-
1
-
-
72449191263
-
In silico prediction of human oral absorption based on QSAR analyses of PAMPA permeability
-
Akamatsu M, Fujikawa M, Nakao K, Shimizu R. 2009. In silico prediction of human oral absorption based on QSAR analyses of PAMPA permeability. Chem. Biodivers. 6:1845-66.
-
(2009)
Chem. Biodivers
, vol.6
, pp. 1845-66
-
-
Akamatsu, M.1
Fujikawa, M.2
Nakao, K.3
Shimizu, R.4
-
2
-
-
34249079154
-
Network motifs: Theory and experimental approaches
-
DOI 10.1038/nrg2102, PII NRG2102
-
Alon U. 2007. Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8:450-61. (Pubitemid 46789247)
-
(2007)
Nature Reviews Genetics
, vol.8
, Issue.6
, pp. 450-461
-
-
Alon, U.1
-
3
-
-
77954001438
-
The future of toxicity testing
-
Andersen ME, Al-Zhoughool M, Croteau M, Westphal M, Krewski D. 2010. The future of toxicity testing. J. Toxicol. Environ. Health. 13:163-96.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 163-96
-
-
Andersen, M.E.1
Al-Zhoughool, M.2
Croteau, M.3
Westphal, M.4
Krewski, D.5
-
4
-
-
59149106151
-
Toxicity testing in the 21st century: Bringing the vision to life
-
Andersen ME, Krewski D. 2009. Toxicity testing in the 21st century: bringing the vision to life. Toxicol. Sci. 107:324-30.
-
(2009)
Toxicol. Sci
, vol.107
, pp. 324-30
-
-
Andersen, M.E.1
Krewski, D.2
-
5
-
-
77955906570
-
The vision of toxicity testing in the 21st century: Moving from discussion to action
-
Andersen ME, Krewski D. 2010. The vision of Toxicity Testing in the 21st Century: moving from discussion to action. Toxicol. Sci. 117:17-24.
-
(2010)
Toxicol. Sci.
, vol.117
, pp. 17-24
-
-
Andersen, M.E.1
Krewski, D.2
-
6
-
-
15944383395
-
Dose-response modeling in reproductive toxicology in the systems biology era
-
DOI 10.1016/j.reprotox.2004.12.004
-
Andersen ME, Thomas RS, Gaido KW, Conolly RB. 2005. Dose-response modeling in reproductive toxicology in the systems biology era. Reprod. Toxicol. 19:327-37. (Pubitemid 40431228)
-
(2005)
Reproductive Toxicology
, vol.19
, Issue.3 SPEC. ISS.
, pp. 327-337
-
-
Andersen, M.E.1
Thomas, R.S.2
Gaido, K.W.3
Conolly, R.B.4
-
8
-
-
67649199702
-
A quantitative structure-activity relationship for predicting metabolic biotransformation rates for organic chemicals in fish
-
Arnot JA, Meylan W, Tunkel J, Howard PH, Mackay D, et al. 2009. A quantitative structure-activity relationship for predicting metabolic biotransformation rates for organic chemicals in fish. Environ. Toxicol. Chem. 28:1168-77.
-
(2009)
Environ. Toxicol. Chem
, vol.28
, pp. 1168-77
-
-
Arnot, J.A.1
Meylan, W.2
Tunkel, J.3
Howard, P.H.4
MacKay, D.5
-
9
-
-
68549122739
-
Biomarkers in population studies: Environmental mutagenesis and risk for cancer
-
Au WW, Ruchirawat M. 2009. Biomarkers in population studies: environmental mutagenesis and risk for cancer. Rev. Environ. Health 24:117-27.
-
(2009)
Rev. Environ. Health
, vol.24
, pp. 117-27
-
-
Au, W.W.1
Ruchirawat, M.2
-
10
-
-
65649131952
-
Quantitative Structure-Activity Relationship (QSAR) modeling of human blood: Air partitioning with proper statistical methods and validation
-
Basak SC, Mills D, HawkinsDM, Kraker JJ. 2009. Quantitative Structure-Activity Relationship (QSAR) modeling of human blood: air partitioning with proper statistical methods and validation. Chem. Biodivers. 6:487-502.
-
(2009)
Chem. Biodivers
, vol.6
, pp. 487-502
-
-
Basak, S.C.1
Mills, D.2
Hawkins, D.M.3
Kraker, J.J.4
-
11
-
-
77954008507
-
Biokinetic modeling and in vitro-in vivo extrapolations
-
Blaauboer BJ. 2010. Biokinetic modeling and in vitro-in vivo extrapolations. J. Toxicol. Environ. Health. 13:242-52.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 242-52
-
-
Blaauboer, B.J.1
-
13
-
-
77951605817
-
Toxicity testing in the 21st century: Using the new toxicity testing paradigm to create a taxonomy of adverse effects
-
Boekelheide K, Campion SN. 2010. Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol. Sci. 114:20-24.
-
(2010)
Toxicol. Sci.
, vol.114
, pp. 20-24
-
-
Boekelheide, K.1
Campion, S.N.2
-
14
-
-
67649354569
-
Minimum Information about aMicroarray Experiment (MIAME)-successes, failures, challenges
-
Brazma A. 2009. Minimum Information About aMicroarray Experiment (MIAME)-successes, failures, challenges. Sci. World J. 9:420-23.
-
(2009)
Sci. World J
, vol.9
, pp. 420-23
-
-
Brazma, A.1
-
15
-
-
44249113841
-
Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth
-
DOI 10.1126/science.1152662
-
Bromberg KD,Ma'ayan A, Neves SR, Iyengar R. 2008. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 320:903-9. (Pubitemid 351929582)
-
(2008)
Science
, vol.320
, Issue.5878
, pp. 903-909
-
-
Bromberg, K.D.1
Ma'ayan, A.2
Neves, S.R.3
Iyengar, R.4
-
16
-
-
74949127956
-
Toxicity testing in the 21st century: A view from the chemical industry
-
Bus JS, Becker RA. 2009. Toxicity testing in the 21st century: a view from the chemical industry. Toxicol. Sci. 112:297-302.
-
(2009)
Toxicol. Sci
, vol.112
, pp. 297-302
-
-
Bus, J.S.1
Becker, R.A.2
-
17
-
-
73249122080
-
Evaluation of a suitable DNA damage biomarker for human biomonitoring of exposed workers
-
Cavallo D, Ursini CL, Rondinone B, Iavicoli S. 2009. Evaluation of a suitable DNA damage biomarker for human biomonitoring of exposed workers. Environ. Mol. Mutagen. 50:781-90.
-
(2009)
Environ. Mol. Mutagen
, vol.50
, pp. 781-90
-
-
Cavallo, D.1
Ursini, C.L.2
Rondinone, B.3
Iavicoli, S.4
-
18
-
-
71049118490
-
Endless possibilities: Stem cells and the vision for toxicology testing in the 21st century
-
Chapin RE, Stedman DB. 2009. Endless possibilities: stem cells and the vision for toxicology testing in the 21st century. Toxicol. Sci. 112:17-22.
-
(2009)
Toxicol Sci
, vol.112
, pp. 17-22
-
-
Chapin, R.E.1
Stedman, D.B.2
-
19
-
-
79952855345
-
-
CIRM workshop report
-
CIRM workshop report. 2008. Stem cells in predictive toxicology. http://www.cirm.ca.gov/pub/pdf/ CIRM-Predictive-Tox.pdf.
-
(2008)
Stem Cells in Predictive Toxicology
-
-
-
20
-
-
75549089630
-
The 2010 Nucleic Acids ResearchDatabase issue and online database collection: A community of data resources
-
Cochrane GR,Galperin MY. 2010. The 2010 Nucleic Acids ResearchDatabase issue and online database collection: a community of data resources. Nucleic Acids Res. 38:D1-4.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Cochrane, G.R.1
Galperin, M.Y.2
-
21
-
-
40749098598
-
Toxicity testing in the 21st century: Better results, less use of animals
-
Cohen KM, Crofton K, Hartung T, Krewski D, Locke P, Stephens ML. 2008. Toxicity testing in the 21st century: better results, less use of animals. Environ. Forum 25:46-51.
-
(2008)
Environ. Forum
, vol.25
, pp. 46-51
-
-
Cohen, K.M.1
Crofton, K.2
Hartung, T.3
Krewski, D.4
Locke, P.5
Stephens, M.L.6
-
22
-
-
39349118236
-
Transforming environmental health protection
-
DOI 10.1126/science.1154619
-
Collins FS, Gray GM, Bucher JR. 2008. Toxicology. Transforming environmental health protection. Science 319:906-7. (Pubitemid 351263750)
-
(2008)
Science
, vol.319
, Issue.5865
, pp. 906-907
-
-
Collins, F.S.1
Gray, G.M.2
Bucher, J.R.3
-
23
-
-
62749148250
-
Commentary on "toxicity testing in the 21st century: Implications for human health risk assessment" by krewski et al
-
Conolly RB. 2009. Commentary on "Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment" by Krewski et al. Risk Anal. 29:480-81.
-
(2009)
Risk Anal
, vol.29
, pp. 480-81
-
-
Conolly, R.B.1
-
24
-
-
67949118928
-
How not to develop a quantitative structure-activity or structure-property relationship (QSAR/QSPR)
-
Dearden JC, Cronin MTD, Kaiser KLE. 2009. How not to develop a quantitative structure-activity or structure-property relationship (QSAR/QSPR). SAR QSAR Environ. Res. 20:241-66.
-
(2009)
SAR QSAR Environ. Res
, vol.20
, pp. 241-66
-
-
Dearden, J.C.1
Cronin, M.T.D.2
Kaiser, K.L.E.3
-
25
-
-
77953977912
-
Meeting the common needs of a more effective and efficient testing and assessment paradigm for chemical risk management
-
Dellarco V, Henry T, Sayre P, Seed J, Bradbury S. 2010. Meeting the common needs of a more effective and efficient testing and assessment paradigm for chemical risk management. J. Toxicol. Environ. Health. 13:347-60.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 347-60
-
-
Dellarco, V.1
Henry, T.2
Sayre, P.3
Seed, J.4
Bradbury, S.5
-
26
-
-
62749133965
-
Needed: A strategy for implementing the vision
-
Elliott ED. 2009. Needed: a strategy for implementing the vision. Risk Anal. 29:482.
-
(2009)
Risk Anal
, vol.29
, pp. 482
-
-
Elliott, E.D.1
-
27
-
-
79952841211
-
Implementing alternatives to animal testing under U.S. toxics and pesticide laws
-
Environ. Law Inst
-
Environ. Law Inst. 2008. Implementing alternatives to animal testing under U.S. toxics and pesticide laws. An Environmental Law Institute white paper. http://www.eli.org/pdf/research/ELI- Implementing-Alternatives-White- Paper-v.1-pdf.
-
(2008)
An Environmental Law Institute White Paper
-
-
-
30
-
-
34447517134
-
Toxicogenomics: A pivotal piece in the puzzle of toxicological research
-
DOI 10.1002/jat.1248
-
Gatzidou ET, Zira AN, Theocharis SE. 2007. Toxicogenomics: a pivotal piece in the puzzle of toxicological research. J. Appl. Toxicol. 27:302-9. (Pubitemid 47066756)
-
(2007)
Journal of Applied Toxicology
, vol.27
, Issue.4
, pp. 302-309
-
-
Gatzidou, E.T.1
Zira, A.N.2
Theocharis, S.E.3
-
31
-
-
66449100893
-
Genomic and proteomic approaches for predicting toxicity and adverse drug reactions
-
Ge F, He QY. 2009. Genomic and proteomic approaches for predicting toxicity and adverse drug reactions. Expert Opin. Drug Metab. Toxicol. 5:29-37.
-
(2009)
Expert Opin. Drug Metab. Toxicol
, vol.5
, pp. 29-37
-
-
Ge, F.1
He, Q.Y.2
-
33
-
-
56749122303
-
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity
-
Harrill AH, Rusyn I. 2008. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opin. Drug Metab. Toxicol. 4:1379-89.
-
(2008)
Expert Opin. Drug Metab. Toxicol
, vol.4
, pp. 1379-89
-
-
Harrill, A.H.1
Rusyn, I.2
-
34
-
-
65549145511
-
A toxicology for the 21stcentury-mapping the road ahead
-
Hartung T. 2009. A toxicology for the 21st century-mapping the road ahead. Toxicol. Sci. 109:18-23.
-
(2009)
Toxicol. Sci
, vol.109
, pp. 18-23
-
-
Hartung, T.1
-
35
-
-
77953995631
-
Lessons learned from alternative methods and their validation for a new toxicology in the 21st century
-
Hartung T. 2010. Lessons learned from alternative methods and their validation for a new toxicology in the 21st century. J. Toxicol. Environ. Health. 13:277-90.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 277-90
-
-
Hartung, T.1
-
36
-
-
62749189128
-
High-throughput testing-TheNRCvision, the challenge ofmodeling dynamic changes in biological systems, and the reality of low-throughput environmental health decisionmaking
-
HattisD. 2009. High-throughput testing-TheNRCvision, the challenge ofmodeling dynamic changes in biological systems, and the reality of low-throughput environmental health decisionmaking. Risk Anal. 29:483-84.
-
(2009)
Risk Anal
, vol.29
, pp. 483-84
-
-
Hattis, D.1
-
37
-
-
77449146554
-
In situ biosynthesis of peptide arrays
-
He M, Stoevesandt O. 2010. In situ biosynthesis of peptide arrays. Methods Mol. Biol. 615:345-56.
-
(2010)
Methods Mol. Biol
, vol.615
, pp. 345-56
-
-
He, M.1
Stoevesandt, O.2
-
38
-
-
34547901382
-
Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach
-
DOI 10.1093/toxsci/kfm151
-
Heneweer M, Houtman R, Poortman J, Groot M, Maliepaard C, Peijnenburg A. 2007. Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach. Toxicol. Sci. 99:303-14. (Pubitemid 47250387)
-
(2007)
Toxicological Sciences
, vol.99
, Issue.1
, pp. 303-314
-
-
Heneweer, M.1
Houtman, R.2
Poortman, J.3
Groot, M.4
Maliepaard, C.5
Peijnenburg, A.6
-
39
-
-
59149098473
-
Forum series: The "vision" for toxicity testing in the 21st century: Promises and conundrums
-
HolsappleMP, AfshariCA, Lehman-McKeeman LD. 2009. Forum series: the "vision" for toxicity testing in the 21st century: promises and conundrums. Toxicol. Sci. 107:307-8.
-
(2009)
Toxicol. Sci
, vol.107
, pp. 307-8
-
-
Holsapple, M.P.1
Afshari, C.A.2
Lehman-Mckeeman, L.D.3
-
40
-
-
85015077644
-
The digital code of DNA
-
DOI 10.1038/nature01410
-
Hood L, Galas D. 2003. The digital code of DNA. Nature 421:444-48. (Pubitemid 36157953)
-
(2003)
Nature
, vol.421
, Issue.6921
, pp. 444-448
-
-
Hood, L.1
Galas, D.2
-
41
-
-
39049168646
-
Understanding mechanisms of toxicity: Insights from drug discovery research
-
DOI 10.1016/j.taap.2007.10.022, PII S0041008X0700467X
-
Houck KA, Kavlock RJ. 2008. Understanding mechanisms of toxicity: insights from drug discovery research. Toxicol. Appl. Pharmacol. 227:163-78. (Pubitemid 351233054)
-
(2008)
Toxicology and Applied Pharmacology
, vol.227
, Issue.2
, pp. 163-178
-
-
Houck, K.A.1
Kavlock, R.J.2
-
42
-
-
63249134666
-
Inorganic arsenic modulates the expression of selenoproteins in mouse embryonic stem cell
-
Huang Z, Li J, Zhang S, Zhang X. 2009. Inorganic arsenic modulates the expression of selenoproteins in mouse embryonic stem cell. Toxicol. Lett. 187:69-76.
-
(2009)
Toxicol. Lett
, vol.187
, pp. 69-76
-
-
Huang, Z.1
Li, J.2
Zhang, S.3
Zhang, X.4
-
43
-
-
70349278813
-
Biologically relevant exposure science for 21st century toxicity testing
-
Hubal EA. 2009. Biologically relevant exposure science for 21st century toxicity testing. Toxicol. Sci. 111:226-32.
-
(2009)
Toxicol. Sci
, vol.111
, pp. 226-32
-
-
Hubal, E.A.1
-
44
-
-
77953990500
-
Advancing exposure characterization for chemical evaluation and risk assessment
-
Hubal EA, Richard A, Aylward L, Edwards S, Gallagher J, et al. 2010. Advancing exposure characterization for chemical evaluation and risk assessment. J. Toxicol. Environ. Health. 13:299-313.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 299-313
-
-
Hubal, E.A.1
Richard, A.2
Aylward, L.3
Edwards, S.4
Gallagher, J.5
-
45
-
-
33746789921
-
Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
-
DOI 10.1073/pnas.0604348103
-
Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, et al. 2006. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. USA 103:11473-78. (Pubitemid 44182476)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.31
, pp. 11473-11478
-
-
Inglese, J.1
Auld, D.S.2
Jadhav, A.3
Johnson, R.L.4
Simeonov, A.5
Yasgar, A.6
Zheng, W.7
Austin, C.P.8
-
46
-
-
34447508068
-
Reporting data from high-throughput screening of small-molecule libraries
-
DOI 10.1038/nchembio0807-438, PII NCHEMBIO0807438
-
Inglese J, Shamu CE,Guy RK. 2007. Reporting data from high-throughput screening of small-molecule libraries. Nat. Chem. Biol. 3:438-41. (Pubitemid 47080377)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.8
, pp. 438-441
-
-
Inglese, J.1
Shamu, C.E.2
Guy, R.K.3
-
47
-
-
77953976931
-
Public databases supporting computational toxicology
-
Judson RS. 2010. Public databases supporting computational toxicology. J. Toxicol. Environ. Health. 13:218-31.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 218-31
-
-
Judson, R.S.1
-
48
-
-
77951675220
-
In vitro screening of environmental chemicals for targeted testing prioritization: The ToxCast project
-
Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, et al. 2010. In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ. Health Perspect. 118:485-92.
-
(2010)
Environ. Health Perspect
, vol.118
, pp. 485-92
-
-
Judson, R.S.1
Houck, K.A.2
Kavlock, R.J.3
Knudsen, T.B.4
Martin, M.T.5
-
49
-
-
19944430116
-
Nuclear oncoprotein prothymosin α is a partner of Keap1: Implications for expression of oxidative stress-protecting genes
-
DOI 10.1128/MCB.25.3.1089-1099.2005
-
Karapetian RN, Evstafieva AG, Abaeva IS, Chichkova NV, FilonovGS, et al. 2005. Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes. Mol. Cell. Biol. 25:1089-99. (Pubitemid 40165815)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1089-1099
-
-
Karapetian, R.N.1
Evstafieva, A.G.2
Abaeva, I.S.3
Chichkova, N.V.4
Filonov, G.S.5
Rubtsov, Y.P.6
Sukhacheva, E.A.7
Melnikov, S.V.8
Schneider, U.9
Wanker, E.E.10
Vartapetian, A.B.11
-
50
-
-
62749084516
-
Toxicity testing in the 21st century: Implications for human health risk assessment
-
Kavlock RJ, Austin CP, Tice RR. 2009. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal. 29:485-87.
-
(2009)
Risk Anal
, vol.29
, pp. 485-87
-
-
Kavlock, R.J.1
Austin, C.P.2
Tice, R.R.3
-
51
-
-
77953981125
-
Computational toxicology as implemented by the US EPA: Providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk
-
Kavlock RJ, Dix DJ. 2010. Computational toxicology as implemented by the US EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk. J. Toxicol. Environ. Health. 13:197-217.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 197-217
-
-
Kavlock, R.J.1
Dix, D.J.2
-
52
-
-
67749113808
-
Transcriptional regulatory circuits: Predicting numbers from alphabets
-
Kim HD, Shay T, O'Shea EK, Regev A. 2009. Transcriptional regulatory circuits: predicting numbers from alphabets. Science 325:429-32.
-
(2009)
Science
, vol.325
, pp. 429-32
-
-
Kim, H.D.1
Shay, T.2
O'Shea, E.K.3
Regev, A.4
-
53
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
DOI 10.1128/MCB.24.16.7130-7139.2004
-
Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, et al. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell Biol. 24:7130-39. (Pubitemid 39014439)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.16
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.-I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
54
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, et al. 2009. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol. Cell. Biol. 29:493-502.
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
Li, L.2
Iwamoto, N.3
Nakajima-Takagi, Y.4
Kaneko, H.5
-
55
-
-
62749109092
-
Toxicity testing in the 21st century: Implications for human health risk assessment
-
Krewski D, Andersen ME, Mantus E, Zeise L. 2009. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal. 29:474-79.
-
(2009)
Risk Anal
, vol.29
, pp. 474-79
-
-
Krewski, D.1
Andersen, M.E.2
Mantus, E.3
Zeise, L.4
-
56
-
-
36248945628
-
An integrated framework for risk management and population health
-
DOI 10.1080/10807030701655798, PII 784032132
-
Krewski D, Hogan V, Turner M, Zeman P, McDowell I, et al. 2007. An integrated framework for risk management and population health. Hum. Ecol. Risk Assess. 13:1288-312. (Pubitemid 350125748)
-
(2007)
Human and Ecological Risk Assessment
, vol.13
, Issue.6
, pp. 1288-1312
-
-
Krewski, D.1
Hogan, V.2
Turner, M.C.3
Zeman, P.L.4
McDowell, I.5
Edwards, N.6
Losos, J.7
-
57
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel gene clusters for cell survival
-
DOI 10.1074/jbc.M211898200
-
Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW. 2003. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identifi- cation of novel gene clusters for cell survival. J. Biol. Chem. 278:8135-45. (Pubitemid 36800555)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.10
, pp. 8135-8145
-
-
Kwak, M.-K.1
Wakabayashi, N.2
Itoh, K.3
Motohashi, H.4
Yamamoto, M.5
Kensler, T.W.6
-
58
-
-
13644268144
-
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
-
DOI 10.1093/toxsci/kfi027
-
Li J, Johnson D, Calkins M, Wright L, Svendsen C, Johnson J. 2005. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol. Sci. 83:313-28. (Pubitemid 40227901)
-
(2005)
Toxicological Sciences
, vol.83
, Issue.2
, pp. 313-328
-
-
Li, J.1
Johnson, D.2
Calkins, M.3
Wright, L.4
Svendsen, C.5
Johnson, J.6
-
59
-
-
77953998797
-
Implementing the National Academy's vision and strategy for toxicity testing: Opportunities and challenges under the US Toxic Substances Control Act
-
Locke P, MyersDB. 2010. Implementing the National Academy's vision and strategy for toxicity testing: opportunities and challenges under the US Toxic Substances Control Act. J. Toxicol. Environ. Health. 13:376-84.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 376-84
-
-
Locke, P.1
Myers, D.B.2
-
60
-
-
67649185786
-
Toxicity testing in the 21st century: A view from the pharmaceutical industry
-
MacDonald JS, Robertson RT. 2009. Toxicity testing in the 21st century: a view from the pharmaceutical industry. Toxicol. Sci. 110:40-46.
-
(2009)
Toxicol. Sci
, vol.110
, pp. 40-46
-
-
MacDonald, J.S.1
Robertson, R.T.2
-
61
-
-
68349148315
-
Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers
-
Manini P, De Palma G, Andreoli R, Marczynski B, Hanova M, et al. 2009. Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers. Toxicol. Lett. 190:41-47.
-
(2009)
Toxicol. Lett
, vol.190
, pp. 41-47
-
-
Manini, P.1
De Palma, G.2
Andreoli, R.3
Marczynski, B.4
Hanova, M.5
-
62
-
-
69049099679
-
A kinetic model of trp-cage folding from multiple biased molecular dynamics simulations
-
Marinelli F, Pietrucci F, Laio A, Piana S. 2009. A kinetic model of trp-cage folding from multiple biased molecular dynamics simulations. PLoS Comput. Biol. 5:e1000452.
-
(2009)
PLoS Comput. Biol
, vol.5
-
-
Marinelli, F.1
Pietrucci, F.2
Laio, A.3
Piana, S.4
-
63
-
-
77049124474
-
Modelling tissues in 3D: The next future of pharmacotoxicology and food research?
-
Mazzoleni G, Di Lorenzo D, Steimberg N. 2009. Modelling tissues in 3D: the next future of pharmacotoxicology and food research? Genes Nutr. 4:13-22.
-
(2009)
Genes Nutr
, vol.4
, pp. 13-22
-
-
Mazzoleni, G.1
Di Lorenzo, D.2
Steimberg, N.3
-
64
-
-
61349141927
-
Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: Another Ames test?. . .or a new edition of "the Red Book"?
-
Meek B, Doull J. 2009. Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test?. . .or a new edition of "the Red Book"? Toxicol. Sci. 108:19-21.
-
(2009)
Toxicol. Sci
, vol.108
, pp. 19-21
-
-
Meek, B.1
Doull, J.2
-
65
-
-
63249128015
-
The role of toxicoproteomics in assessing organ specific toxicity
-
Merrick BA, Witzmann FA. 2009. The role of toxicoproteomics in assessing organ specific toxicity. EXS 99:367-400.
-
(2009)
EXS
, vol.99
, pp. 367-400
-
-
Merrick, B.A.1
Witzmann, F.A.2
-
66
-
-
7244253081
-
Nrf2-Keap1 defines a physiologically important stress response mechanism
-
DOI 10.1016/j.molmed.2004.09.003, PII S1471491404002357
-
Motohashi H, Yamamoto M. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10:549-57. (Pubitemid 39433824)
-
(2004)
Trends in Molecular Medicine
, vol.10
, Issue.11
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
67
-
-
65049087667
-
QSAR application for the prediction of compound permeability with in silico descriptors in practical use
-
NakaoK, FujikawaM, Shimizu R, Akamatsu M. 2009. QSAR application for the prediction of compound permeability with in silico descriptors in practical use. J. Comput. Aided Mol. Des. 23:309-19.
-
(2009)
J. Comput. Aided Mol. des
, vol.23
, pp. 309-19
-
-
Fujikawam, N.1
Shimizu, R.2
Akamatsu, M.3
-
68
-
-
79952837955
-
-
Natl. Acad. Sci
-
Natl. Acad. Sci. 2010. Exposure science in the 21st century. http://dels-old.nas.edu/best/risk-analysis/ ExposureBackground.shtml.
-
(2010)
Exposure Science in the 21st Century
-
-
-
69
-
-
79952848982
-
-
Natl. Acad. Sci.Natl. Acad. Eng. Inst.Med. Natl. Res. Counc. (NRC)
-
Natl. Acad. Sci.,Natl. Acad. Eng., Inst.Med., Natl. Res. Counc. (NRC). 2010. Human and environmental exposure science in the 21st century. http://dels.nas.edu/Study-In-Progress/Human-Environmental- Exposure-Science/ DELS-BEST-09-02.
-
(2010)
Human and Environmental Exposure Science in the 21st Century
-
-
-
74
-
-
34250205752
-
-
Natl. Res. Counc. Natl. Acad. (NRC) Washington, DC: Natl. Acad. Press
-
Natl. Res. Counc. Natl. Acad. (NRC). 2006. Toxicity Testing for Assessment of Enviornmental Agents. Washington, DC: Natl. Acad. Press.
-
(2006)
Toxicity Testing for Assessment of Enviornmental Agents
-
-
-
76
-
-
69549108053
-
Stem cells in drug discovery, tissue engineering, and regenerative medicine: Emerging opportunities and challenges
-
Nirmalanandhan VS, Sittampalam GS. 2009. Stem cells in drug discovery, tissue engineering, and regenerative medicine: emerging opportunities and challenges. J. Biomol. Screen. 14:755-68.
-
(2009)
J. Biomol. Screen
, vol.14
, pp. 755-68
-
-
Nirmalanandhan, V.S.1
Sittampalam, G.S.2
-
77
-
-
68549104172
-
Three-dimensional tissue models for drug discovery and toxicology
-
Pampaloni F, Stelzer EH, Masotti A. 2009. Three-dimensional tissue models for drug discovery and toxicology. Recent Pat. Biotechnol. 3:103-17.
-
(2009)
Recent Pat. Biotechnol
, vol.3
, pp. 103-17
-
-
Pampaloni, F.1
Stelzer, E.H.2
Masotti, A.3
-
80
-
-
62749195174
-
Risk assessment in the 21st century: Changes wrought by changing science
-
Rhomberg LR. 2009. Risk assessment in the 21st century: changes wrought by changing science. Risk Anal. 29:488-89.
-
(2009)
Risk Anal
, vol.29
, pp. 488-89
-
-
Rhomberg, L.R.1
-
81
-
-
77954009528
-
Toxicity testing in the 21st century: How will it affect risk assessment?
-
Rhomberg LR. 2010. Toxicity testing in the 21st century: How will it affect risk assessment? J. Toxicol. Environ. Health. 13:361-75.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 361-75
-
-
Rhomberg, L.R.1
-
82
-
-
41049117650
-
Toxicity data informatics: Supporting a new paradigm for toxicity prediction
-
DOI 10.1080/15376510701857452, PII 791541385
-
Richard AM, Yang C, Judson RS. 2008. Toxicity data informatics: supporting a new paradigm for toxicity prediction. Toxicol. Mech. Methods 18:103-18. (Pubitemid 351419128)
-
(2008)
Toxicology Mechanisms and Methods
, vol.18
, Issue.2-3
, pp. 103-118
-
-
Richard, A.M.1
Yang, C.2
Judson, R.S.3
-
83
-
-
77953983411
-
Xenobiotic metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
-
Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, et al. 2010. Xenobiotic metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. J. Toxicol. Environ. Health. 13:329-46.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 329-46
-
-
Rotroff, D.M.1
Beam, A.L.2
Dix, D.J.3
Farmer, A.4
Freeman, K.M.5
-
84
-
-
28844441670
-
Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis
-
DOI 10.1089/ars.2005.7.1423
-
Sauer H,Wartenberg M. 2005. Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis. Antioxid. Redox. Signal. 7:1423-34. (Pubitemid 41767977)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.11-12
, pp. 1423-1434
-
-
Sauer, H.1
Wartenberg, M.2
-
85
-
-
77954016155
-
TheREACHperspective towards a new concept of toxicity testing
-
SchoetersG. 2010. TheREACHperspective towards a new concept of toxicity testing. J. Toxicol. Environ. Health. 13:232-41.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 232-41
-
-
Schoeters, G.1
-
86
-
-
70350728952
-
Bringing toxicology into the 21st century: A global call to action
-
Seidle T, Stephens ML. 2009. Bringing toxicology into the 21st century: a global call to action. Toxicol. In Vitro 23:1576-79.
-
(2009)
Toxicol in Vitro
, vol.23
, pp. 1576-79
-
-
Seidle, T.1
Stephens, M.L.2
-
88
-
-
71049158357
-
Hypoxia response: A model toxicity pathway for high-throughput screening
-
Simmons SO. 2009. Hypoxia response: a model toxicity pathway for high-throughput screening. Toxicol. Sci. 112:1-3.
-
(2009)
Toxicol. Sci
, vol.112
, pp. 1-3
-
-
Simmons, S.O.1
-
89
-
-
77953998796
-
An animal protection perspective on 21stcentury toxicology
-
Stephens ML. 2010. An animal protection perspective on 21st century toxicology. J. Toxicol. Environ. Health. 13:291-98.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 291-98
-
-
Stephens, M.L.1
-
90
-
-
68449101834
-
Putting chemicals on a path to better risk assessment
-
Stokstad E. 2009. Putting chemicals on a path to better risk assessment. Science 325:694-95.
-
(2009)
Science
, vol.325
, pp. 694-95
-
-
Stokstad, E.1
-
91
-
-
36248966518
-
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
-
DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
-
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-72. (Pubitemid 350138099)
-
(2007)
Cell
, vol.131
, Issue.5
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
92
-
-
58149263824
-
Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells
-
Takahata Y, Takarada T, Iemata M, Yamamoto T, Nakamura Y, et al. 2009. Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. J. Cell Physiol. 218:268-75.
-
(2009)
J. Cell Physiol
, vol.218
, pp. 268-75
-
-
Takahata, Y.1
Takarada, T.2
Iemata, M.3
Yamamoto, T.4
Nakamura, Y.5
-
94
-
-
34249062964
-
The minimum information about a proteomics experiment (MIAPE)
-
DOI 10.1038/nbt1329, PII NBT1329
-
Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK Jr, et al. 2007. The minimum information about a proteomics experiment (MIAPE). Nat. Biotechnol. 25:887-93. (Pubitemid 47236919)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.8
, pp. 887-893
-
-
Taylor, C.F.1
Paton, N.W.2
Lilley, K.S.3
Binz, P.-A.4
Julian Jr., R.K.5
Jones, A.R.6
Zhu, W.7
Apweiler, R.8
Aebersold, R.9
Deutsch, E.W.10
Dunn, M.J.11
Heck, A.J.R.12
Leitner, A.13
Macht, M.14
Mann, M.15
Martens, L.16
Neubert, T.A.17
Patterson, S.D.18
Ping, P.19
Seymour, S.L.20
Souda, P.21
Tsugita, A.22
Vandekerckhove, J.23
Vondriska, T.M.24
Whitelegge, J.P.25
Wilkins, M.R.26
Xenarios, I.27
Yates III, J.R.28
Hermjakob, H.29
more..
-
95
-
-
50949117527
-
Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress
-
Taylor RC, Acquaah-Mensah G, Singhal M, Malhotra D, Biswal S. 2008. Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress. PLoS. Comput. Biol. 4:e1000166.
-
(2008)
PLoS. Comput. Biol
, vol.4
-
-
Taylor, R.C.1
Acquaah-Mensah, G.2
Singhal, M.3
Malhotra, D.4
Biswal, S.5
-
96
-
-
62749188280
-
Advances in toxicity testing herald improvements and challenges for risk assessment
-
Tsuji JS, Garry MR. 2009. Advances in toxicity testing herald improvements and challenges for risk assessment. Risk Anal. 29:490-91.
-
(2009)
Risk Anal
, vol.29
, pp. 490-91
-
-
Tsuji, J.S.1
Garry, M.R.2
-
98
-
-
77953987938
-
-
U. S. Natl. Libr. Med
-
U. S. Natl. Libr. Med. 2010. TOXNET: Toxicology Data Network. http://toxnet.nlm.nih.gov/.
-
(2010)
TOXNET: Toxicology Data Network
-
-
-
100
-
-
70449528780
-
In silico toxicology for the pharmaceutical sciences
-
Valerio LG Jr. 2009. In silico toxicology for the pharmaceutical sciences. Toxicol. Appl. Pharmacol. 241:356-70.
-
(2009)
Toxicol. Appl. Pharmacol
, vol.241
, pp. 356-70
-
-
Valerio Jr., L.G.1
-
101
-
-
67650718169
-
A 21st century paradigm for evaluating the health hazards of nanoscale materials?
-
Walker NJ, Bucher JR. 2009. A 21st century paradigm for evaluating the health hazards of nanoscale materials? Toxicol. Sci. 110:251-54.
-
(2009)
Toxicol Sci
, vol.110
, pp. 251-54
-
-
Walker, N.J.1
Bucher, J.R.2
-
102
-
-
8544277251
-
Toxicoproteomics: Proteomics applied to toxicology and pathology
-
DOI 10.1080/01926230490518244
-
Wetmore BA, Merrick BA. 2004. Toxicoproteomics: proteomics applied to toxicology and pathology. Toxicol. Pathol. 32:619-42. (Pubitemid 39491933)
-
(2004)
Toxicologic Pathology
, vol.32
, Issue.6
, pp. 619-642
-
-
Wetmore, B.A.1
Merrick, B.A.2
-
103
-
-
40849137783
-
Compound cytotoxicity profiling using quantitative high-throughput screening
-
DOI 10.1289/ehp.10727
-
Xia M, Huang R, Witt KL, Southall N, Fostel J, et al. 2008. Compound cytotoxicity profiling using quantitative high-throughput screening. Environ. Health Perspect. 116:284-91. (Pubitemid 351395593)
-
(2008)
Environmental Health Perspectives
, vol.116
, Issue.3
, pp. 284-291
-
-
Xia, M.1
Huang, R.2
Witt, K.L.3
Southall, N.4
Fostel, J.5
Cho, M.-H.6
Jadhav, A.7
Smith, C.S.8
Inglese, J.9
Portier, C.J.10
Tice, R.R.11
Austin, C.P.12
-
104
-
-
40949112779
-
Understanding genetic toxicity through data mining: The process of building knowledge by integrating multiple genetic toxicity databases
-
DOI 10.1080/15376510701857502, PII 791540944
-
Yang C, Hasselgren CH, Boyer S, Arvidson K, Aveston S, et al. 2008. Understanding genetic toxicity through data mining: the process of building knowledge by integratingmultiple genetic toxicity databases. Toxicol. Mech. Methods 18:277-95. (Pubitemid 351414968)
-
(2008)
Toxicology Mechanisms and Methods
, vol.18
, Issue.2-3
, pp. 277-295
-
-
Yang, C.1
Hasselgren, C.H.2
Boyer, S.3
Arvidson, K.4
Aveston, S.5
Dierkes, P.6
Benigni, R.7
Benz, R.D.8
Contrera, J.9
Kruhlak, N.L.10
Matthews, E.J.11
Han, X.12
Jaworska, J.13
Kemper, R.A.14
Rathman, J.F.15
Richard, A.M.16
-
106
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-20.
-
(2007)
Science
, vol.318
, pp. 1917-20
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
Frane, J.L.5
-
107
-
-
77953964154
-
Computational systems biology and doseresponse modeling in relation to new directions in toxicity testing
-
Zhang Q, Battacharya S, Andersen ME, Conolly RB. 2010. Computational systems biology and doseresponse modeling in relation to new directions in toxicity testing. J. Toxicol. Environ. Health. 13:253-76.
-
(2010)
J. Toxicol. Environ. Health.
, vol.13
, pp. 253-76
-
-
Zhang, Q.1
Battacharya, S.2
Andersen, M.E.3
Conolly, R.B.4
-
109
-
-
74049139065
-
Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth
-
Zorina Y, Iyengar R, Bromberg KD. 2010. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J. Biol. Chem. 285:1358-70
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 1358-70
-
-
Zorina, Y.1
Iyengar, R.2
Bromberg, K.D.3
|