Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats

Journal of Periodontology

Volumn 82, Issue 5, 2011, Pages 767-777

  Coimbra, Leila S ^a   Rossa Jr , Carlos ^a   Guimarães, Morgana R ^a   Gerlach, Raquel F ^b   Muscará, Marcelo N ^b   Spolidorio, Denise M P ^a   Herrera, Bruno S ^a   Spolidorio, Luis C ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aspirin; Blood platelets; Clopidogrel; Mediators of inflammation; Periodontitis; Platelet aggregation inhibitors

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; AUTACOID; CLOPIDOGREL; DRUG DERIVATIVE; INTERLEUKIN 6; SIGNAL PEPTIDE; THROMBOXANE A2; TICLOPIDINE; TUMOR NECROSIS FACTOR ALPHA;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BONE DENSITY; BONE REGENERATION; COMPARATIVE STUDY; DRUG EFFECT; JAW DISEASE; LEUKOCYTE; MALE; MICRO-COMPUTED TOMOGRAPHY; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTITIS; PERIODONTIUM; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT; THROMBOCYTE; THROMBOCYTE ACTIVATION; TIME; WOUND HEALING;

ALVEOLAR BONE LOSS; ANIMALS; ASPIRIN; BLOOD PLATELETS; BONE DENSITY; BONE REGENERATION; INFLAMMATION MEDIATORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-6; LEUKOCYTES; MALE; MANDIBULAR DISEASES; PERIODONTAL ATTACHMENT LOSS; PERIODONTITIS; PERIODONTIUM; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; THROMBOXANE A2; TICLOPIDINE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING; X-RAY MICROTOMOGRAPHY;

EID: 79955625450     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.100555     Document Type: Article

References (45)

1. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Madzarevic M, Kenney EB. Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. J Periodontal Res 2002;37:300-306.
2. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 1999;19:40-58.
3. Powell CA, Bannister SR, Mackey SA, Maller SC, McDonnell HT, Deas DE. Periodontal wound healing with and without platelet-rich plasma: Histologic observations and assessment of flap tensile strength. J Periodontol 2009;80:985-992.
4. Raja S, Byakod G, Pudakalkatti P. Growth factors in periodontal regeneration. Int J Dent Hyg 2009;7:82-89.
5. Chen FM, Shelton RM, Jin Y, Chapple IL. Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives. Med Res Rev 2009;29:472-513.
6. Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg 2003;76:2121-2131.
7. Zarbock A, Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of plateletneutrophil aggregation. J Clin Invest 2006;116:3211-3219. (Pubitemid 44878635)
8. Von Hundelshausen P, Weber C. Platelets as immune cells: Bridging inflammation and cardiovascular disease. Circ Res 2007;100:27-40. (Pubitemid 46066771)
9. Weyrich AS, Zimmerman GA. Platelets: Signaling cells in the immune continuum. Trends Immunol 2004;25:489-495. (Pubitemid 39490256)
10. Gentile P, Bottini DJ, Spallone D, Curcio BC, Cervelli V. Application of platelet-rich plasma in maxillofacial surgery: Clinical evaluation. J Craniofac Surg 2010;21:900-904.
11. Spolidorio LC, Herrera BS, Coimbra LS, Figueiredo MN, Spolidorio DM, Muscará MN. Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: Participation of endostatin and vascular endothelial growth factor. J Periodontal Res 2010;45:184-192.
12. Ross R. Atherosclerosis - An inflammatory disease. N Engl J Med 1999;340:115-126. (Pubitemid 29054847)
13. Schömig A, Neumann FJ, Kastrati A, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996;334:1084-1089. (Pubitemid 26120185)
14. Bennett JS. Novel platelet inhibitors. Annu Rev Med 2001;52:161-184. (Pubitemid 32195319)
15. Gao C, Ren C, Li D, Li L. Clopidogrel and aspirin versus clopidogrel alone on graft patency after coronary artery bypass grafting. Ann Thorac Surg 2009;88:59-62.
16. Ashida SI, Abiko Y. Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost 1979;41:436-449.
17. Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL. Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci 2001;98:6470-6475. (Pubitemid 32488261)
18. Sasaki Y, Ishii I, Giddings JC, Yamamoto J. Protective effects of ticlopidine and aspirin, administered alone and in combination, on thrombus formation in rat cerebral vessels. Haemostasis 1996;26:150-156. (Pubitemid 26173493)
19. Taka T, Okano E, Seki J, Yamamoto J. Effects of clopidogrel on platelet activation and coagulation of non-anticoagulated rat blood under high shear stress. Haemostasis 1999;29:189-196. (Pubitemid 30146446)
20. Wallace JL, McKnight W, Del Soldato P, Baydoun AR, Cirino G. Anti-thrombotic effects of a nitric oxidereleasing, gastric-sparing aspirin derivative. J Clin Invest 1995;96:2711-2718.
21. Wallace JL, Del Soldato P, Cirino G, Muscará MN. Nitric oxide-releasing NSAIDs: GI-safe antithrombotics. IDrugs 1999;2:321-326. (Pubitemid 29166794)
22. Holzhausen M, Rossa Júnior C, Marcantonio Júnior E, Nassar PO, Spolidório DM, Spolidório LC. Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. J Periodontol 2002;73:1030-1036.
23. Liu R, Desta T, He H, Graves DT. Diabetes alters the response to bacteria by enhancing fibroblast apoptosis. Endocrinology 2004;145:2997-3003. (Pubitemid 38686249)
24. Cetinkaya BO, Keles GC, Ayas B, Sakallioglu EE, Acikgoz G. The expression of vascular endothelial growth factor in a rat model at destruction and healing stages of periodontal disease. J Periodontol 2007;78:1129-1135.
25. Wilensky A, Gabet Y, Yumoto H, Houri-Haddad Y, Shapira L. Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. J Periodontol 2005;76:1282-1286. (Pubitemid 41245771)
26. Guimarães MR, Nassar PO, Andia DC, et al. Protective effects of tacrolimus, a calcineurin inhibitor, in experimental periodontitis in rats. Arch Oral Biol 2007;52:882-888. (Pubitemid 47125840)
27. Bartold PM, Harkin DG, Bignold LP. Proteoglycans synthesized by human polymorphonuclear leucocytes in vitro. Immunol Cell Biol 1989;67:9-17. (Pubitemid 19175569)
28. Christgau M, Moder D, Hiller KA, Dada A, Schmitz G, Schmalz G. Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes. J Clin Periodontol 2006;33:837-845. (Pubitemid 44511035)
29. Slots J, MacDonald ES, Nowzari H. Infectious aspects of periodontal regeneration. Periodontol 2000 1999;19:164-172.
30. Papapanagiotou D, Nicu EA, Bizzarro S, et al. Periodontitis is associated with platelet activation. Atherosclerosis 2009;202:605-611.
31. Christan C, Dietrich T, Hägewald S, Kage A, Bernimoulin JP. White blood cell count in generalized aggressive periodontitis after non-surgical therapy. J Clin Periodontol 2002;29:201-206. (Pubitemid 41697853)
32. Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 2002;22:913-922. (Pubitemid 35155690)
33. Gupta M, Eisen GM. NSAIDs and the gastrointestinal tract. Curr Gastroenterol Rep 2009;11:345-353.
34. Sugidachi A, Asai F, Ogawa T, Inoue T, Koike H. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br J Pharmacol 2000;129:1439-1446. (Pubitemid 30175717)
35. Holzhausen M, Spolidorio DM, Muscará MN, Hebling J, Spolidorio LC. Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats. J Periodontal Res 2005;40:208-211. (Pubitemid 40655847)
36. Nassar PO, Nassar CA, Guimarães MR, et al. Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats. J Periodontal Res 2009;44:479-488.
37. Judge HM, Buckland RJ, Sugidachi A, Jakubowski JA, Storey RF. The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses. Platelets 2008;19:125-133. (Pubitemid 351302377)
38. Viles-Gonzalez JF, Fuster V, Corti R, et al. Atherosclerosis regression and TP receptor inhibition: Effect of S18886 on plaque size and composition - A magnetic resonance imaging study. Eur Heart J 2005;26:1557-1561. (Pubitemid 41373499)
39. Ayral Y, Rauch U, Goldin-Lang P, et al. Prolonged application of clopidogrel reduces inflammation after percutaneous coronary intervention in the porcine model. Cardiovasc Revasc Med 2007;8:183-188. (Pubitemid 47332357)
40. Zeng C. Clopidogrel application: Beyond coronary artery disease. Clin Sci 2010;118:459-461.
41. Patrono C, Coller B, FitzGerald GA, Hirsh J, Roth G. Platelet-active drugs: The relationships among dose, effectiveness, and side effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(Suppl. 3):234S-264S. (Pubitemid 39297956)
42. Weber C, Erl W, Pietsch A, Weber PC. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 1995;91:1914-1917.
43. Shalom A, Friedman T, Westreich M. The effect of postoperative aspirin on random pattern flaps in rats. Am Surg 2007;73:1126-1128. (Pubitemid 351396520)
44. Graff J, Klinkhardt U, Schini-Kerth VB, et al. Close relationship between the platelet activation marker CD62 and the granular release of platelet-derived growth factor. J Pharmacol Exp Ther 2002;300:952-957. (Pubitemid 34165001)
45. Smith CW, Binford RS, Holt DW, Webb DP. Quality assessment of platelet rich plasma during anti-platelet therapy. Perfusion 2007;22:41-50. (Pubitemid 47018361)