Absence of ERRα in female mice confers resistance to bone loss induced by age or estrogen-deficiency

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Teyssier, Catherine ^a   Gallet, Marlène ^a   Rabier, Bénédicte ^b   Monfoulet, Laurent ^b   Dine, Julien ^b   Macari, Claire ^a   Espallergues, Julie ^b   Horard, Béatrice ^c   Giguère, Vincent ^d   Cohen Solal, Martine ^e   Chassande, Olivier ^a,b   Vanacker, Jean Marc ^a  

^a UNIVERSITÉ DE LYON   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LYON   (France)

^d MCGILL UNIVERSITY   (Canada)

^e HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ESTROGEN RELATED RECEPTOR ALPHA; ESTROGEN; ESTROGEN RECEPTOR ALPHA; OSTEOPONTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MARROW; BONE MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EX VIVO STUDY; FEMALE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE; AGING; ANIMAL; BONE; C57BL MOUSE; CELL LINE; COMPUTER ASSISTED TOMOGRAPHY; GENETICS; METABOLISM; METHODOLOGY; MOUSE MUTANT; PATHOLOGY;

ANIMALIA; MUS;

AGING; ANIMALS; BONE AND BONES; BONE MARROW; CELL DIFFERENTIATION; CELL LINE; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOPONTIN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 70949105650     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007942     Document Type: Article

References (39)

1. Ducy P, Zhang R, Geoffroy V, Rydall AL, Karsenty G (1997) Osf2/Cbfa1, a transcriptional regulator of osteoblast differentiation. Cell 8: 747-754.
2. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, et al. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
3. Komori T (2006) Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99: 1233-1239.
4. Kostenuik PJ (2005) Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 5: 618-625.
5. Xing L, Schwarz EM, Boyce BF (2005) Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev 208: 19-29.
6. Wada T, Nakashima T, Hiroshi N, Penninger JM (2006) RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Endocrinol Metab 12: 17-25.
7. Asagiri M, Takayanagi H (2006) The molecular understanding of osteoclast differentiation. Bone 40: 251-264.
8. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309-19.
9. Boyce BF, Xing L (2008) Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 473: 139-146.
10. Syed F, Khosla S (2004) Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 328: 688-696.
11. Raisz LG (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115: 3318-3325.
12. Laudet V, Gronemeyer H (2002) The nuclear receptor factbook. Academic press: San Diego.
13. Giguère V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20: 689-725.
14. Giguère V, Yang N, Segui P, Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331: 91-94.
15. Tremblay AM, Giguère V (2007) The NR3B subgroup: an ovERRview. Nucl Recept Signal 5: e009.
16. Horard B, Vanacker JM (2003) Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J Mol Endocrinol 31: 349-357.
17. Bonnelye E, Vanacker JM, Spruyt N, Alric S, Fournier B, et al. (1997) Expression of the estrogen related receptor 1 (ERR-1) orphan receptor during mouse development. Mech Dev 65: 71-85.
18. Giguère V (2008) Transcriptional control of energy homeostasis by the estrogen related receptors. Endocr Rev 29: 677-696.
19. Villena JA, Kralli A (2008) ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab 19: 269-76.
20. Ariazi EA, Jordan VC (2006) Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem 6: 203-215.
21. Bianco S, Lanvin O, Tribollet V, Macari C, North S, et al. (2009) Modulating ERRalpha activity inhibits cell proliferation. J Biol Chem 284: 23286-23292.
22. Bonnelye E, Vanacker JM, Dittmar T, Begue A, Desbiens X, et al. (1997) The ERR-1 orphan receptor is a transcriptional activator expressed during bone development. Mol Endocrinol 11: 905-916.
23. Laflamme N, Giroux S, Loredo-Osti JC, Elfassihi L, Dodin S, et al. (2005) A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. J Bone Miner Res 20: 938-944.
24. Reinholt FP, Hultenby K, Oldberg A, Heingard D (1990) Osteopontin, a possible anchor of osteoblasts to bone. Proc Natl Acad Sci USA 87: 4473-4475.
25. Ross FP, Chappel J, Alvarez JI, Sander D, Buttler WT, et al. (1993) Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin avb3 potentiate bone resorption. J Biol Chem 268: 9901-9907.
26. Ishijima M, Rittling SR, Yamashite T, Tsuji K, Kurosawa H, et al. (2001) Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med 193: 399-404.
27. Noda M, Denhardt DT (2002) Osteopontin. In: Bilezikian JP, Raisz LG, Rodan GA, eds. Principle of bone biology, 2nd ed. San Diego: Academic Press, vol1, pp 239-250.
28. Boskey AL, Spevak L, Paschalis E, Doty SD, McKee MD (2002) Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcif Tissue Int 71: 145-154.
29. Shapses SA, Cifuentes M, Spevak L, Chowdury H, Brittingham J, et al. (2003) Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency. Calcif Tissue Int 73: 86-92.
30. Kavukcuoglu NB, Denhardt DT, Guzelsu N, Mann AB (2007) Osteopontin deficiency and aging on nanomechanics of mouse bone. J Biomed Mater Res A 83: 136-144.
31. Vanacker JM, Delmarre C, Guo X, Laudet V (1998) Activation of the osteopontin promoter by the orphan nuclear receptor estrogen receptor related alpha. Cell Growth Differ 9: 1007-1014.
32. Vanacker JM, Pettersson K, Gustafsson JA, Laudet V (1999) Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta. EMBO J 18: 4270-9.
33. Zirngibl RA, Chan JS, Aubin JE (2008) Estrogen receptor-related receptor alpha (ERRalpha) regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner. J Mol Endocrinol 40: 61-73.
34. Bonnelye B, Merdad L, Kung V, Aubin JE (2001) The orphan nuclear estrogen receptor-related receptor α (ERRα) is expressed throughout osteoblast differentiation and regulates bone formation in vitro. J Cell Biol 153: 971-983.
35. Delhon I, Gutzwiller S, Morvan F, Rangwala S, Wyder L, et al. (2009) Absence of estrogen receptor related alpha increases osteoblastic differentiation and cancellous bone mineral density. Endocrinology 150: 4463-4472.
36. Jeong BC, Lee YS, Park YY, Bae ICH, Kim DK, et al. (2009) The orphan nuclear receptor Estrogen-receptor-Related Receptor γ negatively regulates BMP2-induced osteoblast differentiation and bone formation. J Biol Chem 284: 14211-14218.
37. Yoshitake H, Rittling SR, Denhardt DT, Noda M (1999) Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci USA 96: 8156-8160.
38. Luo J, Sladek R, Carrier J, Bader JA, Richard D, et al. (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α. Mol Cell Biol 23: 7947-7956.
39. Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, et al. (2004) The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1a (PGC1α)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101: 6472-6477.