Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

Molecular and Cellular Endocrinology

Volumn 315, Issue 1-2, 2010, Pages 159-167

  Connaughton, Sara ^a   Chowdhury, Farhana ^a   Attia, Ramy R ^a   Song, Shulan ^a   Zhang, Yi ^a   Elam, Marshall B ^a,b   Cook, George A ^a   Park, Edwards A ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Glucocorticoids; Insulin; Pyruvate dehydrogenase kinase (PDK4)

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INSULIN; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE 4; TRANSCRIPTION FACTOR FKHR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; HORMONE ACTION; HORMONE RESPONSE; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; RAT; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; INSULIN; ISOENZYMES; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PROTEIN KINASES; RATS; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RESPONSE ELEMENTS; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 71849109938     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.08.011     Document Type: Article

References (56)

1. Accili D., and Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117 (2004) 421-426
2. Araki M., and Motojima K. Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle. FEBS J. 273 (2006) 1669-1680
3. Barthel A., Schmoll D., and Unterman T.G. FoxO proteins in insulin action and metabolism. Trends Endocrinol. Metab. 16 (2005) 183-189
4. Boustead J.N., Stadelmaier B.T., Eeds A.M., Wiebe P.O., Svitek C.A., Oeser J.K., and O'Brien R.M. Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells. Biochem. J. 369 (2003) 17-22
5. Chakravarty K., Wu S.Y., Chiang C.M., Samols D., and Hanson R.W. SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. J. Biol. Chem. 279 (2004) 15385-15395
6. Chakravarty K., Cassuto H., Reshef L., and Hanson R.W. Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C. Crit. Rev. Biochem. Mol. Biol. 40 (2005) 129-154
7. Crabb D.W., Yount E.A., and Harris R.A. The metabolic effects of dichloroacetate. Metabolism 30 (1981) 1024-1039
8. Dentin R., Liu Y., Koo S.H., Hedrick S., Vargas T., Heredia J., Yates III J., and Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449 (2007) 366-369
9. Dong X., Park S., Lin X., Copps K., Yi X., and White M.F. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J. Clin. Invest. 116 (2006) 101-114
10. Dufour C.R., Wilson B.J., Huss J.M., Kelly D.P., Alaynick W.A., Downes M., Evans R.M., Blanchette M., and Giguere V. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab. 5 (2007) 345-356
11. Duong D.T., Waltner-Law M.E., Sears R., Sealy L., and Granner D.K. Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem. 277 (2002) 32234-32242
12. Furuyama T., Kitayama K., Yamashita H., and Mori N. Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem. J. 375 (2003) 365-371
13. Gaillard S., Grasfeder L.L., Haeffele C.L., Lobenhofer E.K., Chu T.M., Wolfinger R., Kazmin D., Koves T.R., Muoio D.M., Chang C.Y., and McDonnell D.P. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol. Cell 24 (2006) 797-803
14. Hall R.K., Wang X.L., George L., Koch S.R., and Granner D.K. Insulin represses PEPCK gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect. Mol. Endocrinol. (2006)
15. Harris R.A., Huang B., and Wu P. Control of pyruvate dehydrogenase kinase gene expression. Adv. Enzyme Regul. 41 (2001) 269-288
16. Harris R.A., Bowker-Kinley M.M., Huang B., and Wu P. Regulation of the activity of the pyruvate dehydrogenase complex. Adv. Enzyme Regul. 42 (2002) 249-259
17. Heard D.J., Norby P.L., Holloway J., and Vissing H. Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol. Endocrinol. 14 (2000) 382-392
18. Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., Spiegelman B., and Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413 (2001) 179-183
19. Herzog B., Hall R.K., Wang X.L., Waltner-Law M., and Granner D.K. Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression. Mol Endocrinol. 18 (2004) 807-819
20. Holness M.J., Smith N.D., Bulmer K., Hopkins T., Gibbons G.F., and Sugden M.C. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Biochem. J. 364 (2002) 687-694
21. Holness M.J., Bulmer K., Smith N.D., and Sugden M.C. Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. Biochem. J. 369 (2003) 687-695
22. Horard B., and Vanacker J.M. Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J. Mol. Endocrinol. 31 (2003) 349-357
23. Huang B., Wu P., Bowker-Kinley M.M., and Harris R.A. Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin. Diabetes 51 (2002) 276-283
24. Huss J.M., Kopp R.P., and Kelly D.P. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J. Biol. Chem. 277 (2002) 40265-40274
25. Huss J.M., Torra I.P., Staels B., Giguere V., and Kelly D.P. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol. Cell. Biol. 24 (2004) 9079-9091
26. Jeoung N.H., Wu P., Joshi M.A., Jaskiewicz J., Bock C.B., Depaoli-Roach A.A., and Harris R.A. Role of pyruvate dehydrogenase kinase 4 (PDK4) in glucose homeostasis during starvation. Biochem. J. (2006)
27. Kassel O., and Herrlich P. Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects. Mol. Cell. Endocrinol. 275 (2007) 13-29
28. Kwon H.S., and Harris R.A. Mechanisms responsible for regulation of pyruvate dehydrogenase kinase 4 gene expression. Adv. Enzyme Regul. 44 (2004) 109-121
29. Kwon H.S., Huang B., Unterman T.G., and Harris R.A. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53 (2004) 899-910
30. Li X., Monks B., Ge Q., and Birnbaum M.J. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447 (2007) 1012-1016
31. Lin J., Tarr P.T., Yang R., Rhee J., Puigserver P., Newgard C.B., and Spiegelman B.M. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J. Biol. Chem. 278 (2003) 30843-30848
32. Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., Cui L., Manieri M., Donovan M.X., Wu Z., Cooper M.P., Fan M.C., Rohas L.M., Zavacki A.M., Cinti S., Shulman G.I., Lowell B.B., Krainc D., and Spiegelman B.M. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 (2004) 121-135
33. Ma K., Zhang Y., Elam M.B., Cook G.A., and Park E.A. Cloning of the Rat Pyruvate Dehydrogenase Kinase 4 Gene Promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor {gamma} coactivator. J. Biol. Chem. 280 (2005) 29525-29532
34. Meijsing S.H., Pufall M.A., So A.Y., Bates D.L., Chen L., and Yamamoto K.R. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 324 (2009) 407-410
35. Nakae J., Biggs III W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., and Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32 (2002) 245-253
36. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
37. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., and Spiegelman B.M. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423 (2003) 550-555
38. Rena G., Woods Y.L., Prescott A.R., Peggie M., Unterman T.G., Williams M.R., and Cohen P. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J. 21 (2002) 2263-2271
39. Sadana P., and Park E.A. Characterization of the transactivation domain in the peroxisome proliferator activated receptor gamma coactivator (PGC-1). Biochem. J. (2007)
40. Schoneveld O.J., Gaemers I.C., and Lamers W.H. Mechanisms of glucocorticoid signalling. Biochim. Biophys. Acta 1680 (2004) 114-128
41. Scott D.K., Stromstedt P.E., Wang J.C., and Granner D.K. Further characterization of the glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. The role of the glucocorticoid receptor-binding sites. Mol. Endocrinol. 12 (1998) 482-491
42. Sugden M.C., and Holness M.J. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr. Drug Targets Immune Endocr. Metab. Disord. 2 (2002) 151-165
43. Sugden M.C., and Holness M.J. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E855-E862
44. Sugden M.C., Bulmer K., Gibbons G.F., Knight B.L., and Holness M.J. Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin. Biochem. J. 364 (2002) 361-368
45. Vander Kooi B.T., Streeper R.S., Svitek C.A., Oeser J.K., Powell D.R., and O'Brien R.M. The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct. J. Biol. Chem. 278 (2003) 11782-11793
46. Vega R.B., Huss J.M., and Kelly D.P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20 (2000) 1868-1876
47. Wang J.C., Stromstedt P.E., Sugiyama T., and Granner D.K. The phosphoenolpyruvate carboxykinase gene glucocorticoid response unit: identification of the functional domains of accessory factors HNF3 beta (hepatic nuclear factor-3 beta) and HNF4 and the necessity of proper alignment of their cognate binding sites. Mol. Endocrinol. 13 (1999) 604-618
48. Wende A.R., Huss J.M., Schaeffer P.J., Giguere V., and Kelly D.P. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol. 25 (2005) 10684-10694
49. White U.A., Coulter A.A., Miles T.K., and Stephens J.M. The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes. Diabetes 56 (2007) 1623-1629
50. Wu P., Blair P.V., Sato J., Jaskiewicz J., Popov K.M., and Harris R.A. Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch. Biochem. Biophys. 381 (2000) 1-7
51. Wu P., Peters J.M., and Harris R.A. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. Biochem. Biophys. Res. Commun. 287 (2001) 391-396
52. Yamada K., Duong D.T., Scott D.K., Wang J.C., and Granner D.K. CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem. 274 (1999) 5880-5887
53. Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., Newgard C.B., and Spiegelman B.M. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413 (2001) 131-138
54. Zhang X., Gan L., Pan H., Guo S., He X., Olson S.T., Mesecar A., Adam S., and Unterman T.G. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277 (2002) 45276-45284
55. Zhang Y., Ma K., Sadana P., Chowdhury F., Gaillard S., Wang F., McDonnell D.P., Unterman T.G., Elam M.B., and Park E.A. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J. Biol. Chem. 281 (2006) 39897-39906
56. Zhang W., Patil S., Chauhan B., Guo S., Powell D.R., Le J., Klotsas A., Matika R., Xiao X., Franks R., Heidenreich K.A., Sajan M.P., Farese R.V., Stolz D.B., Tso P., Koo S.H., Montminy M., and Unterman T.G. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281 (2006) 10105-10117