Role of connexin43 hemichannels in mechanical stress-induced ATP release in human periodontal ligament cells

Journal of Periodontal Research

Volumn 46, Issue 5, 2011, Pages 607-615

  Luckprom, P ^a   Kanjanamekanant, K ^a   Pavasant, P ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

ATP; Connexin43; Human periodontal ligament cells; Mechanical stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL BLOCKING AGENT; CONNEXIN 43; GAP JUNCTION PROTEIN; PURINERGIC P2 RECEPTOR; PURINERGIC P2 RECEPTOR ANTAGONIST;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CALCIUM SIGNALING; CELL CULTURE; COMPRESSIVE STRENGTH; CYTOLOGY; DENTAL PROCEDURE; FEMALE; GENE SILENCING; GENETICS; HUMAN; LUMINESCENCE; MALE; MECHANICAL STRESS; METABOLISM; METHODOLOGY; PERIODONTAL LIGAMENT; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELLS, CULTURED; COMPRESSIVE STRENGTH; CONNEXIN 43; CONNEXINS; DENTAL STRESS ANALYSIS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUMINESCENT MEASUREMENTS; MALE; PERIODONTAL LIGAMENT; PURINERGIC P2 RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2; STRESS, MECHANICAL; YOUNG ADULT;

EID: 80955179982     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01379.x     Document Type: Article

References (45)

1. Burnstock G. The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology 1997;36:1127-1139.
2. Nakano Y, Addison WN, Kaartinen MT. ATP-mediated mineralization of MC3T3-E1 osteoblast cultures. Bone 2007;41:549-561.
3. Orriss IR, Utting JC, Brandao-Burch A et al. Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. Endocrinology 2007;148:4208-4216.
4. Kawase T, Okuda K, Yoshie H. Extracellular ATP and ATPgammaS suppress the proliferation of human periodontal ligament cells by different mechanisms. J Periodontol 2007;78:748-756.
5. Stout CE, Costantin JL, Naus CC, Charles AC. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 2002;277:10482-10488.
6. Wongkhantee S, Yongchaitrakul T, Pavasant P. Mechanical stress induces osteopontin via ATP/P2Y1 in periodontal cells. J Dent Res 2008;87:564-568.
7. Wan J, Ristenpart WD, Stone HA. Dynamics of shear-induced ATP release from red blood cells. Proc Natl Acad Sci U S A 2008;105:16432-16437.
8. Boudreault F, Grygorczyk R. Cell swelling-induced ATP release is tightly dependent on intracellular calcium elevations. J Physiol 2004;561:499-513.
9. Zhao HB, Yu N, Fleming CR. Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proc Natl Acad Sci U S A 2005;102:18724-18729.
10. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol 2003;64:785-795.
11. Oviedo-Orta E, Evans WH. Gap junctions and connexins: potential contributors to the immunological synapse. J Leukoc Biol 2002;72:636-642.
12. Ebihara L. New roles for connexons. News Physiol Sci 2003;18:100-103.
13. Gomes P, Srinivas SP, Van Driessche W, Vereecke J, Himpens B. ATP release through connexin hemichannels in corneal endothelial cells. Invest Ophthalmol Vis Sci 2005;46:1208-1218.
14. 2+ signals across the inner ear. Proc Natl Acad Sci U S A 2008;105:18770-18775.
15. Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol 2007;212:207-214.
16. Huang YJ, Maruyama Y, Dvoryanchikov G et al. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A 2007;104:6436-6441.
17. Ransford GA, Fregien N, Qiu F et al. Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol 2009;41:525-534.
18. Eltzschig HK, Eckle T, Mager A et al. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res 2006;99:1100-1108.
19. Faigle M, Seessle J, Zug S, El Kasmi KC, Eltzschig HK. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS ONE 2008;3:e2801.
20. Kang J, Kang N, Lovatt D et al. Connexin 43 hemichannels are permeable to ATP. J Neurosci 2008;28:4702-4711.
21. Ralphs JR, Benjamin M, Waggett AD et al. Regional differences in cell shape and gap junction expression in rat Achilles tendon: relation to fibrocartilage differentiation. J Anat 1998;193:215-222.
22. Yamaguchi DT, Ma D, Lee A, Huang J, Gruber HE. Isolation and characterization of gap junctions in the osteoblastic MC3T3-E1 cell line. J Bone Miner Res 1994;9:791-803.
23. Yamaoka Y, Sawa Y, Ebata N et al. Double expressions of connexin 43 and 32 in human periodontal ligament fibroblasts. Tissue Cell 2000;32:328-335.
24. Pearson RA, Dale N, Llaudet E, Mobbs P. ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron 2005;46:731-744.
25. Knight MM, McGlashan SR, Garcia M, Jensen CG, Poole CA. Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium? J Anat 2009;214:275-283.
26. Luckprom P, Wongkhantee S, Yongchaitrakul T, Pavasant P. Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells. J Periodontal Res 2010;45:404-411.
27. Wongkhantee S, Yongchaitrakul T, Pavasant P. Mechanical stress induces osteopontin expression in human periodontal ligament cells through rho kinase. J Periodontol 2007;78:1113-1119.
28. Toma I, Bansal E, Meer EJ et al. Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells. Am J Physiol Regul Integr Comp Physiol 2008;294:R1769-R1776.
29. De Vuyst E, Decrock E, Cabooter L et al. Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J 2006;25:34-44.
30. Furuya K, Sokabe M, Furuya S. Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling. Cell Sci 2005;118:3289-3304.
31. Graff RD, Lazarowski ER, Banes AJ, Lee GM. ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 2000;43:1571-1579.
32. Homolya L, Steinberg TH, Boucher RC. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol 2000;150:1349-1360.
33. Romanello M, Pani B, Bicego M, D'Andrea P. Mechanically induced ATP release from human osteoblastic cells. Biochem Biophys Res Commun 2001;289:1275-1281.
34. Yamaoka Y, Sawa Y, Ebata N, Ibuki N, Yoshida S. Cultured periodontal ligament fibroblasts express diverse connexins. Tissue Cell 2002;34:375-380.
35. Bennett MV, Contreras JE, Bukauskas FF, Sáez JC. New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 2003;26:610-617.
36. Hofbauer LC, Heufelder AE. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 2001;79:243-253.
37. Kanzaki H, Chiba M, Shimizu Y, Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 2002;17:210-220.
38. Tsuji K, Uno K, Zhang GX, Tamura M. Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2. J Bone Miner Metab 2004;22:94-103.
39. Arayatrakoollikit U, Pavasant P, Yongchaitrakul T. Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3'-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells. J Periodontal Res 2008;43:537-543.
40. Li H, Liu TF, Lazrak A et al. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 1996;134:1019-1030.
41. Vergara L, Bao X, Bello-Reuss E, Reuss L. Do connexin 43 gap-junctional hemichannels activate and cause cell damage during ATP depletion of renal-tubule cells? Acta Physiol Scand 2003;179:33-38.
42. Cotrina ML, Lin JH, Alves-Rodrigues A et al. Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A 1998;95:15735-15740.
43. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res 2005;20:41-49.
44. Liu D, Genetos DC, Shao Y et al. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 2008;42:644-652.
45. Schwiebert EM. Extracellular ATP-mediated propagation of Ca(2+) waves. Focus on "mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation". Am J Physiol Cell Physiol 2000;279:C281-C283.