Desensitization, recovery and Ca2+-dependent modulation of ATP-gated P2X receptors in nociceptors

Neuropharmacology

Volumn 36, Issue 9, 1997, Pages 1303-1308

  Cook, S P ^a   McCleskey, E W ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Desensitization; Nociceptor; P2X receptor; Purinergic; Sensory neurons

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINE P2 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; MALE; NERVE ENDING; NERVE TRACT; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

EID: 0030682086     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00132-9     Document Type: Review

References (25)

1. Abbracchio M. P. and Burnstock G. (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacology Therapy 64: 445-475.
2. Bean B. P. (1990) ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. Journal of Neuroscience 10: 1-10.
3. Bean B. P. (1992) Pharmacology and electrophysiology of ATP-activated ion channels. Trends in Pharmacology Science 13: 87-90.
4. Bowie D., Feltz P. and Schlichter R. (1994) Subpopulations of neonatal rat sensory neurons express functional neurotransmitter receptors which elevate intracellular calcium. Neuroscience 58: 141-149.
5. Brake A. J., Wagenbach M. J. and Julius D. (1994) New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371: 519-523.
6. Chen C.-C., Akopian A. N., Sivilotti L., Colquhoun D., Burnstock G. and Wood J. N. (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377: 428-431.
7. 2+ potentiates ATP-activated currents in rat sympathetic neurons. Pflügers Archives 424: 152-158.
8. Collo G., North R. A., Kawashima E., Merlo-Pich E., Neidhart S., Surprenant A. and Buell G. (1996) Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. Journal of Neuroscience 16: 2495-2507.
9. Cook S. P., Vulchanova L., Hargreaves K. M., Elde R. and McCleskey E. W. (1997) Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387: 505-508.
10. Edwards F. A. (1994) ATP receptors. Current Opinions in Neurobiology 4: 347-352.
11. Evans R. J., Lewis C., Virginio C., Lundstrom K., Buell G., Surprenant A. and North R. A. (1996) Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. Journal of Physiology 497: 413-422.
12. Khahk B. S., Humphrey P. P. A. and Surprenant A. (1995) Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones. Journal of Physiology 484: 385-395.
13. Krishtal O. A., Marchenko S. M. and Obukhov A. G. (1988) Cationic channels activated by extracellular ATP in rat sensory neurons. Neuroscience 27: 995-1000.
14. Lewis C., Neidhart S., Holy C., North R. A., Buell G. and Surprenant A. (1995) Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377: 432-435.
15. 2+ potentiates excitatory action of ATP on mammalian neurons. Proceedings of the National Academy of Science of the U.S.A. 90: 8264-8267.
16. 2+ in rat nodose ganglion neurons. Journal of Neurophysiology 76: 3048-3058.
17. 2+. Neuron 6: 533-545.
18. Naruse K., McGehee D. S. and Oxford G. S. (1992) Differential responses of Ca-activated K channels to bradykinin in sensory neurons and F-11 cells. American Journal of Physiology 262: c453-460.
19. Robertson S. J., Rae M. G., Rowan E. G. and Kennedy C. (1996) Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. British Journal of Pharmacology 118: 951-956.
20. Soto F., Garcia-Guzman M., Gomez-Hernandez J. M., Hollmann M., Karschin C. and Stuhmer W. (1996) P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proceedings of the National Academy of Science of the U.S.A. 93: 3684-3688.
21. Surprenant A. (1996) Functional properties of native and cloned P2X receptors. In: P2 Purinoceptors: Localization, Function and Transduction Mechanisms, Ciba Foundation Symposium, Vol. 198 (Chadwick D. J. and Goode J. A., Eds), pp. 208-222. Wiley, West Sussex.
22. 2X receptors bring new structure to ligand-gated ion channels. Trends in Neuroscience 18: 224-229.
23. Taddese A., Nah S. Y. and McCleskey E. W. (1995) Selective opioid inhibition of small nociceptive neurons. Science 270: 1366-1369.
24. Valera S., Hussy N., Evans R. J., Adami N., North R. A., Surprenant A. and Buell G. (1994) A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature 371: 516-519.
25. Werner P., Seward E. P., Buell G. N. and North R. A. (1996) Domains of P2X receptors involved in desensitization. Proceedings of the National Academy of Science of the U.S.A. 93: 15485-15490.