Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

Biotechnology and Bioengineering

Volumn 104, Issue 1, 2009, Pages 193-205

  Mahler, Gretchen J ^a   Esch, Mandy B ^a   Glahn, Raymond P ^b   Shuler, Michael L ^a  

^a Cornell University   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Acetaminophen; Cell culture analog; Drug testing; GI tract; In vitro; Toxicity

Indexed keywords

ACCURATE PREDICTION; ACETAMINOPHEN; CELL POPULATIONS; DOSE-DEPENDENT MANNER; DRUG TESTING; ESSENTIAL NUTRIENTS; EXTERNAL ENVIRONMENTS; GASTROINTESTINAL TRACT; GI TRACT; HUMAN BODIES; IN VITRO; IN-VIVO MEASUREMENT; INTESTINAL ABSORPTION; INTESTINAL EPITHELIUM; LIVER CELLS; MICRO-SCALES; MUCUS LAYER; MULTI-CHAMBER; PROOF OF CONCEPT; SMALL INTESTINE; SYSTEMIC CIRCULATION; TOXICOLOGICAL EVALUATION;

ABSORPTION; ANIMAL CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; CHEMICAL COMPOUNDS; CHEMICALS; DRUG INTERACTIONS; DRUG PRODUCTS; LIVER; PHYSIOLOGICAL MODELS; PUMPS; TOXICITY;

CELL CULTURE;

PARACETAMOL; SILICON;

ARTICLE; BIOLOGICAL MODEL; CELL POPULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGESTION; DRUG METABOLISM; GASTROINTESTINAL TOXICITY; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTESTINE EPITHELIUM; LIVER METABOLISM; LIVER TOXICITY; MUCUS; NANOTECHNOLOGY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; GASTROINTESTINAL TRACT; HUMANS; MICE;

MUS;

EID: 69249095795     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22366     Document Type: Article

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