P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells

Acta Pharmacologica Sinica

Volumn 28, Issue 7, 2007, Pages 1057-1066

  Cui, Qiao ^a   Yu, Jing Hua ^a   Wu, Jin Nan ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Minami, Mutsuhiko ^c   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Apoptosis; Calpain; Caspase 3; Caspase 9; Cell cycle arrest; MCF 7 cells; Mitochondrial pathway; Oridonin; p53

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CALPASTATIN; CASPASE 3; CASPASE 9; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CASPASE INHIBITOR; DNA DIRECTED DNA POLYMERASE ALPHA; DNA FRAGMENT; GENE PRODUCT; HEAT SHOCK PROTEIN 90; LACTATE DEHYDROGENASE; ORIDONIN; PP53 PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; THIAZOLE; UNCLASSIFIED DRUG; Z VAD FMK;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ASSAY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NUCLEOSOME; PHASE CONTRAST MICROSCOPY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYSTEINE PROTEINASE INHIBITORS; DITERPENES, KAURANE; DRUGS, CHINESE HERBAL; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34347385839     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00588.x     Document Type: Article

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