Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes

Drug Metabolism and Disposition

Volumn 30, Issue 12, 2002, Pages 1446-1454

  Lau, Yau Yi ^a   Sapidou, Elpida ^a   Cui, Xiaoming ^a   White, Ronald E ^a   Cheng, K C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CHLORPROTHIXENE; DESIPRAMINE; DIAZEPAM; DILTIAZEM; FUROSEMIDE; IBUPROFEN; IMIPRAMINE; LORAZEPAM; METHYLPREDNISOLONE; MIDAZOLAM; NALOXONE; NIFEDIPINE; OXAZEPAM; PHENAZONE; PREDNISOLONE; PROPRANOLOL; SILDENAFIL; SULPIRIDE; TENOXICAM; TERBUTALINE; THEOPHYLLINE; TOLBUTAMIDE; VERAPAMIL; WARFARIN;

ANIMAL CELL; ARTICLE; CRYOPRESERVATION; DOG; HUMAN; HUMAN CELL; LIVER CELL; LIVER CLEARANCE; MODEL; MONKEY; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; CULTURE TECHNIQUE; CYTOLOGY; MACACA; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PHYSIOLOGY; RAT;

ANIMALIA; CANIS FAMILIARIS;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CRYOPRESERVATION; DOGS; HEPATOCYTES; HUMANS; MACACA FASCICULARIS; METABOLIC CLEARANCE RATE; RATS;

EID: 0036893242     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.12.1446     Document Type: Article

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