Adverse drug reactions in a population of hospitalized very elderly patients

Drugs and Aging

Volumn 29, Issue 8, 2012, Pages 669-679

  Tangiisuran, Balamurugan ^a   Davies, J Graham ^b   Wright, Juliet E ^c   Rajkumar, Chakravarthi ^c  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANALGESIC AGENT; ANTIDIABETIC AGENT; CARDIOVASCULAR AGENT; DIAZEPAM; FUROSEMIDE; INSULIN;

AGED; ARTICLE; FEMALE; GERIATRIC CARE; HOSPITALIZATION; HUMAN; HYPERLIPIDEMIA; INCIDENCE; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; SIDE EFFECT; UNSPECIFIED SIDE EFFECT;

AGED, 80 AND OVER; DRUG TOXICITY; FEMALE; HOSPITALIZATION; HOSPITALS, TEACHING; HUMANS; INPATIENTS; MALE; RISK FACTORS;

EID: 84864134728     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11632630     Document Type: Article

References (44)

1. Department of Health. National service framework for older people. London: The Stationary Office, 2001
2. ElDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther 2007 Sep-Oct; 14 (5): 488-98
3. Bates DW, Cullen DJ, Laird N, et al. Incidence of adverse drug events and potential adverse drug events: implications for prevention. ADE Prevention Study Group. JAMA 1995 Jul 5; 274 (1): 29-34
4. Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group. JAMA 1997 Jan 22-29; 277 (4): 307-11
5. Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospec- tive analysis of 18 820 patients. BMJ 2004 Jul 3; 329 (7456): 15-9
6. Davies EC, Green CF, Taylor S, et al. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 2009; 4 (2): e4439
7. Beijer HJ, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002 Apr; 24 (2): 46-54
8. Azad N, Tierney M, Victor G, et al. Adverse drug events in the elderly population admitted to a tertiary care hospital. J Healthc Manag 2002 Sep-Oct; 47 (5): 295-305
9. Chan M, Nicklason F, Vial JH. Adverse drug events as a cause of hospital admission in the elderly. Intern Med J 2001 May-Jun; 31 (4): 199-205
10. Hallas J, Harvald B, Gram LF, et al. Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med 1990 Aug; 228 (2): 83-90
11. Cunningham G, Dodd TR, Grant DJ, et al. Drug-related problems in elderly patients admitted to Tayside hospitals: methods for prevention and subsequent reassessment. Age Ageing 1997 Sep; 26 (5): 375-82
12. Dartnell JG, Anderson RP, Chohan V, et al. Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs. Med J Australia 1996 Jun 3; 164 (11): 659-62
13. Courtman BJ, Stallings SB. Characterization of drug-related problems in elderly patients on admission to a medical ward. Can J Hosp Pharm 1995 Jun; 48 (3): 161-6
14. Page 2nd RL, Ruscin JM. The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use. Am J Geriatr Pharmacother 2006 Dec; 4 (4): 297-305
15. Gray SL, Sager M, Lestico MR, et al. Adverse drug events in hospitalized elderly. J Gerontol A Biol Sci Med Sci 1998 Jan; 53 (1): M59-63
16. Lindley CM, Tully MP, Paramsothy V, et al. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992 Jul; 21 (4): 294-300
17. Schmader KE, Hanlon JT, Pieper CF, et al. Effect of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004 March 15; 116 (6): 394-401
18. Collin C, Wade DT, Davies S, et al. The Barthel ADL Index: a reliability study. Int Disabil Stud 1988; 10 (2): 61-3
19. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1972 Nov; 1 (4): 233-8
20. Handler SM, Hanlon JT, Perera S, et al. Consensus list of signals to detect potential adverse drug reactions in nursing homes. J Am Geriatr Soc 2008 May; 56 (5): 808-15
21. Rozich JD, Haraden CR, Resar RK. Adverse drug event trigger tool: a practical methodology for measuring medication related harm. Qual Saf Health Care 2003 Jun; 12 (3): 194-200
22. Leendertse AJ, Egberts AC, Stoker LJ, et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med 2008 Sep 22; 168 (17): 1890-6
23. Wiffen P GM, Edwards J, Moore A. Adverse drug reactions in hospital patients: a systematic review of the prospective and retrospective studies. Bandolier Extra Evidence-Based Health Care 2002 Jun: 1-15
24. Howard RL, Avery AJ, Slavenburg S, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol 2007 Feb; 63 (2): 136-47
25. Davies EC, Green CF, Mottram DR, et al. Adverse drug reactions in hospitals: a narrative review. Curr Drug Saf 2007 Jan; 2 (1): 79-87
26. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000 Oct 7; 356 (9237): 1255-9
27. Rawlins MD, Thompson JW. Mechanism of adverse drug reaction. In: Davies DM, editor. Textbook of adverse drug reactions. Oxford: Oxford University Press, 1991: 18-45
28. Gandhi TK, Weingart SN, Borus J, et al. Adverse drug events in ambulatory care. N Engl J Med 2003 Apr 17; 348 (16): 1556-64
29. Morimoto T, Gandhi TK, Seger AC, et al. Adverse drug events and medication errors: detection and classification methods. Qual Saf Health Care 2004 Aug; 13 (4): 306-14
30. Vittinghoff EV, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 2007 Dec; 165: 710-8
31. Hohl CM, Dankoff J, Colacone A, et al. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med 2001 Dec; 38 (6): 666-71
32. Hanlon JT, Schmader KE, Koronkowski MJ, et al. Adverse drug events in high risk older outpatients. J AmGeriatr Soc 1997 Aug; 45 (8): 945-8
33. Bates DW, Miller EB, Cullen DJ, et al. Patient risk factors for adverse drug events in hospitalized patients. Arch Intern Med 1999 Nov 22; 159 (21): 2553-60
34. Onder G, Gambassi G, Scales CJ, et al. Adverse drug reactions and cognitive function among hospitalized older adults. Eur J Clin Pharmacol 2002 Aug; 58 (5): 371-7
35. Carbonin P, Pahor M, Bernabei R, et al. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients. J Am Geriatr Soc 1991 Nov; 39 (11): 1093-9
36. Leach S, Roy SS. Adverse drug reactions: an investigation on an acute geriatric ward. Age Ageing 1986 Jul; 15 (4): 241-6
37. Tangiisuran B, Wright J, Van der Cammen T, et al. Adverse drug reactions in elderly: challenges in identification and improving preventative strategies. Age Ageing 2009; 38 (4): 358-9
38. Seidl LG, Thornton GF, Cluff LE. Epidemiological studies of adverse drug reactions. Am J Public Health Nations Health 1965 Aug; 55: 1170-5
39. Kanjanarat P, Winterstein AG, Johns TE, et al. Nature of preventable adverse drug events in hospitals: a literature review. AmJ Health Syst Pharm 2003 Sep 1; 60 (17): 1750-9
40. Nguyen JK, Fouts MM, Kotabe SE, et al. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother 2006 Mar; 4 (1): 36-41
41. Spino M, Sellers EM, Kaplan HL. Effect of adverse drug reactions on the length of hospitalization. Am J Hosp Pharm 1978 Sep; 35 (9): 1060-4
42. Zopf Y, Rabe C, Neubert A, et al. Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf 2008; 31 (9): 789-98
43. Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Persons Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 2008 Feb; 46 (2): 72-83
44. Onder G, Petrovic M, Tangiisuran B, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med 2010 Jul 12; 170 (13): 1142-8