TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Doyle, Kristian P ^a   Cekanaviciute, Egle ^a   Mamer, Lauren E ^a   Buckwalter, Marion S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ANTIBODY; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENDER; GLIA CELL; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; MOUSE STRAIN; NERVE CELL; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PROTEIN SYNTHESIS; SCAR FORMATION; SIGNAL TRANSDUCTION; STROKE; TISSUE SECTION; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; MACROPHAGE; METABOLISM; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; NEURONS; SIGNAL TRANSDUCTION; STROKE; TRANSFORMING GROWTH FACTOR BETA;

EID: 77957689347     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-62     Document Type: Article

References (37)

1. Buckwalter M, Wyss-Coray T. Modelling neuroinflammatory phenotypes in vivo. J Neuroinflammation 2004, 1:10. 10.1186/1742-2094-1-10, 500895, 15285805.
2. Finch CE, Laping NJ, Morgan TE, Nichols NR, Pasinetti GM. TGF-b1 is an organizer of responses to neurodegeneration. J Cell Biochem 1993, 53:314-322. 10.1002/jcb.240530408, 8300749.
3. Unsicker K, Flanders KC, Cissel DS, Lafyatis R, Sporn MB. Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system. Neuroscience 1991, 44:613-625. 10.1016/0306-4522(91)90082-Y, 1754055.
4. Buisson A, Lesne S, Docagne F, Ali C, Nicole O, MacKenzie ET, Vivien D. Transforming growth factor-beta and ischemic brain injury. Cell Mol Neurobiol 2003, 23:539-550. 10.1023/A:1025072013107, 14514014.
5. Moon LD, Fawcett JW. Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2. Eur J Neurosci 2001, 14:1667-1677. 10.1046/j.0953-816x.2001.01795.x, 11860461.
6. Wang Y, Moges H, Bharucha Y, Symes A. Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex. Exp Neurol 2007, 203:168-184. 10.1016/j.expneurol.2006.08.006, 16996058.
7. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 2007, 74:184-195. 10.1016/j.cardiores.2006.10.002, 1924687, 17109837.
8. Yamashita K, Gerken U, Vogel P, Hossmann K, Wiessner C. Biphasic expression of TGF-beta1 mRNA in the rat brain following permanent occlusion of the middle cerebral artery. Brain Res 1999, 836:139-145. 10.1016/S0006-8993(99)01626-1, 10415412.
9. Wang X, Yue TL, White RF, Barone FC, Feuerstein GZ. Transforming growth factor-beta 1 exhibits delayed gene expression following focal cerebral ischemia. Brain Res Bull 1995, 36:607-609. 10.1016/0361-9230(94)00243-T, 7757496.
10. Ma M, Ma Y, Yi X, Guo R, Zhu W, Fan X, Xu G, Frey WH, Liu X. Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone. BMC Neurosci 2008, 9:117. 10.1186/1471-2202-9-117, 2637876, 19077183.
11. Ruocco A, Nicole O, Docagne F, Ali C, Chazalviel L, Komesli S, Yablonsky F, Roussel S, MacKenzie ET, Vivien D, Buisson A. A transforming growth factor-b antagonist unmasks the neuroprotective role of this endogenous cytokine in excitotoxic and ischemic brain injury. J Cereb Blood Flow Metab 1999, 19:1345-1353. 10.1097/00004647-199912000-00008, 10598939.
12. Kannel WB. The demographics of claudication and the aging of the American population. Vasc Med 1996, 1:60-64.
13. Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T. Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest 2007, 117:3306-3315. 10.1172/JCI31763, 2040317, 17965773.
14. Tamura A, Graham DI, McCulloch J, Teasdale GM. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1981, 1:53-60.
15. Massagué J, Wotton D. Transcriptional control by the TGF-b/Smad signaling system. EMBO J 2000, 19:1745-1754. 10.1093/emboj/19.8.1745, 302010, 10775259.
16. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113:685-700. 10.1016/S0092-8674(03)00432-X, 12809600.
17. Lin AH, Luo J, Mondshein LH, Ten Dijke P, Vivien D, Contag CH, Wyss-Coray T. Global Analysis of Smad2/3-Dependent TGF-{beta} Signaling in Living Mice Reveals Prominent Tissue-Specific Responses to Injury. J Immunol 2005, 175:547-554.
18. Badan I, Buchhold B, Hamm A, Gratz M, Walker LC, Platt D, Kessler C, Popa-Wagner A. Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. J Cereb Blood Flow Metab 2003, 23:845-854. 10.1097/01.WCB.0000071883.63724.A7, 12843788.
19. Kharlamov A, Kharlamov E, Armstrong DM. Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia. J Gerontol A Biol Sci Med Sci 2000, 55:B135-141. discussion B142-133.
20. Petcu EB, Sfredel V, Platt D, Herndon JG, Kessler C, Popa-Wagner A. Cellular and molecular events underlying the dysregulated response of the aged brain to stroke: a mini-review. Gerontology 2008, 54:6-17. 10.1159/000112845, 18160818.
21. Krupinski J, Kumar P, Kumar S, Kaluza J. Increased expression of TGF-b1 in brain tissue after ischemic stroke in humans. Stroke 1996, 27:852-857.
22. Noble NA, Harper JR, Border WA. In vivo interactions of TGF-beta and extracellular matrix. Prog Growth Factor Res 1992, 4:369-382. 10.1016/0955-2235(92)90017-C, 1340215.
23. Ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends in Biochemical Sciences 2004, 29:265-273. 10.1016/j.tibs.2004.03.008, 15130563.
24. Pang L, Ye W, Che XM, Roessler BJ, Betz AL, Yang GY. Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-b1 expression. Stroke 2001, 32:544-552.
25. Buisson A, Nicole O, Docagne F, Sartelet H, MacKenzie ET, Vivien D. Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1. FASEB J 1998, 12:1683-1691.
26. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, et al. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 2006, 116:3060-3069. 10.1172/JCI27341, 1626127, 17080199.
27. Tesseur I, Wyss-Coray T. A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Curr Alzheimer Res 2006, 3:505-513. 10.2174/156720506779025297, 17168649.
28. Knoferle J, Ramljak S, Koch JC, Tonges L, Asif AR, Michel U, Wouters FS, Heermann S, Krieglstein K, Zerr I, et al. TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP. Neurobiol Dis 2010, 38:395-404. 10.1016/j.nbd.2010.02.011, 20211260.
29. Sun M, Gewirtz JC, Bofenkamp L, Wickham RJ, Ge H, O'Connor MB. Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle. J Neurosci 2010, 30:6025-6035. 10.1523/JNEUROSCI.0789-10.2010, 20427661.
30. Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-b type I receptors. EMBO J 2002, 21:1743-1753. 10.1093/emboj/21.7.1743, 125949, 11927558.
31. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol 2005, 6:1191-1197. 10.1038/ni1276, 16369558.
32. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004, 25:677-686. 10.1016/j.it.2004.09.015, 15530839.
33. Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. Astroglial overproduction of TGF-b1 enhances inflammatory central nervous system disease in transgenic mice. J Neuroimmunol 1997, 77:45-50. 10.1016/S0165-5728(97)00049-0, 9209267.
34. Logan A, Berry M, Gonzalez A, Frautschy S, Sporn M, Baird A. Effects of transforming growth factor beta 1 on scar production in the injured central nervous systems of the rat. Eur J Neurosci 1994, 6:355-363. 10.1111/j.1460-9568.1994.tb00278.x, 8019673.
35. Liu BP, Cafferty WB, Budel SO, Strittmatter SM. Extracellular regulators of axonal growth in the adult central nervous system. Philos Trans R Soc Lond B Biol Sci 2006, 361:1593-1610. 10.1098/rstb.2006.1891, 1664666, 16939977.
36. Bye N, Zieba M, Wreford NG, Nichols NR. Resistance of the dentate gyrus to induced apoptosis during ageing is associated with increases in transforming growth factor-b1 messenger RNA. Neuroscience 2001, 105:853-862. 10.1016/S0306-4522(01)00236-6, 11530223.
37. Nichols NR. Glial responses to steroids as markers of brain aging. J Neurobiol 1999, 40:585-601. 10.1002/(SICI)1097-4695(19990915)40:4<585::AID-NEU13>3.0.CO;2-1, 10453058.