Purinergic signalling and bone remodelling

Current Opinion in Pharmacology

Volumn 10, Issue 3, 2010, Pages 322-330

  Orriss, Isabel R ^a   Burnstock, Geoffrey ^b   Arnett, Timothy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOTAXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN E2; PROTEIN KINASE C; PURINERGIC P2 RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X5 RECEPTOR; PURINERGIC P2X6 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; ADENOSINE TRIPHOSPHATE; NUCLEOTIDE;

APOPTOSIS; ARTICULAR CARTILAGE; BONE MINERALIZATION; BONE REMODELING; CELL FUNCTION; CELL FUSION; CELL SURVIVAL; ENZYME ACTIVATION; FRACTURE; HUMAN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; HUMANS; NUCLEOTIDES; OSTEOBLASTS; OSTEOCLASTS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 77954660043     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2010.01.003     Document Type: Review

References (68)

1. Burnstock G. Purinergic nerves. Pharmacol Rev 1972, 24:509-581.
2. Burnstock G., Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor?. Gen Pharmacol 1985, 16:433-440.
3. Abbracchio M.P., Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors?. Pharmacol Ther 1994, 64:445-475.
4. Burnstock G. Purine and pyrimidine receptors. Cell Mol Life Sci 2007, 64:1471-1483.
5. Kumagai H., Sakamoto H., Guggino S., Filburn C.R., Sacktor B. Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells. Calcif Tissue Int 1989, 45:251-254.
6. Yu H., Ferrier J. Osteoblast-like cells have a variable mixed population of purino/nucleotide receptors. FEBS Lett 1993, 328:209-214.
7. 6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Biochem Biophys Res Commun 1997, 240:298-302.
8. Nakamura E., Uezono Y., Narusawa K., Shibuya I., Oishi Y., Tanaka M., Yanagihara N., Nakamura T., Izumi F. ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells. Am J Physiol Cell Physiol 2000, 279:C510-C519.
9. 7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res 2001, 16:846-856.
10. Hoebertz A., Townsend-Nicholson A., Glass R., Burnstock G., Arnett T.R. Expression of P2 receptors in bone and cultured bone cells. Bone 2000, 27:503-510.
11. 7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol 2003, 17:1356-1367.
12. Ihara H., Hirukawa K., Goto S., Togari A. ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. Biochem Biophys Res Commun 2005, 326:329-334.
13. Orriss I.R., Knight G.E., Ranasinghe S., Burnstock G., Arnett T.R. Osteoblast responses to nucleotides increase during differentiation. Bone 2006, 39:300-309.
14. Alqallaf S.M., Evans B.A., Kidd E.J. Atypical P2X receptor pharmacology in two human osteoblast-like cell lines. Br J Pharmacol 2009, 156:1124-1135.
15. 2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase. J Biol Chem 1999, 274:14315-14324.
16. i release in rat osteoblasts independently of Gq activation or cyclic monophosphate accumulation. A mechanism for localizing systemic responses in bone. J Biol Chem 2001, 276:9565-9571.
17. 7 receptors in bone. Purinergic Signal 2009, 5:205-221.
18. 7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem 2007, 282:3403-3412.
19. 7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol 2008, 181:859-871.
20. 7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem 2005, 280:42952-42959.
21. 2+- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 2008, 42:644-652.
22. 2 receptor in bone remodeling. J Cell Biochem 2002, 86:413-419.
23. 2 receptors and pyrophosphate. Endocrinology 2007, 148:4208-4216.
24. Pines A., Bivi N., Romanello M., Damante G., Kelley M.R., Adamson E.D., D'andrea P., Quadrifoglio F., Moro L., Tell G. Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radic Res 2005, 39:269-281.
25. Costessi A., Pines A., D'andrea P., Romanello M., Damante G., Cesaratto L., Quadrifoglio F., Moro L., Tell G. Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 2005, 36:418-432.
26. Katz S., Boland R., Santillan G. Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation. Int J Biochem Cell Biol 2006, 38:2082-2091.
27. 2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases. Arch Biochem Biophys 2008, 477:244-252.
28. Romanello M., Pani B., Bicego M., D'andrea P. Mechanically induced ATP release from human osteoblastic cells. Biochem Biophys Res Commun 2001, 289:1275-1281.
29. Buckley K.A., Golding S.L., Rice J.M., Dillon J.P., Gallagher J.A. Release and interconversion of P2 receptor agonists by human osteoblast-like cells. FASEB J 2003, 17:1401-1410.
30. Genetos D.C., Geist D.J., Liu D., Donahue H.J., Duncan R.L. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res 2005, 20:41-49.
31. Orriss I.R., Knight G.E., Utting J.C., Taylor S.E.B., Burnstock G., Arnett T.R. Hypoxia stimulates vesicular ATP release from rat osteoblasts. J Cell Physiol 2009, 220:155-162.
32. Biswas P., Zanello L.P. 1alpha,25(OH)(2) vitamin D(3) induction of ATP secretion in osteoblasts. J Bone Miner Res 2009, 24:1450-1460.
33. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 2000, 362:299-309.
34. Johnson K.A., Hessle L., Vaingankar S., Wennberg C., Mauro S., Narisawa S., Goding J.W., Sano K., Millan J.L., Terkeltaub R. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol 2000, 279:R1365-R1377.
35. Fleisch H., Bisaz S. Isolation from the plasma of pyrophosphate, an inhibitor of calcification. Helv Physiol Pharmacol Acta 1962, 20:C52-C53.
36. Genetos D.C., Kephart C.J., Zhang Y., Yellowley C.E., Donahue H.J. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol 2007, 212:207-214.
37. Bowler W.B., Birch M.A., Gallagher J.A., Bilbe G. Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts. J Bone Miner Res 1995, 10:1137-1145.
38. 4 purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts. J Cell Sci 1999, 112(Pt 23):4425-4435.
39. Buckley K.A., Hipskind R.A., Gartland A., Bowler W.B., Gallagher J.A. Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone 2002, 31:582-590.
40. 7 activation. Crit Rev Eukaryot Gene Expr 2003, 13:237-242.
41. 6 nucleotide receptors activate NF-{kappa}B and increase survival of osteoclasts. J Biol Chem 2005, 280:16909-16915.
42. 2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption. Bone 1998, 22:195-200.
43. Morrison M.S., Turin L., King B.F., Burnstock G., Arnett T.R. ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J Physiol 1998, 511(Pt 2):495-500.
44. 1 receptor on bone cells. FASEB J 2001, 15:1139-1148.
45. Hoebertz A., Arnett T.R., Burnstock G. Regulation of bone resorption and formation by purines and pyrimidines. Trends Pharmacol Sci 2003, 24:290-297.
46. 7 gene are associated to fracture risk and to effect of estrogen treatment. Pharmacogenet Genomics 2007, 17:555-567.
47. 7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif Tissue Int 2003, 73:361-369.
48. 7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts. J Biomed Sci 2005, 12:1013-1020.
49. 7 receptors to activate NF-kappaB in osteoclasts. J Bone Miner Res 2004, 19:642-651.
50. Armstrong S., Pereverzev A., Dixon S.J., Sims S.M. Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts. J Cell Sci 2009, 122:136-144.
51. 7 receptors. J Biol Chem 2002, 277:7574-7580.
52. Hazama R., Qu X., Yokoyama K., Tanaka C., Kinoshita E., He J., Takahashi S., Tohyama K., Yamamura H., Tohyama Y. ATP-induced osteoclast function: the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk. Genes Cells 2009, 14:871-884.
53. Caswell A.M., Leong W.S., Russell R.G. Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture. Biochim Biophys Acta 1991, 1074:151-158.
54. Koolpe M., Pearson D., Benton H.P. Expression of both P1 and P2 purine receptor genes by human articular chondrocytes and profile of ligand-mediated prostaglandin E2 release. Arthritis Rheum 1999, 42:258-267.
55. Kudirka J.C., Panupinthu N., Tesseyman M.A., Dixon S.J., Bernier S.M. P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. J Cell Physiol 2007, 213:54-64.
56. Knight M.M., McGlashan S.R., Garcia M., Jensen C.G., Poole C.A. Articular chondrocytes express connexin 43 hemichannels and P2 receptors-a putative mechanoreceptor complex involving the primary cilium?. J Anat 2009, 214:275-283.
57. Graff R.D., Lazarowski E.R., Banes A.J., Lee G.M. ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 2000, 43:1571-1579.
58. 1, inhibits cartilage formation in micromass cultures of chick limb mesenchyme. Dev Dyn 2001, 222:494-505.
59. Brown C.J., Caswell A.M., Rahman S., Russell R.G., Buttle D.J. Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Biochim Biophys Acta 1997, 1362:208-220.
60. 3 purinergic receptors in bovine chondrocytes. Osteoarthritis Cartilage 2008, 16:1421-1429.
61. Croucher L.J., Crawford A., Hatton P.V., Russell R.G., Buttle D.J. Extracellular ATP and UTP stimulate cartilage proteoglycan and collagen accumulation in bovine articular chondrocyte pellet cultures. Biochim Biophys Acta 2000, 1502:297-306.
62. Chowdhury T.T., Knight M.M. Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. J Cell Physiol 2006, 209:845-853.
63. 4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures. Cell Calcium 2009, 45:421-430.
64. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007, 87:659-797.
65. 7 receptor as sensitive flow sensor for ERK activation in osteoblasts. Biochem Biophys Res Commun 2008, 372:486-490.
66. Jorgensen N.R., Henriksen Z., Brot C., Eriksen E.F., Sorensen O.H., Civitelli R., Steinberg T.H. Human osteoblastic cells propagate intercellular calcium signals by two different mechanisms. J Bone Miner Res 2000, 15:1024-1032.
67. Pines A., Romanello M., Cesaratto L., Damante G., Moro L., D'andrea P., Tell G. Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line. Biochem J 2003, 373:815-824.
68. Modderman W.E., Weidema A.F., Vrijheid-Lammers T., Wassenaar A.M., Nijweide P.J. Permeabilization of cells of hemopoietic origin by extracellular ATP4: elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments. Calcif Tissue Int 1994, 55:141-150.