Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X 7 receptors

Journal of Physiology

Volumn 590, Issue 10, 2012, Pages 2285-2304

  Xia, Jingsheng ^a   Lim, Jason C ^a   Lu, Wennan ^a   Beckel, Jonathan M ^a   Macarak, Edward J ^a   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 438079; ADENOSINE TRIPHOSPHATE; APYRASE; AZ 10606120; CARBENOXOLONE; CATION CHANNEL; EYE PROTEIN; PANNEXIN PROTEIN; PROBENECID; PROTEIN INHIBITOR; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL ISOLATION; CELL KINETICS; CELL LEVEL; CELL SWELLING; CELL VOLUME; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; INTRAOCULAR PRESSURE; ION CURRENT; MECHANOTRANSDUCTION; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE STIMULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; RECEPTOR BLOCKING; RETINA; RETINA GANGLION CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CONNEXINS; NERVE TISSUE PROTEINS; RATS; RATS, LONG-EVANS; RECEPTORS, PURINERGIC P2X7; RETINAL GANGLION CELLS; STRESS, MECHANICAL;

EID: 84861005703     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.227983     Document Type: Article

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