    Saito, Y.2    Aihara, M.3
  • 104
    • 75649107833 scopus 로고    scopus 로고
    • HLA class i markers in Japanese patients with carbamazepineinduced cutaneous adverse reactions
    • Ikeda H, Takahashi Y, Yamazaki E, et al. HLA class I markers in Japanese patients with carbamazepineinduced cutaneous adverse reactions. Epilepsia 2010; 51 (2): 297-300
    • (2010) Epilepsia , vol.51 , Issue.2 , pp. 297-300
    • Ikeda, H.1    Takahashi, Y.2    Yamazaki, E.3
  • 105
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B&z.ast;5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • Hung SI, Chung WH, Liou LB, et al. HLA-B&z.ast;5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A 2005; 102: 4134-9
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4134-4139
    • Hung, S.I.1    Chung, W.H.2    Liou, L.B.3
  • 106
    • 70249122727 scopus 로고    scopus 로고
    • Strong association between HLA-B&z.ast;5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    • Tassaneeyakul W, Jantararoungtong T, Chen P, et al. Strong association between HLA-B&z.ast;5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics 2009; 19: 704-9
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 704-709
    • Tassaneeyakul, W.1    Jantararoungtong, T.2    Chen, P.3
  • 107
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B&z.ast;5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al. Association between presence of HLA-B&z.ast;5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002; 359: 727-32
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 108
    • 0037197044 scopus 로고    scopus 로고
    • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • Hetherington S, Hughes AR, Mosteller M, et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet 2002; 359: 1121-2
    • (2002) Lancet , vol.359 , pp. 1121-1122
    • Hetherington, S.1    Hughes, A.R.2    Mosteller, M.3
  • 109
    • 12144291646 scopus 로고    scopus 로고
    • Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations
    • Hughes AR, Mosteller M, Bansal AT, et al. Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. Pharmacogenomics 2004; 5: 203-11
    • (2004) Pharmacogenomics , vol.5 , pp. 203-211
    • Hughes, A.R.1    Mosteller, M.2    Bansal, A.T.3
  • 110
    • 38949196447 scopus 로고    scopus 로고
    • PREDICT-1 Study Team HLA-B&z.ast;5701 screening for hypersensitivity to abacavir
    • Mallal S, Phillips E, Carosi G, et al. PREDICT-1 Study Team HLA-B&z.ast;5701 screening for hypersensitivity to abacavir. N Engl J Med 2008; 358: 568-79
    • (2008) N Engl J Med , vol.358 , pp. 568-579
    • Mallal, S.1    Phillips, E.2    Carosi, G.3
  • 111
    • 67649859295 scopus 로고    scopus 로고
    • DILIGEN Study; International SAE Consortium. HLA-B&z.ast;5701 genotype is a major determinant of drug-induced liver injury due toflucloxacillin
    • Jul
    • Daly AK, Donaldson PT, Bhatnagar P, et al., DILIGEN Study; International SAE Consortium. HLA-B&z.ast;5701 genotype is a major determinant of drug-induced liver injury due toflucloxacillin. Nat Genet 2009 Jul; 41 (7): 816-9
    • (2009) Nat Genet , vol.41 , Issue.7 , pp. 816-819
    • Daly, A.K.1    Donaldson, P.T.2    Bhatnagar, P.3
  • 112
    • 77955082302 scopus 로고    scopus 로고
    • A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
    • Aug
    • Singer JB, Lewitzky S, Leroy E, et al. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet 2010 Aug; 42 (8): 711-4
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 711-714
    • Singer, J.B.1    Lewitzky, S.2    Leroy, E.3
  • 113
    • 84862631961 scopus 로고    scopus 로고
    • In silico analysis of HLA associations with drug-induced liver injury: Use of a HLA-genotyped DNA archive from healthy volunteers
    • Jun
    • Alfirevic A, Gonzalez-Galarza F, Bell C, et al. In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. Genome Med 2012 Jun; 4 (6): 51
    • (2012) Genome Med , vol.4 , Issue.6 , pp. 51
    • Alfirevic, A.1    Gonzalez-Galarza, F.2    Bell, C.3
  • 114
    • 85027955716 scopus 로고    scopus 로고
    • The clinical application of UGT1A1 pharmacogenetic testing: Gene-environment interactions
    • Apr
    • Marques SC, Ikediobi ON. The clinical application of UGT1A1 pharmacogenetic testing: gene-environment interactions. Hum Genomics 2010 Apr; 4 (4): 238-49
    • (2010) Hum Genomics , vol.4 , Issue.4 , pp. 238-249
    • Marques, S.C.1    Ikediobi, O.N.2
  • 115
    • 48949119333 scopus 로고    scopus 로고
    • Pharmacogenetics of Gilbert's syndrome
    • Strassburg CP. Pharmacogenetics of Gilbert's syndrome. Pharmacogenomics 2008; 9: 703-15
    • (2008) Pharmacogenomics , vol.9 , pp. 703-715
    • Strassburg, C.P.1
  • 116
    • 47149089807 scopus 로고    scopus 로고
    • Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: Are we there yet?
    • Perera MA, Innocenti F, Ratain MJ. Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet? Pharmacotherapy 2008; 28: 755-68
    • (2008) Pharmacotherapy , vol.28 , pp. 755-768
    • Perera, M.A.1    Innocenti, F.2    Ratain, M.J.3
  • 117
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyl-transferases and clinical drug-drug interactions
    • Kiang TK, Ensom MH, Chang TK. UDP-glucuronosyl-transferases and clinical drug-drug interactions. Pharmacol Ther 2005; 106: 97-132
    • (2005) Pharmacol Ther , vol.106 , pp. 97-132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 118
    • 79651470986 scopus 로고    scopus 로고
    • Pharmacogenomic biomarkers: New tools in current and future drug therapy
    • Feb
    • Sim SC, Ingelman-Sundberg M. Pharmacogenomic biomarkers: new tools in current and future drug therapy. Trends Pharmacol Sci 2011 Feb; 32 (2): 72-81
    • (2011) Trends Pharmacol Sci , vol.32 , Issue.2 , pp. 72-81
    • Sim, S.C.1    Ingelman-Sundberg, M.2
  • 119
    • 34250304874 scopus 로고    scopus 로고
    • Clinical pharmacogenomics of thiopurine S-methyl-transferase
    • Jan
    • Zhou S. Clinical pharmacogenomics of thiopurine S-methyl-transferase. Curr Clin Pharmacol 2006 Jan; 1 (1): 119-28
    • (2006) Curr Clin Pharmacol , vol.1 , Issue.1 , pp. 119-128
    • Zhou, S.1
  • 120
    • 45849107951 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of thiopurines
    • Aug
    • Sahasranaman S, Howard D, Roy S. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol 2008 Aug; 64 (8): 753-67
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.8 , pp. 753-767
    • Sahasranaman, S.1    Howard, D.2    Roy, S.3
  • 121
    • 36049045884 scopus 로고    scopus 로고
    • Immunosuppressive therapy in older cardiac transplant patients
    • Aliabadi AZ, Zuckermann AO, Grimm M. Immunosuppressive therapy in older cardiac transplant patients. Drugs Aging 2007; 24 (11): 913-32
    • (2007) Drugs Aging , vol.24 , Issue.11 , pp. 913-932
    • Aliabadi, A.Z.1    Zuckermann, A.O.2    Grimm, M.3
  • 122
    • 65649138698 scopus 로고    scopus 로고
    • MicroRNA polymorphisms: The future of pharmacogenomics, molecular epidemiology and individualized medicine
    • Mar
    • Mishra PJ, Bertino Jr. MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. Pharmacogenomics. 2009 Mar; 10 (3): 399-416
    • (2009) Pharmacogenomics. , vol.10 , Issue.3 , pp. 399-416
    • Mishra, P.J.1    Bertino, J.R.2
  • 123
    • 37749027621 scopus 로고    scopus 로고
    • Pharmacogenomics of microRNA: A miRSNP towards individualized therapy
    • Dec
    • Bertino JR, Banerjee D, Mishra PJ. Pharmacogenomics of microRNA: a miRSNP towards individualized therapy. Pharmacogenomics. 2007 Dec; 8 (12): 1625-7
    • (2007) Pharmacogenomics , vol.8 , Issue.12 , pp. 1625-1627
    • Bertino, J.R.1    Banerjee, D.2    Mishra, P.J.3
  • 124
    • 34548059198 scopus 로고    scopus 로고
    • A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance
    • Aug 14
    • Mishra PJ, Humeniuk R, Mishra PJ, et al. A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance. Proc Natl Acad Sci U S A. 2007 Aug 14; 104 (33): 13513-8
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.33 , pp. 13513-13518
    • Mishra, P.J.1    Humeniuk, R.2    Mishra, P.J.3
  • 125
    • 42449110323 scopus 로고    scopus 로고
    • MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics
    • Apr 1
    • Mishra PJ, Mishra PJ, Banerjee D, et al. MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: introducing microRNA pharmacogenomics. Cell Cycle 2008 Apr 1; 7 (7): 853-8
    • (2008) Cell Cycle , vol.7 , Issue.7 , pp. 853-85858
    • Mishra, P.J.1    Mishra, P.J.2    Banerjee, D.3
  • 127
    • 83355168713 scopus 로고    scopus 로고
    • A MiR-200b200c429-binding site polymorphism in the 30 untranslated region of the AP-2a gene is associated with cisplatin resistance
    • 2011
    • Wu Y, Xiao Y, Ding X, et al. A miR-200b/200c/429-binding site polymorphism in the 30 untranslated region of the AP-2a gene is associated with cisplatin resistance. PLoS ONE 2011; 6 (12): e29043
    • PLoS ONE , vol.6 , Issue.12
    • Wu, Y.1    Xiao, Y.2    Ding, X.3
  • 128
    • 77949756362 scopus 로고    scopus 로고
    • Genome-wide association studies in pharmacogenomics
    • Daly AK. Genome-wide association studies in pharmacogenomics. Nat Rev Genet 2010; 11: 241-6
    • (2010) Nat Rev Genet , vol.11 , pp. 241-246
    • Daly, A.K.1
  • 129
    • 84863914005 scopus 로고    scopus 로고
    • Recent patents on highthroughput single nucleotide polimorphism (SNP)genotyping methods
    • Paula Careta F, Paneto GG. Recent patents on highthroughput single nucleotide polimorphism (SNP)genotyping methods. Recent Pat DNA Gene Seg 2012; 6: 122-6
    • (2012) Recent Pat DNA Gene Seg , vol.6 , pp. 122-126
    • Paula Careta, F.1    Paneto, G.G.2
  • 130
    • 84878240242 scopus 로고    scopus 로고
    • Pharmacogenomics in colorectal cancer: A genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration
    • Feb 7 (Epub ahead of print)
    • Fernandez-Rozadilla C, Cazier JB, Moreno V, et al. Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration. Pharmacogenomics J 2012 Feb 7 (Epub ahead of print)
    • (2012) Pharmacogenomics J
    • Fernandez-Rozadilla, C.1    Cazier, J.B.2    Moreno, V.3
  • 131
    • 84866415102 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel loci for paclitaxelinduced sensory peripheral neuropathy in CALGB 40101
    • Sep 15
    • Baldwin RM, Owzar K, Zembutsu H, et al. A genome-wide association study identifies novel loci for paclitaxelinduced sensory peripheral neuropathy in CALGB 40101. Clin Cancer Res 2012 Sep 15; 18 (18): 5099-109
    • (2012) Clin Cancer Res , vol.18 , Issue.18 , pp. 5099-5109
    • Baldwin, R.M.1    Owzar, K.2    Zembutsu, H.3
  • 132
    • 84860760398 scopus 로고    scopus 로고
    • Pharmacogenomic study of side-effects for antidepressant treatment options in STAR&z.ast;D
    • Jun
    • Clark SL, Adkins DE, Aberg K, et al. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR&z.ast;D. Psychol Med 2012 Jun; 42 (6): 1151-62
    • (2012) Psychol Med , vol.42 , Issue.6 , pp. 1151-1162
    • Clark, S.L.1    Adkins, D.E.2    Aberg, K.3
  • 133
    • 80053498680 scopus 로고    scopus 로고
    • Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
    • Oct
    • Trompet S, de Craen AJ, Postmus I, et al. Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Med Genet 2011 Oct 6; 12: 131
    • (2011) BMC Med Genet , vol.6 , Issue.12 , pp. 131
    • Trompet, S.1    De Craen, A.J.2    Postmus, I.3
  • 134
    • 63449117825 scopus 로고    scopus 로고
    • A genomewide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    • Mar
    • Takeuchi F, McGinnis R, Bourgeois S, et al. A genomewide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet 2009 Mar; 5 (3): e1000433
    • (2009) PLoS Genet , vol.5 , Issue.3
    • Takeuchi, F.1    McGinnis, R.2    Bourgeois, S.3
  • 135
    • 80051564495 scopus 로고    scopus 로고
    • Genomic technology applied to pharmacological traits
    • Aug 10
    • Yang JJ, Plenge RM. Genomic technology applied to pharmacological traits. JAMA 2011 Aug 10; 306 (6): 652-3
    • (2011) JAMA , vol.306 , Issue.6 , pp. 652-653
    • Yang, J.J.1    Plenge, R.M.2
  • 136
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Mar 18
    • Fellay J, Thompson AJ, Ge D, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010 Mar 18; 464 (7287): 405-8
    • (2010) Nature , vol.464 , Issue.7287 , pp. 405-408
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3
  • 137
    • 79251612707 scopus 로고    scopus 로고
    • Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
    • Feb
    • GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, Wellcome Trust Case Control Consortium 2, Zhou K, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet 2011 Feb; 43 (2): 117-20
    • (2011) Nat Genet , vol.43 , Issue.2 , pp. 117-120
    • Zhou, K.1
  • 138
    • 59149089672 scopus 로고    scopus 로고
    • Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions
    • Feb
    • Nelson MR, Bacanu SA, Mosteller M, et al. Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions. Pharmacogenomics J 2009 Feb; 9 (1): 23-33
    • (2009) Pharmacogenomics J , vol.9 , Issue.1 , pp. 23-33
    • Nelson, M.R.1    Bacanu, S.A.2    Mosteller, M.3
  • 139
    • 84864118842 scopus 로고    scopus 로고
    • Optimizing drug outcomes through pharmacogenetics: A case for preemptive genotyping
    • Schildcrout JS, Denny JC, Bowton E, et al. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clinical Pharmacology & Therapeutics 2012; 92: 235-42
    • (2012) Clinical Pharmacology & Therapeutics , vol.92 , pp. 235-242
    • Schildcrout, J.S.1    Denny, J.C.2    Bowton, E.3
  • 140
    • 70349943777 scopus 로고    scopus 로고
    • An agenda for personalized medicine
    • Oct 8
    • Ng PC, Murray SS, Levy S, et al. An agenda for personalized medicine. Nature 2009 Oct 8; 461 (7265): 724-6
    • (2009) Nature , vol.461 , Issue.7265 , pp. 724-726
    • Ng, P.C.1    Murray, S.S.2    Levy, S.3
  • 141
    • 84858322966 scopus 로고    scopus 로고
    • Pharmacogenetic screening for drug therapy: From single gene markers to decision making in the next generation sequencing era
    • Feb
    • Tzvetkov M, von Ahsen N. Pharmacogenetic screening for drug therapy: from single gene markers to decision making in the next generation sequencing era. Pathology 2012 Feb; 44 (2): 166-80
    • (2012) Pathology , vol.44 , Issue.2 , pp. 166-180
    • Tzvetkov, M.1    Von Ahsen, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.