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Volumn 63, Issue 7, 2003, Pages 1596-1601

Methylation of p16INK4a promoters occurs in vivo in histologically normal human mammary epithelia

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

EID: 0037380886     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (216)

References (29)
  • 1
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov, S. R., Kozakiewicz, B. K., Holst, C. R., Stampfer, M. R., Haupt, L. M., and Tlsty, T. D. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature (Lond.), 409: 633-637, 2001.
    • (2001) Nature (Lond.) , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3    Stampfer, M.R.4    Haupt, L.M.5    Tlsty, T.D.6
  • 3
    • 0345178412 scopus 로고
    • Serum-free growth of human mammary epithelial cells: Rapid clonal growth in defined medium and extended serial passage with pituitary extract
    • Hammond, S. L., Ham, R. G., and Stampfer, M. R. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc. Natl. Acad. Sci. USA, 81: 5435-5439, 1984.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5435-5439
    • Hammond, S.L.1    Ham, R.G.2    Stampfer, M.R.3
  • 4
    • 0032537762 scopus 로고    scopus 로고
    • Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
    • Brenner, A. J., Stampfer, M. R., and Aldaz, C. M. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene, 17: 199-205, 1998.
    • (1998) Oncogene , vol.17 , pp. 199-205
    • Brenner, A.J.1    Stampfer, M.R.2    Aldaz, C.M.3
  • 5
    • 0031899814 scopus 로고    scopus 로고
    • Inactivation of p16 in human mammary epithelial cells by CpG island methylation
    • Foster, S. A., Wong, D. J., Barrett, M. T., and Galloway, D. A. Inactivation of p16 in human mammary epithelial cells by CpG island methylation. Mol. Cell. Biol, 18: 1793-1801, 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1793-1801
    • Foster, S.A.1    Wong, D.J.2    Barrett, M.T.3    Galloway, D.A.4
  • 6
    • 0032528623 scopus 로고    scopus 로고
    • Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
    • Huschtscha, L. I., Noble, J. R., Neumann, A. A., Moy, E. L., Barry, P., Melki, J. R., Clark, S. J., and Reddel, R. R. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res., 58: 3508-3512, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 3508-3512
    • Huschtscha, L.I.1    Noble, J.R.2    Neumann, A.A.3    Moy, E.L.4    Barry, P.5    Melki, J.R.6    Clark, S.J.7    Reddel, R.R.8
  • 8
    • 0034660862 scopus 로고    scopus 로고
    • Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: An implication for mutator phenotype and breast cancer pathogenesis
    • Shen, C. Y., Yu, J. C., Lo, Y. L., Kuo, C. H., Yue, C. T., Jou, Y. S., Huang, C. S., Lung, J. C., and Wu, C. W. Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis. Cancer Res., 60: 3884-3892, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 3884-3892
    • Shen, C.Y.1    Yu, J.C.2    Lo, Y.L.3    Kuo, C.H.4    Yue, C.T.5    Jou, Y.S.6    Huang, C.S.7    Lung, J.C.8    Wu, C.W.9
  • 11
    • 0033607147 scopus 로고    scopus 로고
    • In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
    • Nuovo, G. J., Plaia, T. W., Belinsky, S. A., Baylin, S. B., and Herman, J. G. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc. Natl. Acad. Sci. USA, 96: 12754-12759, 1999.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12754-12759
    • Nuovo, G.J.1    Plaia, T.W.2    Belinsky, S.A.3    Baylin, S.B.4    Herman, J.G.5
  • 12
    • 0001641514 scopus 로고
    • Mutations of bacteria from virus sensitivity to virus resistance
    • Luria, S. E., and Delbrück, M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics, 28: 491-511, 1943.
    • (1943) Genetics , vol.28 , pp. 491-511
    • Luria, S.E.1    Delbrück, M.2
  • 13
    • 0024357990 scopus 로고
    • Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis
    • Tlsty, T. D., Margolin, B. H., and Lum, K. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proc. Natl. Acad. Sci. USA, 86: 9441-9445, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9441-9445
    • Tlsty, T.D.1    Margolin, B.H.2    Lum, K.3
  • 14
    • 0021996908 scopus 로고
    • Breast reductions: What to do with all the tissue specimens?
    • Bondeson, L., Linell, F., and Ringberg, A. Breast reductions: what to do with all the tissue specimens? Histopathology, 9: 281-285, 1985.
    • (1985) Histopathology , vol.9 , pp. 281-285
    • Bondeson, L.1    Linell, F.2    Ringberg, A.3
  • 15
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T., Beart, R. W., Van Tornout, J. M., and Jones, P. A. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55: 4531-4535, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 16
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55: 4525-4530, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 17
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 18
    • 0031710479 scopus 로고    scopus 로고
    • The INK4a/ARF tumor suppressor: One gene-two products-two pathways
    • Chin, L., Pomerantz, J., and DePinho, R. A. The INK4a/ARF tumor suppressor: one gene-two products-two pathways. Trends Biochem. Sci., 23: 291-296, 1998.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 291-296
    • Chin, L.1    Pomerantz, J.2    DePinho, R.A.3
  • 19
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. Cancer cell cycles. Science (Wash. DC), 274: 1672-1677, 1996.
    • (1996) Science (Wash. DC) , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 22
    • 0023589208 scopus 로고
    • Breast cancer and atypia among young and middle-aged women: A study of 110 medicolegal autopsies
    • Nielsen, M., Thomsen, J. L., Primdahl, S., Dyreborg, U., and Andersen, J. A. Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies. Br. J. Cancer, 56: 814-819, 1987.
    • (1987) Br. J. Cancer , vol.56 , pp. 814-819
    • Nielsen, M.1    Thomsen, J.L.2    Primdahl, S.3    Dyreborg, U.4    Andersen, J.A.5
  • 23
    • 0021814507 scopus 로고
    • The prevalence of carcinoma in situ in normal and cancer-associated breasts
    • Alpers, C. E., and Wellings, S. R. The prevalence of carcinoma in situ in normal and cancer-associated breasts. Hum. Pathol., 16: 796-807, 1985.
    • (1985) Hum. Pathol. , vol.16 , pp. 796-807
    • Alpers, C.E.1    Wellings, S.R.2
  • 24
    • 0023629547 scopus 로고
    • Prevalence of benign, atypical, and malignant breast lesions in populations at different risk for breast cancer. A forensic autopsy study
    • Bartow, S. A., Pathak, D. R., Black, W. C., Key, C. R., and Teaf, S. R. Prevalence of benign, atypical, and malignant breast lesions in populations at different risk for breast cancer. A forensic autopsy study. Cancer (Phila.), 60: 2751-2760, 1987.
    • (1987) Cancer (Phila.) , vol.60 , pp. 2751-2760
    • Bartow, S.A.1    Pathak, D.R.2    Black, W.C.3    Key, C.R.4    Teaf, S.R.5
  • 25
    • 0021989888 scopus 로고
    • Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian women
    • Bhathal, P. S., Brown, R. W., Lesueur, G. C., and Russell, I. S. Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian women. Br. J. Cancer, 51: 271-278, 1985.
    • (1985) Br. J. Cancer , vol.51 , pp. 271-278
    • Bhathal, P.S.1    Brown, R.W.2    Lesueur, G.C.3    Russell, I.S.4
  • 26
    • 0030658933 scopus 로고    scopus 로고
    • Using autopsy series to estimate the disease "reservoir" for ductal carcinoma in situ of the breast: How much more breast cancer can we find?
    • Welch, H. G., and Black, W. C. Using autopsy series to estimate the disease "reservoir" for ductal carcinoma in situ of the breast: how much more breast cancer can we find? Ann. Intern. Med., 127: 1023-1028, 1997.
    • (1997) Ann. Intern. Med. , vol.127 , pp. 1023-1028
    • Welch, H.G.1    Black, W.C.2
  • 27
    • 0030461224 scopus 로고    scopus 로고
    • Loss of heterozygosity in normal tissue adjacent to breast carcinomas
    • Deng, G., Lu, Y., Zlotnikov, G., Thor, A. D., and Smith, H. S. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science (Wash. DC), 274: 2057-2059, 1996.
    • (1996) Science (Wash. DC) , vol.274 , pp. 2057-2059
    • Deng, G.1    Lu, Y.2    Zlotnikov, G.3    Thor, A.D.4    Smith, H.S.5
  • 29
    • 0034079977 scopus 로고    scopus 로고
    • p53 protein accumulation and mutations in normal and benign breast tissue
    • Kandel, R., Li, S. Q., Ozcelik, H., and Rohan, T. p53 protein accumulation and mutations in normal and benign breast tissue. Int. J. Cancer, 87: 73-78, 2000.
    • (2000) Int. J. Cancer , vol.87 , pp. 73-78
    • Kandel, R.1    Li, S.Q.2    Ozcelik, H.3    Rohan, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.