Adverse drug reactions (ADRs) associated with hospital admissions - Elderly female patients are at highest risk

International Journal of Clinical Pharmacology and Therapeutics

Volumn 49, Issue 10, 2011, Pages 577-586

  Hofer Dueckelmann, C ^a   Prinz, E ^b   Beindl, W ^a   Szymanski, J ^c   Fellhofer, G ^a   Pichler, M ^b   Schuler, J ^b  

^a Pharmacy Department   (Austria)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Adverse drug reactions; Drug related hospitalization; Gender; Patient safety; Risk factors

Indexed keywords

ACETYLSALICYLIC ACID; AMILORIDE PLUS HYDROCHLOROTHIAZIDE; AMIODARONE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; ANTIVITAMIN K; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIAC GLYCOSIDE; DEXIBUPROFEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; FUROSEMIDE; HYDROCHLOROTHIAZIDE; METFORMIN; MOXIFLOXACIN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; SEROTONIN UPTAKE INHIBITOR; SPIRONOLACTONE; THEOPHYLLINE; THIAMAZOLE;

ACUTE KIDNEY FAILURE; ADULT; ADVERSE DRUG REACTION; AGE; AGED; ANTICOAGULATION; APLASIA; ARTICLE; ASYSTOLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG OVERDOSE; DRUG SURVEILLANCE PROGRAM; ELECTROLYTE DISTURBANCE; FEMALE; GERIATRIC PATIENT; HIGH RISK PATIENT; HOSPITAL ADMISSION; HUMAN; HYPERKALEMIA; INCIDENCE; KIDNEY DISEASE; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LABORATORY TEST; LACTIC ACIDOSIS; LUNG EDEMA; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MENTAL DISEASE; NEPHROTOXICITY; OBSERVATIONAL STUDY; PNEUMONIA; RISK FACTOR; SEX DIFFERENCE; SIDE EFFECT; SUPRAVENTRICULAR TACHYCARDIA; UROSEPSIS;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AGE FACTORS; AGED; AGED, 80 AND OVER; DRUG INTERACTIONS; DRUG TOXICITY; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PATIENT SAFETY; RISK; SEX CHARACTERISTICS;

EID: 80053610820     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CP201514     Document Type: Article

References (27)

1. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004; 329: 15-19. doi:10.1136/bmj.329.7456.15 PubMed (Pubitemid 38869995)
2. Otero López MJ, Alonso Hernández P, Maderuelo Fernández JA, Ceruelo Bermejo J, Domínguez-Gil Hurlé A, Sánchez Rodríguez A. Prevalence and factors associated with preventable adverse drug events leading to hospital admission. Farm Hosp. 2006; 30: 161-170. PubMed (Pubitemid 44272058)
3. Leendertse AJ, Egberts ACG, Stoker LJ, Van den Bemt PMLA; HARM Study Group. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008; 168: 1890-1896. doi: 10.1001/archinternmed.2008.3 PubMed
4. Howard RL, Avery AJ, Howard PD, Partridge M. Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study. Qual Saf Health Care. 2003; 12: 280-285. doi: 10.1136/qhc.12.4.280 PubMed (Pubitemid 36981325)
5. Winterstein AG, Sauer BC, Hepler CD, Poole C. Preventable drug-related hospital admissions. Ann Pharmacother. 2002; 36: 1238-1248. doi: 10.1345/aph.1A225 PubMed (Pubitemid 34755803)
6. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008; 42: 1017-1025. doi: 10.1345/aph.1L037 PubMed
7. Krähenbühl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krähenbühl S. Drug-related problems in hospitals: a review of the recent literature. Drug Saf. 2007; 30: 379-407. PubMed (Pubitemid 46740336)
8. Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther. 2007; 82: 87-96. doi: 10.1038/sj.clpt.6100226 PubMed (Pubitemid 46944201)
9. Schuler J, Dückelmann C, Beindl W, Prinz E, Michalski T, Pichler M. Polypharmacy and inappropriate prescribing in elderly internal-medicine patients in Austria. Wien Klin Wochenschr. 2008; 120: 733-741. doi: 10.1007/s00508-008- 1089-z PubMed
10. Rodríguez-Monguió R, Otero MJ, Rovira J. Assessing the economic impact of adverse drug effects. Pharmacoeconomics. 2003; 21: 623-650. PubMed doi:10.2165/00019053-200321090-00002
11. Schneeweiss S, Hasford J, Göttler M, Hoffmann A, Riethling AK, Avorn J. Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study. Eur J Clin Pharmacol. 2002; 58: 285-291. doi: 10.1007/s00228-002-0467-0 PubMed (Pubitemid 34827858)
12. Davies EC, Green SF, Taylor S, Williamson PR, Mottram DR, Pirmohamed M. Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes. PLOS ONE 2009; 4: e 4439.
13. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000; 356: 1255-1259. doi:10.1016/S0140-6736(00)02799-9 PubMed
14. Schmiedl S, Mertens A, Richter S, Szymanski J, Krahwinkel W, Schroth U, Linke J, Thürmann P, Ludwig WD. Detection of clinically relevant adverse drug reactions (ADRs) in Departments of Internal Medicine. Eur J Clin Pharmacol 2005; 61: 719 (abstr. 113).
15. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30: 239-245. doi:10.1038/clyt.1981. 154 PubMed (Pubitemid 12149145)
16. Digitales Medikamenten-Informations-System Medis® professional, PR-data Datenverarbeitungsund Unternehmensberatungs GmbH, A-1190 Wien Huschkagasse 10/9.
17. http://www.dimdi.de/static/de/amg/abda/index.htm
18. Rawlins MD, Thompson JW. Mechanisms of adverse drug reactions. In: Davies DM, ed. Textbook of adverse drug reactions. Oxford: Oxford University Press, 1991.p. 18-45.
19. Creation of a better patient safety. Building up safe medication practices. Report. Expert group on Safe Medication Practices (2006).
20. Franceschi M, Scarcelli C, Niro V, Seripa D, Pazienza AM, Pepe G, Colussa AM, Pacilli L, Pilotto A. Prevalence, clinical features and avoidability of adverse drug reactions as cause of admission to a geriatric unit: a prospective study of 1756 patients. Drug Saf. 2008; 31: 545-556. doi: 10.2165/00002018- 200831060-00009 PubMed (Pubitemid 351693687)
21. Thomsen LA, Winterstein AG, Søndergaard B, Haugbølle LS, Melander A. Systematic review of the incidence and charactetistics of preventable adverse drug events in ambulatory care. Ann Pharmacother. 2007; 41: 1411-1426. doi: 10.1345/aph.1H658 PubMed (Pubitemid 47311361)
22. Martin RM, Biswas PN, Freemantle SN, Pearce GL, Mann RD. Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies. Br J Clin Pharmacol. 1998; 46: 505-511. doi:10.1046/j.1365-2125.1998.00817.x PubMed (Pubitemid 28484739)
23. Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF. Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Toxicol. 2004; 44: 499-523. doi: 10.1146/annurev.pharmtox.44.101802.121453 (Pubitemid 38263851)
24. Zopf Y, Rabe C, Neubert A, Gassmann KG, Rascher W, Hahn EG, Brune K, Dormann H. Women encounter ADRs more often than do men. Eur J Clin Pharmacol. 2008; 64: 999-1004. doi:10.1007/s00228-008-0494-6 PubMed
25. Kucukarslan SN, Peters M, Mlynarek M, Nafziger DA. Pharmacists on rounding teams reduce preventable adverse drug events in hospital general medicine units. Arch Intern Med. 2003; 163: 2014-2018. doi:10.1001/archinte.163. 17.2014 PubMed (Pubitemid 37151242)
26. Gillespie U, Alassaad A, Henrohn D, Garmo H, Hammarlund-Udenaes M, Toss H, Kettis-Lindblad A, Melhus H, Mörlin C. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009; 169: 894-900. doi: 10.1001/ archinternmed.2009.71 PubMed
27. Kagansky N, Knobler H, Rimon B, Ozer Z, Levy S. Safety of anticoagulation therapy in well-informed older patients. Arch Intern Med. 2004; 164: 2044-2050. doi:10.1001/archinte.164.18.2044 PubMed (Pubitemid 39390563)