Central inhibition of interleukin-1β ameliorates sickness behavior in aged mice

Brain, Behavior, and Immunity

Volumn 23, Issue 3, 2009, Pages 396-401

  Abraham, Jayne ^a   Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Aging; Behavior; Brain; IL 1 ; IL 1ra; Infection

Indexed keywords

INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 1;

AGED; ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; ILLNESS BEHAVIOR; IMMUNE RESPONSE; LOCOMOTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING; ANIMALS; HIPPOCAMPUS; HYPOTHALAMUS; ILLNESS BEHAVIOR; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LOCOMOTION; MALE; MICE; MICE, INBRED BALB C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOCIAL BEHAVIOR; TIME FACTORS;

EID: 61649120189     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2008.12.008     Document Type: Article

References (31)

1. Abraham J., Jang S., Godbout J.P., Chen J., Kelley K.W., Dantzer R., and Johnson R.W. Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120. Neurobiol. Aging 29 (2008) 614-621
2. Armstrong G.L., Conn L.A., and Pinner R.W. Trends in infectious disease mortality in the United States during the 20th century. JAMA 281 (1999) 61-66
3. Barrientos R.M., Higgins E.A., Sprunger D.B., Watkins L.R., Rudy J.W., and Maier S.F. Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav. Brain Res. 134 (2002) 291-298
4. Bluthe R.M., Dantzer R., and Kelley K.W. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res. 573 (1992) 318-320
5. Chen J., Buchanan J.B., Sparkman N.L., Godbout J.P., Freund G.G., and Johnson R.W. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 22 (2008) 301-311
6. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann. NY Acad. Sci. 933 (2001) 222-234
7. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., and Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9 (2008) 46-56
8. Dilger R.N., and Johnson R.W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 84 (2008) 932-939
9. Dunn A.J. The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. Brain Res. Bull. 29 (1992) 807-812
10. Dunn A.J. Effects of the IL-1 receptor antagonist on the IL-1 - and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice. Neuroimmunomodulation 7 (2000) 36-45
11. Friedman W.J. Cytokines regulate expression of the type 1 interleukin-1 receptor in rat hippocampal neurons and glia. Exp. Neurol. 168 (2001) 23-31
12. Giulian D., and Lachman L.B. Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 228 (1985) 497-499
13. Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., and Johnson R.W. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 19 (2005) 1329-1331
14. Godbout J.P., and Johnson R.W. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol. Clin. 24 (2006) 521-538
15. Godbout J.P., Moreau M., Lestage J., Chen J., Sparkman N.L., J O.C., Castanon N., Kelley K.W., Dantzer R., and Johnson R.W. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 33 (2008) 2341-2351
16. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12 (1988) 123-137
17. Henry C.J., Huang Y., Wynne A.M., and Godbout J.P. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav. Immun. (2008)
18. Jackson J.C., Gordon S.M., Hart R.P., Hopkins R.O., and Ely E.W. The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol. Rev. 14 (2004) 87-98
19. Janssens J.P., and Krause K.H. Pneumonia in the very old. Lancet Infect. Dis. 4 (2004) 112-124
20. Johnston M., Wakeling A., Graham N., and Stokes F. Cognitive impairment, emotional disorder and length of stay of elderly patients in a district general hospital. Br. J. Med. Psychol. 60 Pt. 2 (1987) 133-139
21. Kent S., Bluthe R.M., Kelley K.W., and Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 13 (1992) 24-28
22. Lynch A.M., and Lynch M.A. The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation. Eur. J. Neurosci. 15 (2002) 1779-1788
23. Nelson K.P., Marks N.L., Heyen J.R., and Johnson R.W. Behavior of adult and aged mice before and after central injection of interleukin-1beta. Physiol. Behav. 66 (1999) 673-679
24. Perry V.H. A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. J. Neuroimmunol. 90 (1998) 113-121
25. Perry V.H. The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain Behav. Immun. 18 (2004) 407-413
26. Richwine A.F., Parkin A.O., Buchanan J.B., Chen J., Markham J.A., Juraska J.M., and Johnson R.W. Architectural changes to CA1 pyramidal neurons in adult and aged mice after peripheral immune stimulation. Psychoneuroendocrinology 33 (2008) 1369-1377
27. Rogers J., Luber-Narod J., Styren S.D., and Civin W.H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol. Aging 9 (1988) 339-349
28. Sheffield L.G., and Berman N.E. Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol. Aging 19 (1998) 47-55
29. Streit W.J., Sammons N.W., Kuhns A.J., and Sparks D.L. Dystrophic microglia in the aging human brain. Glia 45 (2004) 208-212
30. Swiergiel A.H., and Dunn A.J. The roles of IL-1, IL-6, and TNFalpha in the feeding responses to endotoxin and influenza virus infection in mice. Brain Behav. Immun. 13 (1999) 252-265
31. Wofford J.L., Loehr L.R., and Schwartz E. Acute cognitive impairment in elderly ED patients: etiologies and outcomes. Am. J. Emerg. Med. 14 (1996) 649-653