Inflammation, pain, and pressure - Purinergic signaling in oral tissues

Journal of Dental Research

Volumn 91, Issue 12, 2012, Pages 1103-1109

  Lim, J C ^a   Mitchell, C H ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

inflammasome; mechanosensitivity; neurotransmitter; P2X7; P2Y; periodontal disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; INFLAMMASOME; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y RECEPTOR;

ANIMAL; HUMAN; INFLAMMATION; METABOLISM; MOUTH; MOUTH DISEASE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; INFLAMMASOMES; INFLAMMATION; MOUTH; MOUTH DISEASES; PAIN; RECEPTORS, PURINERGIC P2X; RECEPTORS, PURINERGIC P2Y; SIGNAL TRANSDUCTION;

EID: 84872921225     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034512463239     Document Type: Article

References (85)

1. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 ; 58: 281-341
2. Adachi K, Shimizu K, Hu JW, Suzuki I, Sakagami H, Koshikawa N, et al. Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. Mol Pain. 2010 ; 6: 59
3. Alavi AM, Dubyak GR, Burnstock G. Immunohistochemical evidence for ATP receptors in human dental pulp. J Dent Res. 2001 ; 80: 476-483
4. Ambalavanar R, Dessem D. Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res. 2009 ; 88: 201-211
5. Auchampach JA, Jin X, Wan TC, Caughey GH, Linden J. Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol. 1997 ; 52: 846-860
6. Binderman I, Bahar H, Jacob-Hirsch J, Zeligson S, Amariglio N, Rechavi G, et al. P2X4 is up-regulated in gingival fibroblasts after periodontal surgery. J Dent Res. 2007 ; 86: 181-185
7. Burnstock G Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Straub RW Bolis L, ed. New York, NY: Raven Press ; 1978: 107-118.
8. Burnstock G. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J Anat. 1999 ; 194 (Pt 3). 335-342
9. Burnstock G, Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor?. Gen Pharmacol. 1985 ; 16: 433-440
10. Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol. 2004 ; 240: 31-304
11. Burnstock G, Ulrich H. Purinergic signaling in embryonic and stem cell development. Cell Mol Life Sci. 2011 ; 68: 1369-1394
12. Burnstock G, Krugel U, Abbracchio MP, Illes P. Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol. 2011 ; 95: 229-274
13. Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic SS. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 ; 63: 641-683
14. Coimbra LS, Rossa C, Guimaraes MR, Gerlach RF, Muscara MN, Spolidorio DM, et al. Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats. J Periodontol. 2011 ; 82: 767-777
15. Cook SP, McCleskey EW. Desensitization, recovery and Ca(2+)-dependent modulation of ATP-gated P2X receptors in nociceptors. Neuropharmacology. 1997 ; 36: 1303-1308
16. Cook SP, McCleskey EW. Cell damage excites nociceptors through release of cytosolic ATP. Pain. 2002 ; 95: 41-47
17. Cook SP, Vulchanova L, Hargreaves KM, Elde R, McCleskey EW. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature. 1997 ; 387: 505-508
18. Csoka B, Nemeth ZH, Virag L, Gergely P, Leibovich SJ, Pacher P, et al. A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to. Escherichia coli. Blood. 2007 ; 110: 2685-2695
19. Donnelly-Roberts DL, Jarvis MF. Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol. 2007 ; 151: 571-579
20. Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF. Painful purinergic receptors. J Pharmacol Exp Ther. 2008 ; 324: 409-415
21. Douillet CD, Robinson WP, Milano PM, Boucher RC, Rich PB. Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathways. Am J Physiol Lung Cell Mol Physiol. 2006 ; 291: L734 - L746
22. Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol. 2004 ; 172: 4987-4994
23. Ferrero ME. Purinoceptors in inflammation: potential as anti-inflammatory therapeutic targets. Front Biosci. 2011 ; 16: 2172-2186
24. Fitz JG. Regulation of cellular ATP release. Trans Am Clin Climatol Assoc. 2007 ; 118: 199-208
25. Fountain SJ, Burnstock G. An evolutionary history of P2X receptors. Purinergic Signal. 2009 ; 5: 269-272
26. Fredholm BB, AP IJ, Jacobson KA, Linden J, Muller CE. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors - an update. Pharmacol Rev. 2011 ; 63: 1-34
27. Gao ZG, Jacobson KA. Emerging adenosine receptor agonists: an update. Expert Opin Emerg Drugs. 2011 ; 16: 597-602
28. Gerevich Z, Illes P. P2Y receptors and pain transmission. Purinergic Signal. 2004 ; 1: 3-10
29. Goding JW, Grobben B, Slegers H. Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family. Biochim Biophys Acta. 2003 ; 1638: 1-19
30. Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010 ; 13: 883-888
31. Hashikawa T, Takedachi M, Terakura M, Yamada S, Thompson LF, Shimabukuro Y, et al. Activation of adenosine receptor on gingival fibroblasts. J Dent Res. 2006 ; 85: 739-744
32. Hasko G, Linden J, Cronstein B, Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov. 2008 ; 7: 759-770
33. Hu B, Chiang CY, Hu JW, Dostrovsky JO, Sessle BJ. P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis. J Neurophysiol. 2002 ; 88: 1614-1624
34. Ichikawa H, Fukunaga T, Jin HW, Fujita M, Takano-Yamamoto T, Sugimoto T. VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. Brain Res. 2004 ; 1008: 131-136
35. Jiang J, Gu J. Expression of adenosine triphosphate P2X3 receptors in rat molar pulp and trigeminal ganglia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 ; 94: 622-626
36. Jiang LH, Mackenzie AB, North RA, Surprenant A. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol. 2000 ; 58: 82-88
37. Joseph SM, Buchakjian MR, Dubyak GR. Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem. 2003 ; 278: 23331-23342
38. Kawase T, Okuda K, Yoshie H. Extracellular ATP and ATPgammaS suppress the proliferation of human periodontal ligament cells by different mechanisms. J Periodontol. 2007 ; 78: 748-756
39. Klinger M, Freissmuth M, Nanoff C. Adenosine receptors: G protein-mediated signalling and the role of accessory proteins. Cell Signal. 2002 ; 14: 99-108
40. Kukulski F, Levesque SA, Sevigny J. Impact of ectoenzymes on P2 and P1 receptor signaling. Adv Pharmacol. 2011 ; 61: 263-299
41. Lazarowski ER, Homolya L, Boucher RC, Harden TK. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J Biol Chem. 1997 ; 272: 20402-20407
42. Lazarowski ER, Sesma JI, Seminario-Vidal L, Kreda SM. Molecular mechanisms of purine and pyrimidine nucleotide release. Adv Pharmacol. 2011 ; 61: 221-261
43. Lee MH, Yeon KY, Park CK, Li HY, Fang Z, Kim MS, et al. Eugenol inhibits calcium currents in dental afferent neurons. J Dent Res. 2005 ; 84: 848-851
44. Li HY, Lee BK, Kim JS, Jung SJ, Oh SB. Eugenol inhibits ATP-induced P2X currents in trigeminal ganglion neurons. Korean J Physiol Pharmacol. 2008 ; 12: 315-321
45. Lister MF, Sharkey J, Sawatzky DA, Hodgkiss JP, Davidson DJ, Rossi AG, et al. The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond). 2007 ; 4: 5
46. Luckprom P, Wongkhantee S, Yongchaitrakul T, Pavasant P. Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase- dependent pathway in human periodontal ligament cells. J Periodontal Res. 2010 ; 45: 404-411
47. Luckprom P, Kanjanamekanant K, Pavasant P. Role of connexin43 hemichannels in mechanical stress-induced ATP release in human periodontal ligament cells. J Periodontal Res. 2011 ; 46: 607-615
48. Markowitz K, Moynihan M, Liu M, Kim S. Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg Oral Med Oral Pathol. 1992 ; 73: 729-737
49. Matsuka Y, Neubert JK, Maidment NT, Spigelman I. Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo. Brain Res. 2001 ; 915: 248-255
50. Montreekachon P, Chotjumlong P, Bolscher JG, Nazmi K, Reutrakul V, Krisanaprakornkit S. Involvement of P2X(7) purinergic receptor and MEK1/2 in interleukin-8 up-regulation by LL-37 in human gingival fibroblasts. J Periodontal Res. 2011 ; 46: 327-337
51. Murakami S, Terakura M, Kamatani T, Hashikawa T, Saho T, Shimabukuro Y, et al. Adenosine regulates the production of interleukin-6 by human gingival fibroblasts via cyclic AMP/protein kinase A pathway. J Periodontal Res. 2000 ; 35: 93-101
52. Murakami S, Hashikawa T, Saho T, Takedachi M, Nozaki T, Shimabukuro Y, et al. Adenosine regulates the IL-1 beta-induced cellular functions of human gingival fibroblasts. Int Immunol. 2001 ; 13: 1533-1540
53. North RA. Molecular physiology of P2X receptors. Physiol Rev. 2002 ; 82: 1013-1067
54. North RA. P2X3 receptors and peripheral pain mechanisms. J Physiol. 2004 ; 554 (Pt 2). 301-308
55. Novak I. Purinergic signalling in epithelial ion transport: regulation of secretion and absorption. Acta Physiol (Oxf). 2011 ; 202: 501-522
56. Ohta A, Sitkovsky M. The adenosinergic immunomodulatory drugs. Curr Opin Pharmacol. 2009 ; 9: 501-506
57. Oliveira MC, Parada CA, Veiga MC, Rodrigues LR, Barros SP, Tambeli CH. Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain. Eur J Pain. 2005 ; 9: 87-93
58. Orriss IR, Burnstock G, Arnett TR. Purinergic signalling and bone remodelling. Curr Opin Pharmacol. 2010 ; 10: 322-330
59. Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, et al. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 ; 206: 2543-2555
60. Puklo M, Guentsch A, Hiemstra PS, Eick S, Potempa J. Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol. 2008 ; 23: 328-335
61. Reigada D, Mitchell CH. Release of ATP from RPE cells involves both CFTR and vesicular transport. Am J Physiol Cell Physiol. 2005 ; 288: C132 - C140
62. Satrawaha S, Wongkhantee S, Pavasant P, Sumrejkanchanakij P. Pressure induces interleukin-6 expression via the P2Y6 receptor in human dental pulp cells. Arch Oral Biol. 2011 ; 56: 1230-1237
63. Sessle BJ. Peripheral and central mechanisms of orofacial inflammatory pain. Int Rev Neurobiol. 2011 ; 97: 179-206
64. Sharma CG, Pradeep AR. Gingival crevicular fluid osteopontin levels in periodontal health and disease. J Periodontol. 2006 ; 77: 1674-1680
65. Silverman MH, Strand V, Markovits D, Nahir M, Reitblat T, Molad Y, et al. Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial. J Rheumatol. 2008 ; 35: 41-48
66. Staikopoulos V, Sessle BJ, Furness JB, Jennings EA. Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons. Neuroscience. 2007 ; 144: 208-216
67. Stutz A, Golenbock DT, Latz E. Inflammasomes: too big to miss. J Clin Invest. 2009 ; 119: 3502-3511
68. Sun CX, Wall NR, Angelov N, Ririe C, Chen JW, Boskovic DS, et al. Changes in mRNA expression of adenosine receptors in human chronic periodontitis. Chin J Dent Res. 2011 ; 14: 113-120
69. Surprenant A, Rassendren F, Kawashima E, North RA, Buell G. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science. 1996 ; 272: 735-738
70. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 2002 ; 20: 795-823
71. Thorn JA, Jarvis SM. Adenosine transporters. Gen Pharmacol. 1996 ; 27: 613-620
72. Tomasinsig L, Pizzirani C, Skerlavaj B, Pellegatti P, Gulinelli S, Tossi A, et al. The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner. J Biol Chem. 2008 ; 283: 30471-30481
73. Ulmann L, Hirbec H, Rassendren F. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J. 2010 ; 29: 2290-2300
74. Villa G, Ceruti S, Zanardelli M, Magni G, Jasmin L, Ohara PT, et al. Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. Mol Pain. 2010 ; 6: 89
75. von Kugelgen I, Harden TK. Molecular pharmacology, physiology, and structure of the P2Y receptors. Adv Pharmacol. 2011 ; 61: 373-415
76. Watanabe T, Tsuboi Y, Sessle BJ, Iwata K, Hu JW. P2X and NMDA receptor involvement in temporomandibular joint-evoked reflex activity in rat jaw muscles. Brain Res. 2010 ; 1346: 83-91
77. Wongkhantee S, Yongchaitrakul T, Pavasant P. Mechanical stress induces osteopontin via ATP/P2Y1 in periodontal cells. J Dent Res. 2008 ; 87: 564-568
78. Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM, et al. Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol. 2012 ; 590 (Pt 10). 2285-2304
79. Yilmaz O, Yao L, Maeda K, Rose TM, Lewis EL, Duman M, et al. ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol. 2008 ; 10: 863-875
80. Yilmaz O, Sater AA, Yao L, Koutouzis T, Pettengill M, Ojcius DM. ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell Microbiol. 2010 ; 12: 188-198
81. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 2004 ; 75: 39-48
82. Zhang M, Budak MT, Lu W, Khurana TS, Zhang X, Laties AM, et al. Identification of the A3 adenosine receptor in rat retinal ganglion cells. Mol Vis. 2006 ; 12: 937-948
83. Zhang X, Zhang M, Laties AM, Mitchell CH. Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation. J Neurochem. 2006 ; 98: 566-575
84. Zimmermann H. Ectonucleotidases in the nervous system. Novartis Found Symp. 2006 ; 276: 113-128
85. Zylka MJ. Pain-relieving prospects for adenosine receptors and ectonucleotidases. Trends Mol Med. 2011 ; 17: 188-196