Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 12, 2010, Pages

  Krug, Rosemarie ^a   Benedict, Christian ^a,b   Born, Jan ^a   Hallschmid, Manfred ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; ESTROGEN; GHRELIN; GLUCOSE; LEPTIN; NEUTRAL INSULIN; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TASK PERFORMANCE; WORKING MEMORY;

ANIMALIA; RATTUS;

EID: 78650054323     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0744     Document Type: Article

References (19)

1. Woods SC, Seeley RJ, Baskin DG, Schwartz MW 2003 Insulin and the blood-brain barrier. Curr Pharm Des 9:795-800
2. Zhao WQ, Alkon DL 2001 Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177:125-134
3. Porte Jr D, Woods SC 1981 Regulation of food intake and body weight in insulin. Diabetologia 20(Suppl):274-280
4. Clegg DJ, Riedy CA, Smith KA, Benoit SC, Woods SC 2003 Differential sensitivity to central leptin and insulin in male and female rats. Diabetes 52:682-687
5. Clegg DJ, Brown LM, Woods SC, Benoit SC 2006 Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55:978-987
6. Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL 2002 Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 5:514-516
7. Hallschmid M, Benedict C, Schultes B, Fehm HL, Born J, Kern W 2004 Intranasal insulin reduces body fat in men but not in women. Diabetes 53:3024-3029
8. Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W 2004 Intranasal insulin improves memory in humans. Psychoneuroendocrinology 29:1326-1334
9. Benedict C, Kern W, Schultes B, Born J, Hallschmid M 2008 Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab 93:1339-1344
10. Tewes U 1994 Hamburg-Wechsler-Intelligenztest für Erwachsene - revision (HAWIE-R). Bern, Switzerland: Huber
11. Sommer T, Rose M, Gläscher J, Wolbers T, Büchel C 2005 Dissociable contributions within the medial temporal lobe to encoding of object-location associations. Learn Mem 12:343-351
12. Täuber U, Kuhnz W, Hümpel M 1990 Pharmacokinetics of gestodene and ethinyl estradiol after oral administration of a monophasic contraceptive. Am J Obstet Gynecol 163:1414-1420
13. Kuhl H 2005 Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 8(Suppl 1):3-63
14. Petrides M, Alivisatos B, Meyer E, Evans AC 1993 Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci USA 90:878-882
15. Tulving E, Kapur S, Craik FI, Moscovitch M, Houle S 1994 Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proc Natl Acad Sci USA 91:2016-2020
16. Earles JL, Kersten AW 1999 Processing speed and adult age differences in activity memory. Exp Aging Res 25:243-253
17. Reger MA, Watson GS, Frey 2nd WH, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S 2006 Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 27:451-458
18. Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, DeGroodt W, Mehta P, Craft S 2008 Intranasal insulin improves cognition and modulates β-amyloid in early AD. Neurology 70:440-448
19. Hallschmid M, Schultes B 2009 Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders? Diabetologia 52:2264-2269