Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation

Journal of Neurochemistry

Volumn 98, Issue 2, 2006, Pages 566-575

  Zhang, Xiulan ^a,b   Zhang, Mei ^a,b   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

A3 adenosine receptor; Excitotoxicity; Glaucoma; Neuroprotection; P2X7 receptor; Retinal ganglion cells

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 2 CHLORO N6 (3 IODOBENZYL)ADENOSINE 5' N METHYLURONIMIDE; 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE GAMMA S; CALCIUM ION; NEUROPROTECTIVE AGENT; PROTEIN DERIVATIVE; PURINE DERIVATIVE; PURINE P2X7 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; GLAUCOMA; HYDROLYSIS; NERVE CELL; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; HYDROLYSIS; PURINES; RATS; RATS, LONG-EVANS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECEPTORS, PURINERGIC P2; RETINAL GANGLION CELLS;

EID: 33746567885     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03900.x     Document Type: Article

References (56)

1. Brater M., Li S. N., Gorodezkaya I. J., Andreas K. and Ravens U. (1999) Voltage-sensitive Ca2+ channels, intracellular Ca2+ stores and Ca2+-release-activated Ca2+ channels contribute to the ATP-induced [Ca2+]i increase in differentiated neuroblastoma x glioma NG 108-15 cells. Neurosci. Lett. 264, 97-100.
2. Bryan P. T. and Marshall J. M. (1999) Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia. J. Physiol. 514, 163-175.
3. Burnstock G. (2002) Purinergic signaling and vascular cell proliferation and death. Arterioscl. Thromb. Vas. Biol. 22, 364-373.
4. Chen Y., Shukla A., Namiki S., Insel P. A. and Junger W. G. (2004) A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J. Leuk. Biol. 76, 245-253.
5. Choi D. W. (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11, 465-469.
6. Clapham D. E. (1994) Direct G protein activation of ion channels? Ann. Rev. Neurosci. 17, 441-464.
7. Crack B. E., Pollard C. E., Beukers M. W., Roberts S. M., Hunt S. F., Ingall A. H., McKechnie K. C., Ijzerman A. P. and Leff P. (1995) Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br. J. Pharmacol. 114, 475-481.
8. Das S., Cordis G. A., Maulik N. and Das D. K. (2005) Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. Am. J. Phys. Heart 288, H328-H335.
9. Dolphin A. C. (2003) G protein modulation of voltage-gated calcium channels. Pharmacol. Rev. 55, 607-627.
10. Fedorova I. M., Jacobson M. A., Basile A. and Jacobson K. A. (2003) Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration. Cell Mol. Neurobiol. 23, 431-447.
11. Fredholm B. B., Abbracchio M. P., Burnstock G., Daly J. W., Harden T. K., Jacobson K. A., Leff P. and Williams M. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46, 143-156.
12. Fredholm B. B., Izerman A. P., Jacobson K. A., Klotz K. N. and Linden J. (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53, 527-552.
13. Hartwick A. T. E., Lalonde M. R., Barnes S. and Baldridge W. H. (2004) Adenosine A (1)-receptor modulation of glutamate-induced calcium influx in rat retinal ganglion cells. Invest Ophthalmol. Vis. Sci. 45, 3740-3748.
14. Hartwick A. T., Zhang X., Chauhan B. C. and Baldridge W. H. (2005) Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging. J. Neurochem. 94, 794-807.
15. Hou B., You S. W., Wu M. M., Kuang F., Liu H. L., Jiao X. Y. and Ju G. (2004) Neuroprotective effect of inosine on axotomized retinal ganglion cells in adult rats. Invest. Ophthalmol. Vis. Sci. 45, 662-667.
16. Jacobson K. A., Park K. S., Jiang J. L., Kim Y. C., Olah M. E., Stiles G. L. and Ji X. D. (1997) Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacol. 36, 1157-1165.
17. Jacobson K. A. and Knutsen L. J. S. (2001) P1 and P2 purine and pyramidine receptor ligands, in Purinergic and Pyrimidenergic Signalling I: Molecular, Nervous and Urogenitary System Function (Williams M. P. A. A. M., ed.), pp. 129-175. Springer-Verlag, New York.
18. Jin X., Shepherd R. K., Duling B. R. and Linden J. (1997) Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest. 100, 2849-2857.
19. de Jong J. W., de Jonge R., Keijzer E. and Bradamante S. (2000) The role of adenosine in preconditioning. Pharmacol. Therapeut. 87, 141-149.
20. Karl M. O. J. F., Stamer W. D., Peterson-Yantorno K., Mitchell C. H., Stone R. A. and Civan M. M. (2005) Differential P1-prinergic modulation of human Schlemm's canal inner-wall cells. Am. J. Physiol. Cell Physiol. 288, C784-C794.
21. Kawamura M., Gachet C., Inoue K. and Kato F. (2004) Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice. J. Neurosci. 24, 10835-10845.
22. Kawasaki A., Otori Y. and Barnstable C. J. (2000) Muller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity. Invest Ophthalmol. Vis. Sci. 41, 3444-3450.
23. Klotz K. N. (2000) Adenosine receptors and their ligands. Naunyn Schmiedeberg's Arch. Pharmacol. 362, 382-391.
24. Kvanta A., Seregard S., Sejersen S., Kull B. and Fredholm B. B. (1997) Localization of adenosine receptor messenger RNAs in the rat eye. Exp. Eye Res. 65, 595-602.
25. Larsen A. K. and Osborne N. N. (1996) Involvement of adenosine in retinal ischemia. Studies on the rat. Invest. Ophthalmol. Vis. Sci. 37, 2603-2611.
26. Laudadio M. A. and Psarropoulou C. (2004) The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices. Epilep. Res. 59, 83-94.
27. Li B. and Roth S. (1999) Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction. Invest. Ophthalmol. Vis. Sci. 40, 1200-1216.
28. Li B., Rosenbaum P. S., Jennings N. M., Maxwell K. M. and Roth S. (1999) Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat. Exp. Eye Res. 68, 9-17.
29. Liang B. T. and Jacobson K. A. (1998) A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc. Natl Acad. Sci. USA 95, 6995-6999.
30. Linden J., Patel A. and Sadek S. (1985) [125I]Aminobenzyladenosine, a new radioligand with improved specific binding to adenosine receptors in heart. Circ. Res. 56, 279-284.
31. Meir A., Bell D. C., Stephens G. J., Page K. M. and Dolphin A. C. (2000) Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma. Biophys. J. 79, 731-746.
32. Mitchell C. H., Zhang X., Reigada D. and Laties A. M., (2004) and.Pressure-induced ATP release may stimulate P2X7 receptors to trigger retinal ganglion cell death. Invest. Ophthalmol. Vis. Sci. 45, 2083 (Abstract).
33. Mitchell C. H., Zhang M. and Zhang X. (2005) Retinal ganglion cell survival can be modified by the balance of purines. Ocular Cell Mol. Biol. 41 (Abstract).
34. Naskar R., Quinto K., Romann I., Schuettauf F. and Zurakowski D. (2002) Phenytoin blocks retinal ganglion cell death after partial optic nerve crush. Exp. Eye Res. 74, 747-752.
35. Newman E. A. (2003) Glial cell inhibition of neurons by release of ATP. J. Neurosci. 23, 1659-1666.
36. Oku H., Goto W., Kobayashi T., Okuno T., Hirao M., Sugiyama T., Yoneda S., Hara H. and Ikeda T. (2004) Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors. Curr. Eye Res. 29, 449-455.
37. Roth S., Park S. S., Sikorski C. W., Osinski J., Chan R. and Loomis K. (1997a) Concentrations of adenosine and its metabolites in the rat retina/choroid during reperfusion after ischemia. Curr. Eye Res. 16, 875-885.
38. Roth S., Rosenbaum P. S., Osinski J., Park S. S., Toledano A. Y., Li B. and Moshfeghi A. A. (1997b) Ischemia induces significant changes in purine nucleoside concentration in the retina-choroid in rats. Exp. Eye Res. 65, 771-779.
39. Safran N., Shneyvays V., Balas N., Jacobson K. A., Nawrath H. and Shainberg A. (2001) Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. Mol. Cell Biochem. 217, 143-152.
40. Schulte G. and Fredholm B. B. (2002) Signaling pathway from the human adenosine A (3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. Mol. Pharmacol. 62, 1137-1146.
41. Shapiro M. S., Wollmuth L. P. and Hille B. (1994) Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neurons. J. Neurosci. 14, 7109-7116.
42. Stambaugh K., Jacobson K. A., Jiang J. L. and Liang B. T. (1997) A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. Am. J. Physiol. Heart. 273, H501-H505.
43. Stone T. W. (2002) Purines and neuroprotection. Adv. Exp Med. Biol. 513, 249-280.
44. Sugiyama T., Kawamura H., Yamanishi S., Kobayashi M., Katsumura K. and Puro D. G. (2005) Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels. Am. J Physiol Cell Physiol. 288, C568-576.
45. Sun X., Barnes S. and Baldridge W. H. (2002) Adenosine inhibits calcium channel currents via A1 receptors on salamander retinal ganglion cells in a mini-slice preparation. J. Neurochem. 81, 550-556.
46. Surprenant A., Rassendren F., Kawashima E., North R. A. and Buell G. (1996) The cytolytic P2Z. receptor for extracellular ATP identified as a P2X receptor (P2X7). Science. 272, 735-738.
47. Von Lubitz D. K., Simpson K. L. and Lin R. C. (2001) Right thing at a wrong time? Adenosine A3 receptors and cerebroprotection in stroke. Ann. NY Acad. Sci. 939, 85-96.
48. Yaar R., Lamperti E. D., Toselli P. A. and Ravid K. (2002) Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression. FEBS Lett. 532, 267-272.
49. Zhang M., Budak M. T., Lu W., Khurana T. S., Zhang X., Laties A. M. and Mitchell C. H. (2005a) Identification of the A3 adenosine receptor in rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 46, 4009 (Abstract).
50. Zhang X., Friedman C., Laties A. M. and Mitchell C. H. (2002) Adenosine attenuates the effect of ATP P2X7 agonist on retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 43, U649 (Abstract).
51. Zhang X., Laties A. M. and Mitchell C. H. (2003) Adenosine protects retinal ganglion cells from cytotoxic death following P2X (7) receptor stimulation. Invest. Ophthalmol. Vis. Sci. 44, U735 (Abstract).
52. Zhang X., Zhang M., Laties A. M. and Mitchell C. H. (2005b) Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 46, 2183-2191.
53. Zhou Q. Y., Li C., Olah M. E., Johnson R. A., Stiles G. L. and Civelli O. (1992) Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc. Natl Acad. Sci. USA 89, 7432-7436.
54. Zimmermann H. (2000) Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedeberg's Arch. Pharmacol. 362, 299-309.
55. Zimmermann H. (2001) Ecto-Nucleotidases, in Purinergic and Pyraminergic Signalling I: Molecular, Nervous and Urogenitary System Function (Abbracchio M. P. and Williams P., eds), pp. 209-250. Springer-Verlag, New York.
56. de Zwart M., Link R., von Frijtag Drabbe Kunzel J. K., Cristalli G., Jacobson K. A., Townsend-Nicholson A. and A. P. I. J. (1998) A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonists. Nucleosides Nucleotides 17, 969-985.