Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure

Journal of Biotechnology

Volumn 148, Issue 1, 2010, Pages 70-75

  Sonntag, Frank ^a   Schilling, Niels ^a   Mader, Katja ^a   Gruchow, Mathias ^a   Klotzbach, Udo ^a   Lindner, Gerd ^b   Horland, Reyk ^b   Wagner, Ilka ^b   Lauster, Roland ^b   Howitz, Steffen ^c   Hoffmann, Silke ^d   Marx, Uwe ^e  

^a FRAUNHOFER INSTITUTE FOR MATERIAL AND BEAM TECHNOLOGY IWS   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c GeSiM mbH   (Germany)

^d PROBIOGEN AG   (Germany)

^e TISSUSE GMBH   (Germany)

Author keywords

Micro fluidics; Micro organoid; Micro system technologies; Multi micro organ bioreactor; Organ on a chip

Indexed keywords

BIOREACTOR SYSTEM; BONE MARROW; BRAIN CORTEX; CHIP PROTOTYPES; CULTURE SYSTEMS; DESIGN APPROACHES; FEED SUPPLY; HUMAN CELLS; HUMAN EXPOSURES; HUMAN LIVER; LONG-TERM CULTURE; MANUFACTURING PROCEDURE; MATRIX; MICRO BIOREACTOR; MICRO-ORGANOID; MICRO-SYSTEM TECHNOLOGIES; MICROENVIRONMENTS; MICROSCOPE SLIDE; ORGANOIDS; POSSIBLE SOLUTIONS; PRIMARY CELL CULTURES; PROTOTYPING; PROTOTYPING CYCLES; PROTOTYPING TOOLS; TIME PERIODS;

BIOCONVERSION; BIOREACTORS; BONE; CELL CULTURE; CONCURRENT ENGINEERING; FLUIDICS; JOB ANALYSIS; LIVER; RAPID PROTOTYPING;

ANIMAL CELL CULTURE;

ARTICLE; BIOREACTOR; BIOTECHNOLOGY; BONE MARROW; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; DEVICE; LIVER; MICRO ORGANOID CULURE SYSTEM; MICROENVIRONMENT; OXYGEN SUPPLY; PRIORITY JOURNAL; PROCESS DESIGN; APOPTOSIS; BONE MARROW CELL; CELL PROLIFERATION; CYTOLOGY; CYTOPLASM; DEVICES; FLUORESCENCE MICROSCOPY; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROFLUIDIC ANALYSIS; PROCEDURES; TISSUE CULTURE TECHNIQUE;

APOPTOSIS; BIOREACTORS; BONE MARROW CELLS; CELL PROLIFERATION; CEREBRAL CORTEX; HUMANS; LIVER; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, FLUORESCENCE; ORGANOIDS; OXYGEN; TISSUE CULTURE TECHNIQUES;

OXYGEN;

EID: 77953915335     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.02.001     Document Type: Article

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