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Volumn 7, Issue 1, 2013, Pages 43-55

The emergence of new therapeutic targets in pulmonary arterial hypertension: From now to the near future

Author keywords

anti inflammatory therapy; dehydroepiandrosterone; endothelial dysfunction; microRNA; pulmonary arterial hypertension; pulmonary hypertension; therapeutic targets; tyrosine kinase inhibitors; vascular remodeling

Indexed keywords

FRACTALKINE; IMATINIB; MICRORNA; NILOTINIB; PRASTERONE; STAT3 PROTEIN;

EID: 84873180886     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.12.83     Document Type: Review
Times cited : (14)

References (130)
  • 1
    • 67649579669 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G, Robbins IM, Beghetti M et al. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S43-S54 (2009).
    • (2009) J. Am. Coll. Cardiol , vol.54 SUPPL. 1
    • Simonneau, G.1    Robbins, I.M.2    Beghetti, M.3
  • 2
    • 33646269035 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in France: Results from a national registry
    • Humbert M, Sitbon O, Chaouat A et al.Pulmonary arterial hypertension in France: results from a national registry. Am. J. Respir. Crit. Care Med. 173(9), 1023-1030 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.173 , Issue.9 , pp. 1023-1030
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 5
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N. Engl. J. Med. 351(14), 1425-1436 (2004).
    • (2004) N. Engl. J. Med , vol.351 , Issue.14 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 6
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur. Heart J
    • Galiè N, Hoeper MM, Humbert M et al.; ESC Committee for Practice Guidelines (CPG). Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur. Heart J. 30(20), 2493-2537 (2009).
    • (2009) ESC Committee for Practice Guidelines (CPG , vol.30 , Issue.20 , pp. 2493-2537
    • Galiè, N.1    Hoeper, M.M.2    Humbert, M.3
  • 7
    • 84873126341 scopus 로고    scopus 로고
    • Contemporary trends in the diagnosis and management of pulmonary arterialhypertension: An initiative to close the care gap
    • doi:10.1378/chest.11-3060 Epub ahead of print
    • Mclaughlin VV, Langer A, Tan M et al. Contemporary trends in the diagnosis and management of pulmonary arterialhypertension: an initiative to close the care gap. Chest doi:10.1378/chest.11-3060 (2012) (Epub ahead of print).
    • (2012) Chest
    • McLaughlin, V.V.1    Langer, A.2    Tan, M.3
  • 8
    • 0021193273 scopus 로고
    • Primary pulmonary hypertension: Natural history and the importance of thrombosis
    • Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 70(4), 580-587 (1984). (Pubitemid 14020655)
    • (1984) Circulation , vol.70 , Issue.4 , pp. 580-587
    • Fuster, V.1    Steele, P.M.2    Edwards, W.D.3
  • 9
    • 0031719459 scopus 로고    scopus 로고
    • The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension
    • Rich S, Seidlitz M, Dodin E et al. The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension. Chest 114(3), 787-792 (1998). (Pubitemid 28433741)
    • (1998) Chest , vol.114 , Issue.3 , pp. 787-792
    • Rich, S.1    Seidlitz, M.2    Dodin, E.3    Osimani, D.4    Judd, D.5    Genthner, D.6    McLaughlin, V.7    Francis, G.8
  • 11
    • 84861429418 scopus 로고    scopus 로고
    • Safety and efficacy of exercise training in various forms of pulmonary hypertension
    • Grünig E, Lichtblau M, Ehlken N et al. Safety and efficacy of exercise training in various forms of pulmonary hypertension. Eur. Respir. J. 40(1), 84-92 (2012).
    • (2012) Eur. Respir. J , vol.40 , Issue.1 , pp. 84-92
    • Grünig, E.1    Lichtblau, M.2    Ehlken, N.3
  • 12
    • 67651100501 scopus 로고    scopus 로고
    • Opposite effects of training in rats with stable and progressive pulmonary hypertension
    • Handoko ML, de Man FS, Happé CM et al. Opposite effects of training in rats with stable and progressive pulmonary hypertension. Circulation 120(1), 42-49 (2009).
    • (2009) Circulation , vol.120 , Issue.1 , pp. 42-49
    • Handoko, M.L.1    De Man, F.S.2    Happé, C.M.3
  • 14
    • 0025943997 scopus 로고
    • High dose titration of calcium channel blocking agents for primary pulmonary hypertension: Guidelines for short-term drug testing
    • Rich S, Kaufmann E. High dose titration of calcium channel blocking agents for primary pulmonary hypertension: guidelines for short-term drug testing. J. Am. Coll. Cardiol. 18(5), 1323-1327 (1991).
    • (1991) J. Am. Coll. Cardiol , vol.18 , Issue.5 , pp. 1323-1327
    • Rich, S.1    Kaufmann, E.2
  • 16
    • 46449124591 scopus 로고    scopus 로고
    • Ambrisentan for the treatment of pulmonary arterial hypertension: results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation
    • Galiè N, Olschewski H, Oudiz RJ et al.; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation 117(23), 3010-3019 (2008).
    • (2008) Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group , vol.117 , Issue.23 , pp. 3010-3019
    • Galiè, N.1    Olschewski, H.2    Oudiz, R.J.3
  • 18
    • 45249119855 scopus 로고    scopus 로고
    • Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): A double-blind, randomised controlled trial
    • DOI 10.1016/S0140-6736(08)60919-8, PII S0140673608609198
    • Galiè N, Rubin Lj, Hoeper M et al. Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 371(9630), 2093-2100 (2008). (Pubitemid 351902178)
    • (2008) The Lancet , vol.371 , Issue.9630 , pp. 2093-2100
    • Galie, N.1    Rubin, L.2    Hoeper, M.3    Jansa, P.4    Al-Hiti, H.5    Meyer, G.6    Chiossi, E.7    Kusic-Pajic, A.8    Simonneau, G.9
  • 20
    • 57349133022 scopus 로고    scopus 로고
    • Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist
    • Iglarz M, Binkert C, Morrison K et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J. Pharmacol. Exp. Ther. 327(3), 736-745 (2008).
    • (2008) J. Pharmacol. Exp. Ther , vol.327 , Issue.3 , pp. 736-745
    • Iglarz, M.1    Binkert, C.2    Morrison, K.3
  • 21
    • 84865010567 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans
    • Bruderer S, Hopfgartner G, Seiberling M et al. Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans. Xenobiotica 42(9), 901-910 (2012).
    • (2012) Xenobiotica , vol.42 , Issue.9 , pp. 901-910
    • Bruderer, S.1    Hopfgartner, G.2    Seiberling, M.3
  • 22
    • 84857627857 scopus 로고    scopus 로고
    • Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist
    • Bruderer S, Aänismaa P, Homery MC et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 14(1), 68-78 (2012).
    • (2012) AAPS J , vol.14 , Issue.1 , pp. 68-78
    • Bruderer, S.1    Aänismaa, P.2    Homery, M.C.3
  • 23
    • 84872192521 scopus 로고    scopus 로고
    • Effect of macitentan on morbidity and mortality in pulmonary arterial hypertension (PAH): Results from the SERAPHIN Trial
    • Rubin L, Pulido T, Channick R et al. Effect of macitentan on morbidity and mortality in pulmonary arterial hypertension (PAH): results from the SERAPHIN Trial. Chest 142(4), 1026A-1026A (2012).
    • (2012) Chest , vol.142 , Issue.4
    • Rubin, L.1    Pulido, T.2    Channick, R.3
  • 24
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • Moncada S, Gryglewski R, Bunting S, Vane Jr. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263(5579), 663-665 (1976).
    • (1976) Nature , vol.263 , Issue.5579 , pp. 663-665
    • Moncada, S.1    Gryglewski, R.2    Bunting, S.3    Vane, J.R.4
  • 28
    • 77952301237 scopus 로고    scopus 로고
    • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial
    • McLaughlin VV, Benza RL, Rubin LJ et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J. Am. Coll. Cardiol. 55(18), 1915-1922 (2010).
    • (2010) J. Am. Coll. Cardiol , vol.55 , Issue.18 , pp. 1915-1922
    • McLaughlin, V.V.1    Benza, R.L.2    Rubin, L.J.3
  • 32
    • 84866515810 scopus 로고    scopus 로고
    • Oral Treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (The FREEDOM-C Study): A randomized controlled trial
    • Tapson VF, Torres F, Kermeen F et al. Oral Treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (The FREEDOM-C Study): a randomized controlled trial. Chest 142(6), 1383-1390 (2012).
    • (2012) Chest , vol.142 , Issue.1383-1390
    • Tapson, V.F.1    Torres, F.2    Kermeen, F.3
  • 33
    • 84873198900 scopus 로고    scopus 로고
    • EPITOME-2, an open-label study evaluating a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from Flolan®
    • Sitbon O, Delcroix M, Bergot E et al. EPITOME-2, an open-label study evaluating a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from Flolan®. Am. J. Respir. Crit. Care Med. 185(A2500) (2012).
    • (2012) Am. J. Respir. Crit. Care Med , vol.185
    • Sitbon, O.1    Delcroix, M.2    Bergot, E.3
  • 34
    • 64849109410 scopus 로고    scopus 로고
    • American college of cardiology foundation task force on expert consensus documents; American heart association; American college of chest physicians; American thoracic society, inc; Pulmonary hypertension association. accf/aha 2009 expert consensus document on pulmonary hypertension a report of the american college of cardiology foundation task force on expert consensus documents and the
    • American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association
    • McLaughlin VV, Archer SL, Badesch DB et al.; American College of Cardiology Foundation Task Force on Expert Consensus Documents; American Heart Association; American College of Chest Physicians; American Thoracic Society, Inc; Pulmonary Hypertension Association. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J. Am. Coll. Cardiol. 53(17), 1573-1619 (2009).
    • (2009) J. Am. Coll. Cardiol , vol.53 , Issue.17 , pp. 1573-1619
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 35
    • 84863528040 scopus 로고    scopus 로고
    • Selexipag: An oral, selective prostacyclin receptor agonist for the treatment ofpulmonary arterial hypertension
    • Simonneau G, Torbicki A, Hoeper MM et al. Selexipag: an oral, selective prostacyclin receptor agonist for the treatment ofpulmonary arterial hypertension. Eur. Respir. J. 40(4), 874-880 (2012).
    • (2012) Eur. Respir. J , vol.40 , Issue.4 , pp. 874-880
    • Simonneau, G.1    Torbicki, A.2    Hoeper, M.M.3
  • 36
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil use in pulmonary arterial hypertension (super) study group. Sildenafil citrate therapy for pulmonary arterial hypertension
    • Galiè N, Ghofrani HA, Torbicki A et al.; Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. 353(20), 2148-2157 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.20 , pp. 2148-2157
    • Galiè, N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 37
    • 67649523052 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension and response to tadalafil (phirst) study group tadalafil therapy for pulmonary arterial hypertension
    • Galiè N, Brundage BH, Ghofrani HA et al.; Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST) Study Group. Tadalafil therapy for pulmonary arterial hypertension. Circulation 119(22), 2894-2903 (2009).
    • (2009) Circulation , vol.119 , Issue.22 , pp. 2894-2903
    • Galiè, N.1    Brundage, B.H.2    Ghofrani, H.A.3
  • 39
    • 67651094166 scopus 로고    scopus 로고
    • Discovery of riociguat (BAY 63-2521): A potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
    • Mittendorf J, Weigand S, Alonso-Alija C et al. Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4(5), 853-865 (2009).
    • (2009) ChemMedChem , vol.4 , Issue.5 , pp. 853-865
    • Mittendorf, J.1    Weigand, S.2    Alonso-Alija, C.3
  • 40
    • 53849089139 scopus 로고    scopus 로고
    • Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
    • Schermuly RT, Stasch JP, Pullamsetti SS et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur. Respir. J. 32(4), 881-891 (2008).
    • (2008) Eur. Respir. J , vol.32 , Issue.4 , pp. 881-891
    • Schermuly, R.T.1    Stasch, J.P.2    Pullamsetti, S.S.3
  • 41
    • 82555195583 scopus 로고    scopus 로고
    • Looking to the future: A new decade of pulmonary arterial hypertension therapy
    • McLaughlin VV. Looking to the future: a new decade of pulmonary arterial hypertension therapy. Eur. Respir. Rev. 20(122), 262-269 (2011).
    • (2011) Eur. Respir. Rev , vol.20 , Issue.122 , pp. 262-269
    • McLaughlin, V.V.1
  • 42
    • 77956664858 scopus 로고    scopus 로고
    • Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: A Phase II study
    • Ghofrani HA, Hoeper MM, Halank M et al. Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a Phase II study. Eur. Respir. J. 36(4), 792-799 (2010).
    • (2010) Eur. Respir. J , vol.36 , Issue.4 , pp. 792-799
    • Ghofrani, H.A.1    Hoeper, M.M.2    Halank, M.3
  • 43
    • 84867742487 scopus 로고    scopus 로고
    • Combination therapy improves exercise capacity and reduces risk of clinical worsening in patients with pulmonary arterial hypertension: A meta-analysis
    • Zhu B, Wang L, Sun L, Cao R. Combination therapy improves exercise capacity and reduces risk of clinical worsening in patients with pulmonary arterial hypertension: a meta-analysis. J. Cardiovasc. Pharmacol. 60(4), 342-346 (2012).
    • (2012) J. Cardiovasc. Pharmacol , vol.60 , Issue.4 , pp. 342-346
    • Zhu, B.1    Wang, L.2    Sun, L.3    Cao, R.4
  • 44
    • 84860404865 scopus 로고    scopus 로고
    • Meta-analysis of monotherapy versus combination therapy for pulmonary arterial hypertension
    • Fox BD, Shimony A, Langleben D. Meta-analysis of monotherapy versus combination therapy for pulmonary arterial hypertension. Am. J. Cardiol. 108(8), 1177-1182 (2011).
    • (2011) Am. J. Cardiol , vol.108 , Issue.8 , pp. 1177-1182
    • Fox, B.D.1    Shimony, A.2    Langleben, D.3
  • 45
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122(2), 156-163 (2010).
    • (2010) Circulation , vol.122 , Issue.2 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 46
    • 80755153114 scopus 로고    scopus 로고
    • From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension
    • Paulin R, Courboulin A, Barrier M, Bonnet S. From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension. J. Mol. Med. 89(11), 1089-1101 (2011).
    • (2011) J. Mol. Med , vol.89 , Issue.11 , pp. 1089-1101
    • Paulin, R.1    Courboulin, A.2    Barrier, M.3    Bonnet, S.4
  • 47
    • 0034749277 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide: Cardiovascular effects
    • Henning RJ, Sawmiller DR. Vasoactive intestinal peptide: cardiovascular effects. Cardiovasc. Res. 49(1), 27-37 (2001).
    • (2001) Cardiovasc. Res , vol.49 , Issue.1 , pp. 27-37
    • Henning, R.J.1    Sawmiller, D.R.2
  • 48
    • 77952492039 scopus 로고    scopus 로고
    • New therapies for pulmonary arterial hypertension: An update on current bench to bedside translation
    • Dewachter L, Dewachter C, Naeije R. New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation. Expert Opin. Investig. Drugs 19(4), 469-488 (2010).
    • (2010) Expert Opin. Investig. Drugs , vol.19 , Issue.4 , pp. 469-488
    • Dewachter, L.1    Dewachter, C.2    Naeije, R.3
  • 50
    • 58849114113 scopus 로고    scopus 로고
    • Inhalation of vasoactive intestinal peptide in pulmonary hypertension
    • Leuchte HH, Baezner C, Baumgartner RA et al. Inhalation of vasoactive intestinal peptide in pulmonary hypertension. Eur. Respir. J. 32(5), 1289-1294 (2008).
    • (2008) Eur. Respir. J , vol.32 , Issue.5 , pp. 1289-1294
    • Leuchte, H.H.1    Baezner, C.2    Baumgartner, R.A.3
  • 51
    • 33751415352 scopus 로고    scopus 로고
    • The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: Comparison of pravastatin and atorvastatin
    • DOI 10.1007/s00210-006-0112-z
    • Rakotoniaina Z, Guerard P, Lirussi F et al. The protective effect of HMG-CoA reductase inhibitors against monocrotalineinduced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin. Naunyn Schmiedebergs Arch. Pharmacol. 374(3), 195-206 (2006). (Pubitemid 44819252)
    • (2006) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.374 , Issue.3 , pp. 195-206
    • Rakotoniaina, Z.1    Guerard, P.2    Lirussi, F.3    Goirand, F.4    Rochette, L.5    Dumas, M.6    Bardou, M.7
  • 53
    • 77953273837 scopus 로고    scopus 로고
    • Simvastatin pulmonary hypertension trial (sipht) study group. Simvastatin as a treatment for pulmonary hypertension trial
    • Wilkins MR, Ali O, Bradlow W et al.; Simvastatin Pulmonary Hypertension Trial (SiPHT) Study Group. Simvastatin as a treatment for pulmonary hypertension trial. Am. J. Respir. Crit. Care Med. 181(10), 1106-1113 (2010).
    • (2010) Am. J. Respir. Crit. Care Med , vol.181 , Issue.10 , pp. 1106-1113
    • Wilkins, M.R.1    Ali, O.2    Bradlow, W.3
  • 54
    • 79960020590 scopus 로고    scopus 로고
    • ASA-STAT Study Group. randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension asa
    • Kawut SM, Bagiella E, Lederer DJ et al.; ASA-STAT Study Group. Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT. Circulation 123(25), 2985-2993 (2011).
    • (2011) STAT. Circulation , vol.123 , Issue.25 , pp. 2985-2993
    • Kawut, S.M.1    Bagiella, E.2    Lederer, D.J.3
  • 55
    • 34047108549 scopus 로고    scopus 로고
    • Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: A pilot randomized controlled trial
    • Wang XX, Zhang FR, Shang YP et al. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J. Am. Coll. Cardiol. 49(14), 1566-1571 (2007).
    • (2007) J. Am. Coll. Cardiol , vol.49 , Issue.14 , pp. 1566-1571
    • Wang, X.X.1    Zhang, F.R.2    Shang, Y.P.3
  • 56
    • 77649337086 scopus 로고    scopus 로고
    • Role of apoptosis in pulmonary hypertension: From experimental models to clinical trials
    • Jurasz P, Courtman D, Babaie S, Stewart DJ. Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials. Pharmacol. Ther. 126(1), 1-8 (2010).
    • (2010) Pharmacol. Ther , vol.126 , Issue.1 , pp. 1-8
    • Jurasz, P.1    Courtman, D.2    Babaie, S.3    Stewart, D.J.4
  • 57
    • 57149145794 scopus 로고    scopus 로고
    • Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling
    • Klein M, Schermuly RT, Ellinghaus P et al. Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling. Circulation 118(20), 2081-2090 (2008).
    • (2008) Circulation , vol.118 , Issue.20 , pp. 2081-2090
    • Klein, M.1    Schermuly, R.T.2    Ellinghaus, P.3
  • 59
    • 79960181854 scopus 로고    scopus 로고
    • Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia
    • Dumitrescu D, Seck C, ten Freyhaus H, Gerhardt F, Erdmann E, Rosenkranz S. Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia. Eur. Respir. J. 38(1), 218-220 (2011).
    • (2011) Eur. Respir. J , vol.38 , Issue.1 , pp. 218-220
    • Dumitrescu, D.1    Seck, C.2    Ten Freyhaus, H.3    Gerhardt, F.4    Erdmann, E.5    Rosenkranz, S.6
  • 60
    • 79957500033 scopus 로고    scopus 로고
    • A decade of tyrosine kinase inhibitor therapy: Historical and current perspectives on targeted therapy for GIST
    • Blay JY. A decade of tyrosine kinase inhibitor therapy: historical and current perspectives on targeted therapy for GIST. Cancer Treat. Rev. 37(5), 373-384 (2011).
    • (2011) Cancer Treat. Rev , vol.37 , Issue.5 , pp. 373-384
    • Blay, J.Y.1
  • 61
    • 79953151232 scopus 로고    scopus 로고
    • Molecular and cellular bases of chronic myeloid leukemia
    • Chen Y, Peng C, Li D, Li S. Molecular and cellular bases of chronic myeloid leukemia. Protein Cell 1(2), 124-132 (2010).
    • (2010) Protein Cell 1 , vol.2 , pp. 124-132
    • Chen, Y.1    Peng, C.2    Li, D.3    Li, S.4
  • 62
    • 77958506198 scopus 로고    scopus 로고
    • Changing paradigm of the treatment of Philadelphia chromosomepositive acute lymphoblastic leukemia
    • Ohno R. Changing paradigm of the treatment of Philadelphia chromosomepositive acute lymphoblastic leukemia. Curr. Hematol. Malig. Rep. 5(4), 213-221 (2010).
    • (2010) Curr. Hematol. Malig. Rep , vol.5 , Issue.4 , pp. 213-221
    • Ohno, R.1
  • 63
    • 33744493376 scopus 로고    scopus 로고
    • Targeting tyrosine kinases in cancer: The second wave
    • DOI 10.1126/science.1125951
    • Baselga J. Targeting tyrosine kinases in cancer: the second wave. Science 312(5777), 1175-1178 (2006). (Pubitemid 43801135)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1175-1178
    • Baselga, J.1
  • 64
    • 77956709644 scopus 로고    scopus 로고
    • Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy
    • Ghofrani HA, Morrell NW, Hoeper MM et al. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am. J. Respir. Crit. Care Med. 182(9), 1171-1177 (2010).
    • (2010) Am. J. Respir. Crit. Care Med , vol.182 , Issue.9 , pp. 1171-1177
    • Ghofrani, H.A.1    Morrell, N.W.2    Hoeper, M.M.3
  • 66
    • 84855370905 scopus 로고    scopus 로고
    • Imatinib in pulmonary arterial hypertension a randomized efficacy study (IMPRES)
    • Abstract
    • Hoeper M, Barst RJ, Galié N et al. Imatinib in pulmonary arterial hypertension, a randomized efficacy study (IMPRES). Eur. Respir. J. 38, Abstract 413 (2011).
    • (2011) Eur. Respir. J. , vol.38
    • Hoeper, M.1    Barst, R.J.2    Galié, N.3
  • 67
  • 68
    • 77749324295 scopus 로고    scopus 로고
    • Imatinib treatment for idiopathic pulmonary fibrosis: Randomized placebo-controlled trial results
    • Imatinib-IPF Study Investigators
    • Daniels CE, Lasky JA, Limper AH, Mieras K, Gabor E, Schroeder DR; Imatinib-IPF Study Investigators. Imatinib treatment for idiopathic pulmonary fibrosis: randomized placebo-controlled trial results. Am. J. Respir. Crit. Care Med. 181(6), 604-610 (2010).
    • (2010) Am. J. Respir. Crit. Care Med , vol.181 , Issue.6 , pp. 604-610
    • Daniels, C.E.1    Lasky, J.A.2    Limper, A.H.3    Mieras, K.4    Gabor, E.5    Schroeder, D.R.6
  • 69
    • 84858164702 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) in hepatocellular carcinoma patients: From discovery to clinical development
    • Ranieri G, Gadaleta-Caldarola G, Goffredo V et al. Sorafenib (BAY 43-9006) in hepatocellular carcinoma patients: from discovery to clinical development. Curr. Med. Chem. 19(7), 938-944 (2012).
    • (2012) Curr. Med. Chem , vol.19 , Issue.7 , pp. 938-944
    • Ranieri, G.1    Gadaleta-Caldarola, G.2    Goffredo, V.3
  • 71
    • 47949116252 scopus 로고    scopus 로고
    • SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V et al.; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359(4), 378-390 (2008).
    • (2008) N. Engl. J. Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 72
    • 77149179051 scopus 로고    scopus 로고
    • A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension
    • Gomberg-Maitland M, Maitland ML, Barst RJ et al. A dosing/cross- development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension. Clin. Pharmacol. Ther. 87(3), 303-310 (2010).
    • (2010) Clin. Pharmacol. Ther , vol.87 , Issue.3 , pp. 303-310
    • Gomberg-Maitland, M.1    Maitland, M.L.2    Barst, R.J.3
  • 77
    • 84860346274 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in patients treated by dasatinib
    • Montani D, Bergot E, Günther S et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation 125(17), 2128-2137 (2012).
    • (2012) Circulation , vol.125 , Issue.17 , pp. 2128-2137
    • Montani, D.1    Bergot, E.2    Günther, S.3
  • 80
    • 67649599147 scopus 로고    scopus 로고
    • Cellular and molecular basis of pulmonary arterial hypertension
    • Morrell NW, Adnot S, Archer SL et al. Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54(Suppl 1.), S20-S31 (2009).
    • (2009) J. Am. Coll. Cardiol , vol.54 SUPPL. 1
    • Morrell, N.W.1    Adnot, S.2    Archer, S.L.3
  • 83
    • 34547619198 scopus 로고    scopus 로고
    • Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C
    • DOI 10.1152/ajplung.00101.2006
    • Barman SA. Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Am. J. Physiol. Lung Cell Mol. Physiol. 293(2), L472-L479 (2007). (Pubitemid 47205028)
    • (2007) American Journal of Physiology - Lung Cellular and Molecular Physiology , vol.293 , Issue.2
    • Barman, S.A.1
  • 84
    • 67449105737 scopus 로고    scopus 로고
    • RhoA and Rho kinase activation in human pulmonary hypertension: Role of 5-HT signaling
    • Guilluy C, Eddahibi S, Agard C et al. RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. Am. J. Respir. Crit. Care Med. 179(12), 1151-1158 (2009).
    • (2009) Am. J. Respir. Crit. Care Med , vol.179 , Issue.12 , pp. 1151-1158
    • Guilluy, C.1    Eddahibi, S.2    Agard, C.3
  • 87
    • 80053464564 scopus 로고    scopus 로고
    • Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip via the erk signal pathway
    • Liu AJ, Ling F, Wang D, Wang Q, Lü XD, Liu YL. Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip via the ERK signal pathway. Chin. Med. J. 124(19), 3098-3104 (2011).
    • (2011) Chin. Med. J , vol.124 , Issue.19 , pp. 3098-3104
    • Liu, A.J.1    Ling, F.2    Wang, D.3    Wang, Q.4    Lü, X.D.5    Liu, Y.L.6
  • 88
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
    • Fujita H, Fukumoto Y, Saji K et al. Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 25(2), 144-149 (2010).
    • (2010) Heart Vessels , vol.25 , Issue.2 , pp. 144-149
    • Fujita, H.1    Fukumoto, Y.2    Saji, K.3
  • 89
    • 20444438839 scopus 로고    scopus 로고
    • Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
    • DOI 10.1007/s00535-005-1574-3
    • Jiang Y, Miyazaki T, Honda A et al. Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone. J. Gastroenterol. 40(5), 490-497 (2005). (Pubitemid 40823284)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.5 , pp. 490-497
    • Jiang, Y.1    Miyazaki, T.2    Honda, A.3    Hirayama, T.4    Yoshida, S.5    Tanaka, N.6    Matsuzaki, Y.7
  • 90
    • 79953043420 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension
    • Paulin R, Courboulin A, Meloche J et al. Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation 123(11), 1205-1215 (2011).
    • (2011) Circulation , vol.123 , Issue.11 , pp. 1205-1215
    • Paulin, R.1    Courboulin, A.2    Meloche, J.3
  • 91
    • 79952733132 scopus 로고    scopus 로고
    • Role for miR-204 in human pulmonary arterial hypertension
    • Courboulin A, Paulin R, Giguère NJ et al. Role for miR-204 in human pulmonary arterial hypertension. J. Exp. Med. 208(3), 535-548 (2011).
    • (2011) J. Exp. Med , vol.208 , Issue.3 , pp. 535-548
    • Courboulin, A.1    Paulin, R.2    Giguère, N.J.3
  • 92
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    • Brock M, Trenkmann M, Gay RE et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104(10), 1184-1191 (2009).
    • (2009) Circ. Res , vol.104 , Issue.10 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3
  • 93
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: Choreographing the social lives of cells
    • DOI 10.1016/S0092-8674(02)00699-2
    • Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 109, S67-S79 (2002). (Pubitemid 34457853)
    • (2002) Cell , vol.109 , Issue.2 SUPPL. 1
    • Crabtree, G.R.1    Olson, E.N.2
  • 94
    • 70349664184 scopus 로고    scopus 로고
    • Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-β/NFAT axis
    • Bonnet S, Paulin R, Sutendra G et al. Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-β/NFAT axis. Circulation 120(13), 1231-1240 (2009).
    • (2009) Circulation , vol.120 , Issue.13 , pp. 1231-1240
    • Bonnet, S.1    Paulin, R.2    Sutendra, G.3
  • 96
    • 49049100968 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in protection against monocrotalineinduced pulmonary hypertension in pneumonectomized rats by dehydroepian-drosterone
    • Homma N, Nagaoka T, Karoor V et al. Involvement of RhoA/Rho kinase signaling in protection against monocrotalineinduced pulmonary hypertension in pneumonectomized rats by dehydroepian-drosterone. Am. J. Physiol. Lung Cell Mol. Physiol. 295(1), L71-L78 (2008).
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol , vol.295 , Issue.1
    • Homma, N.1    Nagaoka, T.2    Karoor, V.3
  • 97
    • 84857503172 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): A pilot study
    • Dumas De La Roque E, Savineau J-P, Metivier A-C et al. Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): a pilot study. Ann. Endocrinol. (Paris) 73(1), 20-25 (2012).
    • (2012) Ann. Endocrinol. (Paris , vol.73 , Issue.1 , pp. 20-25
    • De La Dumas, R.E.1    Savineau, J.-P.2    Metivier, A.-C.3
  • 100
    • 0034997949 scopus 로고    scopus 로고
    • Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension
    • Fujita M, Shannon JM, Irvin CG et al. Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 280(1), L39-L49 (2001).
    • (2001) Am. J. Physiol. Lung Cell Mol. Physiol , vol.280 , Issue.1
    • Fujita, M.1    Shannon, J.M.2    Irvin, C.G.3
  • 101
    • 84871720484 scopus 로고    scopus 로고
    • Monocrotalineinduced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats
    • Wang Q, Zuo XR, Wang YY, Xie WP, Wang H, Zhang M. Monocrotalineinduced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats. Vascul. Pharmacol. 58(1-2), 71-77 (2013).
    • Vascul. Pharmacol , vol.58 , Issue.1 , pp. 71-77
    • Wang, Q.1    Zuo, X.R.2    Wang, Y.Y.3    Xie, W.P.4    Wang, H.5    Zhang, M.6
  • 102
    • 84872678224 scopus 로고    scopus 로고
    • The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension
    • Kherbeck N, Tamby MC, Bussone G et al. The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension. Clin. Rev. Allergy Immunol. (2011).
    • Clin. Rev. Allergy Immunol , vol.2011
    • Kherbeck, N.1    Tamby, M.C.2    Bussone, G.3
  • 104
    • 77954458442 scopus 로고    scopus 로고
    • CXC-chemokine ligand 10 in idiopathic pulmonary arterial hypertension: Marker of improved survival
    • Heresi GA, Aytekin M, Newman J, Dweik RA. CXC-chemokine ligand 10 in idiopathic pulmonary arterial hypertension: marker of improved survival. Lung 188(3), 191-197 (2010).
    • (2010) Lung , vol.188 , Issue.3 , pp. 191-197
    • Heresi, G.A.1    Aytekin, M.2    Newman, J.3    Dweik, R.A.4
  • 106
    • 84858997844 scopus 로고    scopus 로고
    • CD44 expression in plexiform lesions of idiopathic pulmonary arterial hypertension
    • Ohta-Ogo K, Hao H, Ishibashi-Ueda H et al. CD44 expression in plexiform lesions of idiopathic pulmonary arterial hypertension. Pathol. Int. 62(4), 219-225 (2012).
    • (2012) Pathol. Int , vol.62 , Issue.4 , pp. 219-225
    • Ohta-Ogo, K.1    Hao, H.2    Ishibashi-Ueda, H.3
  • 108
    • 39749156384 scopus 로고    scopus 로고
    • Immunosuppressive therapy in lupus- and mixed connective tissue disease-associated pulmonary arterial hypertension: A retrospective analysis of twenty-three cases
    • DOI 10.1002/art.23303
    • Jais X, Launay D, Yaici A et al. Immunosuppressive therapy in lupus-and mixed connective tissue disease-associated pulmonary arterial hypertension: a retrospective analysis of twenty-three cases. Arthritis Rheum. 58(2), 521-531 (2008). (Pubitemid 351294886)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.2 , pp. 521-531
    • Jais, X.1    Launay, D.2    Yaici, A.3    Le Pavec, J.4    Tcherakian, C.5    Sitbon, O.6    Simonneau, G.7    Humbert, M.8
  • 109
    • 80054920718 scopus 로고    scopus 로고
    • Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease
    • Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K et al. Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease. Circ. J. 75(11), 2668-2674 (2011).
    • (2011) Circ. J , vol.75 , Issue.11 , pp. 2668-2674
    • Miyamichi-Yamamoto, S.1    Fukumoto, Y.2    Sugimura, K.3
  • 110
    • 0028676054 scopus 로고
    • Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline
    • Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am. J. Respir. Cell Mol. Biol. 11(6), 664-675 (1994).
    • (1994) Am. J. Respir. Cell Mol. Biol , vol.11 , Issue.6 , pp. 664-675
    • Voelkel, N.F.1    Tuder, R.M.2    Bridges, J.3    Arend, W.P.4
  • 111
    • 79953690566 scopus 로고    scopus 로고
    • Dexamethasone reverses monocrotalineinduced pulmonary arterial hypertension in rats
    • Price LC, Montani D, Tcherakian C et al. Dexamethasone reverses monocrotalineinduced pulmonary arterial hypertension in rats. Eur. Respir. J. 37(4), 813-822 (2011).
    • (2011) Eur. Respir. J , vol.37 , Issue.4 , pp. 813-822
    • Price, L.C.1    Montani, D.2    Tcherakian, C.3
  • 112
    • 0033048993 scopus 로고    scopus 로고
    • Treatment of pulmonary hypertension secondary to connective tissue diseases
    • Sanchez O, Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary hypertension secondary to connective tissue diseases. Thorax 54(3), 273-277 (1999). (Pubitemid 29110511)
    • (1999) Thorax , vol.54 , Issue.3 , pp. 273-277
    • Sanchez, O.1    Humbert, M.2    Sitbon, O.3    Simonneau, G.4
  • 113
    • 77950878463 scopus 로고    scopus 로고
    • Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler
    • Caruso P, MacLean MR, Khanin R et al. Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler. Thromb. Vasc. Biol. 30(4), 716-723 (2010).
    • (2010) Thromb. Vasc. Biol , vol.30 , Issue.4 , pp. 716-723
    • Caruso, P.1    MacLean, M.R.2    Khanin, R.3
  • 115
    • 66549093856 scopus 로고    scopus 로고
    • The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis
    • Senis YA, Tomlinson MG, Ellison S et al. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113(20), 4942-4954 (2009).
    • (2009) Blood , vol.113 , Issue.20 , pp. 4942-4954
    • Senis, Y.A.1    Tomlinson, M.G.2    Ellison, S.3
  • 116
    • 79955772507 scopus 로고    scopus 로고
    • Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice
    • Mizuno S, Bogaard HJ, Kraskauskas D et al. p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 300(5), L753-L761 (2011).
    • (2011) Am. J. Physiol. Lung Cell Mol. Physiol , vol.300 , Issue.5
    • Mizuno, S.1    Bogaard, H.J.2    Kraskauskas, D.3
  • 118
    • 71749100911 scopus 로고    scopus 로고
    • An integrated approach for experimental target identification of hypoxia-induced miR-210
    • Fasanaro P, Greco S, Lorenzi M et al. An integrated approach for experimental target identification of hypoxia-induced miR-210. J. Biol. Chem. 284(50), 35134-35143 (2009).
    • (2009) J. Biol. Chem , vol.284 , Issue.50 , pp. 35134-35143
    • Fasanaro, P.1    Greco, S.2    Lorenzi, M.3
  • 119
    • 82755165210 scopus 로고    scopus 로고
    • Molecular signature of a right heart failure program in chronic severe pulmonary hypertension
    • Drake JI, Bogaard HJ, Mizuno S et al. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 45(6), 1239-1247 (2011).
    • (2011) Am. J. Respir. Cell Mol. Biol , vol.45 , Issue.6 , pp. 1239-1247
    • Drake, J.I.1    Bogaard, H.J.2    Mizuno, S.3
  • 121
    • 77956585332 scopus 로고    scopus 로고
    • HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism
    • Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S. HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism. Cardiovasc. Res. 88(1), 196-204 (2010).
    • (2010) Cardiovasc. Res , vol.88 , Issue.1 , pp. 196-204
    • Lambert, C.M.1    Roy, M.2    Robitaille, G.A.3    Richard, D.E.4    Bonnet, S.5
  • 122
    • 33745155785 scopus 로고    scopus 로고
    • An Abnormal mitochondrial-hypoxia inducible factor-1α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • DOI 10.1161/CIRCULATIONAHA.105.609008, PII 0000301720060606000012
    • Bonnet S, Michelakis ED, Porter CJ et al. An abnormal mitochondrial-hypoxia inducible factor-1α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113(22), 2630-2641 (2006). (Pubitemid 43948012)
    • (2006) Circulation , vol.113 , Issue.22 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Andrade-Navarro, M.A.4    Thebaud, B.5    Bonnet, S.6    Haromy, A.7    Harry, G.8    Moudgil, R.9    McMurtry, M.S.10    Weir, E.K.11    Archer, S.L.12
  • 123
    • 56249131779 scopus 로고    scopus 로고
    • A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
    • Greenberger LM, Horak ID, Filpula D et al. A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth. Mol. Cancer Ther. 7(11), 3598-3608 (2008).
    • (2008) Mol. Cancer Ther , vol.7 , Issue.11 , pp. 3598-3608
    • Greenberger, L.M.1    Horak, I.D.2    Filpula, D.3
  • 124
    • 77955635790 scopus 로고    scopus 로고
    • Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension
    • Sutendra G, Bonnet S, Rochefort G et al. Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension. Sci. Transl. Med. 2(44), 44-58 (2010).
    • (2010) Sci. Transl. Med , vol.2 , Issue.44 , pp. 44-58
    • Sutendra, G.1    Bonnet, S.2    Rochefort, G.3
  • 125
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • DOI 10.1161/01.RES.0000145360.16770.9f
    • McMurtry MS, Bonnet S, Wu X et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cellapoptosis. Circ. Res. 95(8), 830-840 (2004). (Pubitemid 39390586)
    • (2004) Circulation Research , vol.95 , Issue.8 , pp. 830-840
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3    Dyck, J.R.B.4    Haromy, A.5    Hashimoto, K.6    Michelakis, E.D.7
  • 128
    • 76549117399 scopus 로고    scopus 로고
    • Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension
    • Mainguy V, Maltais F, Saey D et al. Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension. Thorax 65(2), 113-117 (2010).
    • (2010) Thorax , vol.65 , Issue.2 , pp. 113-117
    • Mainguy, V.1    Maltais, F.2    Saey, D.3


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