Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate

Journal of the American Chemical Society

Volumn 131, Issue 20, 2009, Pages 6989-6996

  Asaba, Tomomi ^a   Suzuki, Takayoshi ^a   Ueda, Rie ^a   Tsumoto, Hiroki ^a   Nakagawa, Hidehiko ^a   Miyata, Naoki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADP-RIBOSE; CATALYTIC MECHANISMS; DOSE-DEPENDENT; DRUG DESIGN; HIGH SELECTIVITY; HUMAN COLON CANCER; IN-SITU; IN-VITRO ASSAYS; INHIBITORY ACTIVITY; KINETIC ANALYSIS; MASS SPECTROSCOPY; MECHANISTIC STUDIES;

AMINO ACIDS; ENZYME ACTIVITY; MASS SPECTROMETRY; SUBSTRATES;

ENZYME INHIBITION;

ADENOSINE DIPHOSPHATE; HYDROLASE INHIBITOR; LYSINE; PROTEIN P53; RIBOSE; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN INHIBITOR; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSE; DRUG DERIVATIVE; SIRT1 PROTEIN, HUMAN;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KINETICS; MASS SPECTROMETRY; WESTERN BLOTTING; CELL STRAIN HCT116; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; NUCLEAR MAGNETIC RESONANCE;

ACETYLATION; ADENOSINE DIPHOSPHATE RIBOSE; HCT116 CELLS; HUMANS; KINETICS; LYSINE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SIRTUIN 1; SIRTUINS;

EID: 70149123204     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja807083y     Document Type: Article

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