The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5)

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28307-28314

  Zhou, Yeyun ^a   Zhang, Hongmin ^b   He, Bin ^a   Du, Jintang ^a   Lin, Hening ^a   Cerione, Richard A ^a   Hao, Quan ^a  

^a Animal Health Diagnostic Center   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; AMINO ACIDS; CATALYSIS; METABOLISM; PEPTIDES; REACTION INTERMEDIATES;

BIOCHEMICAL STUDIES; DEACETYLASE ACTIVITY; ENERGY METABOLISM; INTERMEDIATE STRUCTURES; REACTION MECHANISM; SPECIFIC INHIBITORS; STRUCTURAL INFORMATION; THERAPEUTIC POTENTIALS;

CRYSTAL STRUCTURE;

NICOTINAMIDE; SIRTUIN 3; SIRTUIN 5;

ARTICLE; BETA SHEET; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; DEACYLATION; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

EID: 84865225339     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.384511     Document Type: Article

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