Adverse drug reaction-related hospitalizations in persons aged 55 years and over: A population-based study in the Netherlands

Drugs and Aging

Volumn 29, Issue 3, 2012, Pages 225-232

  Ruiter, Rikje ^a,b   Visser, Loes E ^a   Rodenburg, Eline M ^a,b   Trifir, Gianluca ^a,c   Ziere, Gijsbertus ^a   Stricker, Bruno H ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Drug Safety Unit   (Netherlands)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Adverse drug reactions; Elderly; Hospitalisation.

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; CHOLINE SALICYLATE; CLONIDINE; CODEINE; CORTICOSTEROID; CORTISONE DERIVATIVE; DEOXYCORTICOSTERONE; DIGITALIS GLYCOSIDE; DIGOXIN; DIURETIC AGENT; GLYCOSIDE; GUANETHIDINE; IMMUNOSUPPRESSIVE AGENT; INSULIN DERIVATIVE; LOOP DIURETIC AGENT; MORPHINE; NARCOTIC AGENT; OPIATE; PETHIDINE; RAUWOLFIA ALKALOID; SALICYLIC ACID DERIVATIVE; STROPHANTHIN;

ADULT; ADVERSE DRUG REACTION; AGED; ANGIONEUROTIC EDEMA; ARTICLE; COMA; CONSTIPATION; CONTACT DERMATITIS; DIABETES MELLITUS; ECZEMA; ELDERLY CARE; ENCEPHALITIS; ENCEPHALOMYELITIS; FEMALE; FEVER; GASTROINTESTINAL HEMORRHAGE; GROUPS BY AGE AND SEX; HEART ARRHYTHMIA; HEPATITIS; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HYPOGLYCEMIA; HYPONATREMIA; HYPOTHYROIDISM; INTESTINE OBSTRUCTION; MAJOR CLINICAL STUDY; MALE; MYELITIS; MYOCARDITIS; NETHERLANDS; NEUTROPENIA; PANCREAS DISEASE; POLYNEUROPATHY; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SPINAL CORD DISEASE; STATISTICAL ANALYSIS; STOMACH ULCER; UNSPECIFIED SIDE EFFECT;

AGED; AGING; ANTICOAGULANTS; ANTIRHEUMATIC AGENTS; DATABASES, FACTUAL; DRUG PRESCRIPTIONS; DRUG TOXICITY; FEMALE; HOSPITALIZATION; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; NETHERLANDS; PRESCRIPTION DRUGS; RISK FACTORS; SEX CHARACTERISTICS;

EID: 84857853686     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11599430-000000000-00000     Document Type: Article

References (24)

1. EC. Volume 9A of the rules governing medicinal products in the European Union. 2008 Sep [online]. Available from URL: Http://ec.europa.eu/health/files/ eudralex/vol-9/pdf/vol9a-09-2008-en.pdf [Accessed 2011 Apr 1]
2. Beijer HJ, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): A meta-analysis of observational studies. Pharm World Sci 2002 Apr; 24 (2): 46-54
3. Burgess CL, Holman CD, Satti AG. Adverse drug reactions in older Australians, 1981-2002. Med J Aust 2005 Mar 21; 182 (6): 267-70
4. Onder G, Pedone C, Landi F, et al. Adverse drug reactions as cause of hospital admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc 2002 Dec; 50 (12): 1962-8
5. van der Hooft CS, Sturkenboom MC, van Grootheest K, et al. Adverse drug reaction-related hospitalisations: A nationwide study in the Netherlands. Drug Saf 2006; 29 (2): 161-8
6. Carbonin P, Pahor M, Bernabei R, et al. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients? J Am Geriatr Soc 1991 Nov; 39 (11): 1093-9
7. Trifiro G, Spina E. Age-related changes in pharmacodynamics: Focus on drugs acting on central nervous and cardiovascular systems. Curr Drug Metab 2011 Sep; 12 (7): 611-20
8. Stricker BH, Psaty BM. Detection, verification, and quantification of adverse drug reactions. BMJ 2004 Jul 3; 329 (7456): 44-7
9. NationMaster. Life expectancy at birth by country. 2008 [online]. Available from URL: Http://www.nationmaster. com/graph/hea-lif-exp-at-bir-fem- health-life-expectancybirth- female [Accessed 2011 Apr 1]
10. van Duin C, Garssen J. Bevolkingsprognose 2010-2060: Sterkere vergrijzing, langere levensduur; bevolkingstrends 1e kwartaal 2011. Centraal Bureau voor de Statistiek, 2011
11. [online]. Available from URL: Http://www.cbs.nl/NR/rdonlyres/389D62E2- 7205-42C3-956F-33E17CFE6433/0/2011k1b15p16art.pdf [Accessed 2011 Apr 1]
12. Hartholt KA, van der Velde N, Looman CW, et al. Adverse drug reactions related hospital admissions in persons aged 60 years and over, the Netherlands, 1981-2007: Less rapid increase, different drugs. PLoS One 2010; 5 (11): E13977
13. Dutch hospital data, DBC Information System 2000-2005 [online]. Available from URL: Http://www.swov.nl/nl/re search/kennisbank/inhoud/90-gegevensbronnen/ inhoud/lmr. htm [Accessed 2010 Jan 1]
14. WHO international statistical classification of diseases and related health problems. 9th revision. Oslo: WHO, 1992 [online]. Available from URL: Http://icd9cm.chrisendres.com/[Accessed 2010 Jan 1]
15. Statistics Netherlands (CBS) - StatLine. Inhabitants: Sex and age 2000-2005 [online]. Available from URL: Http://statline.cbs.nl/StatWeb/ publication/?VW=T&DM=SLNL& PA=7461BEV&D1=0&D2=1-2&D3=112- 120&D4=50-55& HD=111021-1420&HDR=T,G3&STB=G1,G2 [Accessed 2010 Nov 1]
16. SFK - Foundation of Pharmaceutical Statistics [online]. Available from URL: Http://www.sfk.nl/[Accessed 2010 Nov 1]
17. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies. JAMA 1998 Apr 15; 279 (15): 1200-5
18. Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: Prospective analysis of 18 820 patients. BMJ 2004 Jul 3; 329 (7456): 15-9
19. van der Hooft CS, Dieleman JP, Siemes C, et al. Adverse drug reaction-related hospitalisations: A population-based cohort study. Pharmacoepidemiol Drug Saf 2008 Apr; 17 (4): 365-71
20. Routledge PA, O Mahony MS, Woodhouse KW. Adverse drug reactions in elderly patients. Br J Clin Pharmacol 2004 Feb; 57 (2): 121-6
21. Zopf Y, Rabe C, Neubert A, et al. Women encounter ADRs more often than do men. Eur J Clin Pharmacol 2008 Oct; 64 (10): 999-1004
22. Howard RL, Avery AJ, Slavenburg S, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol 2007 Feb; 63 (2): 136-47
23. Schneeweiss S, Hasford J, Gottler M, et al. Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: A longitudinal population- based study. Eur J Clin Pharmacol 2002 Jul; 58 (4): 285-91
24. Wiffen P, Gill M, Edwards J, Moore A. Adverse drug reactions in hospital patients. Bandolier Extra 2002 Jun [online]. Available from URL: Http://www.medicine.ox.ac.uk/bandolier/Extraforbando/ADRPM.pdf [Accessed 2011 Apr 1]