Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes

FEBS Letters

Volumn 580, Issue 7, 2006, Pages 1771-1774

  Shinkai, Yasuhiro ^a   Sumi, Daigo ^a   Fukami, Ikuo ^a   Ishii, Tetsuro ^a   Kumagai, Yoshito ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Arsenic; Chemoprevention; Glutathione; Nrf2; Sulforaphane

Indexed keywords

ARSENIC; GLUTATHIONE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; EXTRACELLULAR SPACE; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ARSENIC; ARSENIC POISONING; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEPATOCYTES; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; THIOCYANATES; XENOBIOTICS;

ANIMALIA;

EID: 33644882749     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.02.031     Document Type: Article

References (25)

1. M. Styblo, Z. Drobna, I. Jaspers, S. Lin, and D.J. Thomas The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update Environ. Health Perspect. 110 Suppl. 5 2002 767 771
2. T.W. Gebel Arsenic methylation is a process of detoxification through accelerated excretion Int. J. Hyg. Environ. Health 205 2002 505 508
3. N. Scott, K.M. Hatlelid, N.E. MacKenzie, and D.E. Carter Reactions of arsenic(III) and arsenic(V) species with glutathione Chem. Res. Toxicol. 6 1993 102 106
4. E.M. Leslie, A. Haimeur, and M.P. Waalkes Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required J. Biol. Chem. 279 2004 32700 32708
5. B.P. Rosen Biochemistry of arsenic detoxification FEBS Lett. 529 2002 86 92
6. T. Hayakawa, Y. Kobayashi, X. Cui, and S. Hirano A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19 Arch. Toxicol. 79 2005 183 191
7. K. Itoh, K.I. Tong, and M. Yamamoto Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles Free Radic. Biol. Med. 36 2004 1208 1213
8. M.K. Kwak, N. Wakabayashi, and T.W. Kensler Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers Mutat. Res. 555 2004 133 148
9. J.W. Fahey, X. Haristoy, P.M. Dolan, T.W. Kensler, I. Scholtus, K.K. Stephenson, P. Talalay, and A. Lozniewski Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors Proc. Natl. Acad. Sci. USA 99 2002 7610 7615
10. K. Iida, K. Itoh, Y. Kumagai, R. Oyasu, K. Hattori, K. Kawai, T. Shimazui, H. Akaza, and M. Yamamoto Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis Cancer Res. 64 2004 6424 6431
11. X. Gao, A.T. Dinkova-Kostova, and P. Talalay Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane Proc. Natl. Acad. Sci. USA 98 2001 15221 15226
12. J.F. Liang, and T. Akaike Role of metabolic intermediates in lipopolysaccharide/cytokine-mediated production of nitric oxide in isolated mouse hepatocytes Biochem. Biophys. Res. Commun. 236 1997 379 382
13. F. Denizot, and R. Lang Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability J. Immunol. Meth. 89 1986 271 277
14. R. Sugimoto, Y. Kumagai, Y. Nakai, and T. Ishii 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu, Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis Free Radic. Biol. Med. 38 2005 388 395
15. U.A. Germann, M.M. Gottesman, and I. Pastan Expression of a multidrug resistance-adenosine deaminase fusion gene J. Biol. Chem. 264 1989 7418 7424
16. C. Vignaud, L. Rakotozafy, A. Falguieres, J. Potus, and J. Nicolas Separation and identification by gel filtration and high-performance liquid chromatography with UV or electrochemical detection of the disulphides produced from cysteine and glutathione oxidation J. Chromatogr. A 1031 2004 125 133
17. S. Hirano, X. Cui, S. Li, S. Kanno, Y. Kobayashi, T. Hayakawa, and A. Shraim Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells Arch. Toxicol. 77 2003 305 312
18. J. Liu, H. Chen, D.S. Miller, J.E. Saavedra, L.K. Keefer, D.R. Johnson, C.D. Klaassen, and M.P. Waalkes Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic Mol. Pharmacol. 60 2001 302 309
19. K.S. Vellonen, P. Honkakoski, and A. Urtti Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity Eur. J. Pharm. Sci. 23 2004 181 188
20. S. Lin, Q. Shi, F.B. Nix, M. Styblo, M.A. Beck, K.M. Herbin-Davis, L.L. Hall, J.B. Simeonsson, and D.J. Thomas A novel S-adenosyl-l-methionine: arsenic(III) methyltransferase from rat liver cytosol J. Biol. Chem. 277 2002 10795 10803
21. A. Hayashi, H. Suzuki, K. Itoh, M. Yamamoto, and Y. Sugiyama Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts Biochem. Biophys. Res. Commun. 310 2003 824 829
22. E.M. Leslie, R.G. Deeley, and S.P. Cole Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters Toxicology 167 2001 3 23
23. D.W. Loe, R.K. Stewart, T.E. Massey, R.G. Deeley, and S.P. Cole ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene Mol. Pharmacol. 51 1997 1034 1041
24. J. Aono, T. Yanagawa, K. Itoh, B. Li, H. Yoshida, Y. Kumagai, M. Yamamoto, and T. Ishii Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts Biochem. Biophys. Res. Commun. 305 2003 271 277
25. J. Pi, W. Qu, J.M. Reece, Y. Kumagai, and M.P. Waalkes Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide Exp. Cell Res. 290 2003 234 245