메뉴 건너뛰기




Volumn 28, Issue 2, 2013, Pages 225-233

An energetic orphan in an endocrine tissue: A revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage

Author keywords

chondrocytes; ERR ; fao; osteoblasts; osteoclasts; oxidative stress

Indexed keywords

APELIN RECEPTOR; ESTROGEN RELATED RECEPTOR ALPHA; INSULIN; LEPTIN; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TROGLITAZONE;

EID: 84872440920     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1836     Document Type: Review
Times cited : (34)

References (100)
  • 2
    • 0023857147 scopus 로고
    • Identification of a new class of steroid hormone receptors
    • Giguere V, Yang N, Segui P, Evans RM., Identification of a new class of steroid hormone receptors. Nature. 1988; 331 (6151): 91-4.
    • (1988) Nature. , vol.331 , Issue.6151 , pp. 91-94
    • Giguere, V.1    Yang, N.2    Segui, P.3    Evans, R.M.4
  • 3
    • 0033529498 scopus 로고    scopus 로고
    • Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
    • Hong H, Yang L, Stallcup MR., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999; 274: 22618-26.
    • (1999) J Biol Chem. , vol.274 , pp. 22618-22626
    • Hong, H.1    Yang, L.2    Stallcup, M.R.3
  • 4
    • 0036633114 scopus 로고    scopus 로고
    • To ERR in the estrogen pathway
    • Giguere V., To ERR in the estrogen pathway. Trends Endocrinol Metab. 2002; 13 (5): 220-5.
    • (2002) Trends Endocrinol Metab. , vol.13 , Issue.5 , pp. 220-225
    • Giguere, V.1
  • 5
    • 19844376597 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha: A mediator of estrogen response in bone
    • Bonnelye E, Aubin JE., Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone. J Clin Endocrinol Metab. 2005; 90 (5): 3115-21.
    • (2005) J Clin Endocrinol Metab. , vol.90 , Issue.5 , pp. 3115-3121
    • Bonnelye, E.1    Aubin, J.E.2
  • 6
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • Scarpulla
    • Scarpulla. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. 2011; 1813 (7): 1269-78.
    • (2011) Biochim Biophys Acta. , vol.1813 , Issue.7 , pp. 1269-1278
  • 7
    • 52249090234 scopus 로고    scopus 로고
    • ERRalpha:, a metabolic function for the oldest orphan
    • Villena JA, Kralli A., ERRalpha:, a metabolic function for the oldest orphan. Trends Endocrinol Metab. 2008; 19 (8): 269-76.
    • (2008) Trends Endocrinol Metab. , vol.19 , Issue.8 , pp. 269-276
    • Villena, J.A.1    Kralli, A.2
  • 8
    • 53849088227 scopus 로고    scopus 로고
    • Transcriptional control of energy homeostasis by the estrogen-related receptors
    • Giguère V., Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev. 2008; 29 (6): 677-96.
    • (2008) Endocr Rev. , vol.29 , Issue.6 , pp. 677-696
    • Giguère, V.1
  • 9
    • 33847059267 scopus 로고    scopus 로고
    • The orphan nuclear estrogen receptor-related receptor-(71) regulates cartilage formation in vitro: Implication of Sox9
    • Bonnelye E, Zirngibl RA, Jurdic P, Aubin JE., The orphan nuclear estrogen receptor-related receptor-(71) regulates cartilage formation in vitro: implication of Sox9. Endocrinology. 2007; 148 (3): 1195-205.
    • (2007) Endocrinology. , vol.148 , Issue.3 , pp. 1195-1205
    • Bonnelye, E.1    Zirngibl, R.A.2    Jurdic, P.3    Aubin, J.E.4
  • 10
    • 79961124749 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor - A regulation by interleukin-1b in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes
    • Bonnelye ERP, Duval N, Cardelli M, Aubin JE., Estrogen receptor-related receptor-a regulation by interleukin-1b in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes. Arthritis Rheum. 2011; 63 (8): 2374-84.
    • (2011) Arthritis Rheum. , vol.63 , Issue.8 , pp. 2374-2384
    • Bonnelye, E.R.P.1    Duval, N.2    Cardelli, M.3    Aubin, J.E.4
  • 11
    • 62949150111 scopus 로고    scopus 로고
    • Osteoarthritis revisited - Again
    • Watt I., Osteoarthritis revisited-again ! Skeletal Radiol. 2009; 38 (5): 419-23.
    • (2009) Skeletal Radiol. , vol.38 , Issue.5 , pp. 419-423
    • Watt, I.1
  • 13
    • 56649106684 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor-alpha (ERR-alpha) is dysregulated in inflammatory arthritis
    • Bonnelye E, Laurin N, Jurdic P, Hart DA, Aubin JE., Estrogen receptor-related receptor-alpha (ERR-alpha) is dysregulated in inflammatory arthritis. Rheumatology (Oxford). 2008; 47 (12): 1785-91.
    • (2008) Rheumatology (Oxford). , vol.47 , Issue.12 , pp. 1785-1791
    • Bonnelye, E.1    Laurin, N.2    Jurdic, P.3    Hart, D.A.4    Aubin, J.E.5
  • 15
    • 77956408841 scopus 로고    scopus 로고
    • PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss
    • Wei W, Wang X, Yang M, Smith LC, Dechow PC, Sonoda J, Evans RM, Wan Y., PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 2010; 11 (6): 503-16.
    • (2010) Cell Metab. , vol.11 , Issue.6 , pp. 503-516
    • Wei, W.1    Wang, X.2    Yang, M.3    Smith, L.C.4    Dechow, P.C.5    Sonoda, J.6    Evans, R.M.7    Wan, Y.8
  • 16
    • 61549098167 scopus 로고    scopus 로고
    • Thiazolidinedione-induced skeletal fragility - Mechanisms and implications
    • Grey A., Thiazolidinedione-induced skeletal fragility-mechanisms and implications. Diabetes Obes Metab. 2009; 11 (4): 275-84.
    • (2009) Diabetes Obes Metab. , vol.11 , Issue.4 , pp. 275-284
    • Grey, A.1
  • 17
    • 78650469295 scopus 로고    scopus 로고
    • Involvement of the orphan nuclear estrogen receptor-related receptor a in osteoclast adhesion and transmigration
    • Bonnelye E, Saltel F, Chabadel A, Zirngibl RA, Aubin JE, Jurdic P., Involvement of the orphan nuclear estrogen receptor-related receptor a in osteoclast adhesion and transmigration. J Mol Endocrinol. 2010; 45 (6): 365-77.
    • (2010) J Mol Endocrinol. , vol.45 , Issue.6 , pp. 365-377
    • Bonnelye, E.1    Saltel, F.2    Chabadel, A.3    Zirngibl, R.A.4    Aubin, J.E.5    Jurdic, P.6
  • 18
    • 0037329229 scopus 로고    scopus 로고
    • Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein
    • Destaing O, Saltel F, Geminard JC, Jurdic P, Bard F., Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol Biol Cell. 2003; 14 (2): 407-16.
    • (2003) Mol Biol Cell. , vol.14 , Issue.2 , pp. 407-416
    • Destaing, O.1    Saltel, F.2    Geminard, J.C.3    Jurdic, P.4    Bard, F.5
  • 20
    • 0035947765 scopus 로고    scopus 로고
    • The orphan nuclear estrogen receptor-related receptor (ERR) is expressed throughout osteoblast differentiation and regulates bone formation in vitro
    • Bonnelye E, Merdad L, Kung V, Aubin JE., The orphan nuclear estrogen receptor-related receptor (ERR) is expressed throughout osteoblast differentiation and regulates bone formation in vitro. J Cell Biol. 2001; 153 (5): 971-83.
    • (2001) J Cell Biol. , vol.153 , Issue.5 , pp. 971-983
    • Bonnelye, E.1    Merdad, L.2    Kung, V.3    Aubin, J.E.4
  • 21
    • 77952744606 scopus 로고    scopus 로고
    • ERRalpha regulates osteoblastic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells
    • Rajalin AM, Pollock H, Aarnisalo P., ERRalpha regulates osteoblastic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2010; 396 (2): 477-82.
    • (2010) Biochem Biophys Res Commun. , vol.396 , Issue.2 , pp. 477-482
    • Rajalin, A.M.1    Pollock, H.2    Aarnisalo, P.3
  • 24
    • 0036721591 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha impinges on the estrogen axis in bone: Potential function in osteoporosis
    • Bonnelye E, Kung V, Laplace C, Galson DL, Aubin JE., Estrogen receptor-related receptor alpha impinges on the estrogen axis in bone: potential function in osteoporosis. Endocrinology. 2002; 143 (9): 3658-70.
    • (2002) Endocrinology. , vol.143 , Issue.9 , pp. 3658-3670
    • Bonnelye, E.1    Kung, V.2    Laplace, C.3    Galson, D.L.4    Aubin, J.E.5
  • 25
    • 67649831233 scopus 로고    scopus 로고
    • The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation
    • Jeong BC, Lee YS, Park YY, Bae IH, Kim DK, Koo SH, Choi HR, Kim SH, Franceschi RT, Koh JT, Choi HS., The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation. J Biol Chem. 2009; 284 (21): 14211-8.
    • (2009) J Biol Chem. , vol.284 , Issue.21 , pp. 14211-14218
    • Jeong, B.C.1    Lee, Y.S.2    Park, Y.Y.3    Bae, I.H.4    Kim, D.K.5    Koo, S.H.6    Choi, H.R.7    Kim, S.H.8    Franceschi, R.T.9    Koh, J.T.10    Choi, H.S.11
  • 26
    • 84872466446 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor gamma (ERRγ) is a regulator of bone turnover [Internet]
    • Poster Sessions, Presentation Number: SA0484. [cited 2012 Dec 2]
    • Cardelli M, Guo R, Boetto J, Zirngibl R, Aubin J., Estrogen receptor-related receptor gamma (ERRγ) is a regulator of bone turnover [Internet]. J Bone Miner Res. 2011; 26 (Suppl 1):Poster Sessions, Presentation Number: SA0484. [cited 2012 Dec 2]. Available from: http://www.asbmr.org/ Meetings/AnnualMeeting/AbstractDetail.aspx?aid=7f807fa8-2ec2-48ed-838c- 39cad1d16fdc.
    • (2011) J Bone Miner Res. , vol.26 , Issue.SUPPL. 1
    • Cardelli, M.1    Guo, R.2    Boetto, J.3    Zirngibl, R.4    Aubin, J.5
  • 27
    • 0037127246 scopus 로고    scopus 로고
    • Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms
    • Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS., Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 2002; 277 (3): 1739-48.
    • (2002) J Biol Chem. , vol.277 , Issue.3 , pp. 1739-1748
    • Sanyal, S.1    Kim, J.Y.2    Kim, H.J.3    Takeda, J.4    Lee, Y.K.5    Moore, D.D.6    Choi, H.S.7
  • 28
    • 70450172889 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis
    • Ondracek CR, Rushing CN, Reese VC, Oropeza CE, McLachlan A., Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis. J Virol. 2009; 83 (23): 12535-44.
    • (2009) J Virol. , vol.83 , Issue.23 , pp. 12535-12544
    • Ondracek, C.R.1    Rushing, C.N.2    Reese, V.C.3    Oropeza, C.E.4    McLachlan, A.5
  • 30
    • 45549104823 scopus 로고    scopus 로고
    • Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors
    • Ao A, Wang H, Kamarajugadda S, Lu J., Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors. Proc Natl Acad Sci U S A. 2008; 105 (22): 7821-6.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.22 , pp. 7821-7826
    • Ao, A.1    Wang, H.2    Kamarajugadda, S.3    Lu, J.4
  • 33
    • 78649722176 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: Role of angiopoietin-like 4
    • Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA., Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J. 2010; 24 (12): 4648-59.
    • (2010) FASEB J. , vol.24 , Issue.12 , pp. 4648-4659
    • Knowles, H.J.1    Cleton-Jansen, A.M.2    Korsching, E.3    Athanasou, N.A.4
  • 35
    • 62949222778 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells
    • Stein RA, Gaillard S, McDonnell DP., Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol. 2009; 114 (1-2): 106-12.
    • (2009) J Steroid Biochem Mol Biol. , vol.114 , Issue.12 , pp. 106-112
    • Stein, R.A.1    Gaillard, S.2    McDonnell, D.P.3
  • 36
    • 0242580188 scopus 로고    scopus 로고
    • Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha
    • Luo J, Sladek R, Carrier J, Bader JA, Richard D, Giguere V., Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol. 2003; 23 (22): 7947-56.
    • (2003) Mol Cell Biol. , vol.23 , Issue.22 , pp. 7947-7956
    • Luo, J.1    Sladek, R.2    Carrier, J.3    Bader, J.A.4    Richard, D.5    Giguere, V.6
  • 38
    • 15544385929 scopus 로고    scopus 로고
    • Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair
    • Zelzer E, Olsen BR., Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair. Curr Top Dev Biol. 2005; 65: 169-87.
    • (2005) Curr Top Dev Biol. , vol.65 , pp. 169-187
    • Zelzer, E.1    Olsen, B.R.2
  • 39
    • 80054716866 scopus 로고    scopus 로고
    • The metabolic regulator ERRa, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer
    • Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP., The metabolic regulator ERRa, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 2011; 20 (4): 500-10.
    • (2011) Cancer Cell. , vol.20 , Issue.4 , pp. 500-510
    • Chang, C.Y.1    Kazmin, D.2    Jasper, J.S.3    Kunder, R.4    Zuercher, W.J.5    McDonnell, D.P.6
  • 40
    • 0033958620 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1
    • Klinge CM, Kaur K, Swanson HI., The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Arch Biochem Biophys. 2000; 373 (1): 163-74.
    • (2000) Arch Biochem Biophys. , vol.373 , Issue.1 , pp. 163-174
    • Klinge, C.M.1    Kaur, K.2    Swanson, H.I.3
  • 41
    • 38449097094 scopus 로고    scopus 로고
    • Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor
    • Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE., Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res. 2007; 22 (10): 1571-80.
    • (2007) J Bone Miner Res. , vol.22 , Issue.10 , pp. 1571-1580
    • Ryan, E.P.1    Holz, J.D.2    Mulcahey, M.3    Sheu, T.J.4    Gasiewicz, T.A.5    Puzas, J.E.6
  • 42
    • 77951582963 scopus 로고    scopus 로고
    • Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype
    • Wejheden C, Brunnberg S, Larsson S, Lind PM, Andersson G, Hanberg A., Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. Toxicol Sci. 2012; 114 (1): 48-58.
    • (2012) Toxicol Sci. , vol.114 , Issue.1 , pp. 48-58
    • Wejheden, C.1    Brunnberg, S.2    Larsson, S.3    Lind, P.M.4    Andersson, G.5    Hanberg, A.6
  • 43
    • 80051962186 scopus 로고    scopus 로고
    • A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action
    • Sharan K, Mishra JS, Swarnkar G, Siddiqui JA, Khan K, Kumari R, Rawat P, Maurya R, Sanyal S, Chattopadhyay N., A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action. J Bone Miner Res. 2011; 26 (9): 2096-111.
    • (2011) J Bone Miner Res. , vol.26 , Issue.9 , pp. 2096-2111
    • Sharan, K.1    Mishra, J.S.2    Swarnkar, G.3    Siddiqui, J.A.4    Khan, K.5    Kumari, R.6    Rawat, P.7    Maurya, R.8    Sanyal, S.9    Chattopadhyay, N.10
  • 44
    • 4744371376 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    • Huss JM, Torra IP, Staels B, Giguere V, Kelly DP., Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004; 24 (20): 9079-91.
    • (2004) Mol Cell Biol. , vol.24 , Issue.20 , pp. 9079-9091
    • Huss, J.M.1    Torra, I.P.2    Staels, B.3    Giguere, V.4    Kelly, D.P.5
  • 45
    • 79957507671 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
    • Stunes AK, Westbroek I, Gustafsson BI, Fossmark R, Waarsing JH, Eriksen EF, Petzold C, Reseland JE, Syversen U., The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats. BMC Endocr Disord. 2011; 11: 11.
    • (2011) BMC Endocr Disord. , vol.11 , pp. 11
    • Stunes, A.K.1    Westbroek, I.2    Gustafsson, B.I.3    Fossmark, R.4    Waarsing, J.H.5    Eriksen, E.F.6    Petzold, C.7    Reseland, J.E.8    Syversen, U.9
  • 47
    • 0037007146 scopus 로고    scopus 로고
    • In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis
    • Sekiya I, Vuoristo JT, Larson BL, Prockop DJ., In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A. 2002; 99 (7): 4397-402.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , Issue.7 , pp. 4397-4402
    • Sekiya, I.1    Vuoristo, J.T.2    Larson, B.L.3    Prockop, D.J.4
  • 48
    • 67649784462 scopus 로고    scopus 로고
    • Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
    • Friedman MS, Oyserman SM, Hankenson KD., Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem. 2009; 284 (21): 14117-25.
    • (2009) J Biol Chem. , vol.284 , Issue.21 , pp. 14117-14125
    • Friedman, M.S.1    Oyserman, S.M.2    Hankenson, K.D.3
  • 49
    • 78549241322 scopus 로고    scopus 로고
    • WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration
    • Nov 15
    • Dwyer MA, Joseph JD, Wade HE, Eaton ML, Kunder RS, Kazmin D, Chang CY, McDonnell DP., WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Res. 2010 Nov 15; 70 (22): 9298-308.
    • (2010) Cancer Res. , vol.70 , Issue.22 , pp. 9298-9308
    • Dwyer, M.A.1    Joseph, J.D.2    Wade, H.E.3    Eaton, M.L.4    Kunder, R.S.5    Kazmin, D.6    Chang, C.Y.7    McDonnell, D.P.8
  • 51
    • 0030787844 scopus 로고    scopus 로고
    • The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene
    • Sladek R, Bader JA, Giguere V., The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol. 1997; 17 (9): 5400-9.
    • (1997) Mol Cell Biol. , vol.17 , Issue.9 , pp. 5400-5409
    • Sladek, R.1    Bader, J.A.2    Giguere, V.3
  • 52
    • 0031468588 scopus 로고    scopus 로고
    • A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation
    • Vega RB, Kelly DP., A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation. J Biol Chem. 1997; 272 (50): 31693-9.
    • (1997) J Biol Chem. , vol.272 , Issue.50 , pp. 31693-31699
    • Vega, R.B.1    Kelly, D.P.2
  • 54
    • 28544438180 scopus 로고    scopus 로고
    • PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism
    • Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP., PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol. 2005; 25 (24): 10684-94.
    • (2005) Mol Cell Biol. , vol.25 , Issue.24 , pp. 10684-10694
    • Wende, A.R.1    Huss, J.M.2    Schaeffer, P.J.3    Giguère, V.4    Kelly, D.P.5
  • 55
    • 77449138454 scopus 로고    scopus 로고
    • Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake
    • Nie Y, Wong C., Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake. J Cell Mol Med. 2009; 13 (9B): 3051-60.
    • (2009) J Cell Mol Med. , vol.13 , Issue.9 B , pp. 3051-3060
    • Nie, Y.1    Wong, C.2
  • 58
    • 33646865314 scopus 로고    scopus 로고
    • Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle
    • Araki M, Motojima K., Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle. FEBS J. 2006; 273 (8): 1669-80.
    • (2006) FEBS J. , vol.273 , Issue.8 , pp. 1669-1680
    • Araki, M.1    Motojima, K.2
  • 60
    • 42449096306 scopus 로고    scopus 로고
    • Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
    • Ferron M, Hinoi E, Karsenty G, Ducy P., Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A. 2008; 105 (13): 5266-70.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.13 , pp. 5266-5270
    • Ferron, M.1    Hinoi, E.2    Karsenty, G.3    Ducy, P.4
  • 62
    • 84855987634 scopus 로고    scopus 로고
    • The contribution of bone to whole-organism physiology
    • Karsenty G, Ferron M., The contribution of bone to whole-organism physiology. Nature. 2012; 481 (7381): 314-20.
    • (2012) Nature. , vol.481 , Issue.7381 , pp. 314-320
    • Karsenty, G.1    Ferron, M.2
  • 63
    • 84855866319 scopus 로고    scopus 로고
    • Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice
    • Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G., Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone. 2012; 50 (2): 568-75.
    • (2012) Bone. , vol.50 , Issue.2 , pp. 568-575
    • Ferron, M.1    McKee, M.D.2    Levine, R.L.3    Ducy, P.4    Karsenty, G.5
  • 67
    • 80051927273 scopus 로고    scopus 로고
    • Control of bone metabolism by central nervous system
    • Japanese
    • Takeda S., [Control of bone metabolism by central nervous system]. Clin Calcium. 2011; 21 (5): 691-6. Japanese.
    • (2011) Clin Calcium. , vol.21 , Issue.5 , pp. 691-696
    • Takeda, S.1
  • 68
    • 34248996170 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha modulates the expression of adipogenesis-related genes during adipocyte differentiation
    • Ijichi N, Ikeda K, Horie-Inoue K, Yagi K, Okazaki Y, Inoue S., Estrogen-related receptor alpha modulates the expression of adipogenesis-related genes during adipocyte differentiation. Biochem Biophys Res Commun. 2007; 358 (3): 813-8.
    • (2007) Biochem Biophys Res Commun. , vol.358 , Issue.3 , pp. 813-818
    • Ijichi, N.1    Ikeda, K.2    Horie-Inoue, K.3    Yagi, K.4    Okazaki, Y.5    Inoue, S.6
  • 69
    • 84858181495 scopus 로고    scopus 로고
    • Estrogen related receptor α-induced adipogenesis is PGC-1β-dependent
    • Ju D, He J, Zhao L, Zheng X, Yang G., Estrogen related receptor α-induced adipogenesis is PGC-1β-dependent. Mol Biol Rep. 2012; 39 (3): 3343-54.
    • (2012) Mol Biol Rep. , vol.39 , Issue.3 , pp. 3343-3354
    • Ju, D.1    He, J.2    Zhao, L.3    Zheng, X.4    Yang, G.5
  • 70
    • 73549117208 scopus 로고    scopus 로고
    • Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway
    • Tremblay AM, Dufour CR, Ghahremani M, Reudelhuber TL, Giguère V., Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway. Mol Endocrinol. 2010; 24 (1): 22-32.
    • (2010) Mol Endocrinol. , vol.24 , Issue.1 , pp. 22-32
    • Tremblay, A.M.1    Dufour, C.R.2    Ghahremani, M.3    Reudelhuber, T.L.4    Giguère, V.5
  • 73
    • 69949102009 scopus 로고    scopus 로고
    • PGC-1alpha in aging and anti-aging interventions
    • Anderson R, Prolla T., PGC-1alpha in aging and anti-aging interventions. Biochim Biophys Acta. 2009; 1790 (10): 1059-66.
    • (2009) Biochim Biophys Acta. , vol.1790 , Issue.10 , pp. 1059-1066
    • Anderson, R.1    Prolla, T.2
  • 74
    • 0034842784 scopus 로고    scopus 로고
    • Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
    • Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M., Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. 2001; 2 (3): 165-71.
    • (2001) Biogerontology. , vol.2 , Issue.3 , pp. 165-171
    • Justesen, J.1    Stenderup, K.2    Ebbesen, E.N.3    Mosekilde, L.4    Steiniche, T.5    Kassem, M.6
  • 75
    • 70350451479 scopus 로고    scopus 로고
    • Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton
    • Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL., Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009; 284 (40): 27438-48.
    • (2009) J Biol Chem. , vol.284 , Issue.40 , pp. 27438-27448
    • Almeida, M.1    Ambrogini, E.2    Han, L.3    Manolagas, S.C.4    Jilka, R.L.5
  • 76
    • 79960575561 scopus 로고    scopus 로고
    • Unraveling the role of FoxOs in bone - Insights from mouse models
    • Almeida M., Unraveling the role of FoxOs in bone-insights from mouse models. Bone. 2011; 49 (3): 319-27.
    • (2011) Bone. , vol.49 , Issue.3 , pp. 319-327
    • Almeida, M.1
  • 77
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
    • Manolagas SC., From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010; 31 (3): 266-300.
    • (2010) Endocr Rev. , vol.31 , Issue.3 , pp. 266-300
    • Manolagas, S.C.1
  • 78
    • 79957475932 scopus 로고    scopus 로고
    • FoxOs: Unifying links between oxidative stress and skeletal homeostasis
    • Kousteni S., FoxOs: Unifying links between oxidative stress and skeletal homeostasis. Curr Osteoporos Rep. 2011; 9 (2): 60-6.
    • (2011) Curr Osteoporos Rep. , vol.9 , Issue.2 , pp. 60-66
    • Kousteni, S.1
  • 80
    • 0025236484 scopus 로고
    • Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
    • Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR., Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest. 1990; 85 (3): 632-9.
    • (1990) J Clin Invest. , vol.85 , Issue.3 , pp. 632-639
    • Garrett, I.R.1    Boyce, B.F.2    Oreffo, R.O.3    Bonewald, L.4    Poser, J.5    Mundy, G.R.6
  • 81
    • 32144434247 scopus 로고    scopus 로고
    • Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines
    • Lee DH, Lim BS, Lee YK, Yang HC., Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines. Cell Biol Toxicol. 2006; 22 (1): 39-46.
    • (2006) Cell Biol Toxicol. , vol.22 , Issue.1 , pp. 39-46
    • Lee, D.H.1    Lim, B.S.2    Lee, Y.K.3    Yang, H.C.4
  • 82
    • 77649216353 scopus 로고    scopus 로고
    • Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production
    • Wang J, Wang Y, Wong C., Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production. Cell Prolif. 2010; 43 (2): 103-13.
    • (2010) Cell Prolif. , vol.43 , Issue.2 , pp. 103-113
    • Wang, J.1    Wang, Y.2    Wong, C.3
  • 83
    • 67650711167 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha inverse agonist enhances basal glucose uptake in myotubes through reactive oxygen species
    • Chen L, Wong C., Estrogen-related receptor alpha inverse agonist enhances basal glucose uptake in myotubes through reactive oxygen species. Biol Pharm Bull. 2009; 32 (7): 1199-203.
    • (2009) Biol Pharm Bull. , vol.32 , Issue.7 , pp. 1199-1203
    • Chen, L.1    Wong, C.2
  • 84
    • 77952293181 scopus 로고    scopus 로고
    • Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist
    • Wang Y, Fang F, Wong CW., Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist. Biochem Pharmacol. 2010; 80 (1): 80-5.
    • (2010) Biochem Pharmacol. , vol.80 , Issue.1 , pp. 80-85
    • Wang, Y.1    Fang, F.2    Wong, C.W.3
  • 87
    • 77955347446 scopus 로고    scopus 로고
    • Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
    • Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y., Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One. 2010; 5 (7): e11707.
    • (2010) PLoS One. , vol.5 , Issue.7
    • Kong, X.1    Wang, R.2    Xue, Y.3    Liu, X.4    Zhang, H.5    Chen, Y.6    Fang, F.7    Chang, Y.8
  • 88
    • 77957239867 scopus 로고    scopus 로고
    • ERR receptors as potential targets in osteoporosis
    • Gallet M, Vanacker JM., ERR receptors as potential targets in osteoporosis. Trends Endocrinol Metab. 2010; 21 (10): 637-41.
    • (2010) Trends Endocrinol Metab. , vol.21 , Issue.10 , pp. 637-641
    • Gallet, M.1    Vanacker, J.M.2
  • 89
    • 39549085362 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha (ERRalpha) regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner
    • Zirngibl RA, Chan JS, Aubin JE., Estrogen receptor-related receptor alpha (ERRalpha) regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner. J Mol Endocrinol. 2008; 40 (2): 61-73.
    • (2008) J Mol Endocrinol. , vol.40 , Issue.2 , pp. 61-73
    • Zirngibl, R.A.1    Chan, J.S.2    Aubin, J.E.3
  • 91
    • 0032535306 scopus 로고    scopus 로고
    • Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor
    • Yang C, Zhou D, Chen S., Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor. Cancer Res. 1998; 58 (24): 5695-700.
    • (1998) Cancer Res. , vol.58 , Issue.24 , pp. 5695-5700
    • Yang, C.1    Zhou, D.2    Chen, S.3
  • 92
    • 0037171949 scopus 로고    scopus 로고
    • Regulation of aromatase promoter activity in human breast tissue by nuclear receptors
    • Yang C, Yu B, Zhou D, Chen S., Regulation of aromatase promoter activity in human breast tissue by nuclear receptors. Oncogene. 2002; 21 (18): 2854-63.
    • (2002) Oncogene. , vol.21 , Issue.18 , pp. 2854-2863
    • Yang, C.1    Yu, B.2    Zhou, D.3    Chen, S.4
  • 93
    • 0344198493 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression
    • Sumi D, Ignarro LJ., Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proc Natl Acad Sci U S A. 2003; 100 (24): 14451-6.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.24 , pp. 14451-14456
    • Sumi, D.1    Ignarro, L.J.2
  • 94
    • 0029965083 scopus 로고    scopus 로고
    • Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter
    • Yang N, Shigeta H, Shi H, Teng CT., Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem. 1996; 271 (10): 5795-804.
    • (1996) J Biol Chem. , vol.271 , Issue.10 , pp. 5795-5804
    • Yang, N.1    Shigeta, H.2    Shi, H.3    Teng, C.T.4
  • 95
    • 0034617167 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene
    • Zhang Z, Teng CT., Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene. J Biol Chem. 2000; 275 (27): 20837-46.
    • (2000) J Biol Chem. , vol.275 , Issue.27 , pp. 20837-20846
    • Zhang, Z.1    Teng, C.T.2
  • 96
    • 77953293829 scopus 로고    scopus 로고
    • Lactoferrin as an effector molecule in the skeleton
    • Cornish J, Naot D., Lactoferrin as an effector molecule in the skeleton. Biometals. 2010; 23 (3): 425-30.
    • (2010) Biometals. , vol.23 , Issue.3 , pp. 425-430
    • Cornish, J.1    Naot, D.2
  • 97
    • 84866001590 scopus 로고    scopus 로고
    • Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    • Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR., Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012; 122 (4): 3101-13.
    • (2012) J Clin Invest. , vol.122 , Issue.4 , pp. 3101-3113
    • Liu, Y.1    Berendsen, A.D.2    Jia, S.3    Lotinun, S.4    Baron, R.5    Ferrara, N.6    Olsen, B.R.7
  • 98
    • 1342289558 scopus 로고    scopus 로고
    • Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    • Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, Bouillon R, Carmeliet G., Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest. 2004; 113 (2): 188-99.
    • (2004) J Clin Invest. , vol.113 , Issue.2 , pp. 188-199
    • Maes, C.1    Stockmans, I.2    Moermans, K.3    Van Looveren, R.4    Smets, N.5    Carmeliet, P.6    Bouillon, R.7    Carmeliet, G.8
  • 99
    • 45549085001 scopus 로고    scopus 로고
    • Osteogenesis and angiogenesis: The potential for engineering bone
    • Kanczler JM, Oreffo RO., Osteogenesis and angiogenesis: the potential for engineering bone. Eur Cell Mater. 2008; 15: 100-14.
    • (2008) Eur Cell Mater. , vol.15 , pp. 100-114
    • Kanczler, J.M.1    Oreffo, R.O.2
  • 100
    • 33845401465 scopus 로고    scopus 로고
    • Modeling oxidative stress in the central nervous system
    • Dec
    • Lehtinen MK, Bonni A., Modeling oxidative stress in the central nervous system. Curr Mol Med. 2006 Dec; 6 (8): 871-81.
    • (2006) Curr Mol Med. , vol.6 , Issue.8 , pp. 871-881
    • Lehtinen, M.K.1    Bonni, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.