Inhibition of cancer cell invasion and metastasis by genistein

Cancer and Metastasis Reviews

Volumn 29, Issue 3, 2010, Pages 465-482

  Pavese, Janet M ^a   Farmer, Rebecca L ^a,b   Bergan, Raymond C ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Adhesion; Cancer; Chemoprevention; Genistein; Invasion; Metastasis

Indexed keywords

ESTROGEN; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BLADDER CANCER; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL ADHESION; CELL CYCLE PROGRESSION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CLINICAL TRIAL; COLON CANCER; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; LIVER CELL CARCINOMA; LUNG METASTASIS; METASTASIS; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; SOYBEAN MILK;

ANIMALS; ANTICARCINOGENIC AGENTS; GENISTEIN; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 77957578387     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-010-9238-z     Document Type: Review

References (180)

1. M Messina C Nagata AH Wu 2006 Estimated Asian adult soy protein and isoflavone intakes Nutrition and Cancer 55 1 1 12 1:CAS:528:DC%2BD28XhtFakurbP 16965235 10.1207/s15327914nc55011
2. H Adlercreutz H Markkanen S Watanabe 1993 Plasma concentrations of phyto-oestrogens in Japanese men Lancet 342 8881 1209 1210 1:STN:280: DyaK2c%2FkvVKmsA%3D%3D 7901532 10.1016/0140-6736(93)92188-Y (Pubitemid 23331713)
3. H Adlercreutz 1990 Western diet and western diseases: Some hormonal and biochemical mechanisms and associations Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum 201 3 23 1:STN:280:DyaK3M%2FlslKhsg%3D%3D 2173856 10.3109/00365519009085798
4. RK Severson AM Nomura JS Grove GN Stemmermann 1989 A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii Cancer Research 49 7 1857 1860 1:STN:280:DyaL1M7mvVagtg%3D%3D 2924323
5. H Shimizu RK Ross L Bernstein R Yatani BE Henderson TM Mack 1991 Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles county British Journal of Cancer 63 6 963 966 1:STN:280:DyaK3M3pvFCqtw%3D%3D 2069852
6. YW Hwang SY Kim SH Jee YN Kim CM Nam 2009 Soy food consumption and risk of prostate cancer: A meta-analysis of observational studies Nutrition and Cancer 61 5 598 606 1:CAS:528:DC%2BD1MXht12gsr%2FN 19838933 10.1080/ 01635580902825639
7. HP Lee L Gourley SW Duffy J Esteve J Lee NE Day 1991 Dietary effects on breast-cancer risk in Singapore Lancet 337 8751 1197 1200 1:STN:280: DyaK3M3hvVGrtA%3D%3D 1673746 10.1016/0140-6736(91)92867-2
8. AH Wu RG Ziegler PL Horn-Ross AM Nomura DW West LN Kolonel, et al. 1996 Tofu and risk of breast cancer in Asian-Americans Cancer Epidemiology, Biomarkers & Prevention 5 11 901 906 1:STN:280:DyaK2s%2FotV2lsQ%3D%3D
9. G Bobe LB Sansbury PS Albert AJ Cross L Kahle J Ashby, et al. 2008 Dietary flavonoids and colorectal adenoma recurrence in the polyp prevention trial Cancer Epidemiology, Biomarkers & Prevention 17 6 1344 1353 1:CAS:528:DC%2BD1cXnsVKgtrc%3D 10.1158/1055-9965.EPI-07-0747
10. AG Perkin FG Newbury 1899 The colouring matters contained in dyer's broom (Genista tinctoria) and heather (Calluna vulgaris) Journal of the Chemical Society 75 830 839 1:CAS:528:DyaD28Xmtl2isA%3D%3D
11. Andersen, Ø.M., & Markham, K. R. (2006). Flavonoids: Chemistry, biochemistry, and applications. Boca Raton: CRC.
12. NC Veitch RJ Grayer 2008 Flavonoids and their glycosides, including anthocyanins Natural Product Reports 25 3 555 611 1:CAS:528:DC%2BD1cXmtFemt74%3D 18497898 10.1039/b718040n (Pubitemid 351728058)
13. T Akiyama J Ishida S Nakagawa H Ogawara S Watanabe N Itoh, et al. 1987 Genistein, a specific inhibitor of tyrosine-specific protein kinases The Journal of Biological Chemistry 262 12 5592 5595 1:CAS:528:DyaL2sXktF2rurk%3D 3106339
14. A Matsumura A Ghosh GS Pope PD Darbre 2005 Comparative study of oestrogenic properties of eight phytoestrogens in mcf7 human breast cancer cells The Journal of Steroid Biochemistry and Molecular Biology 94 5 431 443 1:CAS:528:DC%2BD2MXjvVKktr0%3D 15876408 10.1016/j.jsbmb.2004.12.041 (Pubitemid 40616404)
15. RA Dixon D Ferreira 2002 Genistein Phytochemistry 60 3 205 211 1:CAS:528:DC%2BD38XjvVakur4%3D 12031439 10.1016/S0031-9422(02)00116-4 (Pubitemid 34947527)
16. AC Pike AM Brzozowski RE Hubbard T Bonn AG Thorsell O Engstrom, et al. 1999 Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist The EMBO Journal 18 17 4608 4618 1:CAS:528:DyaK1MXmt1yisLo%3D 10469641 10.1093/emboj/18.17.4608 (Pubitemid 29415516)
17. GG Kuiper JG Lemmen B Carlsson JC Corton SH Safe PT van der Saag, et al. 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 10 4252 4263 1:CAS:528:DyaK1cXmsVGmsrw%3D 9751507 10.1210/en.139.10.4252
18. SO Mueller S Simon K Chae M Metzler KS Korach 2004 Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ER alpha) and ER beta in human cells Toxicological Sciences 80 1 14 25 1:CAS:528:DC%2BD2cXkvVSrs7g%3D 15084758 10.1093/toxsci/ kfh147 (Pubitemid 38967392)
19. GG Kuiper B Carlsson K Grandien E Enmark J Haggblad S Nilsson, et al. 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta Endocrinology 138 3 863 870 1:CAS:528:DyaK2sXht1OksrY%3D 9048584 10.1210/en.138.3.863 (Pubitemid 27089735)
20. W Jung O Yu SM Lau DP O'Keefe J Odell G Fader, et al. 2000 Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes Nature Biotechnology 18 2 208 212 1:CAS:528: DC%2BD3cXhtVOltbw%3D 10657130 10.1038/72671 (Pubitemid 30091184)
21. O Yu W Jung J Shi RA Croes GM Fader B McGonigle, et al. 2000 Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues Plant Physiology 124 2 781 794 1:CAS:528:DC%2BD3cXnsF2rsbs%3D 11027726 10.1104/pp.124.2.781
22. E Walter 1941 Genistin (an isoflavone glucoside) and its aglucone, genistein, from soybeans Journal of the American Chemical Society 63 12 3273 3276 1:CAS:528:DyaH38Xmt1Kr 10.1021/ja01857a013
23. S Balasubramanian MG Nair 2000 An efficient "one-pot" synthesis of isoflavones Synthetic Communications 30 469 484 1:CAS:528: DC%2BD3cXhtFemu7w%3D 10.1080/00397910008087343
24. K Wahala TA Hase 1991 Expedient synthesis of polyhydroxyisoflavones Journal of the Chemical Society. Perkin Transactions 1 3005 3008 10.1039/p19910003005
25. YC Chang MG Nair RC Santell WG Helferich 1994 Microwave-mediated synthesis of anticarcinogenic isoflavones from soybeans Journal of Agricultural and Food Chemistry 42 1869 1871 1:CAS:528:DyaK2cXmtVGjsL4%3D 10.1021/jf00045a007
26. Y Kawamura M Maruyama T Tokuoka M Tsukayama 2002 Synthesis of isoflavones from 2′-hydroxychalcones using poly[4-(diacetoxy)iodo]styrene or related hypervalent iodine reagent Synthesis-Stuttgart 17 2490 2496 10.1055/s-2002-35617
27. RB Gammill 1979 A new and efficient synthesis of 3-halogenated 4h-1-benzopyran-4-ones Synthesis-Stuttgart 11 901 903 10.1055/s-1979-28869
28. Y Hoshino N Miyaura A Suzuki 1988 Novel synthesis of isoflavones by the palladium-catalyzed cross-coupling reaction of 3-bromochromone with arylboronic acids or its esters Bulletin. Chemical Society of Japan 61 3008 3010 1:CAS:528:DyaL1MXhvFantbs%3D 10.1246/bcsj.61.3008
29. H Adlercreutz H Honjo A Higashi T Fotsis E Hamalainen T Hasegawa, et al. 1991 Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet The American Journal of Clinical Nutrition 54 6 1093 1100 1:CAS:528:DyaK38XlvVSgsQ%3D%3D 1659780
30. Y Arai S Watanabe M Kimira K Shimoi R Mochizuki N Kinae 2000 Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration The Journal of Nutrition 130 9 2243 2250 1:CAS:528:DC%2BD3cXmsVWlu7g%3D 10958819
31. T Horiuchi T Onouchi M Takahashi H Ito H Orimo 2000 Effect of soy protein on bone metabolism in postmenopausal Japanese women Osteoporosis International 11 8 721 724 1:CAS:528:DC%2BD3cXnsVegtbg%3D 11095177 10.1007/s001980070072
32. M Kimira Y Arai K Shimoi S Watanabe 1998 Japanese intake of flavonoids and isoflavonoids from foods Journal of Epidemiology 8 3 168 175 1:STN:280:DyaK1cvlsF2qsQ%3D%3D 9782673
33. C Nagata S Inaba N Kawakami T Kakizoe H Shimizu 2000 Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men Nutrition and Cancer 36 1 14 18 1:STN:280:DC%2BD3c3lvVGntA%3D%3D 10798211 10.1207/S15327914NC36013 (Pubitemid 30317830)
34. C Nagata M Kabuto Y Kurisu H Shimizu 1997 Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women Nutrition and Cancer 29 3 228 233 1:STN:280:DyaK1c7hvFSrug%3D%3D 9457744 10.1080/01635589709514629
35. C Nagata H Shimizu R Takami M Hayashi N Takeda K Yasuda 2000 Relations of insulin resistance and serum concentrations of estradiol and sex hormone-binding globulin to potential breast cancer risk factors Japanese Journal of Cancer Research 91 9 948 953 1:CAS:528:DC%2BD3cXmvFKhtLw%3D 11011124
36. C Nagata N Takatsuka N Kawakami H Shimizu 2000 Association of diet with the onset of menopause in Japanese women American Journal of Epidemiology 152 9 863 867 1:STN:280:DC%2BD3M%2FkslCrsw%3D%3D 11085398 10.1093/aje/152.9.863
37. C Nagata N Takatsuka Y Kurisu H Shimizu 1998 Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women The Journal of Nutrition 128 2 209 213 1:CAS:528:DyaK1cXhtVeqs7w%3D 9446845
38. N Takatsuka C Nagata Y Kurisu S Inaba N Kawakami H Shimizu 2000 Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women Preventive Medicine 31 4 308 314 1:CAS:528:DC%2BD3cXmslKnsL8%3D 11006055 10.1006/pmed.2000.0714
39. K Wakai I Egami K Kato T Kawamura A Tamakoshi Y Lin, et al. 1999 Dietary intake and sources of isoflavones among Japanese Nutrition and Cancer 33 2 139 145 1:CAS:528:DyaK1MXktVaksbg%3D 10368808 10.1207/S15327914NC330204
40. Y Arai M Uehara Y Sato M Kimira A Eboshida H Adlercreutz, et al. 2000 Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake Journal of Epidemiology 10 2 127 135 1:STN:280:DC%2BD3c3ktVGjtA%3D%3D 10778038
41. S Yamamoto T Sobue S Sasaki M Kobayashi Y Arai M Uehara, et al. 2001 Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones The Journal of Nutrition 131 10 2741 2747 1:CAS:528:DC%2BD3MXnsFKrsrs%3D 11584098
42. M Fukutake M Takahashi K Ishida H Kawamura T Sugimura K Wakabayashi 1996 Quantification of genistein and genistin in soybeans and soybean products Food and Chemical Toxicology 34 5 457 461 1:CAS:528:DyaK28Xjs1arsL4%3D 8655094 10.1016/0278-6915(96)87355-8 (Pubitemid 26171975)
43. I Rowland M Faughnan L Hoey K Wahala G Williamson A Cassidy 2003 Bioavailability of phyto-oestrogens The British Journal of Nutrition 89 Suppl 1 S45 S58 1:CAS:528:DC%2BD3sXltFentrg%3D 12725656
44. J Sfakianos L Coward M Kirk S Barnes 1997 Intestinal uptake and biliary excretion of the isoflavone genistein in rats The Journal of Nutrition 127 7 1260 1268 1:CAS:528:DyaK2sXktlKhtLc%3D 9202077
45. M Murata K Midorikawa M Koh K Umezawa S Kawanishi 2004 Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs Biochemistry 43 9 2569 2577 1:CAS:528:DC%2BD2cXhtVGjurw%3D 14992594 10.1021/bi035613d (Pubitemid 38327852)
46. D Pugazhendhi KA Watson S Mills N Botting GS Pope PD Darbre 2008 Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in mcf-7 human breast cancer cells The Journal of Endocrinology 197 3 503 515 1:CAS:528:DC%2BD1cXntVCgsrc%3D 18492816 10.1677/JOE-07-0384 (Pubitemid 351803955)
47. LS Cook M Goldoft SM Schwartz NS Weiss 1999 Incidence of adenocarcinoma of the prostate in Asian immigrants to the United States and their descendants The Journal of Urology 161 1 152 155 1:STN:280:DyaK1M7lsV2qsA%3D%3D 10037388 10.1016/S0022-5347(01)62086-X (Pubitemid 29422310)
48. R Yatani T Shiraishi K Nakakuki I Kusano H Takanari T Hayashi, et al. 1988 Trends in frequency of latent prostate carcinoma in Japan from 1965-1979 to 1982-1986 Journal of the National Cancer Institute 80 9 683 687 1:STN:280:DyaL1c3jtVGjtg%3D%3D 3373558 10.1093/jnci/80.9.683
49. K Toyomura S Kono 2002 Soybeans, soy foods, isoflavones and risk of colorectal cancer: A review of experimental and epidemiological data Asian Pacific Journal of Cancer Prevention: APJCP 3 2 125 132 12718590
50. Weinberg, R. (2007). The biology of cancer. New York: Garland Science.
51. M Malumbres M Barbacid 2009 Cell cycle, cdks and cancer: A changing paradigm Nature Reviews. Cancer 9 3 153 166 1:CAS:528:DC%2BD1MXit1ans78%3D 19238148 10.1038/nrc2602
52. S Ramos 2007 Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention The Journal of Nutritional Biochemistry 18 7 427 442 1:CAS:528:DC%2BD2sXmtlSku7s%3D 17321735 10.1016/j.jnutbio.2006.11.004 (Pubitemid 46874924)
53. V Cappelletti L Fioravanti P Miodini G Di Fronzo 2000 Genistein blocks breast cancer cells in the g(2)m phase of the cell cycle Journal of Cellular Biochemistry 79 4 594 600
54. YH Choi WH Lee KY Park L Zhang 2000 P53-independent induction of p21 (waf1/cip1), reduction of cyclin b1 and g2/m arrest by the isoflavone genistein in human prostate carcinoma cells Japanese Journal of Cancer Research 91 2 164 173
55. GR Yan CL Xiao GW He XF Yin NP Chen Y Cao, et al. 2010 Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways Proteomics 10 5 976 986 1:CAS:528:DC%2BC3cXis1yntrc%3D 20049867
56. G Ouyang L Yao K Ruan G Song Y Mao S Bao 2009 Genistein induces g2/m cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways Cell Biology International 33 12 1237 1244 1:CAS:528:DC%2BD1MXhsVGltbbM 19732843 10.1016/j.cellbi.2009.08.011
57. SJ Su NH Chow ML Kung TC Hung KL Chang 2003 Effects of soy isoflavones on apoptosis induction and g2-m arrest in human hepatoma cells involvement of caspase-3 activation, bcl-2 and bcl-xl downregulation, and cdc2 kinase activity Nutrition and Cancer 45 1 113 123
58. IA Ismail KS Kang HA Lee JW Kim YK Sohn 2007 Genistein-induced neuronal apoptosis and g2/m cell cycle arrest is associated with mdc1 up-regulation and plk1 down-regulation European Journal of Pharmacology 575 1-3 12 20 1:CAS:528:DC%2BD2sXhtF2lsrvJ 17706963 10.1016/j.ejphar.2007.07.039 (Pubitemid 47576065)
59. YH Choi L Zhang WH Lee KY Park 1998 Genistein-induced g2/m arrest is associated with the inhibition of cyclin b1 and the induction of p21 in human breast carcinoma cells International Journal of Oncology 13 2 391 396 1:CAS:528:DyaK1cXltVKks7k%3D 9664138
60. JM Adams S Cory 2007 The bcl-2 apoptotic switch in cancer development and therapy Oncogene 26 9 1324 1337 1:CAS:528:DC%2BD2sXitVKhsL8%3D 17322918 10.1038/sj.onc.1210220 (Pubitemid 46328466)
61. JM Adams 2003 Ways of dying: Multiple pathways to apoptosis Genes & Development 17 20 2481 2495 1:CAS:528:DC%2BD3sXotlWjtL8%3D 10.1101/gad.1126903 (Pubitemid 37271417)
62. NN Danial SJ Korsmeyer 2004 Cell death: Critical control points Cell 116 2 205 219 1:CAS:528:DC%2BD2cXhtValsrY%3D 14744432 10.1016/S0092-8674(04)00046-7 (Pubitemid 38167313)
63. SW Fesik 2005 Promoting apoptosis as a strategy for cancer drug discovery Nature Reviews. Cancer 5 11 876 885 1:CAS:528:DC%2BD2MXht1Witb7J 16239906 10.1038/nrc1736 (Pubitemid 41746032)
64. E Kyle L Neckers C Takimoto G Curt R Bergan 1997 Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity Molecular Pharmacology 51 2 193 200 1:CAS:528:DyaK2sXhtlWms74%3D 9203623
65. S Banerjee Y Li Z Wang FH Sarkar 2008 Multi-targeted therapy of cancer by genistein Cancer Letters 269 2 226 242
66. FH Sarkar Y Li 2004 The role of isoflavones in cancer chemoprevention Frontiers in Bioscience 9 2714 2724 1:CAS:528:DC%2BD2cXls1entbw%3D 15353308 10.2741/1430
67. A Cuconati K Degenhardt R Sundararajan A Anschel E White 2002 Bak and bax function to limit adenovirus replication through apoptosis induction Journal of Virology 76 9 4547 4558 1:CAS:528:DC%2BD38XivFGisbs%3D 11932420 10.1128/JVI.76.9.4547-4558.2002 (Pubitemid 34309590)
68. SN Willis JI Fletcher T Kaufmann MF van Delft L Chen PE Czabotar, et al. 2007 Apoptosis initiated when bh3 ligands engage multiple bcl-2 homologs, not bax or bak Science 315 5813 856 859 1:CAS:528:DC%2BD2sXhsVShsL4%3D 17289999 10.1126/science.1133289
69. DR Green G Kroemer 2004 The pathophysiology of mitochondrial cell death Science 305 5684 626 629 1:CAS:528:DC%2BD2cXmtFWqsrc%3D 15286356 10.1126/science.1099320 (Pubitemid 39006738)
70. D Acehan X Jiang DG Morgan JE Heuser X Wang CW Akey 2002 Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation Molecular Cell 9 2 423 432 1:CAS:528:DC%2BD38XhvFKgsrg%3D 11864614 10.1016/S1097-2765(02)00442-2 (Pubitemid 34195566)
71. C Tophkhane S Yang W Bales L Archer A Osunkoya AD Thor, et al. 2007 Bcl-2 overexpression sensitizes mcf-7 cells to genistein by multiple mechanisms International Journal of Oncology 31 4 867 874 1:CAS:528:DC%2BD2sXht1SjurbF 17786319
72. Y Li S Upadhyay M Bhuiyan FH Sarkar 1999 Induction of apoptosis in breast cancer cells mda-mb-231 by genistein Oncogene 18 20 3166 3172 1:CAS:528:DyaK1MXjs1Onu74%3D 10340389 10.1038/sj.onc.1202650 (Pubitemid 29261238)
73. S Upadhyay M Neburi SR Chinni S Alhasan F Miller FH Sarkar 2001 Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21(waf1) Clinical Cancer Research 7 6 1782 1789 1:CAS:528:DC%2BD3MXltV2hsL0%3D 11410520
74. JN Davis B Singh M Bhuiyan FH Sarkar 1998 Genistein-induced upregulation of p21waf1, downregulation of cyclin b, and induction of apoptosis in prostate cancer cells Nutrition and Cancer 32 3 123 131 1:CAS:528:DyaK1MXhtlalsrg%3D 10050261 10.1080/01635589809514730
75. F Lian Y Li M Bhuiyan FH Sarkar 1999 P53-independent apoptosis induced by genistein in lung cancer cells Nutrition and Cancer 33 2 125 131 1:CAS:528:DyaK1MXktVaksbo%3D 10368806 10.1207/S15327914NC330202 (Pubitemid 29269998)
76. SA Alhasan H Pietrasczkiwicz MD Alonso J Ensley FH Sarkar 1999 Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line Nutrition and Cancer 34 1 12 19 1:CAS:528: DyaK1MXlslyjsbw%3D 10453436 10.1207/S15327914NC340102
77. B Zhang ZL Shi B Liu XB Yan J Feng HM Tao 2010 Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: The role of akt and nuclear factor-kappab Anti-Cancer Drugs 21 3 288 296 1:CAS:528:DC%2BC3cXhsVWitb0%3D 20038829 10.1097/CAD.0b013e328334da17
78. A Kazi KG Daniel DM Smith NB Kumar QP Dou 2003 Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein Biochemical Pharmacology 66 6 965 976 1:CAS:528:DC%2BD3sXntVCgsbc%3D 12963483 10.1016/S0006-2952(03)00414-3 (Pubitemid 37083593)
79. AV Singh AA Franke GL Blackburn JR Zhou 2006 Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis Cancer Research 66 3 1851 1858 1:CAS:528:DC%2BD28XpsVektw%3D%3D 16452247 10.1158/0008-5472.CAN- 05-1332 (Pubitemid 43259972)
80. LS Po TT Wang ZY Chen LK Leung 2002 Genistein-induced apoptosis in mcf-7 cells involves changes in bak and bcl-x without evidence of anti-oestrogenic effects The British Journal of Nutrition 88 5 463 469 1:CAS:528: DC%2BD38XovFOlsbo%3D 12425726 10.1079/BJN2002693 (Pubitemid 35363350)
81. J Kumi-Diaka NA Sanderson A Hall 2000 The mediating role of caspase-3 protease in the intracellular mechanism of genistein-induced apoptosis in human prostatic carcinoma cell lines, du145 and lncap Biology of the Cell 92 8-9 595 604 1:CAS:528:DC%2BD3MXktVOltLY%3D 11374438 10.1016/S0248-4900(00)01109-6 (Pubitemid 32366627)
82. HY Oh J Leem SJ Yoon S Yoon SJ Hong 2010 Lipid raft cholesterol and genistein inhibit the cell viability of prostate cancer cells via the partial contribution of EGFR-Akt/p70s6k pathway and down-regulation of androgen receptor Biochemical and Biophysical Research Communications 393 2 319 324 1:CAS:528:DC%2BC3cXjtVClu7w%3D 20138837 10.1016/j.bbrc.2010.01.133
83. AC Chen SM Donovan 2004 Genistein at a concentration present in soy infant formula inhibits caco-2bbe cell proliferation by causing g2/m cell cycle arrest The Journal of Nutrition 134 6 1303 1308 1:CAS:528:DC%2BD2cXkslylurk%3D 15173388
84. DM Baxa X Luo FK Yoshimura 2005 Genistein induces apoptosis in T lymphoma cells via mitochondrial damage Nutrition and Cancer 51 1 93 101 1:CAS:528:DC%2BD2MXjtVOgu74%3D 15749635 10.1207/s15327914nc5101-13 (Pubitemid 40365987)
85. A Das NL Banik SK Ray 2010 Flavonoids activated caspases for apoptosis in human glioblastoma t98g and u87mg cells but not in human normal astrocytes Cancer 116 1 164 176 1:CAS:528:DC%2BC3cXitFGitbc%3D 19894226
86. CY Jin C Park GY Kim SJ Lee WJ Kim YH Choi 2009 Genistein enhances trail-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma hep3b cells Chemico-Biological Interactions 180 2 143 150 1:CAS:528:DC%2BD1MXmvF2itb0%3D 19497411 10.1016/j.cbi.2009.03.020
87. P Buchler AS Gukovskaya M Mouria MC Buchler MW Buchler H Friess, et al. 2003 Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid Pancreas 26 3 264 273 1:CAS:528:DC%2BD3sXmvFSntLs%3D 12657953 10.1097/00006676-200304000-00010 (Pubitemid 36384159)
88. SR Datta H Dudek X Tao S Masters H Fu Y Gotoh, et al. 1997 Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery Cell 91 2 231 241 1:CAS:528:DyaK2sXntVyiu7k%3D 9346240 10.1016/S0092-8674(00)80405-5 (Pubitemid 27456390)
89. L del Peso M Gonzalez-Garcia C Page R Herrera G Nunez 1997 Interleukin-3-induced phosphorylation of bad through the protein kinase akt Science 278 5338 687 689 9381178 10.1126/science.278.5338.687 (Pubitemid 27464966)
90. S Wullschleger R Loewith MN Hall 2006 Tor signaling in growth and metabolism Cell 124 3 471 484 1:CAS:528:DC%2BD28Xhslaqs74%3D 16469695 10.1016/j.cell.2006.01.016 (Pubitemid 43199434)
91. DA Cross DR Alessi P Cohen M Andjelkovich BA Hemmings 1998 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase b Nature 378 785 789 10.1038/378785a0
92. CS Mitsiades N Mitsiades M Koutsilieris 2004 The Akt pathway: Molecular targets for anti-cancer drug development Current Cancer Drug Targets 4 3 235 256 1:CAS:528:DC%2BD2cXjs1Gnu78%3D 15134532 10.2174/1568009043333032 (Pubitemid 38560073)
93. Y Li FH Sarkar 2002 Inhibition of nuclear factor kappab activation in pc3 cells by genistein is mediated via akt signaling pathway Clinical Cancer Research 8 7 2369 2377 1:CAS:528:DC%2BD38XmtVWhtro%3D 12114442
94. L Gong Y Li A Nedeljkovic-Kurepa FH Sarkar 2003 Inactivation of NF-kappab by genistein is mediated via Akt signaling pathway in breast cancer cells Oncogene 22 30 4702 4709 1:CAS:528:DC%2BD3sXls1Gjtrk%3D 12879015 10.1038/sj.onc.1206583 (Pubitemid 36976445)
95. JH Peng JD Zhu MT Mi FJ Li L Cai JZ Dong, et al. 2010 Prepubertal genistein exposure affects erbb2/Akt signal and reduces rat mammary tumorigenesis European Journal of Cancer Prevention 19 2 110 119 1:CAS:528:DC%2BC3cXht12gtbs%3D 20051871 10.1097/CEJ.0b013e3283362a3e
96. P Ferenc P Solar J Kleban J Mikes P Fedorocko 2010 Down-regulation of bcl-2 and akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells Journal of Photochemistry and Photobiology. B: Biology 98 1 25 34 1:CAS:528:DC%2BC3cXksVWisg%3D%3D 10.1016/j.jphotobiol.2009. 10.004
97. Y Nakamura S Yogosawa Y Izutani H Watanabe E Otsuji T Sakai 2009 A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer ht-29 cells by inhibiting akt phosphorylation and progression of autophagy Molecular Cancer 8 100 19909554 10.1186/1476-4598-8-100 1:CAS:528:DC%2BD1MXhsVKltLfE
98. BF El-Rayes S Ali IF Ali PA Philip J Abbruzzese FH Sarkar 2006 Potentiation of the effect of erlotinib by genistein in pancreatic cancer: The role of akt and nuclear factor-kappab Cancer Research 66 21 10553 10559 1:CAS:528:DC%2BD28XhtFGjsrfO 17079479 10.1158/0008-5472.CAN-06-2333 (Pubitemid 44799778)
99. SH Kim YB Kim YT Jeon SC Lee YS Song 2009 Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and Akt in cervical cancer cells Annals of the New York Academy of Sciences 1171 495 500 1:CAS:528:DC%2BD1MXht1SntbbL 19723095 10.1111/j.1749-6632.2009.04899.x
100. SJ Park MJ Kim YK Kim SM Kim JY Park H Myoung 2010 Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma Cancer Letters 292 1 54 63 1:CAS:528:DC%2BC3cXksFGktrg%3D 19959278 10.1016/j.canlet.2009.11.004
101. Y Li FH Sarkar 2002 Gene expression profiles of genistein-treated pc3 prostate cancer cells The Journal of Nutrition 132 12 3623 3631 1:CAS:528:DC%2BD38Xps12htbY%3D 12468598
102. JN Davis O Kucuk FH Sarkar 1999 Genistein inhibits NF-kappa b activation in prostate cancer cells Nutrition and Cancer 35 2 167 174 1:CAS:528: DC%2BD3cXhs1emuro%3D 10693171 10.1207/S15327914NC352-11
103. SM Gadgeel S Ali PA Philip A Wozniak FH Sarkar 2009 Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa b in non small cell lung cancer cell lines Cancer 115 10 2165 2176 1:CAS:528:DC%2BD1MXlvFOhsr4%3D 19288574 10.1002/cncr.24250
104. FG Giancotti E Ruoslahti 1999 Integrin signaling Science 285 5430 1028 1032 1:CAS:528:DyaK1MXlt1Gns7o%3D 10446041 10.1126/science.285.5430.1028 (Pubitemid 29385945)
105. RB Nagle JD Knox C Wolf GT Bowden AE Cress 1994 Adhesion molecules, extracellular matrix, and proteases in prostate carcinoma Journal of Cellular Biochemistry. Supplement 19 232 237 1:STN:280:DyaK2M7itl2nsg%3D%3D 7823596
106. AE Cress I Rabinovitz W Zhu RB Nagle 1995 The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression Cancer and Metastasis Reviews 14 3 219 228 1:CAS:528:DyaK28XmslGr 8548870 10.1007/BF00690293
107. M Fornaro G Tallini DQ Zheng WM Flanagan M Manzotti LR Languino 1999 P27(kip1) acts as a downstream effector of and is coexpressed with the beta1c integrin in prostatic adenocarcinoma The Journal of Clinical Investigation 103 3 321 329 1:CAS:528:DyaK1MXovVKntQ%3D%3D 9927492 10.1172/JCI4585
108. KM Yamada 1997 Integrin signaling Matrix Biology 16 4 137 141 1:CAS:528:DyaK2sXnt1Cmur0%3D 9402002 10.1016/S0945-053X(97)90001-9 (Pubitemid 27487654)
109. MJ van Nimwegen B van de Water 2007 Focal adhesion kinase: A potential target in cancer therapy Biochemical Pharmacology 73 5 597 609 16997283 10.1016/j.bcp.2006.08.011 1:CAS:528:DC%2BD2sXhtlOns7s%3D (Pubitemid 46161372)
110. HC Chen PA Appeddu JT Parsons JD Hildebrand MD Schaller JL Guan 1995 Interaction of focal adhesion kinase with cytoskeletal protein talin The Journal of Biological Chemistry 270 28 16995 16999 1:CAS:528:DyaK2MXmvFOku7w%3D 7622520 10.1074/jbc.270.28.16995
111. DJ Sieg CR Hauck D Ilic CK Klingbeil E Schaefer CH Damsky, et al. 2000 Fak integrates growth-factor and integrin signals to promote cell migration Nature Cell Biology 2 5 249 256 1:CAS:528:DC%2BD3cXktlOqs7o%3D 10806474 10.1038/35010517
112. LA Cary JF Chang JL Guan 1996 Stimulation of cell migration by overexpression of focal adhesion kinase and its association with src and fyn Journal of Cell Science 109 Pt 7 1787 1794 1:CAS:528:DyaK28XksFCksb8%3D 8832401
113. K Burridge CE Turner LH Romer 1992 Tyrosine phosphorylation of paxillin and pp 125fak accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly The Journal of Cell Biology 119 4 893 903 1:CAS:528:DyaK38XmtlWjsb4%3D 1385444 10.1083/jcb.119.4.893
114. DJ Webb K Donais LA Whitmore SM Thomas CE Turner JT Parsons, et al. 2004 Fak-src signalling through paxillin, erk and mlck regulates adhesion disassembly Nature Cell Biology 6 2 154 161 1:CAS:528:DC%2BD2cXosFShtw%3D%3D 14743221 10.1038/ncb1094 (Pubitemid 38425715)
115. Y Liu E Kyle R Lieberman J Crowell G Kellof RC Bergan 2000 Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation Clinical & Experimental Metastasis 18 3 203 212 1:CAS:528:DC%2BD3MXjtFKnsbc%3D 10.1023/A:1006729106034 (Pubitemid 32269989)
116. YQ Liu E Kyle S Patel F Housseau F Hakim R Lieberman, et al. 2001 Prostate cancer chemoprevention agents exhibit selective activity against early stage prostate cancer cells Prostate Cancer and Prostatic Diseases 4 2 81 91 1:CAS:528:DC%2BD3MXlvVygu70%3D 12497043 10.1038/sj.pcan.4500506 (Pubitemid 32633383)
117. L Tremblay W Hauck AG Aprikian LR Begin A Chapdelaine S Chevalier 1996 Focal adhesion kinase (pp 125fak) expression, activation and association with paxillin and p50csk in human metastatic prostate carcinoma International Journal of Cancer 68 2 164 171 1:CAS:528:DyaK28XntlKjtbk%3D 10.1002/(SICI)1097- 0215(19961009)68:2<169::AID-IJC4>3.0.CO;2-W (Pubitemid 26380117)
118. S Hiscox NJ Jordan L Morgan TP Green RI Nicholson 2007 Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells Clinical & Experimental Metastasis 24 3 157 167 1:CAS:528:DC%2BD2sXot12ksL4%3D 10.1007/s10585-007-9065-y (Pubitemid 46850227)
119. XN Meng Y Jin Y Yu J Bai GY Liu J Zhu, et al. 2009 Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion British Journal of Cancer 101 2 327 334 1:CAS:528:DC%2BD1MXoslOmu7g%3D 19568240 10.1038/sj.bjc.6605154
120. R Bergan E Kyle P Nguyen J Trepel C Ingui L Neckers 1996 Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin Clinical & Experimental Metastasis 14 4 389 398 1:CAS:528:DyaK28XntVOjsbw%3D 10.1007/BF00123398 (Pubitemid 26363213)
121. M Lakshman L Xu V Ananthanarayanan J Cooper CH Takimoto I Helenowski, et al. 2008 Dietary genistein inhibits metastasis of human prostate cancer in mice Cancer Research 68 6 2024 2032 1:CAS:528:DC%2BD1cXjtFOht7w%3D 18339885 10.1158/0008-5472.CAN-07-1246 (Pubitemid 351416590)
122. HG Farina M Pomies DF Alonso DE Gomez 2006 Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer Oncology Reports 16 4 885 891 1:CAS:528:DC%2BD28XhtFSisrrK 16969510
123. Y Gu CF Zhu YL Dai Q Zhong B Sun 2009 Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma World Journal of Gastroenterology 15 39 4952 4957 1:CAS:528:DC%2BD1MXhtlCiu73M 19842228 10.3748/wjg.15.4952
124. K Miekus Z Madeja 2007 Genistein inhibits the contact-stimulated migration of prostate cancer cells Cellular and Molecular Biology Letters 12 348 361 1:CAS:528:DC%2BD2sXht1GqsLbE 10.2478/s11658-007-0007-0
125. H Sawai Y Okada H Funahashi Y Matsuo H Takahashi H Takeyama, et al. 2005 Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation Molecular Cancer 4 37 16209712 10.1186/1476-4598-4-37 1:CAS:528:DC%2BD28XitFelsbk%3D (Pubitemid 41574004)
126. JD Hood DA Cheresh 2002 Role of integrins in cell invasion and migration Nature Reviews. Cancer 2 2 91 100 12635172 10.1038/nrc727
127. P Friedl K Wolf 2003 Tumour-cell invasion and migration: Diversity and escape mechanisms Nature Reviews. Cancer 3 5 362 374 1:CAS:528: DC%2BD3sXjtlals7o%3D 12724734 10.1038/nrc1075 (Pubitemid 37328856)
128. P Vihinen R Ala-aho VM Kahari 2005 Matrix metalloproteinases as therapeutic targets in cancer Current Cancer Drug Targets 5 3 203 220 1:CAS:528:DC%2BD2MXksFKktr0%3D 15892620 10.2174/1568009053765799 (Pubitemid 40694861)
129. A Jezierska T Motyl 2009 Matrix metalloproteinase-2 involvement in breast cancer progression: A mini-review Medical Science Monitor 15 2 RA32 RA40 1:CAS:528:DC%2BD1MXksVOrurg%3D 19182722
130. SM Wojtowicz-Praga RB Dickson MJ Hawkins 1997 Matrix metalloproteinase inhibitors Investigational New Drugs 15 1 61 75 1:CAS:528:DyaK2sXktlOls7s%3D 9195290 10.1023/A:1005722729132 (Pubitemid 27217752)
131. GA Di Lullo SM Sweeney J Korkko L Ala-Kokko JD San Antonio 2002 Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen The Journal of Biological Chemistry 277 6 4223 4231 11704682 10.1074/jbc.M110709200 1:CAS:528:DC%2BD38XhsFSqs7s%3D (Pubitemid 34968685)
132. IE Collier SM Wilhelm AZ Eisen BL Marmer GA Grant JL Seltzer, et al. 1988 H-ras oncogene-transformed human bronchial epithelial cells (tbe-1) secrete a single metalloprotease capable of degrading basement membrane collagen The
133. T Itoh M Tanioka H Yoshida T Yoshioka H Nishimoto S Itohara 1998 Reduced angiogenesis and tumor progression in gelatinase a-deficient mice Cancer Research 58 5 1048 1051 1:CAS:528:DyaK1cXhsFersLo%3D 9500469
134. X Huang S Chen L Xu Y Liu DK Deb LC Platanias, et al. 2005 Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells Cancer Research 65 8 3470 3478 1:CAS:528:DC%2BD2MXhtVShsbbE 15833883 10.1158/0008-5472.CAN-05-0654 (Pubitemid 41330614)
135. JK Kumi-Diaka M Hassanhi K Merchant V Horman 2006 Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells Journal of Medicinal Food 9 4 491 497 1:CAS:528:DC%2BD2sXht12qsg%3D%3D 17201635 10.1089/jmf.2006.9.491
136. WY Lee SC Huang CC Tzeng TL Chang KF Hsu 2007 Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated hcc1395 breast cancer cells Nutrition and Cancer 58 2 239 246 1:CAS:528:DC%2BD2sXhtVOgtL7N 17640171
137. OC Kousidou TN Mitropoulou AE Roussidis D Kletsas AD Theocharis NK Karamanos 2005 Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors International Journal of Oncology 26 4 1101 1109 1:CAS:528:DC%2BD2MXjtFeltrg%3D 15754008
138. S Puli JC Lai A Bhushan 2006 Inhibition of matrix degrading enzymes and invasion in human glioblastoma (u87mg) cells by isoflavones Journal of Neurooncology 79 2 135 142 1:CAS:528:DC%2BD28XhtFemtLvL 10.1007/s11060-006-9126- 0 (Pubitemid 44349940)
139. LH El Touny PP Banerjee 2009 Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis Cancer Research 69 8 3695 3703 1:CAS:528:DC%2BD1MXksV2htb8%3D 19351854 10.1158/0008-5472.CAN-08-2958
140. Z Wang A Ahmad S Banerjee A Azmi D Kong Y Li, et al. 2010 Foxm1 is a novel target of a natural agent in pancreatic cancer Pharmaceutical Research 27 1159 1168 1:CAS:528:DC%2BC3cXktVahsro%3D 20354770 10.1007/s11095-010-0106-x
141. H Skogseth T Follestad E Larsson J Halgunset 2006 Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 114 5 364 371 16725013
142. L Xu RC Bergan 2006 Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat shock protein pathway Molecular Pharmacology 70 3 869 877 1:CAS:528:DC%2BD28Xps1SmsL0%3D 16772519 10.1124/mol.106.023861
143. L Xu Y Ding WJ Catalona XJ Yang WF Anderson B Jovanovic, et al. 2009 Mek4 function, genistein treatment, and invasion of human prostate cancer cells Journal of the National Cancer Institute 101 16 1141 1155 1:CAS:528: DC%2BD1MXhtVGkur3K 19638505 10.1093/jnci/djp227
144. L Xu S Chen RC Bergan 2006 Mapkapk2 and hsp27 are downstream effectors of p38 map kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer Oncogene 25 21 2987 2998 1:CAS:528: DC%2BD28Xks1Orsbw%3D 16407830 10.1038/sj.onc.1209337 (Pubitemid 43780463)
145. TL Lotan M Lyon D Huo JB Taxy C Brendler BA Foster, et al. 2007 Up-regulation of mkk4, mkk6 and mkk7 during prostate cancer progression: An important role for sapk signalling in prostatic neoplasia The Journal of Pathology 212 4 386 394 1:CAS:528:DC%2BD2sXhtVWiurnM 17577251 10.1002/path.2194 (Pubitemid 47099015)
146. L Wang Y Pan JL Dai 2004 Evidence of mkk4 pro-oncogenic activity in breast and pancreatic tumors Oncogene 23 35 5978 5985 1:CAS:528: DC%2BD2cXmt1KrtL4%3D 15184866 10.1038/sj.onc.1207802 (Pubitemid 39093542)
147. EF Wagner AR Nebreda 2009 Signal integration by jnk and p38 mapk pathways in cancer development Nature Reviews. Cancer 9 8 537 549 1:CAS:528: DC%2BD1MXovFymu7w%3D 19629069 10.1038/nrc2694
148. PA Cornford AR Dodson KF Parsons AD Desmond A Woolfenden M Fordham, et al. 2000 Heat shock protein expression independently predicts clinical outcome in prostate cancer Cancer Research 60 24 7099 7105 1:CAS:528: DC%2BD3MXjsVOhug%3D%3D 11156417
149. N Mounier AP Arrigo 2002 Actin cytoskeleton and small heat shock proteins: How do they interact? Cell Stress & Chaperones 7 2 167 176
150. R Benndorf K Hayess S Ryazantsev M Wieske J Behlke G Lutsch 1994 Phosphorylation and supramolecular organization of murine small heat shock protein hsp25 abolish its actin polymerization-inhibiting activity The Journal of Biological Chemistry 269 32 20780 20784 1:CAS:528:DyaK2cXlsFWlt70%3D 8051180
151. T Miron K Vancompernolle J Vandekerckhove M Wilchek B Geiger 1991 A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein The Journal of Cell Biology 114 2 255 261 1:CAS:528:DyaK38XhtVWgsrc%3D 2071672 10.1083/jcb.114.2.255
152. JN Lavoie E Hickey LA Weber J Landry 1993 Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27 The Journal of Biological Chemistry 268 32 24210 24214 1:CAS:528:DyaK3sXmtVSmtr0%3D 8226968
153. JN Lavoie G Gingras-Breton RM Tanguay J Landry 1993 Induction of Chinese hamster hsp27 gene expression in mouse cells confers resistance to heat shock. Hsp27 stabilization of the microfilament organization The Journal of Biological Chemistry 268 5 3420 3429 1:CAS:528:DyaK3sXhsVCgtrk%3D 8429018
154. JC Hedges MA Dechert IA Yamboliev JL Martin E Hickey LA Weber, et al. 1999 A role for p38(mapk)/hsp27 pathway in smooth muscle cell migration The Journal of Biological Chemistry 274 34 24211 24219 1:CAS:528:DyaK1MXlsVOnur0%3D 10446196 10.1074/jbc.274.34.24211 (Pubitemid 29390357)
155. S Rousseau F Houle J Landry J Huot 1997 P38 map kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells Oncogene 15 18 2169 2177 1:CAS:528:DyaK2sXnsFajsrs%3D 9393975 10.1038/sj.onc.1201380
156. SA Hayes X Huang S Kambhampati LC Platanias RC Bergan 2003 P38 map kinase modulates smad-dependent changes in human prostate cell adhesion Oncogene 22 31 4841 4850 1:CAS:528:DC%2BD3sXlvVKnsrs%3D 12894225 10.1038/sj.onc.1206730 (Pubitemid 36981272)
157. Y Liu B Jovanovic M Pins C Lee RC Bergan 2002 Over expression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion Oncogene 21 54 8272 8281 1:CAS:528:DC%2BD38XovVGmsLs%3D 12447690 10.1038/sj.onc.1206117 (Pubitemid 35477867)
158. CS Craft D Romero CP Vary RC Bergan 2007 Endoglin inhibits prostate cancer motility via activation of the alk2-smad1 pathway Oncogene 26 51 7240 7250 1:CAS:528:DC%2BD2sXht1Oqsb3O 17496924 10.1038/sj.onc.1210533 (Pubitemid 350085322)
159. CS Craft L Xu D Romero CP Vary RC Bergan 2008 Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells Molecular Pharmacology 73 1 235 242 1:CAS:528:DC%2BD1cXkslGisQ%3D%3D 17951357 10.1124/mol.107.038935 (Pubitemid 350294214)
160. LH El Touny PP Banerjee 2007 Genistein induces the metastasis suppressor kangai-1 which mediates its anti-invasive effects in tramp cancer cells Biochemical and Biophysical Research Communications 361 1 169 175 1:CAS:528:DC%2BD2sXotlWrtb8%3D 17658479 10.1016/j.bbrc.2007.07.010 (Pubitemid 47103319)
161. LL Zhang L Li DP Wu JH Fan X Li KJ Wu, et al. 2008 A novel anti-cancer effect of genistein: Reversal of epithelial mesenchymal transition in prostate cancer cells Acta Pharmacologica Sinica 29 9 1060 1068 1:CAS:528: DC%2BD1cXhtV2rurnE 18718175 10.1111/j.1745-7254.2008.00831.x
162. EL Hsu N Chen A Westbrook F Wang R Zhang RT Taylor, et al. 2009 Modulation of cxcr4, cxcl12, and tumor cell invasion potential in vitro by phytochemicals Journal of Oncology 2009 491985 19325924 10.1155/2009/491985 1:CAS:528:DC%2BD1MXhtFaiurrM
163. PJ Magee H McGlynn IR Rowland 2004 Differential effects of isoflavones and lignans on invasiveness of mda-mb-231 breast cancer cells in vitro Cancer Letters 208 1 35 41 1:CAS:528:DC%2BD2cXjsVensL8%3D 15105043 10.1016/j.canlet. 2003.11.012 (Pubitemid 38501781)
164. EM Scholar ML Toews 1994 Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein Cancer Letters 87 2 159 162 1:CAS:528:DyaK2MXis12gs74%3D 7812935 10.1016/0304-3835(94)90217-8
165. M Ogasawara T Matsunaga H Suzuki 2007 Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells Biological & Pharmaceutical Bulletin 30 1 200 204 1:CAS:528:DC%2BD2sXjtlWlt7Y%3D 10.1248/bpb.30.200 (Pubitemid 46066348)
166. JR Zhou L Yu Y Zhong RL Nassr AA Franke SM Gaston, et al. 2002 Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components The Prostate 53 2 143 153 1:CAS:528:DC%2BD38XosFSks7s%3D 12242729 10.1002/pros.10141
167. CE Harper LM Cook BB Patel J Wang IA Eltoum A Arabshahi, et al. 2009 Genistein and resveratrol, alone and in combination, suppress prostate cancer in sv-40 tag rats The Prostate 69 15 1668 1682 1:CAS:528:DC%2BD1MXhsVSntr%2FO 19670229 10.1002/pros.21017
168. R Mentor-Marcel CA Lamartiniere IE Eltoum NM Greenberg A Elgavish 2001 Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (tramp) Cancer Research 61 18 6777 6782 1:CAS:528:DC%2BD3MXntFaisLk%3D 11559550
169. LH El Touny PP Banerjee 2007 Akt gsk-3 pathway as a target in genistein-induced inhibition of tramp prostate cancer progression toward a poorly differentiated phenotype Carcinogenesis 28 8 1710 1717 1:CAS:528:DC%2BD2sXpt1ehsbk%3D 17468512 10.1093/carcin/bgm103 (Pubitemid 47289033)
170. Y Sato N Seo E Kobayashi 2006 Genetic background differences between fvb and c57bl/6 mice affect hypnotic susceptibility to pentobarbital, ketamine and nitrous oxide, but not isoflurane Acta Anaesthesiologica Scandinavica 50 5 553 556 1:CAS:528:DC%2BD28Xls1Cqtb0%3D 16643223 10.1111/j.1399-6576.2006.001002.x
171. M Messina W McCaskill-Stevens JW Lampe 2006 Addressing the soy and breast cancer relationship: Review, commentary, and workshop proceedings Journal of the National Cancer Institute 98 18 1275 1284 16985246 10.1093/jnci/djj356 (Pubitemid 44530723)
172. H Iishi M Tatsuta M Baba H Yano N Sakai H Akedo 2000 Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar rats International Journal of Cancer 86 3 416 420 1:CAS:528: DC%2BD3cXivVyju78%3D 10.1002/(SICI)1097-0215(20000501)86:3<416::AID- IJC17>3.0.CO;2
173. CH Takimoto K Glover X Huang SA Hayes L Gallot M Quinn, et al. 2003 Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer Cancer Epidemiology, Biomarkers & Prevention 12 11 Pt 1 1213 1221 1:CAS:528:DC%2BD3sXptlyjtb4%3D
174. MG Busby AR Jeffcoat LT Bloedon MA Koch T Black KJ Dix, et al. 2002 Clinical characteristics and pharmacokinetics of purified soy isoflavones: Single-dose administration to healthy men The American Journal of Clinical Nutrition 75 1 126 136 1:CAS:528:DC%2BD38XhslylsQ%3D%3D 11756070
175. L Fischer C Mahoney AR Jeffcoat MA Koch BE Thomas JL Valentine, et al. 2004 Clinical characteristics and pharmacokinetics of purified soy isoflavones: Multiple-dose administration to men with prostate neoplasia Nutrition and Cancer 48 2 160 170 1:CAS:528:DC%2BD2cXmslGqtrk%3D 15231450 10.1207/s15327914nc48025
176. LT Bloedon AR Jeffcoat W Lopaczynski MJ Schell TM Black KJ Dix, et al. 2002 Safety and pharmacokinetics of purified soy isoflavones: Single-dose administration to postmenopausal women The American Journal of Clinical Nutrition 76 5 1126 1137 1:CAS:528:DC%2BD38XosF2qsLg%3D 12399289
177. JM Pendleton WW Tan S Anai M Chang W Hou KT Shiverick, et al. 2008 Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy BMC Cancer 8 132 18471323 10.1186/1471-2407-8-132 1:CAS:528:DC%2BD1cXotleksr0%3D (Pubitemid 351737018)
178. RW deVere White RM Hackman SE Soares LA Beckett Y Li B Sun 2004 Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer Urology 63 2 259 263 14972467 10.1016/j.urology.2003.09.061 (Pubitemid 38234414)
179. El-Rayes, B. F., Philip, P. A., Sarkar, F. H., Shields, A. F., Ferris, A. M., Hess, K., et al. (2010). A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer. Investigational New Drugs. doi: 10.1007/s10637-010-9386-6.
180. U Vaishampayan M Hussain M Banerjee S Seren FH Sarkar J Fontana, et al. 2007 Lycopene and soy isoflavones in the treatment of prostate cancer Nutrition and Cancer 59 1 1 7 1:CAS:528:DC%2BD2sXht1CltrfI 17927495