Canine mast cell adenosine receptors: Cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A(2B) receptor

Molecular Pharmacology

Volumn 52, Issue 5, 1997, Pages 846-860

  Auchampach, John A ^a   Jin, Xiaowei ^a   Wan, Tina C ^a   Caughey, George H ^b   Linden, Joel ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 AMINO 3 IODOBENZYL) 8 OXYACETATE 1 PROPYLXANTHINE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 8 (4 SULFOPHENYL)THEOPHYLLINE; 8 [4 (2 AMINOETHYLCARBAMOYL)METHOXYPHENYL] 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CALCIUM ION; CYCLIC AMP; ENPROFYLLINE; INOSITOL TRISPHOSPHATE; RECOMBINANT ADENOSINE A1 RECEPTOR; RECOMBINANT ADENOSINE A3 RECEPTOR; UNCLASSIFIED DRUG; XANTHINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; MALE; MAST CELL DEGRANULATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

EID: 0030817408     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.5.846     Document Type: Article

References (41)

1. Meyerhof, W., R. Müller-Brechlin, and D. Richter. Molecular Cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Lett. 284:155-160 (1991).
2. 3 adenosine receptor. Proc. Natl. Acad. Sci. USA 89:7432-7436 (1992).
3. 3 adenosine receptor. Proc. Natl. Acad. Sci. USA 90:10365-10369 (1993).
4. 3 adenosine receptor with widespread tissue distribution. Mol. Pharmacol. 44:524-532 (1993).
5. Hill, R. J., J. J. Oleynek, C. F. Hoth, M. A. R. Kiron, W. F. Weng, R. T. Wester, W. R. Tracey, D. R. Knight, R. A. Buchholz, and S. P. Kennedy. Cloning, expression and pharmacological characterization of rabbit adenosine A(1) and A(3) receptors. J. Pharmacol. Exp. Ther. 280:122-128 (1997).
6. 3 adenosine receptor. Mol. Pharmacol. 45:978-982 (1994).
7. Gilfillan, A. M., G. A. Wiggan, and A. F. Welton. Pertussis toxin pretreatment reveals differential effects of adenosine analogs on IgE-dependent histamine and peptidoleukotriene release from RBL-2H3 cells. Biochim. Biophys. Acta 1052:467-474 (1990).
8. 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 268:16887-16890 (1993).
9. Shepherd, R. K., J. Linden, and B. R. Duling. Adenosine-induced vasoconstriction in vivo: role of the mast cell and A(3) adenosine receptor. Circ. Res. 78:627-634 (1996).
10. Bjorck, T., L. E. Gustafsson, and S. E. Dahlen. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am. Rev. Respir. Dis. 145:1087-1091 (1992).
11. Cushley, M. J., and S. T. Holgate. Adenosine-induced bronchoconstriction in asthma: role of mast cell-mediator release. J. Aller. Clin. Immunol. 75:272-278 (1985).
12. 3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol. Sci. 15:298-306 (1994).
13. Caughey, G. H., S. C. Lazarus, N. F. Viro, W. M. Gold, and J. A. Nadel. Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines. Immunology 63:339-344 (1988).
14. Chapman, K. R., K. Ljungholm, and A. Kallen. Long-term xanthine therapy of asthma: enprofylline and theophylline compared: International Enprofylline Study Group. Chest 106:1407-1413 (1994).
15. 125I]Aminobenzyladenosine, a new radioligand with improved specific binding to adenosine receptors in heart. Circ. Res. 56:279-284 (1985).
16. Cullen, B. R. Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684-703 (1987).
17. Sambrook, J., E. F. Fritsch, and T. Maniatis. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989).
18. Marquardt, D. M. An algorithm for least-squares estimation of nonlinear parameters. J. Soc. Indust. Appl. Math. 11:431-441 (1963).
19. Linden, J. Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radiolabel binding by 50%. J. Cyclic Nucleotide Res. 8:163-172 (1982).
20. Schwartz, L. B., K. F. Austen, and S. I. Wasserman. Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells. J. Immunol. 123:1445-1450 (1979).
21. Marquardt, D. L., L. L. Walker, and S. Heinemann. Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J. Immunol. 152:4508-4515 (1994).
22. Motulsky, H. J., and L. A. Ransnas. Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J. 1:365-374 (1987).
23. Peachell, P. T., M. Columbo, A. Kagey-Sobotka, L. M. Lichtenstein, and G. Marone. Adenosine potentiates mediator release from human lung mast cells. Am. Rev. Respir. Dis. 138:1143-1151 (1988).
24. ++-ionophore-induced secretion in a rat mast cell line. J. Pharmacol. Exp. Ther. 276: 837-845 (1996).
25. 3 receptor-mediated hypotensive response in the rat. Eur. J. Pharmacol. 250:185-188 (1993).
26. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem. Pharmacol. 47:801-814 (1994).
27. Robeva, A. S., R. Woodard, X. Jin, Z. Gao, S. Bhattacharya, H. E. Taylor, D. L. Rosin, and J. Linden. Molecular characterization of recombinant human adenosine receptors. Drug Dev. Res. 39:243-252 (1996).
28. Clarke, H., M. J. Cushley, C. G. Persson, and S. T. Holgate. The protective effects of intravenous theophylline and enprofylline against histamine-and adenosine 5′-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma. Pul. Pharmacol. 2:147-154 (1989).
29. 1 adenosine receptors in Sf9 cell membranes with recombinant G proteins of defined composition. Mol. Pharmacol. 50:1587-1595 (1996).
30. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:3099-3108 (1973).
31. 1 adenosine receptors. J. Pharmacol. Exp. Ther. 276:490-499 (1996).
32. 2b receptors in Xenopus oocytes. Mol. Pharmacol. 43:277-280 (1993).
33. Katsuyama, M., Y. Sugimoto, T. Namba, A. Irie, M. Negishi, S. Narumiya, and A. Ichikawa. Cloning and expression of a cDNA for the human prostacyclin receptor. FEBS Lett. 344:74-78 (1994).
34. 2-purinoceptor mediated mechanism. Biochem. Pharmacol. 33: 3847-3852 (1984).
35. Lohse, M. J., K. Maurer, H. P. Gensheimer, and U. Schwabe. Dual actions of adenosine on rat peritoneal mast cells. Naunyn-Schmiedebergs Arch. Pharmacol. 335:555-560 (1987).
36. Nyce, J. W., and W. J. Metzger. DNA antisense therapy for asthma in an animal model. Nature (Lond.) 385:721-725 (1997).
37. Doyle, M. P., J. Linden, and B. R. Duling. Nucleoside-induced arteriolar constriction: a mast cell-dependent response. Am. J. Physiol. 266:H2042-H2050 (1994).
38. Hoffman, H. M., L. L. Walker, and D. L. Marquardt. Mast cell adenosine induced calcium mobilization via G(i3) and G(q) proteins. Inflammation 21:55-68 (1997).
39. Shin, Y., J. W. Daly, and K. A. Jacobson. Activation of phosphoinositide breakdown and elevation of intracellular calcium in a rat RBL-2H3 mast cell line by adenosine analogs: involvement of A(3)-adenosine receptors. Drug Dev. Res. 39:36-46 (1996).
40. Marquardt, D. L., and L. L. Walker. Alteration of mast cell responsiveness to adenosine by pertussis toxin. Biochem. Pharmacol. 37:4019-4025 (1988).
41. 2b receptors evoke interleukin-8 secretion in human mast cells: an enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest. 96:1979-1986 (1995).