The effect of long-term dietary supplementation with antioxidants

Annals of the New York Academy of Sciences

Volumn 854, Issue , 1998, Pages 352-360

  Meydani, M ^a   Lipman, R D ^a   Han, S N ^a   Wu, D ^a   Beharka, A ^a   Martin, K R ^a   Bronson, R ^a   Cao, G ^a   Smith, D ^a   Meydani, S N ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; FREE RADICAL; GLUTATHIONE; MELATONIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ATHEROSCLEROSIS; CALORIC RESTRICTION; CANCER; CELL FUNCTION; CELL INTERACTION; CONFERENCE PAPER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; HEART DISEASE; IMMUNITY; IMMUNOCOMPETENT CELL; INFLUENZA; LIFESPAN; LIPID PEROXIDATION; LIVER; LONG TERM CARE; LONGEVITY; LUNG; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROVOCATION TEST; VIRUS LOAD;

ANIMALIA; FRAGARIA X ANANASSA;

EID: 0032421444     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09915.x     Document Type: Conference Paper

References (50)

1. HARMAN, D. 1956. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 11: 198-300.
2. YU, B.P. 1993. Free Radicals in Aging. CRC Press. Boca Raton, FL.
3. YU, B.P. 1993. In Free Radicals in Aging. B.P. YU, Ed.:57-88. CRC Press. Boca Raton, FL.
4. CUTLER, R.G. 1991. Antioxidants and aging. Am. J. Clin. Nutr. 53: 373S-379S.
5. TOLMASOFF, J. M. et al. 1980. Superoxide dismutase: Correlation with life span and specific metabolic rate in primate species. Proc. Natl. Acad. Sci. USA 77: 2777-2781.
6. SOHAL, R.S., & WEINDRUCH, R. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59-63.
7. SOHAL, R.S., et al. 1995. Simultaneous overexpression of copper- and zinc-containing Superoxide dismutase and catalase retard age-related oxidative damage and increases metabolic potential on Drosophila melanogaster. J. Biol. Chem. 270: 15671-15674.
8. HARMAN, D. 1968. Free radical theory of aging: Effect of free radical inhibitors on the mortality rate of male LFA mice. J. Gerontol. 23: 476-482.
9. COMFORT, A. 1971. Effect of ethoxyquin on the longevity of C3H mice. Nature 229: 254-255.
10. KOHN, R.R. 1971. Effect of antioxidants on life span of C57/BL mice. J. Gerontol. 26: 376-380.
11. CLAPP, N.K. et al. 1979. Effects of the antioxidant buthylated hydroxytoluene (BHT) on mortality in BALB/c mice. J. Gerontol. 34: 497-501.
12. HARMAN, D. 1980. Free radical theory of aging: Beneficial effect of antioxidants on the life span of male NZB mice; role of free radical reactions in the deterioration of the immune system with age and in the pathogenesis of systemic lupus erythematosus. Age 3: 64-73.
13. HARMAN, D. 1994. Aging: Prospect for further increases in the functional life span. Age 17: 119-146.
14. MEYDANI, S.N. et al. 1986. Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice. Mech. Aging Dev. 34: 191-201.
15. FURUKAWA, T. et al. 1987. Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mech. Aging Dev. 38: 107-117.
16. REITER, R.J., M.I. PABLOS, T.T. AGAPITO & J.M. GUERRERO. 1996. Melatonin in the context of the free radical theory of aging. Ann. N.Y. Acad. Sci. 786: 362-378.
17. PIERPAOLI, W. & W. REGELSON. 1994. Pineal control of aging: Effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA 91: 787-791.
18. WANG, H. et al. 1996. Total antioxidant capacity of fruits. J. Agric. Food Chem. 44: 701-705.
19. BEXLEPKIN, V.G. et al. 1996. The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet. Mech. Aging. Dev. 92: 227-234.
20. GOODRICK, C.L. et al. 1990. Effects of intermittent feeding upon body weight and life span in inbred mice: Interaction of genotype and age. Mech. Aging. Dev. 55: 69-87.
21. TURTURRO, A.K. BLANK, D. MURASKO & R. HART. 1994. Mechanisms of caloric restriction affecting aging and disease. Ann. N.Y. Acad. Sci. 719: 159-170.
22. HENNET, T. et al. 1992. Alterations in antioxidant defenses in lung and liver of mice infected with influenza A virus. J. Gen. Virol. 73: 39-46.
23. PETERHANS, E. 1994. In Natural Antioxidants in Human Health and Disease. B. Frei, Ed.: 489-514. Academic Press. San Diego.
24. BUFFINTON, G.D. et al. 1992. Oxidative stress in lung of mice infected with influenza A virus. Free Radical Res. Commun. 16: 99-110.
25. MEYDANI, S.N. et al. 1990. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am. J. Clin. Nutr. 52: 557-563.
26. MEYDANI, S.N. et al. 1997. Vitamin E supplementation enhances in vivo immune response in healthy elderly: A dose-response study. J. Am. Med. Assoc. 277: 1380-1386.
27. HALLIWELL, B. 1994. Free radicals and antioxidants: A personal view. Nutr. Rev. 52: 253-265.
28. HALLIWELL, B. & J.M.C. GUTTERIDGE. 1995. Free Radicals in Biology and Medicine. Oxford University Press. Oxford.
29. FREI, B. 1994. Natural Antioxidants in Human Health and Disease. Academic Press. San Diego.
30. AMES, B.N. et al. 1993. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90: 7915-7922.
31. MEYDANI, M. 1995. Vitamin E. Lancet 345: 170-175.
32. BLOCK, G. 1991. Vitamin C and cancer prevention: The epidemiologic evidence. Am. J. Clin. Nutr. 53: 270S-282S.
33. MEYDANI, S.N. et al. 1995. Antioxidants and the immune response in aged persons: Overview of the present evidence. Am. J. Clin. Nutr. 62: 1462S-1476S.
34. BLOT, W.J. et al. 1995. The Linxian Trials: Mortality rates by vitamin-mineral intervention group. Am. J. Clin. Nutr. 62(suppl): 1425S-1426S.
35. The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group. 1994. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330: 1029-1035.
36. GOODMAN, G.E. et al. 1996. The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer. Cancer Epidemiol. Biomarks Prev. 5: 815-821.
37. HENNEKENS, C.H. et al. 1996. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 334: 1145-1149.
38. KNIGHT, J.A. 1995. Diseases related to oxygen-derived free radicals. Ann. Clin. Lab. Sci. 25: 111-121.
39. GEY, K.F. et al. 1987. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am. J. Clin. Nutr. 45: 1368-1377.
40. RIMM, E.B. et al. 1993. Vitamin E consumption and the risk of coronary heart disease in men. N. Engl. J. Med. 328: 1450-1456.
41. STAMPFER, M.J. et al. 1993. Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 328: 1444-1449.
42. LOSONCZY, K.G. et al. 1996. Vitamin E and vitamin C supplementation use and risk of all-cause and coronary heart disease mortality in older persons: The Established Populations for Epidemiologic Studies of the Elderly. Am. J. Clin. Nutr. 64: 190-196.
43. KUSHI, L.H. et al. 1996. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N. Engl. J. Med. 334: 1156-1162.
44. HODIS, H.N. et al. 1995. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. J. Am. Med. Assoc. 273: 1849-1854.
45. STEPHENS, N.G. et al. 1996. Randomized, controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347: 781-786.
46. FARUQI, R. et al. 1994. α-Tocopherol inhibits against induced monocytic cell adhesion to cultured human endothelial cells. J. Clin. Invest. 94: 592-600.
47. MARTIN, A. et al. 1997. Vitamin E inhibits low density lipoprotein-induced adhesion of monocytes to human aortic endothclial cells m vitro. Arteriosclcr. Thromb. Vasc. Biol. 17: 429-436.
48. MEYDANI, S.N. & R.P. TENGERDY. 1992. In Vitamin E in Health and Disease. L. Packer & J. Fuchs, Eds.: 549-562. Marcel Dekker. New York.
49. SANO, M. et al. 1997. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336: 1216-1222.
50. FAHN, S. 1991. An open trial of high-dosase antioxidants in early Parkinson's disease. Am. J. Clin. Nutr. 53: 380S-382S.