-
1
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory S, Adams JM. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2:647-56.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
2
-
-
14944348965
-
The role of BH3-only proteins in the immune system
-
Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005; 5:189-200.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 189-200
-
-
Strasser, A.1
-
3
-
-
0036097786
-
Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
-
Puthalakath H, Strasser A. Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 2002; 9:505-12.
-
(2002)
Cell Death Differ
, vol.9
, pp. 505-512
-
-
Puthalakath, H.1
Strasser, A.2
-
4
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-30.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
5
-
-
27544446991
-
-
Willis SN, Adams JM. Life in the balance: How BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005; 17:617-25.
-
Willis SN, Adams JM. Life in the balance: How BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005; 17:617-25.
-
-
-
-
6
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005; 17:393-403.
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.10
-
7
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005; 19:1294-305.
-
(2005)
Genes Dev
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.8
-
8
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002; 2:183-92.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
9
-
-
33846964621
-
-
Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DCS. Apoptosis initiated when BH ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315:856-9.
-
Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DCS. Apoptosis initiated when BH ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315:856-9.
-
-
-
-
10
-
-
0036091728
-
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis
-
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol 2002; 22:3577-89.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3577-3589
-
-
Marani, M.1
Tenev, T.2
Hancock, D.3
Downward, J.4
Lemoine, N.R.5
-
11
-
-
0032518787
-
-
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC. Bim: A novel member of the Bcl-2 family that promotes apoptosis. EMBO J 1998; 17:384-95.
-
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC. Bim: A novel member of the Bcl-2 family that promotes apoptosis. EMBO J 1998; 17:384-95.
-
-
-
-
12
-
-
15844422694
-
Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells
-
Gomez-Bougie P, Bataille R, Amiot M. Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. Eur J Immunol 2005; 35:971-6.
-
(2005)
Eur J Immunol
, vol.35
, pp. 971-976
-
-
Gomez-Bougie, P.1
Bataille, R.2
Amiot, M.3
-
13
-
-
34250892541
-
ERK1/2-dependent phosphorylation of Bim(EL) promotes its rapid dissociation from Mcl-1 and Bcl-x(L)
-
Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ. ERK1/2-dependent phosphorylation of Bim(EL) promotes its rapid dissociation from Mcl-1 and Bcl-x(L). EMBO J 2007; 26:2856-67.
-
(2007)
EMBO J
, vol.26
, pp. 2856-2867
-
-
Ewings, K.E.1
Hadfield-Moorhouse, K.2
Wiggins, C.M.3
Wickenden, J.A.4
Balmanno, K.5
Gilley, R.6
Degenhardt, K.7
White, E.8
Cook, S.J.9
-
14
-
-
0034640281
-
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.
-
-
-
-
15
-
-
0035265686
-
-
Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683-94.
-
Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683-94.
-
-
-
-
16
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94:491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
17
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91:231-41.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
18
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999; 286:1358-62.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
Greenberg, M.E.6
-
19
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 2000; 6:41-51.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
Greenberg, M.E.7
-
20
-
-
0037422172
-
Activation of ERK1/2 by ΔRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways
-
Weston CR, Balmanno K, Chalmers C, Hadfield K, Molton SA, Ley R, Wagner EF, Cook SJ. Activation of ERK1/2 by ΔRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways. Oncogene 2003; 22:1281-93.
-
(2003)
Oncogene
, vol.22
, pp. 1281-1293
-
-
Weston, C.R.1
Balmanno, K.2
Chalmers, C.3
Hadfield, K.4
Molton, S.A.5
Ley, R.6
Wagner, E.F.7
Cook, S.J.8
-
21
-
-
0141905920
-
Thrombin inhibits Bim expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1
-
Chalmers CJ, Balmanno K, Hadfield K, Ley R, Cook SJ. Thrombin inhibits Bim expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. Biochem J 2003; 375:99-109.
-
(2003)
Biochem J
, vol.375
, pp. 99-109
-
-
Chalmers, C.J.1
Balmanno, K.2
Hadfield, K.3
Ley, R.4
Cook, S.J.5
-
22
-
-
0038482050
-
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
-
Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 2003; 278:18811-16.
-
(2003)
J Biol Chem
, vol.278
, pp. 18811-18816
-
-
Ley, R.1
Balmanno, K.2
Hadfield, K.3
Weston, C.4
Cook, S.J.5
-
23
-
-
0242521470
-
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
-
Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 2003; 22:6785-93.
-
(2003)
Oncogene
, vol.22
, pp. 6785-6793
-
-
Luciano, F.1
Jacquel, A.2
Colosetti, P.3
Herrant, M.4
Cagnol, S.5
Pages, G.6
Auberger, P.7
-
24
-
-
1642343617
-
Role of Bim in the survival pathway induced by Raf in epithelial cells
-
Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene 2004; 23:2431-41.
-
(2004)
Oncogene
, vol.23
, pp. 2431-2441
-
-
Marani, M.1
Hancock, D.2
Lopes, R.3
Tenev, T.4
Downward, J.5
Lemoine, N.R.6
-
25
-
-
23044514254
-
Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK
-
Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK. Cell Death Differ 2005; 12:1008-14.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1008-1014
-
-
Ley, R.1
Ewings, K.E.2
Hadfield, K.3
Cook, S.J.4
-
26
-
-
10744232926
-
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
-
Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 2003; 24:6653-64.
-
(2003)
EMBO J
, vol.24
, pp. 6653-6664
-
-
Akiyama, T.1
Bouillet, P.2
Miyazaki, T.3
Kadono, Y.4
Chikuda, H.5
Hikita, A.6
Seto, H.7
Okada, T.8
Inaba, T.9
Sanjay, A.10
Baron, R.11
Kawaguchi, H.12
Oda, H.13
Nakamura, K.14
Strasser, A.15
Tanaka, S.16
-
29
-
-
33644865025
-
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
-
Qi XJ, Wildey GM, Howe PH. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem 2006; 281:813-23.
-
(2006)
J Biol Chem
, vol.281
, pp. 813-823
-
-
Qi, X.J.1
Wildey, G.M.2
Howe, P.H.3
-
30
-
-
4744348299
-
Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins
-
Wang P, Gilmore AP, Streuli CH. Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins. J Biol Chem 2004; 279:41280-5.
-
(2004)
J Biol Chem
, vol.279
, pp. 41280-41285
-
-
Wang, P.1
Gilmore, A.P.2
Streuli, C.H.3
-
31
-
-
18944395927
-
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes
-
Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol 2005; 25:4591-601.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4591-4601
-
-
Reginato, M.J.1
Mills, K.R.2
Becker, E.B.3
Lynch, D.K.4
Bonni, A.5
Muthuswamy, S.K.6
Brugge, J.S.7
-
32
-
-
11244309014
-
Proteolysis: From the lysosome to ubiquitin and the proteasome
-
Ciechanover A. Proteolysis: From the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 2005; 6:79-87.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 79-87
-
-
Ciechanover, A.1
-
33
-
-
9644273891
-
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin
-
Willems AR, Schwab M, Tyers M. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta 2004; 1695:133-70.
-
(2004)
Biochim Biophys Acta
, vol.1695
, pp. 133-170
-
-
Willems, A.R.1
Schwab, M.2
Tyers, M.3
-
34
-
-
4444318673
-
The SCF ubiquitin ligase: Insights into a molecular machine
-
Cardozo T, Pagano M. The SCF ubiquitin ligase: Insights into a molecular machine. Nat Rev Mol Cell Biol 2004; 5:739-51.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 739-751
-
-
Cardozo, T.1
Pagano, M.2
-
35
-
-
0029670083
-
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
-
DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol 1996; 16:1295-304.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1295-1304
-
-
DiDonato, J.1
Mercurio, F.2
Rosette, C.3
Wu-Li, J.4
Suyang, H.5
Ghosh, S.6
Karin, M.7
-
36
-
-
0033569756
-
Beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta
-
Wu C, Ghosh S. Beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. J Biol Chem 1999; 274:29591-4.
-
(1999)
J Biol Chem
, vol.274
, pp. 29591-29594
-
-
Wu, C.1
Ghosh, S.2
-
37
-
-
33845486323
-
Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
-
Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL. Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death Differ 2007; 14:128-36.
-
(2007)
Cell Death Differ
, vol.14
, pp. 128-136
-
-
Hinds, M.G.1
Smits, C.2
Fredericks-Short, R.3
Risk, J.M.4
Bailey, M.5
Huang, D.C.6
Day, C.L.7
-
38
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 2005; 121:1085-95.
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
Gao, W.2
Du, F.3
Wang, X.4
-
39
-
-
26844454131
-
BH3-ligand regulates access of MCL-1 to its E3 ligase
-
Warr MR, Acoca S, Liu Z, Germain M, Watson M, Blanchette M, Wing SS, Shore GC. BH3-ligand regulates access of MCL-1 to its E3 ligase. FEBS Lett 2005; 579:5603-8.
-
(2005)
FEBS Lett
, vol.579
, pp. 5603-5608
-
-
Warr, M.R.1
Acoca, S.2
Liu, Z.3
Germain, M.4
Watson, M.5
Blanchette, M.6
Wing, S.S.7
Shore, G.C.8
-
40
-
-
34547098188
-
Structural insights into the degradation of Mcl-1 induced by BH3 domains
-
Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci USA 2007; 104:6217-22.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6217-6222
-
-
Czabotar, P.E.1
Lee, E.F.2
van Delft, M.F.3
Day, C.L.4
Smith, B.J.5
Huang, D.C.6
Fairlie, W.D.7
Hinds, M.G.8
Colman, P.M.9
-
41
-
-
27944477367
-
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl
-
El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, Cunha S, Beaudoin C, Morel L, Benahmed M, Regnier DC. Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. J Cell Biol 2005; 171:651-61.
-
(2005)
J Cell Biol
, vol.171
, pp. 651-661
-
-
El Chami, N.1
Ikhlef, F.2
Kaszas, K.3
Yakoub, S.4
Tabone, E.5
Siddeek, B.6
Cunha, S.7
Beaudoin, C.8
Morel, L.9
Benahmed, M.10
Regnier, D.C.11
-
42
-
-
27444445613
-
c-Cbl and Cbl-b ubiquitin ligases: Substrate diversity and the negative regulation of signaling responses
-
Thien CB, Langdon WY. c-Cbl and Cbl-b ubiquitin ligases: Substrate diversity and the negative regulation of signaling responses. Biochem J 2005; 391:153-66.
-
(2005)
Biochem J
, vol.391
, pp. 153-166
-
-
Thien, C.B.1
Langdon, W.Y.2
-
43
-
-
33845965024
-
Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70
-
Matsui H, Asou H, Inaba T. Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70. Mol Cell 2007; 25:99-112.
-
(2007)
Mol Cell
, vol.25
, pp. 99-112
-
-
Matsui, H.1
Asou, H.2
Inaba, T.3
-
44
-
-
14844285335
-
Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene BIM
-
Tagawa H, Karnan S, Suzuki R, Matsuo K, Zhang X, Ota A, Morishima Y, Nakamura S, Seto M. Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 2005; 24:1348-58.
-
(2005)
Oncogene
, vol.24
, pp. 1348-1358
-
-
Tagawa, H.1
Karnan, S.2
Suzuki, R.3
Matsuo, K.4
Zhang, X.5
Ota, A.6
Morishima, Y.7
Nakamura, S.8
Seto, M.9
|