-
1
-
-
0033920730
-
Management of cancer in the older person: a practical approach
-
Balducci L., Extermann M. Management of cancer in the older person: a practical approach. Oncologist 2000, 5:224-237.
-
(2000)
Oncologist
, vol.5
, pp. 224-237
-
-
Balducci, L.1
Extermann, M.2
-
2
-
-
33644781621
-
The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets
-
[Epub 2005 November 15]
-
Sieburg H.B., Cho R.H., Dykstra B., Uchida N., Eaves C.J., Muller-Sieburg C.E. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood 2006, 107:2311-2316. [Epub 2005 November 15].
-
(2006)
Blood
, vol.107
, pp. 2311-2316
-
-
Sieburg, H.B.1
Cho, R.H.2
Dykstra, B.3
Uchida, N.4
Eaves, C.J.5
Muller-Sieburg, C.E.6
-
3
-
-
84863229585
-
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
-
Wang J., Sun Q., Morita Y., et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell 2012, 148:1001-1014.
-
(2012)
Cell
, vol.148
, pp. 1001-1014
-
-
Wang, J.1
Sun, Q.2
Morita, Y.3
-
5
-
-
77949904634
-
Alterations of the systemic environment are the primary cause of impaired b and t lymphopoiesis in telomere-dysfunctional mice
-
Song Z., Wang J., Guachalla L.M., et al. Alterations of the systemic environment are the primary cause of impaired b and t lymphopoiesis in telomere-dysfunctional mice. Blood 2010, 115:1481-1489.
-
(2010)
Blood
, vol.115
, pp. 1481-1489
-
-
Song, Z.1
Wang, J.2
Guachalla, L.M.3
-
6
-
-
34250017413
-
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
-
Ju Z., Jiang H., Jaworski M., et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nature Medicine 2007, 13:742-747.
-
(2007)
Nature Medicine
, vol.13
, pp. 742-747
-
-
Ju, Z.1
Jiang, H.2
Jaworski, M.3
-
7
-
-
33846111415
-
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
-
[Epub 2006 November 20]
-
Franceschi C., Capri M., Monti D., et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of Ageing and Development 2007, 128:92-105. [Epub 2006 November 20].
-
(2007)
Mechanisms of Ageing and Development
, vol.128
, pp. 92-105
-
-
Franceschi, C.1
Capri, M.2
Monti, D.3
-
8
-
-
34948813493
-
Interleukin-1 receptor antagonist, interleukin-6, and c-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study
-
Jylha M., Paavilainen P., Lehtimaki T., et al. Interleukin-1 receptor antagonist, interleukin-6, and c-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2007, 62:1016-1021.
-
(2007)
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
, vol.62
, pp. 1016-1021
-
-
Jylha, M.1
Paavilainen, P.2
Lehtimaki, T.3
-
9
-
-
84873526545
-
Interleukin-6, c-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals
-
Giovannini S., Onder G., Liperoti R., et al. Interleukin-6, c-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. Journal of the American Geriatrics Society 2011, 2011:1532-5415.
-
(2011)
Journal of the American Geriatrics Society
, vol.2011
, pp. 1532-5415
-
-
Giovannini, S.1
Onder, G.2
Liperoti, R.3
-
10
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Experimental Cell Research 1961, 25:585-621.
-
(1961)
Experimental Cell Research
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
11
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16ink4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16ink4a. Cell 1997, 88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
12
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
[Epub 2003 November 5]
-
d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198. [Epub 2003 November 5].
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
-
14
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova O.A., Horikawa I., Zimonjic D.B., Popescu N.C., Bonner W.M., Barrett J.C. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biology 2004, 6:168-170.
-
(2004)
Nature Cell Biology
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, I.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
15
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends in Cell Biology 2001, 11:S27-S31.
-
(2001)
Trends in Cell Biology
, vol.11
-
-
Campisi, J.1
-
16
-
-
41549149451
-
Cellular senescence in vivo: a barrier to tumorigenesis
-
[Epub 2008 March 18]
-
Prieur A., Peeper D.S. Cellular senescence in vivo: a barrier to tumorigenesis. Current Opinion in Cell Biology 2008, 20:150-155. [Epub 2008 March 18].
-
(2008)
Current Opinion in Cell Biology
, vol.20
, pp. 150-155
-
-
Prieur, A.1
Peeper, D.S.2
-
17
-
-
72949096792
-
Senescence in tumours: evidence from mice and humans
-
Collado M., Serrano M. Senescence in tumours: evidence from mice and humans. Nature Reviews Cancer 2010, 10:51-57.
-
(2010)
Nature Reviews Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
18
-
-
79957895030
-
Evolved tumor suppression: why are we so good at not getting cancer?
-
[Epub 2011 May 24]
-
DeGregori J Evolved tumor suppression: why are we so good at not getting cancer?. Cancer 2011, 71:3739-3744. [Epub 2011 May 24].
-
(2011)
Cancer
, vol.71
, pp. 3739-3744
-
-
DeGregori, J.1
-
19
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppe J.P., Desprez P.Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Review of Pathology 2010, 5:99-118.
-
(2010)
Annual Review of Pathology
, vol.5
, pp. 99-118
-
-
Coppe, J.P.1
Desprez, P.Y.2
Krtolica, A.3
Campisi, J.4
-
20
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph K.L., Chang S., Lee H.W., et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999, 96:701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
-
21
-
-
45449092970
-
Hgps and related premature aging disorders: from genomic identification to the first therapeutic approaches
-
Pereira S., Bourgeois P., Navarro C., et al. Hgps and related premature aging disorders: from genomic identification to the first therapeutic approaches. Mechanisms of Ageing and Development 2008, 129:449-459.
-
(2008)
Mechanisms of Ageing and Development
, vol.129
, pp. 449-459
-
-
Pereira, S.1
Bourgeois, P.2
Navarro, C.3
-
22
-
-
0036200639
-
Immunosenescence phenotypes in the telomerase knockout mouse
-
Blasco M.A. Immunosenescence phenotypes in the telomerase knockout mouse. Springer Seminars in Immunopathology 2002, 24:75-85.
-
(2002)
Springer Seminars in Immunopathology
, vol.24
, pp. 75-85
-
-
Blasco, M.A.1
-
23
-
-
33645508898
-
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation
-
Vulliamy T.J., Marrone A., Knight S.W., Walne A., Mason P.J., Dokal I. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation. Blood 2006, 107:2680-2685.
-
(2006)
Blood
, vol.107
, pp. 2680-2685
-
-
Vulliamy, T.J.1
Marrone, A.2
Knight, S.W.3
Walne, A.4
Mason, P.J.5
Dokal, I.6
-
24
-
-
34548828783
-
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
-
[Epub 2007 April 27]
-
Alter B.P., Baerlocher G.M., Savage S.A., et al. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood 2007, 110:1439-1447. [Epub 2007 April 27].
-
(2007)
Blood
, vol.110
, pp. 1439-1447
-
-
Alter, B.P.1
Baerlocher, G.M.2
Savage, S.A.3
-
25
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16ink4a
-
Janzen V., Forkert R., Fleming H.E., et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16ink4a. Nature 2006, 443:421-426.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
-
26
-
-
0034613690
-
Age-associated characteristics of murine hematopoietic stem cells
-
Sudo K., Ema H., Morita Y., Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. Journal of Experimental Medicine 2000, 192:1273-1280.
-
(2000)
Journal of Experimental Medicine
, vol.192
, pp. 1273-1280
-
-
Sudo, K.1
Ema, H.2
Morita, Y.3
Nakauchi, H.4
-
27
-
-
34547692981
-
Long-term propagation of distinct hematopoietic differentiation programs in vivo
-
Dykstra B., Kent D., Bowie M., et al. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 2007, 1:218-229.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 218-229
-
-
Dykstra, B.1
Kent, D.2
Bowie, M.3
-
28
-
-
77449145533
-
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
-
Challen G.A., Boles N.C., Chambers S.M., Goodell M.A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell 2010, 6:265-278.
-
(2010)
Cell
, vol.6
, pp. 265-278
-
-
Challen, G.A.1
Boles, N.C.2
Chambers, S.M.3
Goodell, M.A.4
-
29
-
-
47049099198
-
A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
-
Cho R.H., Sieburg H.B., Muller-Sieburg C.E. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 2008, 111:5553-5561.
-
(2008)
Blood
, vol.111
, pp. 5553-5561
-
-
Cho, R.H.1
Sieburg, H.B.2
Muller-Sieburg, C.E.3
-
30
-
-
58149388235
-
Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach
-
Roeder I., Horn K., Sieburg H.B., Cho R., Muller-Sieburg C., Loeffler M. Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. Blood 2008, 112:4874-4883.
-
(2008)
Blood
, vol.112
, pp. 4874-4883
-
-
Roeder, I.1
Horn, K.2
Sieburg, H.B.3
Cho, R.4
Muller-Sieburg, C.5
Loeffler, M.6
-
31
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
33
-
-
33646546302
-
Aging of the immune system: how much can the adaptive immune system adapt?
-
Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006, 24:495-499.
-
(2006)
Immunity
, vol.24
, pp. 495-499
-
-
Weng, N.P.1
-
34
-
-
25844467829
-
Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review
-
Jefferson T., Rivetti D., Rivetti A., Rudin M., Di Pietrantonj C., Demicheli V. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 2005, 366:1165-1174.
-
(2005)
Lancet
, vol.366
, pp. 1165-1174
-
-
Jefferson, T.1
Rivetti, D.2
Rivetti, A.3
Rudin, M.4
Di Pietrantonj, C.5
Demicheli, V.6
-
35
-
-
33947592372
-
Immunosenescence: role and measurement in influenza vaccine response among the elderly
-
[Epub 2007 January 16]
-
Targonski P.V., Jacobson R.M., Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 2007, 25:3066-3069. [Epub 2007 January 16].
-
(2007)
Vaccine
, vol.25
, pp. 3066-3069
-
-
Targonski, P.V.1
Jacobson, R.M.2
Poland, G.A.3
-
36
-
-
58149358477
-
Immune receptor signaling, aging and autoimmunity
-
Larbi A., Fulop T., Pawelec G. Immune receptor signaling, aging and autoimmunity. Advances in Experimental Medicine and Biology 2008, 640:312-324.
-
(2008)
Advances in Experimental Medicine and Biology
, vol.640
, pp. 312-324
-
-
Larbi, A.1
Fulop, T.2
Pawelec, G.3
-
40
-
-
33748974393
-
Eortc guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours
-
Aapro M.S., Cameron D.A., Pettengell R., et al. Eortc guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. European Journal of Cancer 2006, 42:2433-2453.
-
(2006)
European Journal of Cancer
, vol.42
, pp. 2433-2453
-
-
Aapro, M.S.1
Cameron, D.A.2
Pettengell, R.3
-
41
-
-
78650515906
-
2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours
-
Aapro M.S., Bohlius J., Cameron D.A., et al. 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. European Journal of Cancer 2011, 47:8-32.
-
(2011)
European Journal of Cancer
, vol.47
, pp. 8-32
-
-
Aapro, M.S.1
Bohlius, J.2
Cameron, D.A.3
-
42
-
-
33745989223
-
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
-
Smith T.J., Khatcheressian J., Lyman G.H., et al. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. Journal of Clinical Oncology 2006, 24:3187-3205.
-
(2006)
Journal of Clinical Oncology
, vol.24
, pp. 3187-3205
-
-
Smith, T.J.1
Khatcheressian, J.2
Lyman, G.H.3
-
43
-
-
45149117448
-
Hematopoietic growth factors: ESMO recommendations for the applications
-
Greil R., Psenak O., Roila F. Hematopoietic growth factors: ESMO recommendations for the applications. Annals of Oncology 2008, 19:ii116-ii118.
-
(2008)
Annals of Oncology
, vol.19
-
-
Greil, R.1
Psenak, O.2
Roila, F.3
-
44
-
-
0343080998
-
A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer
-
Dees E.C., O'Reilly S., Goodman S.N., et al. A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer. Cancer Investigation 2000, 18:521-529.
-
(2000)
Cancer Investigation
, vol.18
, pp. 521-529
-
-
Dees, E.C.1
O'Reilly, S.2
Goodman, S.N.3
-
45
-
-
0037039381
-
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent
-
[Epub 2001 December 18]
-
Chang B.D., Swift M.E., Shen M., Fang J., Broude E.V., Roninson I.B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:389-394. [Epub 2001 December 18].
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 389-394
-
-
Chang, B.D.1
Swift, M.E.2
Shen, M.3
Fang, J.4
Broude, E.V.5
Roninson, I.B.6
-
46
-
-
0037452888
-
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
-
[Epub 2003 March 7]
-
Zhang H., Pan K.H., Cohen S.N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:3251-3256. [Epub 2003 March 7].
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 3251-3256
-
-
Zhang, H.1
Pan, K.H.2
Cohen, S.N.3
-
47
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
-
[Epub 2005 January 18]
-
Parrinello S., Coppe J.P., Krtolica A., Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. Journal of Cell Science 2005, 118:485-496. [Epub 2005 January 18].
-
(2005)
Journal of Cell Science
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
48
-
-
31544479046
-
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
-
Bavik C., Coleman I., Dean J.P., Knudsen B., Plymate S., Nelson P.S. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Research 2006, 66:794-802.
-
(2006)
Cancer Research
, vol.66
, pp. 794-802
-
-
Bavik, C.1
Coleman, I.2
Dean, J.P.3
Knudsen, B.4
Plymate, S.5
Nelson, P.S.6
-
49
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic ras and the p53 tumor suppressor
-
Coppe J.P., Patil C.K., Rodier F., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic ras and the p53 tumor suppressor. PLoS Biology 2008, 6:2853-2868.
-
(2008)
PLoS Biology
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
-
50
-
-
58849154235
-
Senescence-messaging secretome: Sms-ing cellular stress
-
[Epub 2009 January 9]
-
Kuilman T., Peeper D.S. Senescence-messaging secretome: Sms-ing cellular stress. Nature Reviews Cancer 2009, 9:81-94. [Epub 2009 January 9].
-
(2009)
Nature Reviews Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
51
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
[Epub 2001 October 2]
-
Krtolica A., Parrinello S., Lockett S., Desprez P.Y., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:12072-12077. [Epub 2001 October 2].
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
52
-
-
34248197982
-
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
-
Liu D., Hornsby P.J. Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Research 2007, 67:3117-3126.
-
(2007)
Cancer Research
, vol.67
, pp. 3117-3126
-
-
Liu, D.1
Hornsby, P.J.2
-
53
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
[Epub 2007 January 24]
-
Xue W., Zender L., Miething C., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660. [Epub 2007 January 24].
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
-
54
-
-
14644442350
-
Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?
-
[Epub 2004 December 15]
-
Puzianowska-Kuznicka M., Kuznicki J. Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?. International Journal of Biochemistry and Cell Biology 2005, 37:947-960. [Epub 2004 December 15].
-
(2005)
International Journal of Biochemistry and Cell Biology
, vol.37
, pp. 947-960
-
-
Puzianowska-Kuznicka, M.1
Kuznicki, J.2
-
56
-
-
0037380886
-
Methylation of p16(ink4a) promoters occurs in vivo in histologically normal human mammary epithelia
-
Holst C.R., Nuovo G.J., Esteller M., et al. Methylation of p16(ink4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Research 2003, 63:1596-1601.
-
(2003)
Cancer Research
, vol.63
, pp. 1596-1601
-
-
Holst, C.R.1
Nuovo, G.J.2
Esteller, M.3
-
57
-
-
32644444587
-
Development and validation of a prognostic index for 4-year mortality in older adults
-
Lee S.J., Lindquist K., Segal M.R., Covinsky K.E. Development and validation of a prognostic index for 4-year mortality in older adults. Journal of the American Medical Association 2006, 295:801-808.
-
(2006)
Journal of the American Medical Association
, vol.295
, pp. 801-808
-
-
Lee, S.J.1
Lindquist, K.2
Segal, M.R.3
Covinsky, K.E.4
-
58
-
-
84855781583
-
Long-term non-cancer mortality in pediatric and young adult cancer survivors in Finland
-
Prasad P.K., Signorello L.B., Friedman D.L., Boice J.D., Pukkala E. Long-term non-cancer mortality in pediatric and young adult cancer survivors in Finland. Pediatric Blood & Cancer 2012, 58:421-427.
-
(2012)
Pediatric Blood & Cancer
, vol.58
, pp. 421-427
-
-
Prasad, P.K.1
Signorello, L.B.2
Friedman, D.L.3
Boice, J.D.4
Pukkala, E.5
-
59
-
-
0029924534
-
From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
-
Vaziri H., Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Experimental Gerontology 1996, 31:295-301.
-
(1996)
Experimental Gerontology
, vol.31
, pp. 295-301
-
-
Vaziri, H.1
Benchimol, S.2
-
60
-
-
35848943667
-
Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
-
[Epub 2007 July 18]
-
Rossi D.J., Seita J., Czechowicz A., Bhattacharya D., Bryder D., Weissman I.L. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle 2007, 6:2371-2376. [Epub 2007 July 18].
-
(2007)
Cell Cycle
, vol.6
, pp. 2371-2376
-
-
Rossi, D.J.1
Seita, J.2
Czechowicz, A.3
Bhattacharya, D.4
Bryder, D.5
Weissman, I.L.6
-
61
-
-
79952338609
-
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
-
Rube C.E., Fricke A., Widmann T.A., et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS ONE 2011, 6:e17487.
-
(2011)
PLoS ONE
, vol.6
-
-
Rube, C.E.1
Fricke, A.2
Widmann, T.A.3
-
62
-
-
0023663881
-
The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
-
Greider C.W., Blackburn E.H. The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987, 51:887-898.
-
(1987)
Cell
, vol.51
, pp. 887-898
-
-
Greider, C.W.1
Blackburn, E.H.2
-
63
-
-
0030271719
-
The roles of telomeres and telomerase in cell life span
-
Counter C.M. The roles of telomeres and telomerase in cell life span. Mutation Research 1996, 366:45-63.
-
(1996)
Mutation Research
, vol.366
, pp. 45-63
-
-
Counter, C.M.1
-
64
-
-
0037308404
-
Association between telomere length in blood and mortality in people aged 60 years or older
-
Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
-
(2003)
Lancet
, vol.361
, pp. 393-395
-
-
Cawthon, R.M.1
Smith, K.R.2
O'Brien, E.3
Sivatchenko, A.4
Kerber, R.A.5
-
65
-
-
84857129282
-
Telomere length in early life predicts lifespan
-
Heidinger B.J., Blount J.D., Boner W., Griffiths K., Metcalfe N.B., Monaghan P. Telomere length in early life predicts lifespan. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:1743-1748.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 1743-1748
-
-
Heidinger, B.J.1
Blount, J.D.2
Boner, W.3
Griffiths, K.4
Metcalfe, N.B.5
Monaghan, P.6
-
66
-
-
79957789230
-
Leukocyte telomere length and mortality in the cardiovascular health study
-
Fitzpatrick A.L., Kronmal R.A., Kimura M., et al. Leukocyte telomere length and mortality in the cardiovascular health study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2011, 66:421-429.
-
(2011)
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
, vol.66
, pp. 421-429
-
-
Fitzpatrick, A.L.1
Kronmal, R.A.2
Kimura, M.3
-
67
-
-
33644822655
-
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study
-
Martin-Ruiz C.M., Gussekloo J., van Heemst D., von Zglinicki T., Westendorp R.G. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005, 4:287-290.
-
(2005)
Aging Cell
, vol.4
, pp. 287-290
-
-
Martin-Ruiz, C.M.1
Gussekloo, J.2
van Heemst, D.3
von Zglinicki, T.4
Westendorp, R.G.5
-
68
-
-
80053384309
-
Assessment of a large panel of candidate biomarkers of ageing in the newcastle 85+ study
-
[Epub 2011 August 16]
-
Martin-Ruiz C., Jagger C., Kingston A., et al. Assessment of a large panel of candidate biomarkers of ageing in the newcastle 85+ study. Mechanisms of Ageing and Development 2011, 132:496-502. [Epub 2011 August 16].
-
(2011)
Mechanisms of Ageing and Development
, vol.132
, pp. 496-502
-
-
Martin-Ruiz, C.1
Jagger, C.2
Kingston, A.3
-
70
-
-
67650660751
-
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study
-
[Epub 2009 May 12]
-
Njajou O.T., Hsueh W.C., Blackburn E.H., et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2009, 64:860-864. [Epub 2009 May 12].
-
(2009)
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
, vol.64
, pp. 860-864
-
-
Njajou, O.T.1
Hsueh, W.C.2
Blackburn, E.H.3
-
71
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann M.T., Strong M.A., Hao L.Y., Greider C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107:67-77.
-
(2001)
Cell
, vol.107
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
73
-
-
84873522952
-
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease
-
Watabe-Rudolph M., Song Z., Lausser L., et al. Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease. Neurology 2012, 2012:8.
-
(2012)
Neurology
, vol.2012
, pp. 8
-
-
Watabe-Rudolph, M.1
Song, Z.2
Lausser, L.3
-
74
-
-
77955841722
-
Structural identity of telomeric complexes
-
Giraud-Panis M.J., Pisano S., Poulet A., Le Du M.H., Gilson E. Structural identity of telomeric complexes. FEBS Letters 2010, 584:3785-3799.
-
(2010)
FEBS Letters
, vol.584
, pp. 3785-3799
-
-
Giraud-Panis, M.J.1
Pisano, S.2
Poulet, A.3
Le Du, M.H.4
Gilson, E.5
-
75
-
-
27144515686
-
Xpf nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
-
[Epub 2005 September 4]
-
Munoz P., Blanco R., Flores J.M., Blasco M.A. Xpf nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nature Genetics 2005, 37:1063-1071. [Epub 2005 September 4].
-
(2005)
Nature Genetics
, vol.37
, pp. 1063-1071
-
-
Munoz, P.1
Blanco, R.2
Flores, J.M.3
Blasco, M.A.4
-
76
-
-
80051553764
-
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation
-
Augereau A., T'Kint de Roodenbeke C., Simonet T., et al. Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood 2011, 118:1316-1322.
-
(2011)
Blood
, vol.118
, pp. 1316-1322
-
-
Augereau, A.1
T'Kint de Roodenbeke, C.2
Simonet, T.3
-
77
-
-
78049441699
-
Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood
-
[Epub 2010 June 17]
-
Song Z., von Figura G., Liu Y., et al. Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell 2010, 9:607-615. [Epub 2010 June 17].
-
(2010)
Aging Cell
, vol.9
, pp. 607-615
-
-
Song, Z.1
von Figura, G.2
Liu, Y.3
-
80
-
-
27844443561
-
Associations of stress and depressive symptoms with cancer in older Mexican Americans
-
Schneider M.G., Chiriboga D.A. Associations of stress and depressive symptoms with cancer in older Mexican Americans. Ethnicity and Disease 2005, 15:698-704.
-
(2005)
Ethnicity and Disease
, vol.15
, pp. 698-704
-
-
Schneider, M.G.1
Chiriboga, D.A.2
-
81
-
-
21244450353
-
The atm/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
-
Zhang X., Li J., Sejas D.P., Pang Q. The atm/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells. Journal of Biological Chemistry 2005, 280:19635-19640.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 19635-19640
-
-
Zhang, X.1
Li, J.2
Sejas, D.P.3
Pang, Q.4
-
82
-
-
33746616991
-
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
-
[Epub 2006 July 23]
-
Kortlever R.M., Higgins P.J., Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nature Cell Biology 2006, 8:877-884. [Epub 2006 July 23].
-
(2006)
Nature Cell Biology
, vol.8
, pp. 877-884
-
-
Kortlever, R.M.1
Higgins, P.J.2
Bernards, R.3
-
84
-
-
1842861744
-
Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
-
Munro J., Barr N.I., Ireland H., Morrison V., Parkinson E.K. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. Experimental Cell Research 2004, 295:525-538.
-
(2004)
Experimental Cell Research
, vol.295
, pp. 525-538
-
-
Munro, J.1
Barr, N.I.2
Ireland, H.3
Morrison, V.4
Parkinson, E.K.5
-
85
-
-
79953086335
-
Expression of p16(ink4a) prevents cancer and promotes aging in lymphocytes
-
[Epub 2011 January 18]
-
Liu Y., Johnson S.M., Fedoriw Y., et al. Expression of p16(ink4a) prevents cancer and promotes aging in lymphocytes. Blood 2011, 117:3257-3267. [Epub 2011 January 18].
-
(2011)
Blood
, vol.117
, pp. 3257-3267
-
-
Liu, Y.1
Johnson, S.M.2
Fedoriw, Y.3
-
86
-
-
80054926719
-
P16 ink4a: a central player in cellular senescence and a promising aging biomarker in elderly cancer patients
-
Vandenberk B., Brouwers B., Hatse S., Wildiers H. P16 ink4a: a central player in cellular senescence and a promising aging biomarker in elderly cancer patients. Journal of Geriatric Oncology 2011, 2:259-269.
-
(2011)
Journal of Geriatric Oncology
, vol.2
, pp. 259-269
-
-
Vandenberk, B.1
Brouwers, B.2
Hatse, S.3
Wildiers, H.4
-
87
-
-
0030058847
-
Early lymphopenia after cytotoxic chemotherapy as a risk factor for febrile neutropenia
-
Blay J.Y., Chauvin F., Le Cesne A., et al. Early lymphopenia after cytotoxic chemotherapy as a risk factor for febrile neutropenia. Journal of Clinical Oncology 1996, 14:636-643.
-
(1996)
Journal of Clinical Oncology
, vol.14
, pp. 636-643
-
-
Blay, J.Y.1
Chauvin, F.2
Le Cesne, A.3
-
88
-
-
0037468101
-
Baseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy
-
Ray-Coquard I., Borg C., Bachelot T., et al. Baseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy. British Journal of Cancer 2003, 88:181-186.
-
(2003)
British Journal of Cancer
, vol.88
, pp. 181-186
-
-
Ray-Coquard, I.1
Borg, C.2
Bachelot, T.3
-
89
-
-
25844515277
-
Lymphopenia: a new independent prognostic factor for survival in patients treated with whole brain radiotherapy for brain metastases from breast carcinoma
-
Claude L., Perol D., Ray-Coquard I., et al. Lymphopenia: a new independent prognostic factor for survival in patients treated with whole brain radiotherapy for brain metastases from breast carcinoma. Radiotherapy and Oncology 2005, 76:334-339.
-
(2005)
Radiotherapy and Oncology
, vol.76
, pp. 334-339
-
-
Claude, L.1
Perol, D.2
Ray-Coquard, I.3
-
90
-
-
67650481213
-
Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas
-
[Epub 2009 June 23]
-
Ray-Coquard I., Cropet C., Van Glabbeke M., et al. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Research 2009, 69:5383-5391. [Epub 2009 June 23].
-
(2009)
Cancer Research
, vol.69
, pp. 5383-5391
-
-
Ray-Coquard, I.1
Cropet, C.2
Van Glabbeke, M.3
-
91
-
-
79955466842
-
Immune profile of elderly patients admitted in a geriatric short care unit
-
Cretel E., Veen I., Pierres A., et al. Immune profile of elderly patients admitted in a geriatric short care unit. La Revue de Médecine Interne 2011, 32:275-282.
-
(2011)
La Revue de Médecine Interne
, vol.32
, pp. 275-282
-
-
Cretel, E.1
Veen, I.2
Pierres, A.3
-
92
-
-
50649111879
-
The immune risk profile is associated with age and gender: findings from three swedish population studies of individuals 20-100 years of age
-
Wikby A., Mansson I.A., Johansson B., Strindhall J., Nilsson S.E. The immune risk profile is associated with age and gender: findings from three swedish population studies of individuals 20-100 years of age. Biogerontology 2008, 9:299-308.
-
(2008)
Biogerontology
, vol.9
, pp. 299-308
-
-
Wikby, A.1
Mansson, I.A.2
Johansson, B.3
Strindhall, J.4
Nilsson, S.E.5
-
93
-
-
0032524932
-
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the swedish longitudinal octo-immune study
-
Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F.G. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the swedish longitudinal octo-immune study. Mechanisms of Ageing and Development 1998, 102:187-198.
-
(1998)
Mechanisms of Ageing and Development
, vol.102
, pp. 187-198
-
-
Wikby, A.1
Maxson, P.2
Olsson, J.3
Johansson, B.4
Ferguson, F.G.5
-
94
-
-
0037398104
-
Survival in a population sample is predicted by proportions of lymphocyte subsets
-
Huppert F.A., Pinto E.M., Morgan K., Brayne C. Survival in a population sample is predicted by proportions of lymphocyte subsets. Mechanisms of Ageing and Development 2003, 124:449-451.
-
(2003)
Mechanisms of Ageing and Development
, vol.124
, pp. 449-451
-
-
Huppert, F.A.1
Pinto, E.M.2
Morgan, K.3
Brayne, C.4
-
95
-
-
59049088629
-
B-cell diversity decreases in old age and is correlated with poor health status
-
[Epub 2008 November 5]
-
Gibson K.L., Wu Y.C., Barnett Y., et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 2009, 8:18-25. [Epub 2008 November 5].
-
(2009)
Aging Cell
, vol.8
, pp. 18-25
-
-
Gibson, K.L.1
Wu, Y.C.2
Barnett, Y.3
-
96
-
-
0242317690
-
Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination - an impact of immunosenescence
-
Trzonkowski P., Mysliwska J., Szmit E., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination - an impact of immunosenescence. Vaccine 2003, 21:3826-3836.
-
(2003)
Vaccine
, vol.21
, pp. 3826-3836
-
-
Trzonkowski, P.1
Mysliwska, J.2
Szmit, E.3
-
97
-
-
57949087452
-
Molecular inflammation: underpinnings of aging and age-related diseases
-
[Epub 2008 July 18]
-
Chung H.Y., Cesari M., Anton S., et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Research Reviews 2009, 8:18-30. [Epub 2008 July 18].
-
(2009)
Ageing Research Reviews
, vol.8
, pp. 18-30
-
-
Chung, H.Y.1
Cesari, M.2
Anton, S.3
-
98
-
-
73749083928
-
Gene variants as determinants of longevity: focus on the inflammatory factors
-
Jylhava J., Hurme M. Gene variants as determinants of longevity: focus on the inflammatory factors. Pflugers Archiv 2009, 459:239-246.
-
(2009)
Pflugers Archiv
, vol.459
, pp. 239-246
-
-
Jylhava, J.1
Hurme, M.2
-
99
-
-
79751537155
-
Inflammaging: the driving force in osteoporosis?
-
Lencel P., Magne D. Inflammaging: the driving force in osteoporosis?. Medical Hypotheses 2011, 76:317-321.
-
(2011)
Medical Hypotheses
, vol.76
, pp. 317-321
-
-
Lencel, P.1
Magne, D.2
-
100
-
-
77952302657
-
Inflammaging (inflammation+aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
-
Goto M. Inflammaging (inflammation+aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?. BioScience Trends 2008, 2:218-230.
-
(2008)
BioScience Trends
, vol.2
, pp. 218-230
-
-
Goto, M.1
-
101
-
-
83555165089
-
C-reactive protein as a biomarker for urological cancers
-
Saito K., Kihara K C-reactive protein as a biomarker for urological cancers. Nature Reviews Urology 2011, 8:659-666.
-
(2011)
Nature Reviews Urology
, vol.8
, pp. 659-666
-
-
Saito, K.1
Kihara, K.2
|