How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations

Journal of the American Chemical Society

Volumn 130, Issue 12, 2008, Pages 3806-3813

  Hu, Po ^a   Wang, Shenglong ^a   Zhang, Yingkai ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYL-TRANSFER REACTION; RUBISCO LARGE SUBUNIT METHYLTRANSFERASE (LSMT); SET-DOMAIN;

ACTIVATION ENERGY; BINDING SITES; COMPUTER SIMULATION; METHYLATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; QUANTUM THEORY;

PROTEINS;

LYSINE METHYLTRANSFERASE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING SITE; METHYLATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PROTEIN BINDING; PROTEIN DOMAIN; QUANTUM MECHANICS; SIMULATION;

COMPUTER SIMULATION; HISTONE-LYSINE N-METHYLTRANSFERASE; METHYLATION; MODELS, CHEMICAL; QUANTUM THEORY; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 41149125431     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja075896n     Document Type: Article

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