Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics

Risk Analysis

Volumn 19, Issue 4, 1999, Pages 547-558

  Clewell, Harvey J ^a   Gearhart, Jeffery M ^b   Gentry, P Robinan ^a   Covington, Tammie R ^a   VanLandingham, Cynthia B ^a   Crump, Kenny S ^a   Shipp, Annette M ^a  

^a ICF INTERNATIONAL   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

MeHg; PBPK model; Pharmacokinetics; Risk assessment; Variability

Indexed keywords

COMPUTER SIMULATION; EPIDEMIOLOGY; MERCURY COMPOUNDS; MONTE CARLO METHODS; PHARMACOKINETICS; RANDOM PROCESSES; RISK ASSESSMENT; STANDARDS; STATISTICAL METHODS;

INTERINDIVIDUAL VARIABILITY; METHYLMERCURY; ORAL REFERENCE DOSE; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL;

DRUG DOSAGE;

METHYLMERCURY;

HEALTH RISK; MEDICAL GEOGRAPHY; METHYLMERCURY; UNCERTAINTY ROLE;

ARTICLE; FISH; FOOD CONTAMINATION; FOOD INTAKE; HUMAN; MERCURIALISM; REFERENCE VALUE; RISK ASSESSMENT; SYSTEM ANALYSIS; TOXICOKINETICS;

ADULT; FEMALE; HAIR; HUMANS; MALE; METHYLMERCURY COMPOUNDS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RISK ASSESSMENT;

EID: 0033177872     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007017116171     Document Type: Article

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