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Volumn 9, Issue 4, 2012, Pages 209-222

The effect of glucagon-like peptide 1 on cardiovascular risk

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADX 91886; ALBIGLUTIDE; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLYMERA; INSULIN; INSULIN GLARGINE; ITCA 650; LIRAGLUTIDE; LIXISENATIDE; LX 4211; LY 2428757; MAR 701; METFORMIN; NN 9924; ORMD 0901; PC DAC; PF 04603629; SEMAGLUTIDE; SULFONYLUREA; TASPOGLUTIDE; TTP 054; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST; VRS 859; ZP 2929;

EID: 84859103180     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2011.211     Document Type: Review
Times cited : (130)

References (135)
  • 2
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053 (2004). (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 3
    • 79951602196 scopus 로고    scopus 로고
    • Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare center
    • Mata-Cases, M. et al. Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare center. Int. J. Clin. Pract. 65, 299-307 (2011).
    • (2011) Int. J. Clin. Pract. , vol.65 , pp. 299-307
    • Mata-Cases, M.1
  • 4
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • DOI 10.1056/NEJM199807233390404
    • Haffner, S. M., Lehto, S., Ronnemaa, T., Pyorala, K. & Laakso, M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N. Engl. J. Med. 339, 229-234 (1998). (Pubitemid 28350165)
    • (1998) New England Journal of Medicine , vol.339 , Issue.4 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 5
    • 33644696797 scopus 로고    scopus 로고
    • Type 2 diabetes as a "coronary heart disease equivalent": An 18-year prospective population-based study in Finnish subjects
    • DOI 10.2337/diacare.28.12.2901
    • Juutilainen, A., Lehto, S., Ronnemaa, T., Pyorala, K. & Laakso, M. Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects. Diabetes Care 28, 2901-2907 (2005). (Pubitemid 43942922)
    • (2005) Diabetes Care , vol.28 , Issue.12 , pp. 2901-2907
    • Juutilainen, A.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 6
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck, M. A. et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C peptide responses. J. Clin. Endocrinol. Metab. 63, 492-498 (1986). (Pubitemid 16035703)
    • (1986) Journal of Clinical Endocrinology and Metabolism , vol.63 , Issue.2 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 7
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • Holst, J. J. The physiology of glucagon-like peptide 1. Physiol. Rev. 87, 1409-1439 (2007). (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 8
    • 79960181204 scopus 로고    scopus 로고
    • 4th edn (eds Holt R. I. G. Cockram C. S. Flyvbjerg A & Goldstein B) Wiley-Blackwell Publishing, New Jersey, (
    • Holst, J. J., Madsbad, S. & Schmitz, O. in Textbook of Diabetes 4th edn (eds Holt, R. I. G., Cockram, C. S., Flyvbjerg, A & Goldstein, B) 478-493 (Wiley-Blackwell Publishing, New Jersey, (2010).
    • (2010) Textbook of Diabetes , pp. 478-493
    • Holst, J.J.1    Madsbad, S.2    Schmitz, O.3
  • 9
    • 0031782440 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
    • DOI 10.1007/s001250050903
    • Deacon, C. F. et al. Dipeptidyl peptidase IV resistant analogs of glucagon-like peptide 1 which have extended metabolic stability and improved biological activity. Diabetologia 41, 271-278 (1998). (Pubitemid 28254820)
    • (1998) Diabetologia , vol.41 , Issue.3 , pp. 271-278
    • Deacon, C.F.1    Knudsen, L.B.2    Madsen, K.3    Wiberg, F.C.4    Jacobsen, O.5    Holst, J.J.6
  • 10
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon, C. F. et al. Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44, 1126-1131 (1995).
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1
  • 11
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • DOI 10.2337/diabetes.54.1.146
    • Bose, A. K., Mocanu, M. M., Carr, R. D., Brand, C. L. & Yellon, D. M. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 54, 146-151 (2005). (Pubitemid 40105106)
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 13
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by gip in obese type ii diabetic patients
    • DOI 10.1007/s00125-002-0878-6
    • Vilsbøll, T., Krarup, T., Madsbad, S. & Holst, J. J. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia 45, 1111-1119 (2002). (Pubitemid 34985287)
    • (2002) Diabetologia , vol.45 , Issue.8 , pp. 1111-1119
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.4
  • 14
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • DOI 10.1210/jc.2002-021053
    • Vilsbøll, T., Agersø, H., Krarup, T. & Holst, J. J. Similar elimination rates of glucagon-like peptide 1 in obese type 2 diabetic patients and healthy subjects. J. Clin. Endocrinol. Metab. 88, 220-224 (2003). (Pubitemid 36115169)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.1 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 16
    • 0028226343 scopus 로고
    • Ligand-specificity of the rat GLP I receptor recombinantly expressed in Chinese hamster ovary (CHO ) cells
    • Fehmann, H. C. et al. Ligand-specificity of the rat GLP I receptor recombinantly expressed in Chinese hamster ovary (CHO ) cells. Z. Gastroenterol. 32, 203-207 (1994).
    • (1994) Z. Gastroenterol. , vol.32 , pp. 203-207
    • Fehmann, H.C.1
  • 18
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • DOI 10.1161/CIRCULATIONAHA.107.739938, PII 0000301720080506000007
    • Ban, K. et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 117, 2340-2350 (2008). (Pubitemid 351653542)
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.-S.4    Drucker, D.J.5    Husain, M.6
  • 19
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • DOI 10.1210/en.137.7.2968
    • Bullock, B. P., Heller, R. S. & Habener, J. F. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide 1 receptor. Endocrinology 137, 2968-2978 (1996). (Pubitemid 26192194)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 20
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    • DOI 10.1210/en.134.5.2156
    • Campos, R. V., Lee, Y. C. & Drucker, D. J. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide 1 in the mouse. Endocrinology 134, 2156-2164 (1994). (Pubitemid 24142957)
    • (1994) Endocrinology , vol.134 , Issue.5 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 21
    • 0028077525 scopus 로고
    • Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: One of several potential extrapancreatic sites of GLP-1 action
    • DOI 10.1210/en.135.5.2070
    • Egan, J. M., Montrose-Rafizadeh, C., Wang, Y., Bernier, M. & Roth, J. Glucagon-like peptide 1(7-36) amide (GLP 1) enhances insulin-stimulated glucose metabolism in 3T3 L1 adipocytes: one of several potential extrapancreatic sites of GLP 1 action. Endocrinology 135, 2070-2075 (1994). (Pubitemid 24363904)
    • (1994) Endocrinology , vol.135 , Issue.5 , pp. 2070-2075
    • Egan, J.M.1    Montrose-Rafizadeh, C.2    Wang, Y.3    Bernier, M.4    Roth, J.5
  • 22
    • 0024253412 scopus 로고
    • Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung
    • DOI 10.1016/0014-5793(88)81063-9
    • Kanse, S. M., Kreymann, B., Ghatei, M. A. & Bloom, S. R. Identification and characterization of glucagon-like peptide 1 7-36 amide-binding sites in the rat brain and lung. FEBS Lett. 241, 209-212 (1988). (Pubitemid 19005008)
    • (1988) FEBS Letters , vol.241 , Issue.1-2 , pp. 209-212
    • Kanse, S.M.1    Kreymann, B.2    Ghatei, M.A.3    Bloom, S.R.4
  • 23
    • 34250635159 scopus 로고    scopus 로고
    • GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting
    • DOI 10.2967/jnumed.106.038679
    • Korner, M., Stockli, M., Waser, B. & Reubi, J. C. GLP 1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J. Nucl. Med. 48, 736-743 (2007). (Pubitemid 47604973)
    • (2007) Journal of Nuclear Medicine , vol.48 , Issue.5 , pp. 736-743
    • Korner, M.1    Stockli, M.2    Waser, B.3    Reubi, J.C.4
  • 25
    • 0031029936 scopus 로고    scopus 로고
    • Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
    • DOI 10.1016/S0306-4522(96)00434-4, PII S0306452296004344
    • Larsen, P. J., Tang-Christensen, M., Holst, J. J. & Orskov, C. Distribution of glucagon-like peptide 1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 77, 257-270 (1997). (Pubitemid 27060323)
    • (1997) Neuroscience , vol.77 , Issue.1 , pp. 257-270
    • Larsen, P.J.1    Tang-Christensen, M.2    Holst, J.J.3    Orskov, C.4
  • 26
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • DOI 10.1002/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5
    • Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre pro glucagon and glucagon-like peptide 1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261-280 (1999). (Pubitemid 28566834)
    • (1999) Journal of Comparative Neurology , vol.403 , Issue.2 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 27
    • 0026063183 scopus 로고
    • Glucagonlike peptide I (7-36)-amide receptors only in islets of langerhans autoradiographic survey of extracerebral tissues in rats
    • Orskov, C. & Poulsen, S. S. Glucagonlike peptide I (7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats. Diabetes 40, 1292-1296 (1991).
    • (1991) Diabetes , vol.40 , pp. 1292-1296
    • Orskov, C.1    Poulsen, S.S.2
  • 28
    • 0027495779 scopus 로고
    • GLP 1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery
    • Richter, G. et al. GLP 1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery. Am. J. Physiol. 265, L374-L381 (1993).
    • (1993) Am. J. Physiol. , vol.265
    • Richter, G.1
  • 29
    • 0034456578 scopus 로고    scopus 로고
    • Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: Lack of coupling to either stimulation or inhibition of adenylyl cyclase
    • DOI 10.1210/en.141.4.1301
    • Satoh, F. et al. Characterization of human and rat glucagon-like peptide 1 receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase. Endocrinology 141, 1301-1309 (2000). (Pubitemid 32269096)
    • (2000) Endocrinology , vol.141 , Issue.4 , pp. 1301-1309
    • Satoh, F.1    Beak, S.A.2    Small, C.J.3    Falzon, M.4    Ghatei, M.A.5    Bloom, S.R.6    Smith, D.M.7
  • 30
    • 0023266561 scopus 로고
    • Identification and localization of glucagon-like peptide-1 and its receptor in rat brain
    • Shimizu, I., Hirota, M., Ohboshi, C. & Shima, K. Identification and localization of glucagon-like peptide 1 and its receptor in rat brain. Endocrinology 121, 1076-1082 (1987). (Pubitemid 17139162)
    • (1987) Endocrinology , vol.121 , Issue.3 , pp. 1076-1082
    • Shimizu, I.1    Hirota, M.2    Ohboshi, C.3    Shima, K.4
  • 31
    • 0025246652 scopus 로고
    • Characterization of high-affinity receptors for truncated glucagon-like peptide-1 in rat gastric glands
    • DOI 10.1016/0014-5793(90)80173-G
    • Uttenthal, L. O. & Blazquez, E. Characterization of high-affinity receptors for truncated glucagon-like peptide 1 in rat gastric glands. FEBS Lett. 262, 139-141 (1990). (Pubitemid 20104280)
    • (1990) FEBS Letters , vol.262 , Issue.1 , pp. 139-141
    • Uttenthal, L.O.1    Blazquez, E.2
  • 32
    • 0026521197 scopus 로고
    • Autoradiographic localization of receptors for glucagon-like peptide 1 (7-36) amide in rat brain
    • Uttenthal, L. O., Toledano, A. & Blazquez, E. Autoradiographic localization of receptors for glucagon-like peptide 1 (7-36) amide in rat brain. Neuropeptides 21, 143-146 (1992).
    • (1992) Neuropeptides , vol.21 , pp. 143-146
    • Uttenthal, L.O.1    Toledano, A.2    Blazquez, E.3
  • 33
    • 0028900758 scopus 로고
    • Tissue-specific expression of the human receptor for glucagon-like peptide I: Brain, heart and pancreatic forms have the same deduced amino acid sequences
    • Wei, Y. & Mojsov, S. Tissue-specific expression of the human receptor for glucagon-like peptide I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 358, 219-224 (1995).
    • (1995) FEBS Lett. , vol.358 , pp. 219-224
    • Wei, Y.1    Mojsov, S.2
  • 34
    • 59849106762 scopus 로고    scopus 로고
    • Effect of exendin 4 treatment upon glucose uptake parameters in rat liver and muscle, in normal and type 2 diabetic state
    • Arnes, L., Moreno, P., Nuche-Berenguer, B., Valverde, I. & Villanueva-Penacarrillo, M. L. Effect of exendin 4 treatment upon glucose uptake parameters in rat liver and muscle, in normal and type 2 diabetic state. Regul. Pept. 153, 88-92 (2009).
    • (2009) Regul. Pept. , vol.153 , pp. 88-92
    • Arnes, L.1    Moreno, P.2    Nuche-Berenguer, B.3    Valverde, I.4    Villanueva-Penacarrillo, M.L.5
  • 35
    • 52049093652 scopus 로고    scopus 로고
    • GLP 1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    • Green, B. D. et al. GLP 1 and related peptides cause concentration- dependent relaxation of rat aorta through a pathway involving KATP and cAMP. Arch. Biochem. Biophys. 478, 136-142 (2008).
    • (2008) Arch. Biochem. Biophys. , vol.478 , pp. 136-142
    • Green, B.D.1
  • 36
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like Peptide 1 receptor agonists activate rodent thyroid C cells causing calcitonin release and C cell proliferation
    • Bjerre Knudsen, L. et al. Glucagon-like Peptide 1 receptor agonists activate rodent thyroid C cells causing calcitonin release and C cell proliferation. Endocrinology 151, 1473-1486 (2010).
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1
  • 38
    • 79952284556 scopus 로고    scopus 로고
    • GLP 1 and calcitonin concentration in humans: Lack of evidence of calcitonin release from sequential screening in over 5,000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP 1 analog, liraglutide
    • Hegedüs, L., Moses, AC, Zdravkovic, M, Le Thi, T. & Daniels, GH. GLP 1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5,000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP 1 analog, liraglutide. J. Clin. Endocrinol. Metab. 96, 853-860 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 853-860
    • Hegedüs, L.1    Moses, A.C.2    Zdravkovic, M.3    Le Thi, T.4    Daniels, G.H.5
  • 40
    • 38149083367 scopus 로고    scopus 로고
    • Protective effects of GLP 1 analogs exendin 4 and GLP 1(9-36) amide against ischemia-reperfusion injury in rat heart
    • Sonne, D. P., Engstrom, T. & Treiman, M. Protective effects of GLP 1 analogs exendin 4 and GLP 1(9-36) amide against ischemia-reperfusion injury in rat heart. Regul Pept 146, 243-249 (2008).
    • (2008) Regul. Pept. , vol.146 , pp. 243-249
    • Sonne, D.P.1    Engstrom, T.2    Treiman, M.3
  • 42
    • 62349092599 scopus 로고    scopus 로고
    • Prevalence of cardiovascular disease and risk factors in a type 2 diabetic population of the North Catalonia diabetes study
    • Jurado, J. et al. Prevalence of cardiovascular disease and risk factors in a type 2 diabetic population of the North Catalonia diabetes study. J. Am. Acad. Nurse. Pract. 21, 140-148 (2009).
    • (2009) J. Am. Acad. Nurse. Pract. , vol.21 , pp. 140-148
    • Jurado, J.1
  • 44
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group.
    • UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317, 703-713 (1998).
    • (1998) BMJ , vol.317 , pp. 703-713
  • 45
    • 2942668372 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
    • Gutzwiller, J. P. et al. Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men. J. Clin. Endocrinol. Metab. 89, 3055-3061 (2004).
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3055-3061
    • Gutzwiller, J.P.1
  • 46
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP 1 analog, liraglutide
    • Astrup, A. et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP 1 analog, liraglutide. Int. J. Obes. (Lond) http://dx.doi.org/10.1038/ijo.2011.158.
    • Int. J. Obes. (Lond.
    • Astrup, A.1
  • 48
    • 0035892681 scopus 로고    scopus 로고
    • Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    • DOI 10.1016/S0167-0115(01)00300-7, PII S0167011501003007
    • Golpon, H. A., Puechner, A., Welte, T., Wichert, P. V. & Feddersen, C. O. Vasorelaxant effect of glucagon-like peptide (7-36)amide and amylin on the pulmonary circulation of the rat. Regul. Pept. 102, 81-86 (2001). (Pubitemid 33135568)
    • (2001) Regulatory Peptides , vol.102 , Issue.2-3 , pp. 81-86
    • Golpon, H.A.1    Puechner, A.2    Welte, T.3    Wichert, P.V.4    Feddersen, C.O.5
  • 49
    • 9944251347 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • DOI 10.1016/j.regpep.2004.08.024, PII S0167011504003179
    • Nystrom, T., Gonon, A. T., Sjoholm, A. & Pernow, J. Glucagon-like peptide 1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul. Pept. 125, 173-177 (2005). (Pubitemid 39593722)
    • (2005) Regulatory Peptides , vol.125 , Issue.1-3 , pp. 173-177
    • Nystrom, T.1    Gonon, A.T.2    Sjoholm, A.3    Pernow, J.4
  • 50
    • 22144437777 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats
    • DOI 10.1159/000084277
    • Ozyazgan, S., Kutluata, N., Afsar, S., Ozdas, S. B. & Akkan, A. G. Effect of glucagon-like peptide 1(7-36) and exendin 4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats. Pharmacology 74, 119-126 (2005). (Pubitemid 40981097)
    • (2005) Pharmacology , vol.74 , Issue.3 , pp. 119-126
    • Ozyazgan, S.1    Kutluata, N.2    Afsar, S.3    Ozdas, S.B.4    Akkan, A.G.5
  • 51
    • 0842346386 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum
    • DOI 10.1016/j.regpep.2003.10.021
    • Hansen, L., Hartmann, B., Mineo, H. & Holst, J. J. Glucagon-like peptide 1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum. Regul. Pept. 118, 11-18 (2004). (Pubitemid 38167361)
    • (2004) Regulatory Peptides , vol.118 , Issue.1-2 , pp. 11-18
    • Hansen, L.1    Hartmann, B.2    Mineo, H.3    Holst, J.J.4
  • 52
    • 0028042205 scopus 로고
    • Changes in arterial blood pressure and heart rate induced by glucagon-like peptide 1 (7- 36) amide in rats
    • Barragan, J. M., Rodriguez, R. E. & Blazquez, E. Changes in arterial blood pressure and heart rate induced by glucagon-like peptide 1 (7-36) amide in rats. Am. J. Physiol. 266, E459-E466 (1994).
    • (1994) Am. J. Physiol. , Issue.266
    • Barragan, J.M.1    Rodriguez, R.E.2    Blazquez, E.3
  • 53
    • 0030583731 scopus 로고    scopus 로고
    • Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats
    • DOI 10.1016/S0167-0115(96)00113-9, PII S0167011596001139
    • Barragan, J. M., Rodriguez, R. E., Eng, J. & Blazquez, E. Interactions of exendin (9-39) with the effects of glucagon-like peptide 1 (7-36) amide and of exendin 4 on arterial blood pressure and heart rate in rats. Regul. Pept. 67, 63-68 (1996). (Pubitemid 26384196)
    • (1996) Regulatory Peptides , vol.67 , Issue.1 , pp. 63-68
    • Barragan, J.M.1    Rodriguez, R.E.2    Eng, J.3    Blazquez, E.4
  • 54
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio, L. L. & Drucker, D. J. Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131-2157 (2007). (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 55
    • 67449169287 scopus 로고    scopus 로고
    • Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide 1 in the rat
    • e78
    • Bucinskaite, V. et al. Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide 1 in the rat. Neurogastroenterol. Motil. 21, 978 e78 (2009).
    • (2009) Neurogastroenterol. Motil. , vol.21 , pp. 978
    • Bucinskaite, V.1
  • 57
    • 0032714917 scopus 로고    scopus 로고
    • Neural contribution to the effect of glucagon-like peptide 1 (7- 36) amide on arterial blood pressure in rats
    • Barragan, J. M., Eng, J., Rodriguez, R. & Blazquez, E. Neural contribution to the effect of glucagon-like peptide 1 (7-36) amide on arterial blood pressure in rats. Am. J. Physiol. 277, E784-E791 (1999).
    • (1999) Am. J. Physiol. , Issue.277
    • Barragan, J.M.1    Eng, J.2    Rodriguez, R.3    Blazquez, E.4
  • 58
    • 0034725655 scopus 로고    scopus 로고
    • Effects of centrally or systemically injected glucagon-like peptide 1 (7- 36) amide on release of neurohypophysial hormones and blood pressure in the rat
    • Bojanowska, E. & Stempniak, B. Effects of centrally or systemically injected glucagon-like peptide 1 (7-36) amide on release of neurohypophysial hormones and blood pressure in the rat. Regul. Pept. 91, 75-81 (2000).
    • (2000) Regul. Pept. , Issue.91 , pp. 75-81
    • Bojanowska, E.1    Stempniak, B.2
  • 59
    • 0842346377 scopus 로고    scopus 로고
    • Effects of intracerebroventricularly injected glucagon-like peptide-1 on cardiovascular parameters; role of central cholinergic system and vasopressin
    • DOI 10.1016/j.regpep.2003.10.025
    • Isbil-Buyukcoskun, N. & Gulec, G. Effects of intracerebroventricularly injected glucagon-like peptide 1 on cardiovascular parameters; role of central cholinergic system and vasopressin. Regul. Pept. 118, 33-38 (2004). (Pubitemid 38167364)
    • (2004) Regulatory Peptides , vol.118 , Issue.1-2 , pp. 33-38
    • Isbil-Buyukcoskun, N.1    Gulec, G.2
  • 62
    • 0037059530 scopus 로고    scopus 로고
    • Renal effects of glucagon-like peptide in rats
    • DOI 10.1016/S0014-2999(01)01542-4, PII S0014299901015424
    • Moreno, C., Mistry, M. & Roman, R. J. Renal effects of glucagon-like peptide in rats. Eur. J. Pharmacol. 434, 163-167 (2002). (Pubitemid 34056575)
    • (2002) European Journal of Pharmacology , vol.434 , Issue.3 , pp. 163-167
    • Moreno, C.1    Mistry, M.2    Roman, R.J.3
  • 63
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • DOI 10.2337/diacare.22.7.1137
    • Toft-Nielsen, M. B., Madsbad, S. & Holst, J. J. Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 22, 1137-1143 (1999). (Pubitemid 29293967)
    • (1999) Diabetes Care , vol.22 , Issue.7 , pp. 1137-1143
    • Toft-Nielsen, M.-B.1    Madsbad, S.2    Holst, J.J.3
  • 64
    • 77749273703 scopus 로고    scopus 로고
    • Cardiovascular and metabolic effects of 48 h glucagon-like peptide 1 infusion in compensated chronic patients with heart failure
    • Halbirk, M. et al. Cardiovascular and metabolic effects of 48 h glucagon-like peptide 1 infusion in compensated chronic patients with heart failure. Am. J. Physiol. Heart Circ. Physiol. 298, H1096-H1102 (2010).
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298
    • Halbirk, M.1
  • 65
    • 33746619693 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 is involved in sodium and water homeostasis in humans
    • Gutzwiller, J. P. et al. Glucagon-like peptide 1 is involved in sodium and water homeostasis in humans. Digestion 73, 142-150 (2006).
    • (2006) Digestion , vol.73 , pp. 142-150
    • Gutzwiller, J.P.1
  • 66
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson, T., Yan, P., Stonehouse, A. & Brodows, R. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am. J. Hypertens. 23, 334-339 (2010).
    • (2010) Am. J. Hypertens. , vol.23 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3    Brodows, R.4
  • 67
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION 2): A randomised trial
    • Bergenstal, R. M. et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION 2): a randomised trial. Lancet 376, 431-439 (2010).
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1
  • 68
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION 3): An open-label randomised trial
    • Diamant, M. et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION 3): an open-label randomised trial. Lancet 375, 2234-2243 (2010).
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1
  • 69
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker, D. J. et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 372, 1240-1250 (2008).
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1
  • 70
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD 6
    • Buse, J. B. et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD 6). Lancet 374, 39-47 (2009).
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1
  • 71
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD 3 mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber, A. et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD 3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 373, 473-481 (2009).
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1
  • 72
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP 1 analog, added to a sulfonylurea over 26 weeks produces greater improvements in glycemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD 1 SU
    • Marre, M. et al. Liraglutide, a once-daily human GLP 1 analog, added to a sulfonylurea over 26 weeks produces greater improvements in glycemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD 1 SU). Diabet. Med. 26, 268-278 (2009).
    • (2009) Diabet. Med. , vol.26 , pp. 268-278
    • Marre, M.1
  • 73
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes) 2 study
    • Nauck, M. et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes) 2 study. Diabetes Care 32, 84-90 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1
  • 74
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD 5 met+SU): Arandomised controlled trial
    • Russell-Jones, D. et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD 5 met+SU): arandomised controlled trial. Diabetologia 52, 2046-2055 (2009).
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1
  • 75
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide 1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD 4 Met+TZD
    • Zinman, B. et al. Efficacy and safety of the human glucagon-like peptide 1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD 4 Met+TZD). Diabetes Care 32, 1224-1230 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1
  • 76
    • 18844368814 scopus 로고    scopus 로고
    • Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
    • DOI 10.1093/eurheartj/ehi190
    • Diaz, A., Bourassa, M. G., Guertin, M. C. & Tardif, J. C. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur. Heart J. 26, 967-974 (2005). (Pubitemid 40695027)
    • (2005) European Heart Journal , vol.26 , Issue.10 , pp. 967-974
    • Diaz, A.1    Bourassa, M.G.2    Guertin, M.-C.3    Tardif, J.-C.4
  • 77
    • 84856877681 scopus 로고    scopus 로고
    • Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: The copenhagen city heart study
    • Jensen, M. T., Marott, J. L., Allin, K. H., Nordestgaard, B. G. & Jensen, G. B. Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: The Copenhagen City Heart Study. Eur. J. Cardiovasc. Prev. Rehabil. http://dx.doi.org/10.1177/ 1741826710394274.
    • Eur. J. Cardiovasc. Prev. Rehabil.
    • Jensen, M.T.1    Marott, J.L.2    Allin, K.H.3    Nordestgaard, B.G.4    Jensen, G.B.5
  • 79
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross, R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 80
    • 77958052010 scopus 로고    scopus 로고
    • A glucagon-like peptide 1 (GLP 1) analog, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells
    • Hattori, Y. et al. A glucagon-like peptide 1 (GLP 1) analog, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells. Diabetologia 53, 2256-2263 (2010).
    • (2010) Diabetologia , vol.53 , pp. 2256-2263
    • Hattori, Y.1
  • 81
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide 1 receptor agonist, exendin 4
    • Arakawa, M. et al. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide 1 receptor agonist, exendin 4. Diabetes 59, 1030-1037 (2010).
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1
  • 82
    • 84859099405 scopus 로고    scopus 로고
    • Incretins directly suppress the development of macrophage-driven atherosclerosis in apolipoprotein E null mice
    • Hirano, T. et al. Incretins directly suppress the development of macrophage-driven atherosclerosis in apolipoprotein E null mice. Diabetologia 53(Supl. 1), S72 (2010).
    • (2010) Diabetologia , vol.53 , Issue.SUPL1
    • Hirano, T.1
  • 83
    • 80054110585 scopus 로고    scopus 로고
    • Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
    • Nagashima, M. et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia 54, 2649-2659 (2011).
    • (2011) Diabetologia , vol.54 , pp. 2649-2659
    • Nagashima, M.1
  • 84
    • 67650057935 scopus 로고    scopus 로고
    • A long-acting glucagon-like peptide 1 analog attenuates induction of plasminogen activator inhibitor type 1 and vascular adhesion molecules
    • Liu, H., Dear, A. E., Knudsen, L. B. & Simpson, R. W. A long-acting glucagon-like peptide 1 analog attenuates induction of plasminogen activator inhibitor type 1 and vascular adhesion molecules. J. Endocrinol. 201, 59-66 (2009).
    • (2009) J. Endocrinol. , vol.201 , pp. 59-66
    • Liu, H.1    Dear, A.E.2    Knudsen, L.B.3    Simpson, R.W.4
  • 85
    • 77954743683 scopus 로고    scopus 로고
    • The once-daily human GLP-1 analogue liraglutide significantly reduces markers of cardiovascular risk in type 2 diabetes: A meta-analysis of six clinical trials [abstract
    • Plutzky, J., Garber, A., Falahati, A., Toft, A. D. & Poulter, N. R. The once-daily human GLP-1 analogue, liraglutide, significantly reduces markers of cardiovascular risk in type 2 diabetes: a meta-analysis of six clinical trials [abstract]. Eur. Heart J. 30 (Suppl. 1), 917 (2009).
    • (2009) Eur. Heart J. , vol.30 , Issue.SUPPL1 , pp. 917
    • Plutzky, J.1    Garber, A.2    Falahati, A.3    Toft, A.D.4    Poulter, N.R.5
  • 86
    • 35148814453 scopus 로고    scopus 로고
    • Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin
    • Viswanathan, P. et al. Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin. Endocr. Pract. 13, 444-450 (2007).
    • (2007) Endocr. Pract. , vol.13 , pp. 444-450
    • Viswanathan, P.1
  • 87
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide 1 analog, on cardiovascular risk biomarkers in patients with type 2 diabetes
    • Courreges, J. P. et al. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide 1 analog, on cardiovascular risk biomarkers in patients with type 2 diabetes. Diabet. Med. 25, 1129-1131 (2008).
    • (2008) Diabet. Med. , vol.25 , pp. 1129-1131
    • Courreges, J.P.1
  • 88
    • 77958184434 scopus 로고    scopus 로고
    • Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition
    • Bunck, M. C. et al. Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care 33, 1734-1737 (2010).
    • (2010) Diabetes Care , vol.33 , pp. 1734-1737
    • Bunck, M.C.1
  • 89
    • 84859106175 scopus 로고    scopus 로고
    • Impact of exenatide once weekly and insulin glargine on glucose control and cardiovascular risk f actors in subjects with type 2 diabetes [abstract
    • Diamant, M. et al. Impact of exenatide once weekly and insulin glargine on glucose control and cardiovascular risk f actors in subjects with type 2 diabetes [abstract]. Diabetologia 53 (Suppl. 1), S344 (2010).
    • (2010) Diabetologia , vol.53 , Issue.SUPPL1
    • Diamant, M.1
  • 90
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon, D. M. & Hausenloy, D. J. Myocardial reperfusion injury. N. Engl. J. Med. 357, 1121-1135 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 91
    • 20044367874 scopus 로고    scopus 로고
    • Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model
    • DOI 10.1007/s10557-005-6892-4
    • Bose, A. K., Mocanu, M. M., Carr, R. D. & Yellon, D. M. Glucagon like peptide 1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovasc. Drugs Ther. 19, 9-11 (2005). (Pubitemid 40767767)
    • (2005) Cardiovascular Drugs and Therapy , vol.19 , Issue.1 , pp. 9-11
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 92
    • 34548545405 scopus 로고    scopus 로고
    • Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway
    • DOI 10.1007/s10557-007-6030-6
    • Bose, A. K., Mocanu, M. M., Carr, R. D. & Yellon, D. M. Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide 1 (GLP 1) in the in vitro rat heart and may involve the p70s6K pathway. Cardiovasc. Drugs Ther. 21, 253-256 (2007). (Pubitemid 47387464)
    • (2007) Cardiovascular Drugs and Therapy , vol.21 , Issue.4 , pp. 253-256
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 93
    • 69549089903 scopus 로고    scopus 로고
    • The cardioprotective and inotropic components of the postconditioning effects of GLP 1 and GLP 1(9- 36)a in an isolated rat heart
    • Ossum, A., van Deurs, U., Engstrom, T., Jensen, J. S. & Treiman, M. The cardioprotective and inotropic components of the postconditioning effects of GLP 1 and GLP 1(9-36)a in an isolated rat heart. Pharmacol. Res. 60, 411-417 (2009).
    • (2009) Pharmacol. Res. , Issue.60 , pp. 411-417
    • Ossum, A.1    Van Deurs, U.2    Engstrom, T.3    Jensen, J.S.4    Treiman, M.5
  • 95
    • 58949084130 scopus 로고    scopus 로고
    • Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
    • Timmers, L. et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J. Am. Coll. Cardiol. 53, 501-510 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 501-510
    • Timmers, L.1
  • 96
    • 69049113026 scopus 로고    scopus 로고
    • Lack of cardioprotection from subcutaneously and preischemic administered liraglutide in a closed chest porcine ischemia reperfusion model
    • Kristensen, J. et al. Lack of cardioprotection from subcutaneously and preischemic administered liraglutide in a closed chest porcine ischemia reperfusion model. BMC Cardiovasc. Disord. 9, 31 (2009).
    • (2009) BMC Cardiovasc. Disord. , vol.9 , pp. 31
    • Kristensen, J.1
  • 97
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf, M. H. et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 58, 975-983 (2009).
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1
  • 99
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis, LA. et al. Effects of glucagon-like peptide 1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109, 962-965 (2004). (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 100
    • 84860390563 scopus 로고    scopus 로고
    • A pilot study to assess whether glucagon-like peptide 1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans
    • Read, P. A. et al. A pilot study to assess whether glucagon-like peptide 1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans. Circ. Cardiovasc. Interv. 4, 266-272 (2011).
    • (2011) Circ. Cardiovasc. Interv. , vol.4 , pp. 266-272
    • Read, P.A.1
  • 101
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST segment elevation myocardial infarction
    • Lønborg, J. et al. Exenatide reduces reperfusion injury in patients with ST segment elevation myocardial infarction. Eur. Heart J. http://dx.doi.org/10.1093/eurheartj/ehr309.
    • Eur. Heart J.
    • Lønborg, J.1
  • 103
    • 0037629509 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
    • DOI 10.1016/S0196-9781(03)00108-6
    • Kavianipour, M. et al. Glucagon-like peptide 1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium. Peptides 24, 569-578 (2003). (Pubitemid 36829346)
    • (2003) Peptides , vol.24 , Issue.4 , pp. 569-578
    • Kavianipour, M.1    Ehlers, M.R.2    Malmberg, K.3    Ronquist, G.4    Ryden, L.5    Wikstrom, G.6    Gutniak, M.7
  • 104
    • 0035980166 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes
    • Vila Petroff, M. G., Egan, J. M., Wang, X. & Sollott, S. J. Glucagon-like peptide 1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ. Res. 89, 445-452 (2001). (Pubitemid 34132661)
    • (2001) Circulation Research , vol.89 , Issue.5 , pp. 445-452
    • Vila Petroff, M.G.1    Egan, J.M.2    Wang, X.3    Sollott, S.J.4
  • 105
    • 77955480007 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy
    • Bhashyam, S. et al. Glucagon-like peptide 1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy. Circ. Heart Fail. 3, 512-521 (2010).
    • (2010) Circ. Heart Fail. , vol.3 , pp. 512-521
    • Bhashyam, S.1
  • 106
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis, L. A. et al. Recombinant glucagon-like peptide 1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 110, 955-961 (2004). (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 107
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • DOI 10.1152/ajpheart.00347.2005
    • Nikolaidis, L. A., Elahi, D., Shen, Y. T. & Shannon, R. P. Active metabolite of GLP 1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 289, H2401-H2408 (2005). (Pubitemid 41698549)
    • (2005) American Journal of Physiology - Heart and Circulatory Physiology , vol.289 , Issue.6-58
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.-T.3    Shannon, R.P.4
  • 109
    • 84859101510 scopus 로고    scopus 로고
    • Oleate controls the effects of GLP 1 and exendin 4 on myocardial glucose utilization and contractile function [abstract
    • Nguyen, T. D. Oleate controls the effects of GLP 1 and exendin 4 on myocardial glucose utilization and contractile function [abstract]. Eur. Heart J. 37 (Suppl. 1), 937 (2010).
    • (2010) Eur. Heart J. , vol.37 , Issue.SUPPL1 , pp. 937
    • Nguyen, T.D.1
  • 110
    • 79851489434 scopus 로고    scopus 로고
    • Plasma levels of glucagon like peptide 1 associate with diastolic function in elderly men
    • Nathanson, D. et al. Plasma levels of glucagon like peptide 1 associate with diastolic function in elderly men. Diabet. Med. 28, 301-305 (2011).
    • (2011) Diabet. Med. , vol.28 , pp. 301-305
    • Nathanson, D.1
  • 111
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • DOI 10.1016/j.cardfail.2006.08.211, PII S1071916406011092
    • Sokos, G. G., Nikolaidis, L. A., Mankad, S., Elahi, D. & Shannon, R. P. Glucagon-like peptide 1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J. Card. Fail. 12, 694-699 (2006). (Pubitemid 44881367)
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 112
    • 51749088973 scopus 로고    scopus 로고
    • Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes
    • Mussig, K. et al. Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes. Am. J. Cardiol. 102, 646-647 (2008).
    • (2008) Am. J. Cardiol. , vol.102 , pp. 646-647
    • Mussig, K.1
  • 113
    • 0036021740 scopus 로고    scopus 로고
    • Abnormalities of the electrocardiogram during hypoglycemia: The cause of the dead in bed syndrome
    • Heller, S. R. Abnormalities of the electrocardiogram during hypoglycemia: the cause of the dead in bed syndrome? Int. J. Clin. Pract. Suppl. 129, 27-32 (2002).
    • (2002) Int. J. Clin. Pract. Suppl. , vol.129 , pp. 27-32
    • Heller, S.R.1
  • 114
    • 80053606722 scopus 로고    scopus 로고
    • A thorough QT study to evaluate the effects of singledose exenatide 10 mug on cardiac repolarization in healthy subjects
    • Linnebjerg, H. et al. A thorough QT study to evaluate the effects of singledose exenatide 10 mug on cardiac repolarization in healthy subjects. Int. J. Clin. Pharmacol. Ther. 49, 594-604 (2011).
    • (2011) Int. J. Clin. Pharmacol. Ther. , vol.49 , pp. 594-604
    • Linnebjerg, H.1
  • 115
    • 70350430650 scopus 로고    scopus 로고
    • Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP 1 analog for treatment of type 2 diabetes
    • Chatterjee, D. J., Khutoryansky, N., Zdravkovic, M., Sprenger, C. R. & Litwin, J. S. Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP 1 analog for treatment of type 2 diabetes. J. Clin. Pharmacol. 49, 1353-1362 (2009).
    • (2009) J. Clin. Pharmacol. , vol.49 , pp. 1353-1362
    • Chatterjee, D.J.1    Khutoryansky, N.2    Zdravkovic, M.3    Sprenger, C.R.4    Litwin, J.S.5
  • 117
    • 0033807248 scopus 로고    scopus 로고
    • Intentional weight loss and mortality among overweight individuals with diabetes
    • Williamson, D. F. et al. Intentional weight loss and mortality among overweight individuals with diabetes. Diabetes Care 23, 1499-1504 (2000).
    • (2000) Diabetes Care , vol.23 , pp. 1499-1504
    • Williamson, D.F.1
  • 119
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto, T. J. et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin. Ther. 30, 1448-1460 (2008).
    • (2008) Clin. Ther. , vol.30 , pp. 1448-1460
    • Moretto, T.J.1
  • 120
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide 1 analog for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle, J. et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide 1 analog for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes. Metab. 11, 1163-1172 (2009).
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 1163-1172
    • Jendle, J.1
  • 121
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh, J. et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 53, 552-561 (2010).
    • (2010) Diabetologia , vol.53 , pp. 552-561
    • Hsieh, J.1
  • 122
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz, E. A. et al. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis 212, 217-222 (2010).
    • (2010) Atherosclerosis , vol.212 , pp. 217-222
    • Schwartz, E.A.1
  • 123
    • 77952889531 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP 1) attenuates post-resuscitation myocardial microcirculatory dysfunction
    • Dokken, B. B. et al. Glucagon-like peptide 1 (GLP 1) attenuates post-resuscitation myocardial microcirculatory dysfunction. Resuscitation 81, 755-760 (2010).
    • (2010) Resuscitation , vol.81 , pp. 755-760
    • Dokken, B.B.1
  • 124
    • 78649930490 scopus 로고    scopus 로고
    • GLP 1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats
    • Ku, H. C., Chen, W. P. & Su, M. J. GLP 1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats. Naunyn-Schmiedebergs Archives of Pharmacology 382, 463-474 (2010).
    • (2010) Naunyn-Schmiedebergs Archives of Pharmacology , vol.382 , pp. 463-474
    • Ku, H.C.1    Chen, W.P.2    Su, M.J.3
  • 125
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S. E. & Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356, 2457-2471 (2007). (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 126
    • 49649098865 scopus 로고    scopus 로고
    • Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality: A meta-analysis of observational studies
    • Rao, A. D., Kuhadiya, N., Reynolds, K. & Fonseca, V. A. Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies. Diabetes Care 31, 1672-1678 (2008).
    • (2008) Diabetes Care , vol.31 , pp. 1672-1678
    • Rao, A.D.1    Kuhadiya, N.2    Reynolds, K.3    Fonseca, V.A.4
  • 127
    • 79955049820 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 drugs use of GLP 1 analogs needs great caution
    • Yudkin, J. S., Lehman, R. & Krumholz, H. M. Glucagon-like peptide 1 drugs. Use of GLP 1 analogs needs great caution. BMJ 342, d1478 (2011).
    • (2011) BMJ , vol.342
    • Yudkin, J.S.1    Lehman, R.2    Krumholz, H.M.3
  • 128
    • 79951702236 scopus 로고    scopus 로고
    • Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP 1) receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the lifelink database
    • Best, J. H. et al. Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP 1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database. Diabetes Care 34, 90-95 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 90-95
    • Best, J.H.1
  • 129
    • 79955661908 scopus 로고    scopus 로고
    • DURATION 5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    • Blevins, T. et al. DURATION 5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 96, 1301-1310 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1301-1310
    • Blevins, T.1
  • 130
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • DOI 10.2337/diacare.27.11.2628
    • Buse, J. B. et al. Effects of exenatide (exendin 4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27, 2628-2635 (2004). (Pubitemid 39441462)
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 131
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2
    • DOI 10.2337/diacare.28.5.1092
    • DeFronzo, R. A. et al. Effects of exenatide (exendin 4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28, 1092-1100 (2005). (Pubitemid 40616618)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 132
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • DOI 10.2337/diacare.28.5.1083
    • Kendall, D. M. et al. Effects of exenatide (exendin 4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28, 1083-1091 (2005). (Pubitemid 40616617)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 133
    • 79953702801 scopus 로고    scopus 로고
    • Role of glucagon-like peptide 1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts
    • Barakat, G. M. et al. Role of glucagon-like peptide 1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts. Gen. Physiol. Biophys. 30, 34-44 (2011).
    • (2011) Gen. Physiol. Biophys. , vol.30 , pp. 34-44
    • Barakat, G.M.1
  • 135
    • 0028925896 scopus 로고
    • Glucagon-like peptide 1 binding to rat skeletal muscle
    • Delgado, E. et al. Glucagon-like peptide 1 binding to rat skeletal muscle. Peptides 16, 225-229 (1995).
    • (1995) Peptides , vol.16 , pp. 225-229
    • Delgado, E.1


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