메뉴 건너뛰기




Volumn 4, Issue 4, 2010, Pages 238-249

The clinical application of UGT1A1 pharmacogenetic testing: Gene– environment interactions

Author keywords

Drug therapy; Ethnicity; Pharmacogenetics; Polymorphism; UDP glucuronosyltransferase; UGT1A1

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLUCURONOSYLTRANSFERASE; PHENOL GLUCURONOSYLTRANSFERASE;

EID: 85027955716     PISSN: 14739542     EISSN: 14797364     Source Type: Journal    
DOI: 10.1186/1479-7364-4-4-238     Document Type: Review
Times cited : (58)

References (50)
  • 1
    • 48949119333 scopus 로고    scopus 로고
    • Pharmacogenetics of Gilbert’s syndrome
    • Strassburg, C.P. (2008), ‘Pharmacogenetics of Gilbert’s syndrome’, Pharmacogenomics Vol. 9, pp. 703–715.
    • (2008) Pharmacogenomics , vol.9 , pp. 703-715
    • Strassburg, C.P.1
  • 2
    • 47149089807 scopus 로고    scopus 로고
    • Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorph-isms: Are we there yet?
    • Perera, M.A., Innocenti, F. and Ratain, M.J. (2008), ‘Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorph-isms: Are we there yet?’, Pharmacotherapy Vol. 28, pp. 755–768.
    • (2008) Pharmacotherapy , vol.28 , pp. 755-768
    • Perera, M.A.1    Innocenti, F.2    Ratain, M.J.3
  • 3
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyl-transferases and clinical drug-drug interactions
    • Kiang, T.K., Ensom, M.H. and Chang, T.K. (2005), ‘UDP-glucuronosyl-transferases and clinical drug-drug interactions’, Pharmacol. Ther. Vol. 106, pp. 97–132.
    • (2005) Pharmacol. Ther , vol.106 , pp. 97-132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 4
    • 64549133772 scopus 로고    scopus 로고
    • Gilbert’s syndrome and hyperbilirubinemia in protease inhibitor therapy — An extended haplotype of genetic variants increases risk in indinavir treatment
    • Lankisch, T.O., Behrens, G., Ehmer, U., Möbius, U. et al. (2009), ‘Gilbert’s syndrome and hyperbilirubinemia in protease inhibitor therapy — An extended haplotype of genetic variants increases risk in indinavir treatment’, J. Hepatol. Vol. 50, pp. 1010–1018.
    • (2009) J. Hepatol , vol.50 , pp. 1010-1018
    • Lankisch, T.O.1    Behrens, G.2    Ehmer, U.3    Möbius, U.4
  • 5
    • 36348940478 scopus 로고    scopus 로고
    • Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism
    • Zhang, D., Zhang, D., Cui, D., Gambardella, J. et al. (2007), ‘Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism’, Drug Metab. Dispos. Vol. 35, pp. 2270–2280.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 2270-2280
    • Zhang, D.1    Zhang, D.2    Cui, D.3    Gambardella, J.4
  • 6
    • 0035057872 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer agents: Lessons from amonafide and irinotecan
    • Innocenti, F., Iyer, L. and Ratain, M.J. (2001), ‘Pharmacogenetics of anticancer agents: Lessons from amonafide and irinotecan’, Drug Metab. Dispos. Vol. 29, pp. 596–600.
    • (2001) Drug Metab. Dispos , vol.29 , pp. 596-600
    • Innocenti, F.1    Iyer, L.2    Ratain, M.J.3
  • 7
    • 10744221514 scopus 로고    scopus 로고
    • The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk
    • Duguay, Y., McGrath, M., Lépine, J., Gagné, J.F. et al. (2004), ‘The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk’, Cancer Res. Vol. 64, pp. 1202–1207.
    • (2004) Cancer Res , vol.64 , pp. 1202-1207
    • Duguay, Y.1    McGrath, M.2    Lépine, J.3    Gagné, J.F.4
  • 8
    • 0034652640 scopus 로고    scopus 로고
    • Genetic polymorphisms in uridine diphospho-glucuronosyltrans-ferase 1A1 and association with breast cancer among African Americans
    • Guillemette, C., Millikan, R.C., Newman, B., Housman, D.E. et al. (2000), ‘Genetic polymorphisms in uridine diphospho-glucuronosyltrans-ferase 1A1 and association with breast cancer among African Americans’, Cancer Res. Vol. 60, pp. 950–956.
    • (2000) Cancer Res , vol.60 , pp. 950-956
    • Guillemette, C.1    Millikan, R.C.2    Newman, B.3    Housman, D.E.4
  • 9
    • 4644371620 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    • Sparks, R., Ulrich, C.M., Bigler, J., Tworoger, S.S. et al. (2004), ‘UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients’, Breast Cancer Res. Vol. 6, pp. R488–R498.
    • (2004) Breast Cancer Res , vol.6 , pp. R488-R498
    • Sparks, R.1    Ulrich, C.M.2    Bigler, J.3    Tworoger, S.S.4
  • 10
    • 0036079698 scopus 로고    scopus 로고
    • In vitro induction of bilirubin conjugation in primary rat hepatocyte culture
    • Jemnitz, K., Lengyel, G. and Vereczkey, L. (2002), ‘In vitro induction of bilirubin conjugation in primary rat hepatocyte culture’, Biochem. Biophys. Res. Commun. Vol. 291, pp. 29–33.
    • (2002) Biochem. Biophys. Res. Commun , vol.291 , pp. 29-33
    • Jemnitz, K.1    Lengyel, G.2    Vereczkey, L.3
  • 11
    • 66949149605 scopus 로고    scopus 로고
    • Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharma-cokinetics of raltegravir
    • Wenning,L.A.,Hanley,W.D.,Brainard,D.M.,Petry,A.S.et al. (2009), ‘Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharma-cokinetics of raltegravir’, Antimicrob. Agents Chemother. Vol. 53, pp. 2852–2856.
    • (2009) Antimicrob. Agents Chemother , vol.53 , pp. 2852-2856
    • Wenning, L.A.1    Hanley, W.D.2    Brainard, D.M.3    Petry, A.S.4
  • 12
    • 0343924387 scopus 로고    scopus 로고
    • Regulation of the human bilirubin UDP-glucuronosyltransferase gene
    • Brierley, C.H., Senafi, S.B., Clarke, D., Hsu, M.H. et al. (1996), ‘Regulation of the human bilirubin UDP-glucuronosyltransferase gene’, Adv. Enzyme Regul. Vol. 36, pp. 85–97.
    • (1996) Adv. Enzyme Regul , vol.36 , pp. 85-97
    • Brierley, C.H.1    Senafi, S.B.2    Clarke, D.3    Hsu, M.H.4
  • 13
    • 31344440241 scopus 로고    scopus 로고
    • Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes
    • Ramírez, J., Komoroski, B.J., Mirkov, S., Graber, A.Y. et al. (2006), ‘Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes’, Pharmacogenet. Genomics Vol. 16, pp. 79–86.
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 79-86
    • Ramírez, J.1    Komoroski, B.J.2    Mirkov, S.3    Graber, A.Y.4
  • 14
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti, F., Undevia, S.D., Iyer, L., Chen, P.X. et al. (2004), ‘Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan’, J. Clin. Oncol. Vol. 22, pp. 1382–1388.
    • (2004) J. Clin. Oncol , vol.22 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3    Chen, P.X.4
  • 15
    • 34548598459 scopus 로고    scopus 로고
    • UGT1A1*28 genotype and irinotecan-induced neutropenia: Dose matters
    • Hoskins, J.M., Goldberg, R.M., Qu, P., Ibrahim, J.G. et al. (2007), ‘UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters’, J. Natl. Cancer Inst. Vol. 99, pp. 1290–1295.
    • (2007) J. Natl. Cancer Inst , vol.99 , pp. 1290-1295
    • Hoskins, J.M.1    Goldberg, R.M.2    Qu, P.3    Ibrahim, J.G.4
  • 16
    • 66349133649 scopus 로고    scopus 로고
    • Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan
    • Cecchin, E., Innocenti, F., D’Andrea, M., Corona, G. et al. (2009), ‘Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan’, J. Clin. Oncol. Vol. 27, pp. 2457–2465.
    • (2009) J. Clin. Oncol , vol.27 , pp. 2457-2465
    • Cecchin, E.1    Innocenti, F.2    D’Andrea, M.3    Corona, G.4
  • 17
    • 40949156763 scopus 로고    scopus 로고
    • Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi’s sarcoma
    • Corona, G., Vaccher, E., Sandron, S. et al. (2008), ‘Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi’s sarcoma’, Clin. Pharm. Ther. Vol. 83, pp. 601–606.
    • (2008) Clin. Pharm. Ther , vol.83 , pp. 601-606
    • Corona, G.1    Vaccher, E.2    Sandron, S.3
  • 18
    • 63849264200 scopus 로고    scopus 로고
    • Effects of UGT1A1*28 polymorphism on raloxifene pharmacokinetics and phar-macodynamics
    • Trontelj, J., Marc, J., Zavratnik, A., Bogataj, M. et al. (2009), ‘Effects of UGT1A1*28 polymorphism on raloxifene pharmacokinetics and phar-macodynamics’, Br. J. Clin. Pharmacol. Vol. 67, pp. 437–444.
    • (2009) Br. J. Clin. Pharmacol , vol.67 , pp. 437-444
    • Trontelj, J.1    Marc, J.2    Zavratnik, A.3    Bogataj, M.4
  • 19
    • 67349217885 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in individuals with UGT1A1 poly-morphisms
    • Wenning, L.A., Petry, A.S., Kost, J.T., Jin, B. et al. (2009), ‘Pharmacokinetics of raltegravir in individuals with UGT1A1 poly-morphisms’, Clin. Pharmacol. Ther. Vol. 85, pp. 623–627.
    • (2009) Clin. Pharmacol. Ther , vol.85 , pp. 623-627
    • Wenning, L.A.1    Petry, A.S.2    Kost, J.T.3    Jin, B.4
  • 21
    • 25844446183 scopus 로고    scopus 로고
    • Gilbert syndrome and the development of antiretroviral therapy-associated hyper-bilirubinemia
    • Rotger, M., Taffé, P., Bleiber, G., Gunthard, H.F. et al. (2005), ‘Gilbert syndrome and the development of antiretroviral therapy-associated hyper-bilirubinemia’, J. Infect. Dis. Vol. 192, pp. 1381–1386.
    • (2005) J. Infect. Dis , vol.192 , pp. 1381-1386
    • Rotger, M.1    Taffé, P.2    Bleiber, G.3    Gunthard, H.F.4
  • 22
    • 33751005307 scopus 로고    scopus 로고
    • Gilbert’s disease and atazanavir: From phenotype to UDP-glucuronosyl-transferase haplotype
    • Lankisch, T.O., Moebius, U., Wehmeier, M., Behrens, G. et al. (2006), ‘Gilbert’s disease and atazanavir: From phenotype to UDP-glucuronosyl-transferase haplotype’, Hepatology Vol. 44, pp. 1324–1332.
    • (2006) Hepatology , vol.44 , pp. 1324-1332
    • Lankisch, T.O.1    Moebius, U.2    Wehmeier, M.3    Behrens, G.4
  • 23
    • 73949129834 scopus 로고    scopus 로고
    • Atazanavir pharmacokinetics in genetically determined CYP3A5 expressors versus non-expressors
    • Anderson, P.L., Aquilante, C.L., Gardner, E.M., Predhomme, J. et al. (2009), ‘Atazanavir pharmacokinetics in genetically determined CYP3A5 expressors versus non-expressors’, J. Antimicrob. Chemother. Vol. 64, pp. 1071–1079.
    • (2009) J. Antimicrob. Chemother , vol.64 , pp. 1071-1079
    • Anderson, P.L.1    Aquilante, C.L.2    Gardner, E.M.3    Predhomme, J.4
  • 24
    • 33745929357 scopus 로고    scopus 로고
    • Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study
    • Anderson, P.L., Lamba, J., Aquilante, C.L., Schuetz, E. et al. (2006), ‘Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study’, J. Acquir. Immune Defic. Syndr. Vol. 42, pp. 441–449.
    • (2006) J. Acquir. Immune Defic. Syndr , vol.42 , pp. 441-449
    • Anderson, P.L.1    Lamba, J.2    Aquilante, C.L.3    Schuetz, E.4
  • 25
    • 68249135542 scopus 로고    scopus 로고
    • UGT1A1 polymorphism and hyperbilirubinemia in a patient who received sorafenib
    • Meza-Junco, J., Chu, Q.S., Christensen, O., Rajagopalan, P. et al. (2009), ‘UGT1A1 polymorphism and hyperbilirubinemia in a patient who received sorafenib’, Cancer Chemother. Pharmacol. Vol. 65, pp. 1–4.
    • (2009) Cancer Chemother. Pharmacol , vol.65 , pp. 1-4
    • Meza-Junco, J.1    Chu, Q.S.2    Christensen, O.3    Rajagopalan, P.4
  • 26
    • 33846020023 scopus 로고    scopus 로고
    • Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib
    • Mross, K., Steinbild, S., Baas, F., Gmehling, D. et al. (2007), ‘Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib’, Eur. J. Cancer Vol. 43, pp. 55–63.
    • (2007) Eur. J. Cancer , vol.43 , pp. 55-63
    • Mross, K.1    Steinbild, S.2    Baas, F.3    Gmehling, D.4
  • 27
    • 33847358669 scopus 로고    scopus 로고
    • UDP-glucuro-nosyltransferase 1A1 is the principal enzyme responsible for etoposide glu-curonidation in human liver and intestinal microsomes: Structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics
    • Wen,Z.,Tallman,M.N.,Ali,S.Y.andSmith,P.C.(2007),‘UDP-glucuro-nosyltransferase 1A1 is the principal enzyme responsible for etoposide glu-curonidation in human liver and intestinal microsomes: Structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics’, Drug Metab. Dispos. Vol. 35, pp. 371–380.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 371-380
    • Wen, Z.1    Tallman, M.N.2    Aliandsmith, S.Y.P.C.3
  • 28
    • 0033054393 scopus 로고    scopus 로고
    • Contribution of the TATA-box genotype (Gilbert syndrome) to serum bilirubin concentrations in the Italian population
    • Biondi, M.L., Turri, O., Dilillo, D., Stival, G. et al. (1999), ‘Contribution of the TATA-box genotype (Gilbert syndrome) to serum bilirubin concentrations in the Italian population’, Clin. Chem. Vol. 45, pp. 897–898.
    • (1999) Clin. Chem , vol.45 , pp. 897-898
    • Biondi, M.L.1    Turri, O.2    Dilillo, D.3    Stival, G.4
  • 29
    • 17744374081 scopus 로고    scopus 로고
    • Polymorphism in the promoter region of the bilirubin UDP-glucuronosyltransferase (Gilbert’s syndrome) in healthy Dutch sub-jects
    • Te Morsche, R.H., Zusterzeel, P.L., Raijmakers, M.T., Roes, E.M. et al. (2001), ‘Polymorphism in the promoter region of the bilirubin UDP-glucuronosyltransferase (Gilbert’s syndrome) in healthy Dutch sub-jects’, Hepatology Vol. 33, p. 765.
    • (2001) Hepatology , vol.33 , pp. 765
    • Te Morsche, R.H.1    Zusterzeel, P.L.2    Raijmakers, M.T.3    Roes, E.M.4
  • 30
    • 0034727348 scopus 로고    scopus 로고
    • Distribution of the A(TA)7TAA genotype associated with Gilbert syndrome in the Spanish population
    • Fernández Salazar, J.M., Remacha Sevilla, A., del Río Conde, E. and Baiget Bastús, M. (2000), ‘Distribution of the A(TA)7TAA genotype associated with Gilbert syndrome in the Spanish population’, Med. Clin. (Barc.) Vol. 115, pp. 540–541.
    • (2000) Med. Clin. (Barc , vol.115 , pp. 540-541
    • Fernández Salazar, J.M.1    Remacha Sevilla, A.2    Del Río Conde, E.3    Baiget Bastús, M.4
  • 31
    • 0032847365 scopus 로고    scopus 로고
    • Molecular genetic basis of Gilbert’s syndrome
    • Burchell, B. and Hume, R. (1999), ‘Molecular genetic basis of Gilbert’s syndrome’, J. Gastroenterol. Hepatol. Vol. 14, pp. 960–966.
    • (1999) J. Gastroenterol. Hepatol , vol.14 , pp. 960-966
    • Burchell, B.1    Hume, R.2
  • 32
    • 0036498731 scopus 로고    scopus 로고
    • Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
    • Fertrin, K.Y., Gonçalves, M.A., Saad, S.T. and Costa, F.F. (2002), ‘Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil’, Am. J. Med. Genet. Vol. 118, pp. 117–119.
    • (2002) Am. J. Med. Genet , vol.118 , pp. 117-119
    • Fertrin, K.Y.1    Gonçalves, M.A.2    Saad, S.T.3    Costa, F.F.4
  • 33
    • 0038351780 scopus 로고    scopus 로고
    • The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): Hematologic and evolutionary implications
    • Premawardhena, A., Fisher, C.A., Liu, Y.T., Verma, I.C. et al. (2003), ‘The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): Hematologic and evolutionary implications’, Blood Cells Mol. Dis. Vol. 31, pp. 98–101.
    • (2003) Blood Cells Mol. Dis , vol.31 , pp. 98-101
    • Premawardhena, A.1    Fisher, C.A.2    Liu, Y.T.3    Verma, I.C.4
  • 34
    • 34547788826 scopus 로고    scopus 로고
    • Pole of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C.A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients
    • Jada, S.R., Lim, R., Wong, C.I., Shu, X. et al. (2007), ‘Pole of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C.A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients’, Cancer Sci. Vol. 98, pp. 1461–1467.
    • (2007) Cancer Sci , vol.98 , pp. 1461-1467
    • Jada, S.R.1    Lim, R.2    Wong, C.I.3    Shu, X.4
  • 35
    • 34748857912 scopus 로고    scopus 로고
    • Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations
    • Zhang, A., Xing, Q., Qin, S., Du, J. et al. (2007), ‘Intra-ethnic differences in genetic variants of the UGT-glucuronosyltransferase 1A1 gene in Chinese populations’, Pharmacogenomics J. Vol. 7, pp. 333–338.
    • (2007) Pharmacogenomics J , vol.7 , pp. 333-338
    • Zhang, A.1    Xing, Q.2    Qin, S.3    Du, J.4
  • 36
    • 33645897347 scopus 로고    scopus 로고
    • Relationship between hyperbilirubinaemia and UDP-glucuronosyltransfer-ase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir
    • Boyd, M.A., Srasuebkul, P., Ruxrungtham, K., Mackenzie, P.I. et al. (2006), ‘Relationship between hyperbilirubinaemia and UDP-glucuronosyltransfer-ase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir’, Pharmacogenet. Genomics Vol. 16, pp. 321–329.
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 321-329
    • Boyd, M.A.1    Srasuebkul, P.2    Ruxrungtham, K.3    Mackenzie, P.I.4
  • 37
    • 4544326498 scopus 로고    scopus 로고
    • Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert’s syndrome as well as in healthy Japanese subjects
    • Takeuchi, K., Kobayashi, Y., Tamaki, S. et al. (2004), ‘Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert’s syndrome as well as in healthy Japanese subjects’, J. Gastroenterol. Hepatol. Vol. 19, pp. 1023–1028.
    • (2004) J. Gastroenterol. Hepatol , vol.19 , pp. 1023-1028
    • Takeuchi, K.1    Kobayashi, Y.2    Tamaki, S.3
  • 38
    • 56749161670 scopus 로고    scopus 로고
    • Emerging ethnic differences in lung cancer therapy
    • Sekine, I., Yamamoto, N., Nishio, K. and Saijo, N. (2008), ‘Emerging ethnic differences in lung cancer therapy’, Br.J.CancerVol. 99, pp. 1757–1762.
    • (2008) Br.J.Cancervol. , vol.99 , pp. 1757-1762
    • Sekine, I.1    Yamamoto, N.2    Nishio, K.3    Saijo, N.4
  • 39
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced poly-morphism for regulation of bilirubin metabolism?
    • Beutler, E., Gelbart, T. and Demina, A. (1998), ‘Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced poly-morphism for regulation of bilirubin metabolism?’, Proc. Natl. Acad. Sci. USAVol. 95, pp. 8170–8174.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 40
    • 59549101479 scopus 로고    scopus 로고
    • Biological risks for neurological abnormalities associated with hyperbilir-ubinemia
    • Suppl. 1)
    • Brites, D., Fernandes, A., Falcão, A.S., Gordo, A.C. et al. (2009), ‘Biological risks for neurological abnormalities associated with hyperbilir-ubinemia’, J. Perinatol. Vol. 29 (Suppl. 1), pp. S8–13.
    • (2009) J. Perinatol , vol.29 , pp. S8-S13
    • Brites, D.1    Fernandes, A.2    Falcão, A.S.3    Gordo, A.C.4
  • 41
    • 34447551611 scopus 로고    scopus 로고
    • Cigarette smoking and irinotecan treatment: Pharmacokinetic interaction and effects on neutropenia
    • van der Bol, J.M., Mathijssen, R.H., Loos, W.J., Friberg, L.E. et al. (2007), ‘Cigarette smoking and irinotecan treatment: Pharmacokinetic interaction and effects on neutropenia’, J. Clin. Oncol. Vol. 25, pp. 2719–2726.
    • (2007) J. Clin. Oncol , vol.25 , pp. 2719-2726
    • van der Bol, J.M.1    Mathijssen, R.H.2    Loos, W.J.3    Friberg, L.E.4
  • 42
    • 18344383946 scopus 로고    scopus 로고
    • Cruciferae interact with the UGT1A1*28 polymorphism to determine serum biliru-bin levels in humans
    • Peterson, S., Bigler, J., Horner, N.K., Potter, J.D. et al. (2005), ‘Cruciferae interact with the UGT1A1*28 polymorphism to determine serum biliru-bin levels in humans’, J. Nutr. Vol. 135, pp. 1051–1055.
    • (2005) J. Nutr , vol.135 , pp. 1051-1055
    • Peterson, S.1    Bigler, J.2    Horner, N.K.3    Potter, J.D.4
  • 43
    • 74549132748 scopus 로고    scopus 로고
    • Interindividual variability in hepatic drug glucuro-nidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system
    • Court, M.H. (2010), ‘Interindividual variability in hepatic drug glucuro-nidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system’, Drug Metab. Rev. Vol. 42, pp. 202–217.
    • (2010) Drug Metab. Rev , vol.42 , pp. 202-217
    • Court, M.H.1
  • 44
    • 62749139545 scopus 로고    scopus 로고
    • Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism
    • Saracino, M.R., Bigler, J., Schwarz, Y., Chang, J.L. et al. (2009), ‘Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism’, J. Nutr. Vol. 139, pp. 555–560.
    • (2009) J. Nutr , vol.139 , pp. 555-560
    • Saracino, M.R.1    Bigler, J.2    Schwarz, Y.3    Chang, J.L.4
  • 45
    • 34247094146 scopus 로고    scopus 로고
    • UGT1A1 poly-morphism is associated with serum bilirubin concentrations in a random-ized, controlled, fruit and vegetable feeding trial
    • Chang, J.L., Bigler, J., Schwarz, Y., Li, S.S. et al. (2007), ‘UGT1A1 poly-morphism is associated with serum bilirubin concentrations in a random-ized, controlled, fruit and vegetable feeding trial’, J. Nutr. Vol. 137, pp. 890–897.
    • (2007) J. Nutr , vol.137 , pp. 890-897
    • Chang, J.L.1    Bigler, J.2    Schwarz, Y.3    Li, S.S.4
  • 46
    • 33846395708 scopus 로고    scopus 로고
    • Green tea may inhibit warfarin
    • Cheng, T.O. (2007), ‘Green tea may inhibit warfarin’, Int. J. Cardiol. Vol. 115, p. 236.
    • (2007) Int. J. Cardiol , vol.115 , pp. 236
    • Cheng, T.O.1
  • 47
    • 39749144515 scopus 로고    scopus 로고
    • Not only green tea but also green leafy vegetables inhibit warfarin
    • Cheng, T.O. (2008), ‘Not only green tea but also green leafy vegetables inhibit warfarin’, Int. J. Cardiol. Vol. 125, p. 101.
    • (2008) Int. J. Cardiol , vol.125 , pp. 101
    • Cheng, T.O.1
  • 48
    • 67650635229 scopus 로고    scopus 로고
    • Addressing the challenges of the clinical application of pharmacogenetic testing
    • Ikediobi, O.N., Shin, J., Nussbaum, R.L., Phillips, K.A. et al. (2009), ‘Addressing the challenges of the clinical application of pharmacogenetic testing’, Clin. Pharmacol. Ther. Vol. 86, pp. 28–31.
    • (2009) Clin. Pharmacol. Ther , vol.86 , pp. 28-31
    • Ikediobi, O.N.1    Shin, J.2    Nussbaum, R.L.3    Phillips, K.A.4
  • 49
    • 69249104215 scopus 로고    scopus 로고
    • Cost-effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for meta-static colorectal cancer
    • Gold, H.T., Hall, M.J., Blinder, V. and Schackman, B.R. (2009), ‘Cost-effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for meta-static colorectal cancer’, Cancer Vol. 115, pp. 3858–3867.
    • (2009) Cancer , vol.115 , pp. 3858-3867
    • Gold, H.T.1    Hall, M.J.2    Blinder, V.3    Schackman, B.R.4
  • 50
    • 44949103148 scopus 로고    scopus 로고
    • Cost-effectiveness of UGT1A1 genotyping in second line, high-dose, once every 3 weeks irinotecan mono-therapy treatment of colorectal cancer
    • Obradovic, M., Mrhar, A. and Kos, M. (2008), ‘Cost-effectiveness of UGT1A1 genotyping in second line, high-dose, once every 3 weeks irinotecan mono-therapy treatment of colorectal cancer. Pharmacogenomics Vol. 9, pp. 539–549.
    • (2008) Pharmacogenomics , vol.9 , pp. 539-549
    • Obradovic, M.1    Mrhar, A.2    Kos, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.