메뉴 건너뛰기




Volumn 24, Issue 12, 2010, Pages 4648-4659

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: Role of angiopoietin-like 4

Author keywords

Differentiation; Osteoblast; Osteoclastogenesis; Pathological bone resorption; Proliferation

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE 4; DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR; MIMOSINE; UNCLASSIFIED DRUG;

EID: 78649722176     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-162230     Document Type: Article
Times cited : (106)

References (64)
  • 2
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick, R. K., and McKnight, S. L. (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 3
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris, A. L. (2002) Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2, 38-47
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 6
    • 73849108257 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development
    • Shomento, S. H., Wan, C., Cao, X., Faugere, M. C., Bouxsein, M. L., Clemens, T. L., and Riddle, R. C. (2010) Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development. J. Cell. Biochem. 109, 196-204
    • (2010) J. Cell. Biochem. , vol.109 , pp. 196-204
    • Shomento, S.H.1    Wan, C.2    Cao, X.3    Faugere, M.C.4    Bouxsein, M.L.5    Clemens, T.L.6    Riddle, R.C.7
  • 8
    • 34247259929 scopus 로고    scopus 로고
    • Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1α deficiency
    • Komatsu, D. E., Bosch-Marce, M., Semenza, G. L., and Hadjiargyrou, M. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1α deficiency. J. Bone Miner. Res. 22, 366-374
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 366-374
    • Komatsu, D.E.1    Bosch-Marce, M.2    Semenza, G.L.3    Hadjiargyrou, M.4
  • 9
    • 66849097919 scopus 로고    scopus 로고
    • Acute hypoxia and osteoclast activity: A balance between enhanced resorption and increased apoptosis
    • Knowles, H. J., and Athanasou, N. A. (2009) Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis. J. Pathol. 218, 256-264
    • (2009) J. Pathol. , vol.218 , pp. 256-264
    • Knowles, H.J.1    Athanasou, N.A.2
  • 11
    • 33845385925 scopus 로고    scopus 로고
    • Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat
    • Muzylak, M., Price, J. S., and Horton, M. A. (2006) Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat. Calcif. Tissue Int. 79, 301-309
    • (2006) Calcif. Tissue Int. , vol.79 , pp. 301-309
    • Muzylak, M.1    Price, J.S.2    Horton, M.A.3
  • 13
    • 0034666157 scopus 로고    scopus 로고
    • Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    • Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., and Wahli, W. (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 275, 28488-28493
    • (2000) J. Biol. Chem. , vol.275 , pp. 28488-28493
    • Kersten, S.1    Mandard, S.2    Tan, N.S.3    Escher, P.4    Metzger, D.5    Chambon, P.6    Gonzalez, F.J.7    Desvergne, B.8    Wahli, W.9
  • 14
    • 0343060983 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
    • Yoon, J. C., Chickering, T. W., Rosen, E. D., Dussault, B., Qin, Y. B., Soukas, A., Friedman, J. M., Holmes, W. E., and Spiegelman, B. M. (2000) Peroxisome proliferator-activated receptor γ target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol. Cell. Biol. 20, 5343-5349
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5343-5349
    • Yoon, J.C.1    Chickering, T.W.2    Rosen, E.D.3    Dussault, B.4    Qin, Y.B.5    Soukas, A.6    Friedman, J.M.7    Holmes, W.E.8    Spiegelman, B.M.9
  • 15
    • 0034654426 scopus 로고    scopus 로고
    • Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
    • Kim, I., Kim, H. G., Kim, H., Kim, H. H., Park, S. K., Uhm, C. S., Lee, Z. H., and Koh, G. Y. (2000) Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem. J. 346, 603-610
    • (2000) Biochem. J. , vol.346 , pp. 603-610
    • Kim, I.1    Kim, H.G.2    Kim, H.3    Kim, H.H.4    Park, S.K.5    Uhm, C.S.6    Lee, Z.H.7    Koh, G.Y.8
  • 16
    • 4544274752 scopus 로고    scopus 로고
    • The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    • Mandard, S., Zandbergen, F., Tan, N. S., Escher, P., Patsouris, D., Koenig, W., Kleemann, R., Bakker, A., Veenman, F., Wahli, W., Muller, M., and Kersten, S. (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J. Biol. Chem. 279, 34411-34420
    • (2004) J. Biol. Chem. , vol.279 , pp. 34411-34420
    • Mandard, S.1    Zandbergen, F.2    Tan, N.S.3    Escher, P.4    Patsouris, D.5    Koenig, W.6    Kleemann, R.7    Bakker, A.8    Veenman, F.9    Wahli, W.10    Muller, M.11    Kersten, S.12
  • 17
    • 0036660804 scopus 로고    scopus 로고
    • Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: Role of hypoxia inducible factor 1 α
    • Belanger, A. J., Lu, H. W., Date, L., Liu, L. X., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., and Jiang, C. W. (2002) Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1 α. J. Mol. Cell. Cardiol. 34, 765-774
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 765-774
    • Belanger, A.J.1    Lu, H.W.2    Date, L.3    Liu, L.X.4    Vincent, K.A.5    Akita, G.Y.6    Cheng, S.H.7    Gregory, R.J.8    Jiang, C.W.9
  • 18
    • 44749093281 scopus 로고    scopus 로고
    • The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
    • Warnecke, C., Weidemann, A., Volke, M., Schietke, R., Wu, X. Q., Knaup, K. X., Hackenbeck, T., Bernhardt, W., Willam, C., Eckardt, K. U., and Wiesener, M. S. (2008) The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp. Cell Res. 314, 2016-2027
    • (2008) Exp. Cell Res. , vol.314 , pp. 2016-2027
    • Warnecke, C.1    Weidemann, A.2    Volke, M.3    Schietke, R.4    Wu, X.Q.5    Knaup, K.X.6    Hackenbeck, T.7    Bernhardt, W.8    Willam, C.9    Eckardt, K.U.10    Wiesener, M.S.11
  • 19
    • 35448934913 scopus 로고    scopus 로고
    • Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    • DOI 10.1007/s00424-007-0301-8
    • Wang, B., Wood, I. S., and Trayhurn, P. (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflügers Arch. 455, 479-492 (Pubitemid 47624196)
    • (2007) Pflugers Archiv European Journal of Physiology , vol.455 , Issue.3 , pp. 479-492
    • Wang, B.1    Wood, I.S.2    Trayhurn, P.3
  • 21
    • 58149215819 scopus 로고    scopus 로고
    • Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: Role of angiopoietin-like-4 in the expression of matrix metalloproteinases and cartilage degradation
    • Murata, M., Yudo, K., Nakamura, H., Chiba, J., Okamoto, K., Suematsu, N., Nishioka, K., Beppu, M., Inoue, K., Kato, T., and Masuko, K. (2009) Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: role of angiopoietin-like-4 in the expression of matrix metalloproteinases and cartilage degradation. J. Orthop. Res. 27, 50-57
    • (2009) J. Orthop. Res. , vol.27 , pp. 50-57
    • Murata, M.1    Yudo, K.2    Nakamura, H.3    Chiba, J.4    Okamoto, K.5    Suematsu, N.6    Nishioka, K.7    Beppu, M.8    Inoue, K.9    Kato, T.10    Masuko, K.11
  • 22
    • 0026570044 scopus 로고
    • Phenotypic characterisation of mononuclear and multinucleated cells of giant cell tumour of bone
    • Joyner, C. J., Quinn, J. M., Triffitt, J. T., Owen, M. E., and Athanasou, N. A. (1992) Phenotypic characterisation of mononuclear and multinucleated cells of giant cell tumour of bone. Bone Miner. 16, 37-48
    • (1992) Bone Miner. , vol.16 , pp. 37-48
    • Joyner, C.J.1    Quinn, J.M.2    Triffitt, J.T.3    Owen, M.E.4    Athanasou, N.A.5
  • 23
    • 24344444472 scopus 로고    scopus 로고
    • Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue
    • Lau, Y. S., Sabokbar, A., Gibbons, C. L., Giele, H., and Athanasou, N. (2005) Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. Hum. Pathol. 36, 945-954
    • (2005) Hum. Pathol. , vol.36 , pp. 945-954
    • Lau, Y.S.1    Sabokbar, A.2    Gibbons, C.L.3    Giele, H.4    Athanasou, N.5
  • 26
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V. G., Tibshirani, R., and Chu, G. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98, 5116-5121
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 27
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia
    • Sowter, H. M., Raval, R. R., Moore, J. W., Ratcliffe, P. J., and Harris, A. L. (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130-6134
    • (2003) Cancer Res. , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 28
    • 2342559147 scopus 로고    scopus 로고
    • An alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction
    • Gregory, C. A., Gunn, W. G., Peister, A., and Prockop, D. J. (2004) An alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal. Biochem. 329, 77-84
    • (2004) Anal. Biochem. , vol.329 , pp. 77-84
    • Gregory, C.A.1    Gunn, W.G.2    Peister, A.3    Prockop, D.J.4
  • 30
    • 42949153257 scopus 로고    scopus 로고
    • Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
    • Knowles, H. J., and Athanasou, N. A. (2008) Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF. J. Pathol. 215, 56-66
    • (2008) J. Pathol. , vol.215 , pp. 56-66
    • Knowles, H.J.1    Athanasou, N.A.2
  • 32
    • 56449120476 scopus 로고    scopus 로고
    • Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation
    • Patntirapong, S., Habibovic, P., and Hauschka, P. V. (2009) Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation. Biomaterials 30, 548-555
    • (2009) Biomaterials , vol.30 , pp. 548-555
    • Patntirapong, S.1    Habibovic, P.2    Hauschka, P.V.3
  • 35
    • 33751341522 scopus 로고    scopus 로고
    • Extracellular matrix-bound angiopoietinlike 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
    • Cazes, A., Galaup, A., Chomel, C., Bignon, M., Brechot, N., Le Jan, S., Weber, H., Corvol, P., Muller, L., Germain, S., and Monnot, C. (2006) Extracellular matrix-bound angiopoietinlike 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ. Res. 99, 1207-1215
    • (2006) Circ. Res. , vol.99 , pp. 1207-1215
    • Cazes, A.1    Galaup, A.2    Chomel, C.3    Bignon, M.4    Brechot, N.5    Le Jan, S.6    Weber, H.7    Corvol, P.8    Muller, L.9    Germain, S.10    Monnot, C.11
  • 36
    • 61449185483 scopus 로고    scopus 로고
    • Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity
    • Chomel, C., Cazes, A., Faye, C., Bignon, M., Gomez, E., Ardidie- Robouant, C., Barret, A., Ricard-Blum, S., Muller, L., Germain, S., and Monnot, C. (2009) Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity. FASEB J. 23, 940-949
    • (2009) FASEB J. , vol.23 , pp. 940-949
    • Chomel, C.1    Cazes, A.2    Faye, C.3    Bignon, M.4    Gomez, E.5    Ardidie-Robouant, C.6    Barret, A.7    Ricard-Blum, S.8    Muller, L.9    Germain, S.10    Monnot, C.11
  • 41
    • 34249791173 scopus 로고    scopus 로고
    • Regulation and enzymatic basis of bone resorption by human osteoclasts
    • Fuller, K., Kirstein, B., and Chambers, T. J. (2007) Regulation and enzymatic basis of bone resorption by human osteoclasts. Clin. Sci. 112, 567-575
    • (2007) Clin. Sci. , vol.112 , pp. 567-575
    • Fuller, K.1    Kirstein, B.2    Chambers, T.J.3
  • 42
    • 42149108104 scopus 로고    scopus 로고
    • Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. Arterioscler
    • Yang, Y. H., Wang, Y., Lam, K. S., Yau, M. H., Cheng, K. K., Zhang, J., Zhu, W., Wu, D., and Xu, A. (2008) Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. Arterioscler. Thrombosis Vasc. Biol. 28, 835-840
    • (2008) Thrombosis Vasc. Biol. , vol.28 , pp. 835-840
    • Yang, Y.H.1    Wang, Y.2    Lam, K.S.3    Yau, M.H.4    Cheng, K.K.5    Zhang, J.6    Zhu, W.7    Wu, D.8    Xu, A.9
  • 44
    • 38149050613 scopus 로고    scopus 로고
    • The role of angiopoietin-like proteins in angiogenesis and metabolism
    • Hato, T., Tabata, M., and Oike, Y. (2008) The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc. Med. 18, 6-14
    • (2008) Trends Cardiovasc. Med. , vol.18 , pp. 6-14
    • Hato, T.1    Tabata, M.2    Oike, Y.3
  • 45
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbaum, S. L., and Ross, F. P. (2003) Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4, 638-649
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 46
    • 0032737614 scopus 로고    scopus 로고
    • The developmental control of osteoblast- Specific gene expression: Role of specific transcription factors and the extracellular matrix environment
    • Franceschi, R. T. (1999) The developmental control of osteoblast- specific gene expression: role of specific transcription factors and the extracellular matrix environment. Crit. Rev. Oral Biol. Med. 10, 40-57
    • (1999) Crit. Rev. Oral Biol. Med. , vol.10 , pp. 40-57
    • Franceschi, R.T.1
  • 49
    • 32644454369 scopus 로고    scopus 로고
    • The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    • Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Muller, M., and Kersten, S. (2006) The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem. 281, 21575-21575
    • (2006) J. Biol. Chem. , vol.281 , pp. 21575-21575
    • Mandard, S.1    Zandbergen, F.2    Van Straten, E.3    Wahli, W.4    Kuipers, F.5    Muller, M.6    Kersten, S.7
  • 51
    • 33645529346 scopus 로고    scopus 로고
    • Genetics and regulation of angiopoietin-like proteins 3 and 4
    • Li, C. (2006) Genetics and regulation of angiopoietin-like proteins 3 and 4. Curr. Opin. Lipidol. 17, 152-156
    • (2006) Curr. Opin. Lipidol. , vol.17 , pp. 152-156
    • Li, C.1
  • 52
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin - Implications for metabolic regulation and bioactivity
    • Pajvani, U. B., Du, X. L., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., and Scherer, P. E. (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin - Implications for metabolic regulation and bioactivity. J. Biol. Chem. 278, 9073-9085
    • (2003) J. Biol. Chem. , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.L.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6    Engel, J.7    Brownlee, M.8    Scherer, P.E.9
  • 53
    • 2442707674 scopus 로고    scopus 로고
    • Disulfide-dependent multimeric assembly of resistin family hormones
    • Patel, S. D., Rajala, M. W., Rossetti, L., Scherer, P. E., and Shapiro, L. (2004) Disulfide-dependent multimeric assembly of resistin family hormones. Science 304, 1154-1158
    • (2004) Science , vol.304 , pp. 1154-1158
    • Patel, S.D.1    Rajala, M.W.2    Rossetti, L.3    Scherer, P.E.4    Shapiro, L.5
  • 54
    • 0024404853 scopus 로고
    • IL-6 inhibits lipopolysaccharide-induced tumour necrosis factor production in human monocytes, U937 cells, and in mice
    • Aderka, D., Le, J. M., and Vilcek, J. (1989) IL-6 inhibits lipopolysaccharide-induced tumour necrosis factor production in human monocytes, U937 cells, and in mice. J. Immunol. 143, 3517-3523
    • (1989) J. Immunol. , vol.143 , pp. 3517-3523
    • Aderka, D.1    Le, J.M.2    Vilcek, J.3
  • 56
    • 63649146266 scopus 로고    scopus 로고
    • Canonical and non-canonical pathways of osteoclast formation
    • Knowles, H. J., and Athanasou, N. A. (2009) Canonical and non-canonical pathways of osteoclast formation. Histol. Histopathol. 24, 337-346
    • (2009) Histol. Histopathol. , vol.24 , pp. 337-346
    • Knowles, H.J.1    Athanasou, N.A.2
  • 58
    • 43149099312 scopus 로고    scopus 로고
    • Resistin, an adipocytokine, stimulates osteoblast and osteoclast proliferation
    • Cornish, J., Callon, K. E., Watson, M., Lin, J. M., and Reid, I. R. (2006) Resistin, an adipocytokine, stimulates osteoblast and osteoclast proliferation. Bone 38, S9-S9
    • (2006) Bone , vol.38
    • Cornish, J.1    Callon, K.E.2    Watson, M.3    Lin, J.M.4    Reid, I.R.5
  • 61
    • 33749244468 scopus 로고    scopus 로고
    • Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway
    • Luo, X. H., Guo, L. J., Xie, H., Yuan, L. Q., Wu, X. P., Zhou, H. D., and Liao, E. Y. (2006) Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J. Bone Miner. Res. 21, 1648-1656
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 1648-1656
    • Luo, X.H.1    Guo, L.J.2    Xie, H.3    Yuan, L.Q.4    Wu, X.P.5    Zhou, H.D.6    Liao, E.Y.7
  • 62
    • 43149117061 scopus 로고    scopus 로고
    • Relationships between fat and bone
    • Reid, I. R. (2008) Relationships between fat and bone. Osteoporos. Int. 19, 595-606
    • (2008) Osteoporos. Int. , vol.19 , pp. 595-606
    • Reid, I.R.1
  • 63
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-γ regulates osteoclastogenesis in mice
    • Wan, Y. H., Chong, L. W., and Evans, R. M. (2007) PPAR-γ regulates osteoclastogenesis in mice. Nat. Med. 13, 1496-1503
    • (2007) Nat. Med. , vol.13 , pp. 1496-1503
    • Wan, Y.H.1    Chong, L.W.2    Evans, R.M.3
  • 64
    • 37749034527 scopus 로고    scopus 로고
    • Skeletal consequences of thiazolidinedione therapy
    • Grey, A. (2008) Skeletal consequences of thiazolidinedione therapy. Osteoporos. Int. 19, 129-137
    • (2008) Osteoporos. Int. , vol.19 , pp. 129-137
    • Grey, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.