Incidence and predictors of adverse drug reactions caused by drug-drug interactions in elderly outpatients: A prospective cohort study

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 15, Issue 2, 2012, Pages 332-343

  Neto, Paulo Roque Obreli ^a   Nobili, Alessandro ^b   de Lyra, Divaldo Pereira ^c   Pilger, Diogo ^d   Guidoni, Camilo Molino ^e   de Oliveira, André Baldoni ^e   Cruciol Souza, Joice Mara ^f   de Carvalho, Ana Luiza Freitas ^g   Tettamanti, Mauro ^b   Gaeti, Walderez Penteado ^a   Cuman, Roberto Kenji Nakamura ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f STATE UNIVERSITY OF LONDRINA   (Brazil)

^g Faculdades Integradas de Ourinhos (FIO)   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; AMITRIPTYLINE; AMLODIPINE; ATENOLOL; BEZAFIBRATE; CAPTOPRIL; CIPROFLOXACIN; CLOPIDOGREL; DICLOFENAC; DIGOXIN; ENALAPRIL; ERYTHROMYCIN; FLUOXETINE; FUROSEMIDE; GLIBENCLAMIDE; HALOPERIDOL; HYDROCHLOROTHIAZIDE; LOSARTAN; MELOXICAM; METFORMIN; METOCLOPRAMIDE; NAPROXEN; OMEPRAZOLE; PIROXICAM; SIMVASTATIN; SPIRONOLACTONE; WARFARIN;

ADULT; ADVERSE DRUG REACTION; AGE; AGED; ALGORITHM; ARTICLE; BLOOD CLOTTING DISORDER; BRAZIL; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRUG DRUG INTERACTION; DRUG INTERACTION; FEMALE; GASTROINTESTINAL HEMORRHAGE; GENDER; GERIATRIC PATIENT; HEART ARRHYTHMIA; HUMAN; HYPERKALEMIA; HYPOKALEMIA; INCIDENCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MYOPATHY; OUTPATIENT; OVERANTICOAGULATION; PARKINSONISM; PATIENT ASSESSMENT; PATIENT SELECTION; PHARMACIST; POLYPHARMACY; PREDICTION; PRIMARY HEALTH CARE; PROSPECTIVE STUDY; RISK; SEROTONIN SYNDROME; VOMITING;

EID: 84860869658     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3cc86     Document Type: Article

References (33)

1. Hansten, P.D.; Horn, J.R. Horn, Drug Interactions Analysis and Management, Facts & Comparisons. Lippincott Williams & Wilkins, Philadelphia, PA, USA, 2009.
2. Shad MU, Marsh C, Preskorn SH. The economic consequences of a drug-drug interaction. J Clin Psychopharmacol, 2001; 21: 119-120.
3. Grymonpre RE, Mitenko PA, Sitar DS, Aoki FY, Montgomery PR. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc, 1998; 36: 1092-1098.
4. Hamilton RA, Briceland LL, Andritz MH. Frequency of hospitalization after exposure to known drug-drug interactions in a Medicaid population. Pharmacotherapy, 1998; 18: 1112-1120.
5. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol, 2004; 57: 6-14.
6. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet, 2007; 370: 185-191.
7. Obreli-Neto PR, Vieira JC, Teixeira DRA, Silva FP, Gaeti WP, Cuman RKN. Potential risks in drug prescriptions to elderly: a cross-sectional study in the public primary health care system of Ourinhos micro-region, Brazil. Acta Farm Bonaerense, 2011; 30: 629-635.
8. Tulner LR, Frankfort SV, Gijsen GJ, van Campen JP, Koks CH, Beijnen JH. Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance. Drugs Aging, 2008; 25: 343-355.
9. Obreli-Neto PR, Nobili A, Marusic S, Pilger D, Guidoni CM, Baldoni AO, Cruciol-Souza JM, da Cruz AN, Gaeti WP, Cuman RKN. Prevalence and predictors of potential drug-drug interactions in the elderly: a cross-sectional study in the Brazilian primary public-health system. J Pharm Pharm Sci, 2012; in press.
10. Gagne JJ, Maio V, Rabinowitz C. Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy. J Clin Pharm Ther, 2008; 33: 141-151.
11. Nobili A, Pasina L, Tettamanti M, Lucca U, Riva E, Marzona I, Monesi L, Cucchiani R, Bortolotti A, Fortino I, Merlino L, Walter Locatelli G, Giuliani G. Potentially severe druginteractions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther, 2009; 34: 377-386.
12. Brasil. Lei n. 8080, 19 de setembro de 1990. Dispõe sobre as condições para a promoção, proteção e recuperação da saúde, a organização e o funcionamento dos serviços correspondentes e dá outras providências. Diário Oficial da União, Sept 20, 1990.
13. Brasil. Lei n. 8142, de 28 de dezembro de 1990. Dispõe sobre a participação da comunidade na gestão do Sistema Único de Saúde (SUS) e sobre as transferências intergovernamentais de recursos financeiros na área da saúde e dá outras providências. Diário Oficial da União, Dec 30, 1990.
14. DrugDigest. Check interactions. In: www.drugdigest.org/wps/portal/ddigest.
15. Drugs. Drug interaction checker. In: www.drugd.com/drug_interactions.html.
16. Medscape. Drug information. In: http://www.medscape.com/druginfo/druginterchecker.
17. Micromedex. Micromedex healthcare series. In: http://www.periodicos.capes.gov.br/.
18. Karch FE, Lasagna L. Toward the operational identification of adverse drug reactions. Clin Pharmacol Ther, 1977; 21: 247-254.
19. Kramer MS, Leventhal JM, Hutchinson TA, Feinstein AR. An algorithm for the operational assessment of adverse drug reactions. I. Background, description, and instructions for use. JAMA, 1979; 242:623-632.
20. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther, 1981; 30: 239-245.
21. Macedo AF, Marques FB, Ribeiro CF, Teixeira F. Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability. J Clin Pharm Ther, 2003; 28: 137-143.
22. WHO Collaborating Centre for Drug Statistics Methodology. ACT/DDD Index. In: http://www.whocc.no/atcddd/.
23. Sandson N. Drug-drug interactions: the silent epidemic. Psychiatr Serv, 2005; 56: 22-24.
24. Janchawee B, Wongpoowarak W, Owatranporn T, Chongsuvivatwong V. Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand. J Clin Pharm Ther, 2005; 30: 13-20.
25. Lin CF, Wang CY, Bai CH. Polypharmacy, aging and potential drug-drug interactions in outpatients in Taiwan: a retrospective computerized screening study. Drugs Aging, 2011; 28: 219-225.
26. Bjerrum L, Andersen M, Petersen G, Kragstrup J. Exposure to potential drug interactions in primary health care. Scand J Prim Health Care, 2003; 21: 153-158.
27. Atuah KN, Hughes D, Pirmohamed M. Clinical pharmacology: special safety considerations in drug development and pharmacovigilance. Drug Saf, 2004; 27: 535-554.
28. Johnell K, Klarin I. The relationship between number of drugs and potential drug-drug interactions in the elderly. A survey of over 600 000 elderly patients from the Swedish Prescribed Drug Register. Drug Saf, 2007; 30: 911-918.
29. Costa AJ. Potential drug interactions in an ambulatory geriatric population. Fam Pract, 1991; 8: 234-236.
30. Abarca J, Malone DC, Armstrong EP, Grizzle AJ, Hansten PD, Van Bergen RC, Lipton RB. Concordance of severity ratings provided in four drug interaction compendia. J Am Pharm Assoc, 2003; 44: 136-141.
31. Guidoni CM, Baldoni AO, Obreli-Neto PR, Pereira LRL. Fontes de informações sobre interações medicamentosas: Há concordância entre elas? Rev Univ Vale Rio Verde, 2011; 9:84-91.
32. Vitry AI. Comparative assessment of four drug interaction compendia. Br J Clin Pharmacol, 2007; 63: 709-714.
33. Caccia S, Garanttini S, Pasina L, Nobili A. Predicting the clinical relevance of drug interactions from pre-approval studies. Drug Saf, 2009; 32: 1017-1039.